D T Manallack

Publications (4)7.66 Total impact

• Article: Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors.

  A D Baxter, R Bhogal, J Bird, J F Keily, D T Manallack, J G Montana, D A Owen, W R Pitt, R J Watson, R E Wills
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  ABSTRACT: A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer.
  Bioorganic & Medicinal Chemistry Letters 07/2001; 11(11):1465-8. · 2.55 Impact Factor
• Article: Theoretical hydrogen bonding parameters for drug design.

  E Gancia, J G Montana, D T Manallack
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  ABSTRACT: Hydrogen bonding interactions play a major role in many chemical and biological processes. This article describes the development of a method for the quantitative estimation of the hydrogen-bonding donor strengths of OH/NH moieties and of the hydrogen bonding acceptor strengths of O/N atoms in different chemical structures. The method is based on the correlation of experimentally observed hydrogen-bonding strengths with quantum-mechanical derived properties, calculated on the acceptor atom (for hydrogen-bond acceptors) and on the heavy atom attached to the donor hydrogen (for hydrogen-bond donors). The properties giving the best correlation with the experimental hydrogen bonding scales were electrophilic superdelocalizability and self-atom polarizability. The best equations found have been implemented in a Web-based tool for hydrogen-bond strength prediction.
  Journal of Molecular Graphics and Modelling 02/2001; 19(3-4):349-62. · 2.18 Impact Factor
• Article: ChemInform Abstract: Arylsulfonyl Hydroxamic Acids: Potent and Selective Matrix Metalloproteinase Inhibitors.

  A D Baxter, R Bhogal, J Bird, J F Keily, D T Manallack, J G Montana, D A Owen, W R Pitt, R J Watson, R E Wills
  ChemInform 01/2001; 32(37):no-no.
• Article: The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x).

  P V Murphy, R E Hubbard, D T Manallack, R E Wills, J G Montana, R J Taylor
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  ABSTRACT: The design and synthesis of a series of analogues of sialyl Lewis(x)(1) which incorporate conformationally rigid tetralin and naphthalene ring systems(2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion.
  Bioorganic & Medicinal Chemistry 01/1999; 6(12):2421-39. · 2.92 Impact Factor