D Darmaun

Publications (84)201.43 Total impact

• Article: [Processed baby foods for infants and young children: A dietary advance? A position paper by the Committee on Nutrition of the French Society of Paediatrics.]

  J Ghisolfi, A Bocquet, J-L Bresson, A Briend, J-P Chouraqui, D Darmaun, C Dupont, M L Frelut, J-P Girardet, O Goulet, R Hankard, D Rieu, U Siméoni, D Turck, M Vidailhet
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  ABSTRACT: Processed baby foods designed for infants (4-12months) and toddlers (12-36months) (excluding infant formula, follow-on formula, the so-called growing-up milks, and cereal-based foods for infants), which are referred to as baby foods, are specific products defined by a European regulation (Directive 2006/125/CE). According to this Directive, such foods have a composition adapted to the nutritional needs of children of this age and should comply with specifications related to food safety in terms of ingredients, production processes, and prevention of infectious and toxicological hazards. Hence, they differ from ordinary foods and from non-specific processed foods. This market segment includes the full range of foods that can be part of children's diet: dairy products (dairy desserts, yoghurts, and fresh cheese), sweet products (nondairy desserts, fruit, and drinks), and salty products (soups, vegetable-based foods, meat, fish, and full dishes). This market amounted to 89,666 MT in France in 2011 and 83,055 MT in 2010 (a total of 325,524 MT in the 27 countries of the European Union in 2010, including 90,438 MT in Germany, 49,144 MT in Spain, and 40,438 MT in Italy). The consumption of baby foods in France varies with infant age and parental choice. Baby foods account for 7 % of total energy intake at 4-5months, 28 % at 6-7months, 27 % at 8-11months, 17 % at 1-17months, and 11 % at 18-24months. Among parents, 24 % never offer their children any baby foods, 13 % do so 1-3 days/week and 63 % 4-7days/week. Among consumers, 55 % of children eat more than 250g/day of baby foods. As baby foods only account for a minor fraction of overall food intake, their impact on the quality of young children's diet is much less than that of growing-up milks, particularly for preventing insufficient iron and vitamin D intake. Their consumption, however, has an indirect benefit on the nutritional quality of the diet and on food safety, particularly regarding toxicological hazards, as it postpones the introduction of non-specific processed foods, which are inadequate for this age group owing to both their nutritional composition and lower food safety control. Baby foods represent a family of products meeting parents' expectations and adapted to infants and young children. They are clearly beneficial in terms of food safety, but the nutritional benefit to be expected from their consumption is minimal: their main advantage is postponing or decreasing the consumption of non-specific industrially processed foods.
  Archives de Pédiatrie 04/2013; · 0.30 Impact Factor
• Article: [Malnutrition screening in clinical practice].

  R Hankard, V Colomb, H Piloquet, A Bocquet, J-L Bresson, A Briend, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, J-P Girardet, O Goulet, D Rieu, U Simeoni, D Turck, M Vidailhet
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  ABSTRACT: Protein energy malnutrition (PEM) occurs when energy and protein intake do not meet requirements. It has a functional and structural impact and increases both morbidity and mortality of a given disease. The Nutrition Committee of the French Pediatric Society recommends weighing and measuring any child when hospitalized or seen in consultation. The body mass index (BMI) must be calculated and analyzed according to references any time growth kinetics cannot be analyzed. Any child with a BMI below the third centile or -2 standard deviations for age and sex needs to be examined looking for clinical signs of malnutrition and signs orienting toward an etiology and requires having his BMI and height dynamics plotted on a chart. PEM warrants drawing up a nutritional strategy along with the overall care plan. A target weight needs to be determined as well as the quantitative and qualitative nutritional care including its implementation. This plan must be evaluated afterwards in order to adapt the nutritional therapy.
  Archives de Pédiatrie 09/2012; 19(10):1110-7. · 0.30 Impact Factor
• Article: Vitamin D: still a topical matter in children and adolescents. A position paper by the Committee on Nutrition of the French Society of Paediatrics.

