Deniz Sagdic

Izmir Katip Celebi Universitesi, Temnos, İzmir, Turkey

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Publications (14)12.63 Total impact

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    ABSTRACT: The purpose of this study was to evaluate the effects of rapid maxillary expansion on nasal cavity volume by using 3-dimensional simulation and modeling programs. The study group consisted of 15 patients (9 boys, 6 girls; mean age, 13.86 years) with maxillary constriction. Computed tomography scans were obtained before treatment and 6 months after the end of expansion. All computed tomography data were transferred to a computer, and the nasal cavity and maxillary teeth were segmented by using the Mimics and Simplant Ortho software programs (both, Materialise, Leuven, Belgium). Paired samples t tests were used to compare pretreatment and posttreatment nasal cavity volumes and maxillary areas. Data analysis was performed by using the software program SPSS for Windows (version 15.00; SPSS, Chicago, Ill). Rapid maxillary expansion treatment induced significant increases in nasal cavity volume (P ≤ 0.001) and maxillary transverse dimensions (P ≤ 0.001). Both anterior-to-posterior and coronal-to-cranial expansions were observed after rapid maxillary expansion treatment, with the direction of expansion most likely affected by resistance from the cranial bones.
    American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 11/2011; 140(5):633-40. · 1.33 Impact Factor
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    ABSTRACT: The aims of this study were to evaluate the effect of an antibacterial monomer-containing self-etching adhesive in reducing enamel demineralization around orthodontic brackets in vivo and to compare it with the conventional adhesive system quantitatively. Fourteen orthodontic patients were randomly divided into 2 equal groups; they received brackets fitted to all their teeth, bonded with either Clearfil Protect Bond (Kuraray Medical, Okayama, Japan) (experimental group) or Transbond XT (3M Unitek, Monrovia, Calif) (control group). Block randomization to obtain equal numbers in each group was used. After 30 days, all first premolars were extracted with orthodontic indications and longitudinally sectioned. Demineralization was assessed by cross-sectional microhardness. Determinations were made at the bracket edge cementing limits and at occlusal and cervical points 100 and 200 μm away from the edge. In all of these positions, 6 indentations were made at depths of 10 to 90 μm from the enamel surface. Analysis of variance (ANOVA) and the Tukey post-hoc test were used. The statistical significance level was set at P <0.05. ANOVA showed statistically significant differences for adhesive type, position, depth, and their interactions (P <0.05). The multiple comparison test showed that the antibacterial monomer-containing adhesive was significantly more efficient than the conventional adhesive system, reducing enamel demineralization in almost all evaluations (P <0.05). The results indicated that using antibacterial monomer-containing adhesive for bonding orthodontic brackets successfully inhibited caries in vivo. This cariostatic effect was localized at the area around the brackets and was significant after 30 days.
    American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 05/2011; 139(5):650-6. · 1.33 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the effects of local resveratrol (RSVL) administration on bone formation in response to expansion of the inter-premaxillary suture, in rats. Twenty 50- to 60-day-old male Wistar rats were separated into two equal groups. Both groups were subjected to expansion, and 30 cN of force was applied to the maxillary incisors with helical-spring. Twenty-four hours after appliance placement, single-dose 10 μmol/kg RSVL in the dimethylsulfoxide (DMSO) was injected to the inter-premaxillary suture in the experimental group. In the control group, the same amount of DMSO was injected to the suture of rats. Bone formation in the suture was evaluated histomorphometrically. The area of new bone (μm(2)), the perimeter around the new bone (μm), Feret's diameter (μm), the percentage of new bone to non-ossified tissue (%), and the number of osteoblast were measured and compared. Mann-Whitney U-test was used for statistical evaluation at p < 0.05 level. Statistically significant differences were found between the groups for all histomorphometric parameters. New bone area (p < 0.001), bone perimeter (p < 0.001), Feret's diameter (p < 0.001), percentage of new bone (p < 0.001), and the number of osteoblast (p < 0.001) were significantly larger in the experimental group when compared with the control. Bone histomorphometric measurements revealed that bone architecture in the RSVL treated rats was improved. Local application of RSVL during the early stages to orthopedically expanded inter-premaxillary suture area may stimulate bone formation and shorten the retention period, in rats.
