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Publications (5)2.42 Total impact

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    ABSTRACT: Type 2 diabetes is now the most rapidly growing form of diabetes and has become increasingly common among children. This paper presents our work of implementing an individualized real time predictive system for blood glucose in type 2 diabetes in an iPhone application. The developed application, called HealthiManage, provides relevant feedback to patients at each glucose input reading comparing the measured and predicted readings, facilitating improved self-management of the disease. The application incorporates activity recognition via a built-in accelerometer on the iPhone, which monitors any physical activity and adjusts predictions accordingly. Also, a reward component interface was incorporated that is intended to enhance patient compliance and encourage mainly teenagers to take control and improve their blood glucose regulation. The individualized prediction algorithm was tested and verified with real patient data. Different physical activities were also examined and classified for an accurate activity recognition component. The designed application with its predictive model, activity recognition, and other elements provide what we believe to be helpful feedback to monitor and manage type 2 diabetes and improve patient compliance.
    01/2011;
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    ABSTRACT: To review the effectiveness and safety of surgical intervention for obstructive sleep apnea in Prader-Willi syndrome. The muscle hypotonia and obesity associated with Prader-Willi syndrome (PWS) result in a high rate of obstructive sleep apnea (OSA). The use of growth hormone therapy in these patients has been associated with sudden death, raising concerns that such treatment may exacerbate obstructive sleep apnea. As a result, it has been suggested that children with PWS be evaluated for OSA and indications for adenotonsillectomy prior to instituting growth hormone therapy. The true effectiveness of surgical intervention in these cases, however, remains in doubt. Retrospective review of patients with a diagnosis of PWS who underwent adenoidectomy or adenotonsillectomy from January 2001 to July 2009 at a regional, tertiary care children's hospital. Patients underwent pre-operative and post-operative polysomnography. Differences between pre-operative and post-operative body-mass index (BMI), apnea-hypopnea index (AHI), and median oxygen saturation and oxygen saturation nadir were analyzed. Five patients were identified during the study period. Three patients underwent adenotonsillectomy, 1 patient adenoidectomy alone, and another adenotonsillectomy with uvulopalatopharyngoplasty (UPPP). While median AHI was found to have decreased from 16.4 to 4.4, no statistically significant change could be demonstrated (p=0.274). Mean O(2) and nadir O(2) saturation also improved, but without reaching statistical significance. No intra-operative complications were noted. Our series, and other small case series, have demonstrated that complete resolution of sleep apnea in PWS patients is difficult to obtain with upper airway surgery alone. It is suggested that children with PWS being considered for growth hormone therapy undergo assessment for OSA by polysomnography. Patients identified with OSA should be referred for management by tonsillectomy and/or continuous positive airway pressure (CPAP) and then reassessed for residual airway obstruction prior to instituting hormonal therapy.
    International journal of pediatric otorhinolaryngology 09/2010; 74(11):1270-2. · 0.85 Impact Factor
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    Bin Wang, Hui Hu, Ayodeji Demuren, Eric Gyuricsko
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    ABSTRACT: In recent years, there is a surge in the popularity of using insulin pump or continuous subcutaneous insulin infusion (CSII) therapy, as opposed to multiple daily injections (MDI) by insulin syringe or an insulin pen. Some case studies have suggested that insulin delivery failure may be caused by the precipitation of insulin within the infusion set. Speculation also exists that the flow of insulin through an insulin infusion set may be reduced or inhibited by air bubbles entrained into the micro-sized capillary tubing system since there are chances that air be introduced into the insulin reservoir during the filling process. In the present study, an experimental study was conducted to investigate the pulsed microflow inside the micro-sized infusion tubing system driven by an insulin pump. A microscopic Particle Image Velocimtry (micro-PIV) system was used to conduct detailed flow velocity field measurements to characterize the transient behavior of the pulsed micro-flows inside the micro-sized tubing system of an insulin infusion set with an insulin pump operating in basal mode (i.e., pulsed insulin pumping). The effects of the air bubbles entrained into the micro-sized capillary tubing system on the insulin delivery process were also assessed based on the micro-PIV measurements.
    01/2010;
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    Bin Wang, Ayodeji Demuren, Eric Gyuricsko, Hui Hu
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    ABSTRACT: An experimental study was conducted to investigate the unsteady micro-flow driven by an insulin pump commonly used in continuous subcutaneous insulin infusion (CSII) therapy. A microscopic particle image velocimetry (PIV) system was used to characterize the transient behavior of the micro-flow upon the pulsed excitation of the insulin pump in order to elucidate the underlying physics for a better understanding of the microphysical process associated with the insulin delivery in CSII therapy. The effects of air bubbles entrained inside the micro-sized CSII tubing system on the insulin delivery process were also assessed based on the micro-PIV measurements. While most solutions to insulin occlusion-related problems are currently based on clinical trials, the findings derived from the present study can be used to provide a better guidance for the troubleshooting of insulin occlusion in CSII therapy.
    Experiments in Fluids 01/2010; 51(1):65-74. · 1.57 Impact Factor
  • Bing Wang, Ayodeji Demuren, Eric Gyuricsko, Hui Hu
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    ABSTRACT: In recent years, there is a surge in the popularity of using insulin pump or continuous subcutaneous insulin infusion therapy, as opposed to multiple daily injections by insulin syringe or an insulin pen. Some case studies have suggested that insulin delivery failure may be caused by precipitation of insulin within the infusion set. Speculation also exists that the flow of insulin through an insulin infusion set may be reduced or inhibited by air bubbles entrained into the micro-sized tubing system since there are chances that air be introduced into the insulin reservoir during the filling process. In the present study, a microscopic Particle Image Velocimtry (micro-PIV) system was used to characterize the transient behavior of the pulsed micro-flows inside the micro-sized tubing system of an insulin infusion set with insulin pump operating in basal mode (i.e., pulsed insulin pumping). The effects of the air bubbles entrained into the micro-sized tubing system on the insulin delivery process were assessed based on the micro-PIV measurements.
    11/2009;