  M Vidailhet, E Mallet, A Bocquet, J-L Bresson, A Briend, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, J Ghisolfi, J-P Girardet, O Goulet, R Hankard, D Rieu, U Simeoni, D Turck
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  ABSTRACT: The aims of the present position paper by the Committee on Nutrition of the French Society of Paediatrics were to summarize the recently published data on vitamin D in infants, children and adolescents, i.e., on metabolism, physiological effects, and requirements and to make recommendations on supplementation after careful review of the evidence. Scientific evidence indicates that calcium and vitamin D play key roles in bone health. The current evidence, limited to observational studies, however, does not support other benefits for vitamin D. More targeted research should continue, especially interventional studies. In the absence of any underlying risk of vitamin D deficiency, the recommendations are as follows: pregnant women: a single dose of 80,000 to 100,000 IU at the beginning of the 7th month of pregnancy; breastfed infants: 1000 to 1200 IU/day; children less than 18 months of age, receiving milk supplemented with vitamin D: an additional daily dose of 600 to 800 IU; children less than 18 months of age receiving milk not supplemented with vitamin D: daily dose of 1000 to 1200 IU; children from 18 months to 5 years of age: 2 doses of 80,000 to 100,000 IU every winter (November and February). In the presence of an underlying risk of vitamin D deficiency (dark skin; lack of exposure of the skin to ultraviolet B [UVB] radiation from sunshine in summer; skin disease responsible for decreased exposure of the skin to UVB radiation from sunshine in summer; wearing skin-covering clothes in summer; intestinal malabsorption or maldigestion; cholestasis; renal insufficiency; nephrotic syndrome; drugs [rifampicin; antiepileptic treatment: phenobarbital, phenytoin]; obesity; vegan diet), it may be justified to start vitamin D supplementation in winter in children 5 to 10 years of age as well as to maintain supplementation of vitamin D every 3 months all year long in children 1 to 10 years of age and in adolescents. In some pathological conditions, doses of vitamin D can be increased. If necessary, the determination of 25(OH) vitamin D serum concentration will help determine the level of vitamin D supplementation.
  Archives de Pédiatrie 03/2012; 19(3):316-28. · 0.30 Impact Factor
• Article: Dietary treatment of cows' milk protein allergy in childhood: a commentary by the Committee on Nutrition of the French Society of Paediatrics.

  C Dupont, J P Chouraqui, D de Boissieu, A Bocquet, J L Bresson, A Briend, D Darmaun, M L Frelut, J Ghisolfi, J P Girardet, O Goulet, R Hankard, D Rieu, M Vidailhet, D Turck
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  ABSTRACT: The diagnosis of cows' milk protein allergy (CMPA) requires first the suspicion of diagnosis based on symptoms described in the medical history, and, second, the elimination of cows' milk proteins (CMP) from the infant's diet. Without such rigorous analysis, the elimination of CMP is unjustified, and sometimes harmful. The elimination diet should be strictly followed, at least until 9-12 months of age. If the child is not breast fed or the mother cannot or no longer wishes to breast feed, the first choice is an extensively hydrolysed formula (eHF) of CMP, the efficacy of which has been demonstrated by scientifically sound studies. If it is not tolerated, an amino acid-based formula is warranted. A rice protein-based eHF can be an alternative to a CMP-based eHF. Soya protein-based infant formulae are also a suitable alternative for infants >6 months, after establishing tolerance to soya protein by clinical challenge. CMPA usually resolves during the first 2-3 years. However, the age of recovery varies depending on the child and the type of CMPA, especially whether it is IgE-mediated or not, with the former being more persistent. Once the child reaches the age of 9-12 months, an oral food challenge is carried out in the hospital ward to assess the development of tolerance and, if possible, to allow for the continued reintroduction of CMP at home. Some children with CMPA will tolerate only a limited daily amount of CMP. The current therapeutic options are designed to accelerate the acquisition of tolerance thereof, which seems to be facilitated by repeated exposure to CMP.
  The British journal of nutrition 11/2011; 107(3):325-38. · 3.45 Impact Factor
• Article: [Cows' milk or growing-up milk: what should we recommend for children between 1 and 3 years of age?].