    Orthodontics and Craniofacial Research 05/2011; 14(2):80-7. · 1.19 Impact Factor
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    ABSTRACT: To test the null hypothesis that there is no significant difference between the chitosan-containing and conventional nonfluoridated dentifrices in inhibition of enamel demineralization around orthodontic brackets. Sixteen orthodontic patients who were scheduled to have extraction of four first premolars for orthodontic reasons were divided into two groups after the power of the study was estimated. Patients in the experimental group were instructed to use chitosan-containing dentifrice (AloeDent), and patients in the control group were instructed to use nonfluoridated dentifrice (Sensodyne Mint). After 60 days, the teeth were extracted and longitudinally sectioned. The demineralization was assessed by cross-sectional microhardness. The determinations were made at the bracket edge cementing limits and at occlusal and cervical points, 100 µm and 200 µm away from the edge. In all these positions, indentations were made at depths of 10, 20, 30, 50, 70, and 90 µm from the enamel surface. Analysis of variance (ANOVA) and Tukey test were used for statistical evaluation at P < .05 level. ANOVA showed statistically significant differences for the factors of dentifrice type, position, and depth (P  =  .000). Statistically significant differences for microhardness values between two tested dentifrices were observed up to 20 µm of depth from the enamel surface (P < .05). Lower microhardness values were found for nonfluoridated dentifrice. Significant microhardness differences were also determined between materials at occlusal and cervical 0 µm positions (P < .05). At these positions, chitosan-containing dentifrice showed lower demineralization than the control. Chitosan-containing dentifrice may reduce the enamel decalcification found in patients with poor oral hygiene. The null hypothesis is rejected.
    The Angle Orthodontist 03/2011; 81(2):319-25. · 1.18 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the in vivo effects of an amorphous calcium phosphate-containing orthodontic composite in reducing enamel demineralization around orthodontic brackets, and to compare it with the control. Fourteen orthodontic patients were divided into two equal groups. They received brackets fitted to all first premolars, bonded with either Aegis Ortho® (The Bosworth Co.), an ACP-containing orthodontic composite (experimental group), or Concise® (3M Dental Products), a resin-based orthodontic composite (control group). After 30 days, the teeth were extracted and longitudinally sectioned, and evaluated by superficial-microhardness analysis. The determinations were made at the bracket edge cementing limits and at occlusal and cervical points 100 and 200 μm away from the edge. In all of these positions, indentations were made at depths of 10, 20, 30, 50, 70, and 90 μm from the enamel surface. Analysis of variance (ANOVA) and Tukey post hoc test was used. The statistical significance level was set at p<0.05. The ANOVA showed statistically significant differences for position, material, depth, and their interactions (p<0.001). The multiple comparison test showed that the ACP-containing orthodontic composite was significantly more efficient than the control composite, reducing enamel demineralization in almost all evaluations (p<0.001). Present results indicated that ACP-containing orthodontic composite for bonding orthodontic brackets successfully inhibited demineralization in vivo. This effect was localized to the area around the brackets and was statistically significant after 30 days.
    Australian Dental Journal 09/2010; 55(3):285-91. · 1.37 Impact Factor
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    ABSTRACT: Objectives: Epidemiological studies reveal the existence of anatomical differences in the upper airway dimensions between sexes. The purposes of this study were to establish normative data for airway and tongue size; hyoid position and to evaluate the cervico-craniofacial skeletal morphology using cephalometric radiography. Methods: The upper airways of 50 male and 53 female healthy volunteers were retrospectively evaluated by lateral skull radiographs. Male and female subjects enrolled in the study were similar regarding their mean age (17.2 2.8 years and 18.4 2.9 years, respectively) and Body Mass Index (BMI) (24.8 1.4 kg/m and 23.9 3.7 kg/m, respectively). Anatomical pharyngeal linear measurements and craniocervical postural relationships were analyzed with cephalometric radiographs. Results: The mean sagittal pharyngeal dimensions were fallows; nasopharynx: 7.31.88mm, velopharynx: 9.42.32mm, oropharynx: 9.612.74mm and hypopharynx: 4.781.45mm. Mean sagittal pharyngeal dimensions of male subjects were significantly greater when compared to the female subjects at all levels. The mean length and height of the tongue was 71.986.09mm and 30.163.71mm. The tongue length of male subjects was also significantly greater than female subjects. The mean soft palate length and thickness dimensions were 38.194.58mm and 7.361.47mm respectively. These dimensions were also greater in male subjects. The mean vertical distances between the hyoid bone and Walker point between the hyoid bone and C3-RGn line were 109.159.49 and 5.844.9 respectively. The mean horizontal distance of hyoid bone was 39.145.37mm. Male subjects also showed significantly larger distances in vertical and horizontal position of hyoid bone compared to female subjects. However, all angular measurements related to craniocervical angulations and head posture were similar in men and women. Conclusions: Cephalometric images of healthy male individuals showed significantly greater mean sagittal pharyngeal structural dimensions compared to those obtained from healthy female subjects, with the exception of the craniocervical angulations related to head posture.
    IADR General Session 2010; 07/2010
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    ABSTRACT: The aims of this study were to evaluate the in-vivo reaction of newly erupted enamel to demineralization around orthodontic brackets and to compare it with that of mature enamel. Thirteen orthodontic patients scheduled to have 4 first premolars extracted for orthodontic reasons were divided into 2 groups. Group 1 included 7 younger patients with newly erupted teeth (4 boys, 3 girls; mean age, 11.21 +/- 1.12 years; range, 11-13 years). Group 2 contained 6 adults with mature teeth (5 men, 1 woman; mean age, 34.64 +/- 4.01 years; range, 25-41 years). Brackets were placed, and, 30 days later, the teeth were extracted. These teeth were longitudinally sectioned, and demineralization was assessed by cross-sectional microhardness. Determinations were made at the bracket-edge composite limits and at occlusal and cervical points 100 mum away. Evaluations under the brackets and at the lingual surfaces were made as controls. In all these positions, 6 indentations were made at depths from 10 to 90 mum from the enamel surface. Analysis of variance (ANOVA) and Tukey tests were used for statistical evaluation at the P <0.05 level. ANOVA showed statistically significant differences for tooth type, position, depth, and their interactions (P <0.05), except the tooth type and position interaction. The multiple comparison test showed less demineralization in the enamel around orthodontic brackets bonded to mature teeth campared with newly erupted teeth (P <0.05). During the 30-day study period, the tooth enamel in the adult orthodontic patients was more resistant to demineralization than that of the younger patients.
    American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 05/2010; 137(5):582.e1-6; discussion 582-3. · 1.33 Impact Factor
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    ABSTRACT: A preliminary study using laser fluorescence suggested that amorphous phosphate-containing orthodontic composites may prevent demineralisation around bonded orthodontic brackets. To compare the microhardness of the enamel around brackets bonded with an amorphous calcium phosphate-containing orthodontic composite (ACP-containing) with the microhardness of the enamel around brackets bonded with a conventional composite resin. Forty extracted upper premolars were used. Orthodontic brackets were bonded to the teeth with either an ACP-containing composite resin (N = 20) or a conventional composite resin (N = 20). The latter were used as the control. The crowns of all teeth were painted with an acid resistant varnish, leaving a 2 mm ring of exposed enamel around the brackets. The teeth were then subjected to a daily cycle of demineralisation for 6 hours and remineralisation for 18 hours for 21 days. Each tooth was sectioned and the microhardness of the enamel determined 25, 50, 75, 100 and 150 microm from the surface. The enamel was significantly harder 25 microm (p = 0.000) and 50 microm (p = 0.001) from the enamel surface in the teeth with brackets bonded with the ACP-containing composite resin as compared with the control teeth. ACP-containing orthodontic composite resins may reduce the enamel decalcification found in patients with poor oral hygiene.