  J Ghisolfi, M Vidailhet, M Fantino, A Bocquet, J-L Bresson, A Briend, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, J-P Girardet, O Goulet, R Hankard, D Rieu, D Turck
  Archives de Pédiatrie 03/2011; 18(4):355-8. · 0.30 Impact Factor
• Article: [Recommendations for children with hypercholesterolemia].

  J-P Girardet, G Luc, D Rieu, E Bruckert, D Darmaun, M Farnier
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  ABSTRACT: Some cases of hypercholesterolemia observed in childhood present a high risk of premature cardiovascular disease, such as in monogenic dominantly inherited hypercholesterolemia, particularly familial hypercholesterolemia due to mutations on the LDL receptor gene. This article, jointly written by the Société Française de Pédiatrie Nutrition Committee and the Nouvelle Société Française d'Athérosclérose, proposes recommendations for a screening strategy and management of childhood hypercholesterolemia. A practical approach to high-risk cases of inherited hypercholesterolemia is detailed and the dietary management, indications, and supervision of lipid-lowering drug therapy in children are discussed.
  Archives de Pédiatrie 02/2011; 18(2):217-29. · 0.30 Impact Factor
• Article: [Dietetic treatment of cow's milk protein allergy].

  C Dupont, J-P Chouraqui, D de Boissieu, A Bocquet, J-L Bresson, A Briend, D Darmaun, M-L Frelut, J Ghisolfi, J-P Girardet, O Goulet, R Hankard, D Rieu, J Rigo, M Vidailhet, D Turck
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  ABSTRACT: New data on food allergy has recently changed the management of children with cow's milk protein allergy (CMPA). The diagnosis of CMPA first requires the elimination of cow's milk proteins and then an oral provocation test following a standard diagnostic procedure for food allergy, without which the elimination diet is unjustified and sometimes harmful. Once the diagnosis is made, the elimination diet is strict, at least until the age of 9-12 months. If the child is not breastfed or the mother cannot or no longer wishes to breastfeed, the first choice is a formula based on extensive hydrolyzate of cow's milk (eHF), provided that its effectiveness has been demonstrated. When eHF fails, a formula based on amino acids is warranted. eHF based on rice protein hydrolysates is an alternative to cow's milk eHF. Infant formulas based on soy protein can be used after the age of 6 months, after verification of good clinical tolerance to soy. Most commonly, CMPA disappears within 2 or 3 years of life. However, the age of recovery varies depending on the child and the type of CMPA, and whether or not it is IgE-mediated, the first being more sustainable. When the child grows, a hospital oral provocation test evaluates the development of tolerance and, if possible, authorizes continuing the reintroduction of milk proteins at home. Some children with CMPA will tolerate only a limited daily amount of cow's milk proteins. The current therapeutic options are designed to accelerate the acquisition of tolerance, which seems facilitated by regular exposure to cow's milk proteins.
  Archives de Pédiatrie 01/2011; 18(1):79-94. · 0.30 Impact Factor
• Article: Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition

  C Agostoni, G Buonocore, VP Carnielli, M De Curtis, D Darmaun, T Decsi, M Domellöf, ND Embleton, C Fusch, O Genzel-Boroviczeny, [......], A Riskin, B Salle, P Sauer, R Shamir, H Szajewska, P Thureen, D Turck, JB van Goudoever, EE Ziegler, for the ESPGHAN Committee on Nutrition
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  ABSTRACT: The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline on nutrition of preterm infants from the Committee on Nutrition of the European Society of Paediatric Gastroenterology and Nutrition in 1987 has made a new guideline necessary. Thus, an ad hoc expert panel was convened by the Committee on Nutrition of the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition in 2007 to make appropriate recommendations. The present guideline, of which the major recommendations are summarised here (for the full report, see http://links.lww.com/A1480), is consistent with, but not identical to, recent guidelines from the Life Sciences Research Office of the American Society for Nutritional Sciences published in 2002 and recommendations from the handbook Nutrition of the Preterm Infant. Scientific Basis and Practical Guidelines, 2nd ed, edited by Tsang et al, and published in 2005. The preferred food for premature infants is fortified human milk from the infant's own mother, or, alternatively, formula designed for premature infants. This guideline aims to provide proposed advisable ranges for nutrient intakes for stable-growing preterm infants up to a weight of approximately 1800 g, because most data are available for these infants. These recommendations are based on a considered review of available scientific reports on the subject, and on expert consensus for which the available scientific data are considered inadequate.
  Journal of Pediatric Gastroenterology and Nutrition 12/2009; 50(1):85–91. · 2.30 Impact Factor
• Article: [Childhood diet and cardiovascular risk factors].