    Australian orthodontic journal 05/2010; 26(1):10-5. · 0.28 Impact Factor
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    ABSTRACT: The aim of this experimental study was to evaluate the effects of ED-71, a new active vitamin D analog, on bone regeneration in response to expansion of the mid-palatal suture, in rats, histomorphometrically. Sixteen male 50-60 days old Wistar rats were separated into two equal groups (control and experimental). Both groups were subjected to expansion, and 30 grams of force was applied to the maxillary incisors with a helical-spring. Experimental group was treated with single-dose ED-71 (0.8 mug/kg body weight) in the mid-palatal suture locally and eight control animals received vehicle solution. Bone regeneration in the mid-palatal suture was evaluated by bone histomorphometric method and mineralized area (Md.Ar), fibrosis area (Fb.Ar), mineralized area/fibrosis area (Md.Ar/Fb.Ar), bone area (B.Ar) and osteoblast number (N.Ob) parameters were evaluated. Mann Whitney-U test was used for statistical evaluation at P<.05 level. Statistical analysis showed significant differences between groups for all investigated histomorphometric parameters. Md.Ar (P<.001), Md.Ar/Fb.Ar (P<.001), B.Ar (P<.01) and N.Ob (P<.001) parameters were significantly increased and Fb.Ar (P<.001) measurement was significantly decreased in experimental group. ED-71 group with a mean of 24.55+/-6.47 showed statistically higher N.Ob than the control group (mean N.Ob: 12.82+/-5.81). ED-71 has positive effects on early phase of bone regeneration in the mid-palatal suture in response to expansion and may be beneficial in routine maxillary expansion procedures.
    European journal of dentistry 07/2009; 3(3):165-72.
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    ABSTRACT: The aim of this in vitro study was to compare the efficacy of Amorphous Calcium Phosphate (ACP)-containing orthodontic composite and resin-modified glass ionomer cement (RMGIC) on enamel demineralization adjacent to orthodontic brackets evaluated by a new laser fluorescence device. Sixty extracted maxillary premolars were used in the present study. Twenty orthodontic brackets were bonded with ACP-containing orthodontic adhesive (Aegis-Ortho), 20 were bonded with RMGIC (Fuji Ortho LC) and 20 were bonded with Transbond XT composite as the control. All samples were then cycled for 21 days through a daily procedure of demineralization for 6 hours and remineralization for 17 hours. After this procedure, demineralization evaluations were undertaken by a pen-type laser fluorescence device (DIAGNO-dent Pen). Analysis of variance (ANOVA) and Tukey test was used for statistical evaluation, at P<.05 level. According to ANOVA, significant demineralization variations (DeltaD) were determined among groups (F=6.650; P<.01). The ACP-containing composite showed the lowest (mean: 8.98+/-2.38) and the control composite showed the highest (mean:12.15+/-3.83) DeltaD, during 21 days demineralization process (P<.01). Significant difference was also observed between the DeltaD scores of the RMGIC (mean: 9.24+/-2.73) and control (P<.05). No significant differences was found in preventive effects of ACP-containing composite and RMGIC (P<.05) against demineralization. The use of both ACP-containing orthodontic composite and RMGIC should be recommended for any at-risk orthodontic patient to provide preventive actions and potentially remineralize subclinical enamel demineralization.
    European journal of dentistry 04/2009; 3(2):127-34.
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    ABSTRACT: To determine the effects of hyperbaric oxygen (HBO) on bone remodeling during orthodontic tooth movement. Twenty-four male, adult Sprague Dawley rats were randomly divided into two groups. HBO was administered in the first group, and the second group served as a control. The mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. Results were evaluated histomorphometrically and the parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were evaluated at the interradicular bone area of the mandibular first molars. Increases in BV/TV and Tr.N and decreases in Tr.Sep revealed the osteoblastic activity of HBO. HBO application caused an increase in bone apposition and osteoblastic activity or a decrease in osteoclastic activity. HBO enhanced the bone formation during experimental tooth movement. Therefore, the findings of this study support our hypothesis that osteoblastic activity might be modulated by changes in the environmental oxygen tension.
    The Angle Orthodontist 04/2008; 78(2):304-8. · 1.18 Impact Factor
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    ABSTRACT: To compare the effects of Forsus Nitinol Flat Spring (FNFS) and Jasper Jumper (JJ) in the correction of Class II division I malocclusions. Our research was conducted on 48 adolescents, who had a normal or horizontal growth pattern and retrognathic mandible. The patients were divided into three equal groups randomly. First group was treated with FNFS, and the second group was treated with JJ appliances, whereas the third group was the control group. Lateral cephalograms and study models were obtained after the leveling phase and at time of the removal of the appliances. Cephalometric analysis revealed that both the appliances stimulated mandibular growth, increased the anterior face height because of the lower face, and elongated the posterior face height because of the growth of temporomandibular joint. Maxillary central incisors were extruded, retruded, and distally tipped. Contrarily, intrusion, protrusion, and labial tipping were observed in the mandibular central incisors. Distal movement and intrusion of the maxillary first molars and mesial movement and extrusion of the mandibular first molars were the other dental alterations. Overjet and overbite were decreased, and a Class I molar relationship and improvement in the profile were attained in both treatment groups. Cast model analysis showed expansion in the maxillary and mandibular dental arches. Both the appliances were effective in the treatment of Class II malocclusion and revealed nearly same alterations in the skeletal, dental, and soft tissue parameters.
    The Angle Orthodontist 08/2006; 76(4):666-72. · 1.18 Impact Factor
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    Erol Akin, A Umit Gurton, Deniz Sagdic
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    ABSTRACT: The aim of the present investigation was to evaluate the skeletal and dentoalveolar treatment effects of a segmented removable appliance [removable molar distalizer (RMD)] for molar distalization. The study was conducted on 28 patients (12 females and 16 males), with a mean age of 11.8 years. All presented with a skeletal Class I malocclusion and a bilateral dental Class II molar relationship. The pre- and post-distalization records included lateral head films, study models and standard photographs. The findings were evaluated with a paired samples t-test. The average maxillary first molar distalization with the RMD was 3.98 mm, with 4.61 degrees of distal tipping. The maxillary second premolars drifted distally 2.13 mm on average with 1.54 degrees of distal tipping, while the maxillary first premolars showed 1.23 mm of mesial movement and 1.98 degrees of mesial tipping. The incisors protruded 1.09 mm with 1.27 degrees of labial tipping. The RMD was effective in distal molar movement and all patients attained a bilateral Class I molar relationship in an average period of 4.5 months. Hygiene problems and mucosal irritations, frequently found with fixed intraoral distalization techniques, were not observed during the distalization period.
    The European Journal of Orthodontics 03/2006; 28(1):65-73. · 1.08 Impact Factor
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    ABSTRACT: This study evaluates the effects of prostacyclin (PGI2) and thromboxane A2 (TxA2) in orthodontic tooth movement and osteoclastic activity in rats. The study sample consisted of 150 male Sprague-Dawley rats. The rats were randomly divided into five equal groups, and each group was again equally divided into three subgroups (SGs). Twenty grams of reciprocal force was applied to maxillary incisors of the rats with a spring bent from 0.35 mm stainless steel wire, except for the rats in the last SG. Iloprost (PGI2 analog), indomethacin (PGI2 inhibitor), U 46619 (TxA2 analog), and imidazole (TxA2 inhibitor) were dissolved in 0.9% NaCl (saline solution), and each material was prepared in three different concentrations (10(-4), 10(-5), and 10(-6) M/L). Iloprost was administered (20 microL/12 hours) in the first three SGs with the sequence of 10(-4), 10(-5), and 10(-6) M/L. Indomethacin, U 46619, and imidazole were administered in the next nine SGs with the same sequence and dose. In SG 13, 0.9% NaCl solution was administered (20 microL/ 12 hours) to the rats together with orthodontic force. Only orthodontic force was not used in SG 14, and neither any solution nor orthodontic force was used in the last SG. The rats were sacrificed on the fifth day of the experiment, premaxillae were dissected, and cross samples were taken. The results showed that PGI2 and TxA2 analogs increased the number of multinuclear osteoclasts, osteoclastic bone resorption, and rate of orthodontic tooth movement.
    The Angle Orthodontist 09/2004; 74(4):526-32. · 1.18 Impact Factor