  J-P Girardet, D Rieu, A Bocquet, J-L Bresson, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, J Ghisolfi, O Goulet, J Rigo, D Turck, M Vidailhet
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  ABSTRACT: Atherosclerosis begins during childhood. From childhood, a strong relation has been shown between the prevalence and extent of the asymptomatic atherosclerosis lesions and cardiovascular risk factors such as elevation in body mass index, blood pressure and plasma lipid concentrations. These risk factors depend not only on the subjects' genetic predisposition, but also on environmental parameters, particularly diet. The Committee on Nutrition reviewed the scientific basis of dietary recommendations for children that could reduce the risk factors and thereby, reduce the risk of coronary heart disease in later life: the effects of prenatal nutrition; the beneficial consequences of breast-feeding on later levels of cholesterolemia, blood pressure and corpulence; the role of dietary lipids on plasma lipid concentration, of salt and potassium on blood pressure, and of lifestyle on corpulence.
  Archives de Pédiatrie 11/2009; 17(1):51-9. · 0.30 Impact Factor
• Article: Enteral nutrient supply for preterm infants: Commentary from the european society of paediatric gastroenterology, hepatology and nutrition committee on nutrition

  C. Agostoni, G. Buonocore, V. P. Carnielli, M. De Curtis, D. Darmaun, T. Decsi, M. Domellöf, N. D. Embleton, C. Fusch, O. Genzel-Boroviczeny, [......], J. Rigo, A. Riskin, B. Salle, P. Sauer, R. Shamir, H. Szajewska, P. Thureen, D. Turck, J. B. Van Goudoever, E. E. Ziegler
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  ABSTRACT: The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline on nutrition of preterm infants from the Committee on Nutrition of the European Society of Paediatric Gastroenterology and Nutrition in 1987 has made a new guideline necessary. Thus, an ad hoc expert panel was convened by the Committee on Nutrition of the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition in 2007 to make appropriate recommendations. The present guideline, of which the major recommendations are summarised here (for the full report, see http://links.lww.com/A1480), is consistent with, but not identical to, recent guidelines from the Life Sciences Research Office of the American Society for Nutritional Sciences published in 2002 and recommendations from the handbook Nutrition of the Preterm Infant. Scientific Basis and Practical Guidelines, 2nd ed, edited by Tsang et al, and published in 2005. The preferred food for premature infants is fortified human milk from the infant's own mother, or, alternatively, formula designed for premature infants. This guideline aims to provide proposed advisable ranges for nutrient intakes for stable-growing preterm infants up to a weight of approximately 1800 g, because most data are available for these infants. These recommendations are based on a considered review of available scientific reports on the subject, and on expert consensus for which the available scientific data are considered inadequate.
  Journal of pediatric gastroenterology and nutrition 10/2009; 50(1):85-91. · 2.18 Impact Factor
• Article: [Promotion of breastfeeding and information to parents on infant formulas: are these 2 communication policies really incompatible?].

  J Ghisolfi, D Turck, M Vidailhet, J-P Girardet, A Bocquet, J-L Bresson, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, O Goulet, D Rieu, J Rigo
  Archives de Pédiatrie 07/2009; 16(7):971-5. · 0.30 Impact Factor
• Article: [French national program for nutrition and health: effects on children's health].

  J P Girardet, A Bocquet, J L Bresson, J P Chouraqui, D Darmaun, C Dupont, M L Frelut, J Ghisolfi, O Goulet, D Rieu, J Rigo, H Thibault, D Turck, M Vidailhet
  Archives de Pédiatrie 01/2009; 16(1):3-6. · 0.30 Impact Factor
• Article: [Folic acid and prevention of neural tube closure defects: the question is not solved yet].

  M Vidailhet, A Bocquet, J-L Bresson, A Briend, J-P Chouraqui, C Dupont, D Darmaun, M-L Frelut, J Ghisolfi, J-P Girardet, O Goulet, G Putet, D Rieu, J Rigo, D Turck
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  ABSTRACT: Between 1981 and 1996, several interventional studies proved the efficacy of periconceptional folic acid supplementation in the prevention of neural tube closure defects (NTCD), first in women at risk (with a previous case of NTCD) and also in women of the general population in age to become pregnant. The poor observance of this supplementation led several countries (USA, Canada, Chile...) to decide mandatory folic acid fortification of cereals, which permitted a 30% (USA) to 46% (Canada) reduction in the incidence of NTCD. Moreover, this benefit was accompanied by a diminished incidence of several other malformations and of stroke and coronary accidents in elderly people. However, several papers drew attention to an increased risk of colorectal and breast cancer in relation with high blood folate levels and the use of folic acid supplements. A controlled interventional study showed a higher rate of recurrence of colic adenomas and a higher percentage of advanced adenomas in subjects receiving 1mg/day of folic acid. A recent study demonstrated an abrupt reversal of the downward trend in colorectal cancer 1 year after the beginning of cereal folic acid fortification in the USA and Canada. Two studies also reported impaired cognitive functions in elder persons with defective vitamin B(12) status. Taken in aggregate, these studies question the wisdom of a nationwide, mandatory, folic acid fortification of cereals. As of today, despite their limited preventive efficacy, a safe approach is to keep our current French recommendations and to increase the awareness of all caregivers, so as to improve the observance of these recommendations.
  Archives de Pédiatrie 08/2008; 15(7):1223-31. · 0.30 Impact Factor
• Article: [Feeding during the first months of life and prevention of allergy].

  J-P Chouraqui, C Dupont, A Bocquet, J-L Bresson, A Briend, D Darmaun, M-L Frelut, J Ghisolfi, J-P Girardet, O Goulet, G Putet, D Rieu, J Rigo, D Turck, M Vidailhet
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  ABSTRACT: Allergy consists in the different manifestations resulting from immune reactions triggered by food or respiratory allergens. Both its frequency and severity are increasing. The easiest intervention process for allergy prevention is the reduction of the allergenic load which, for a major allergen such as peanuts, has to begin in utero. The primary prevention strategy relies first on the detection of at risk newborns, i.e. with allergic first degree relatives. In this targeted population, as well as for the general population, exclusive breastfeeding is recommended until the age of 6 months. The elimination from the mother's diet of major food allergens potentially transmitted via breast milk may be indicated on an individual basis, except for peanut, which is systematically retrieved. In the absence of breastfeeding, prevention consists in feeding at-risk newborns until the age of 6 months with a hypoallergenic formula, provided that its efficiency has been demonstrated by well-designed clinical trials. Soy based formulae are not recommended for allergy prevention. Complementary feeding should not be started before the age of 6 months. Introduction of egg and fish into the diet can be made after 6 months but the introduction of potent food allergens (kiwi, celery, crustaceans, seafood, nuts, especially tree nuts and peanuts) should be delayed after 1 year. This preventive policy seems partially efficacious on early manifestations of allergy but does not restrain the allergic march, especially in its respiratory manifestations. Probiotics, prebiotics as well as n-3 fatty polyunsaturated acids have not yet demonstrated any definitive protective effect.
  Archives de Pédiatrie 05/2008; 15(4):431-42. · 0.30 Impact Factor
• Article: [Phytoestrogens and soy foods in infants and children: caution is needed].

  D Rieu, A Bocquet, J-L Bresson, A Briend, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, J Ghisolfi, J-P Girardet, O Goulet, G Putet, J Rigo, D Turck, M Vidailhet
  Archives de Pédiatrie 08/2006; 13(7):1091-3. · 0.30 Impact Factor
• Article: [The morning snack at school is inadequate and unnecessary].

  A Bocquet, J-L Bresson, A Briend, J-P Chouraqui, D Darmaun, C Dupont, M-L Frelut, J Ghisolfi, J-P Girardet, O Goulet, G Putet, D Rieu, J Rigo, D Turck, M Vidailhet
  Archives de Pédiatrie 12/2003; 10(11):945-7. · 0.30 Impact Factor
• Article: [Feeding of infants based on age. Practice guidelines].

  A Bocquet, J L Bresson, A Briend, J P Chouraqui, D Darmaun, C Dupont, M L Frelut, J Ghisolfi, O Goulet, G Putet, D Rieu, D Turck, M Vidailhet, J P Merlin, J J Rives
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  ABSTRACT: This paper presents practical guidelines for nutrition and feeding of infants and toddlers including vitamin D, vitamin K and fluoride supplementations and preventive measures at risk for food allergy based on family history.
  Archives de Pédiatrie 02/2003; 10(1):76-81. · 0.30 Impact Factor
• Article: [Fluoride supplementation must be initiated at birth in children in France].

  A Bocquet, J L Bresson, A Briend, J P Chouraqui, D Darmaun, C Dupont, M L Frelut, J Ghisolfi, O Goulet, G Putet, D Rieu, D Turck, M Vidailhet
  Archives de Pédiatrie 12/2002; 9(11):1211-2. · 0.30 Impact Factor
• Article: [Nutritional treatment of acute diarrhea in an infant and young child].

  A Bocquet, J L Bresson, A Briend, J P Chouraqui, D Darmaun, C Dupont, M L Frelut, J Ghisolfi, O Goulet, G Putet, D Rieu, D Turck, M Vidailhet
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  ABSTRACT: This paper written by the Comité de nutrition de la Société française de pédiatrie is specially devoted to the nutritional treatment of infant and child acute diarrhea, i.e. oral rehydration with salts solution and feeding. It complements an article on drug therapy of child acute diarrhea written by the Groupe francophone d'hépatologie, gastroentérologie et nutrition pédiatriques, and published in this same issue of the Archives de pédiatrie.
  Archives de Pédiatrie 07/2002; 9(6):610-9. · 0.30 Impact Factor
• Article: A new labeling approach using stable isotopes to study in vivo plasma cholesterol metabolism in humans.

  K Ouguerram, M Krempf, C Maugeais, P Maugère, D Darmaun, T Magot
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  ABSTRACT: A method to study reverse cholesterol transport in humans was developed using stable isotopes and kinetic analysis. Three normolipidemic subjects received simultaneous intravenous infusions of deuterated leucine and (13)C-acetate for 14 and 8 hours, respectively. Deuterium enrichment was measured in protein-bound leucine in apolipoproteins (apo) B-100 and A-I (using gas chromatography coupled with mass spectrometry [GCMS]) and (13)C-enrichment in unesterified cholesterol and cholesteryl ester (using gas chromatography coupled to isotope ratio mass spectrometry [GC-C-IRMS]) in very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) during the tracer infusion. Curves were analyzed using multicompartmental analysis. This protocol is suitable to quantify the different processes involved in reverse cholesterol transport (RCT) in humans, including cholesterol esterification, transfer of cholesteryl ester from HDL towards apo B-100-containing lipoproteins, and the contribution of VLDL, LDL, and HDL in the final steps of RCT. In agreement with previous data from kinetic analysis of radiotracer experiments, our results suggest that in fasting normolipidemic subjects the major fraction of cholesteryl ester enters plasma through esterification in HDL (more than 95%). The major fraction of cholesteryl ester disappears through apo B-100-containing lipoproteins (VLDL and LDL) catabolism (mean of 82%) rather than through removal from HDL (mean of 18% with approximately an equal part for apo AI-dependent and independent catabolism, respectively, 7% and 11%). We conclude that this protocol could be applied to study the modulation of these processes by nutrition, diseases, or pharmacologic treatments.
  Metabolism 02/2002; 51(1):5-11. · 2.66 Impact Factor