Chul Han Kim

Soonchunhyang University, Onyang, South Chungcheong, South Korea

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Publications (52)51.95 Total impact

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    ABSTRACT: Reactive oxygen species (ROS) damages cell molecules, and modifies cell signaling. The nuclear factor E2-related factor (Nrf2) is a critical transcription regulator, which protects cells against oxidative damage. Nrf2 expression is increased in a large number of cancers. However, little information has been reported regarding the expression of Nrf2 in skin cancers. Hence, we explored the expression of Nrf2 protein in skin cancers.
    Archives of plastic surgery. 11/2014; 41(6):654-60.
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    ABSTRACT: Patients with diabetes mellitus often have a difficult life, suffering from foot ulceration or amputation. Diabetes is characterized by chronic inflammation, and one of the features of inflammation is hypoxia. Recently, it has been reported that KAI1 is a hypoxia target gene. There is no published research on hypoxia-related KAI1 protein levels in human diabetic skin. Therefore, we have investigated the expression of KAI1 protein in diabetic skin tissue in vivo.
    Archives of plastic surgery. 05/2014; 41(3):248-52.
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    ABSTRACT: Primary mucosal melanomas of the head and neck are rare. In addition, second primary mucosal melanoma following primary cutaneous malignant melanomas is very rare. We report a second primary mucosal melanoma. A 76-year-old woman, who had a previously cutaneous malignant melanoma of the left foot, visited with a complaint of a foreign body sensation of the throat. Endoscopy revealed a black mass at the left piriform sinus of the hypopharynx. After wide surgical excision of the lesion and reconstruction with a radial forearm free flap, the histopathology was confirmed to be a second primary mucosal malignant melanoma of the hypopharynx. Five months postoperatively, masses were palpated in the neck, and metastasis was diagnosed. The patient was treated with adjuvant chemotherapy and radiotherapy. Eight months postoperatively, computed tomography scans showed other metastatic masses in the liver, spleen, both adrenal glands, soft tissues of the abdominal wall, and both lungs. After that, the patient died 9 months postoperatively. We report a rare case of second primary mucosal malignant melanoma of the hypopharynx. Although rare, this case shows that a detailed examination of the hypopharynx and the head and neck should be a part of the follow-up examination in all cutaneous malignant melanoma patients.
    The Journal of craniofacial surgery 02/2014; · 0.81 Impact Factor
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    ABSTRACT: Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
    Archives of plastic surgery. 01/2014; 41(1):35-9.
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    Archives of plastic surgery. 01/2014; 41(1):93-5.
  • Chul Han Kim
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    ABSTRACT: The author reports a rare case of Horner syndrome in a patient who resulted from stenosis of the vertebral artery after blunt trauma. A 31-year-old man was transferred to our department for evaluation of left medial orbital wall and nasal bone fractures. Five days ago, he was hospitalized due to multiple second to fourth rib fractures of the right chest following blunt trauma of the face, neck, and chest. Surgery was performed. Ten days later, he complained of drooping of the right eyelid. Physical examination revealed a discrete miosis and ptosis with normal levator function in the right eye. A workup for Horner syndrome was performed. Magnetic resonance angiography of the head and neck revealed a stenosis of the distal part of the right vertebral artery without the abnormality of carotid artery. He wore a cervical collar and underwent anticoagulation. However, Horner syndrome was not resolved over the next 12 months. Acute traumatic Horner syndrome may be associated with vertebral artery dissection in which the possibility of life-threatening injury can be masked.
    The Journal of craniofacial surgery 11/2013; 24(6):2047-9. · 0.81 Impact Factor
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    Chul Han Kim
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    ABSTRACT: Diabetes is characterized by chronic hyperglycemia, which can increase reactive oxygen species (ROS) production by the mitochondrial electron transport chain. The formation of ROS induces oxidative stress and activates oxidative damage-inducing genes in cells. No research has been published on oxidative damage-related extracellular superoxide dismutase (EC-SOD) protein levels in human diabetic skin. We investigated the expression of EC-SOD in diabetic skin compared with normal skin tissue in vivo. The expression of EC-SOD protein was evaluated by western blotting in 6 diabetic skin tissue samples and 6 normal skin samples. Immunohistochemical staining was also carried out to confirm the EC-SOD expression level in the 6 diabetic skin tissue samples. The western blotting showed significantly lower EC-SOD protein expression in the diabetic skin tissue than in the normal tissue. Immunohistochemical examination of EC-SOD protein expression supported the western blotting analysis. Diabetic skin tissues express a relatively small amount of EC-SOD protein and may not be protected against oxidative stress. We believe that EC-SOD is related to the altered metabolic state in diabetic skin, which elevates ROS production.
    Archives of plastic surgery. 09/2013; 40(5):517-521.
  • Chul Han Kim, Jang Hyun Lee
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    ABSTRACT: The authors retracted the infraorbital nerve (ION) using a vessel loop to explore the orbital floor fracture site and analysed when the traction of the ION was needed. In ninety-one patients, the location of the fracture according to its position relative to the infraorbital groove, the location of the infraorbital groove from the midpoint of the orbital floor, and involvement of the ION in the fracture site were recorded retrospectively from computed tomography scans. An analysis of any associations between the traction of ION and the location of the fracture and ION passage was performed. Traction of the ION was performed in 14 cases, of which 10 cases had involvement of the ION in the fracture site and 4 cases did not. All of them were posterior fractures. In 51 cases with posterior fractures, the ION passage in patients who had ION traction was statistically located more medially (0.50 ± 1.19 mm) than in patients who had no traction (2.38 ± 1.12 mm) (p < 0.05). The ION may interfere with the exposure of the fracture site in a posterior orbital floor fracture with the involvement of the ION in the fracture site and a medially located ION passage.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 07/2013; · 1.25 Impact Factor
  • Chul Han Kim
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    ABSTRACT: The performance of reflective electro-absorption modulator (R-EAM) based optical source has been evaluated for the use in high-capacity wavelength-division multiplexed passive optical networks (WDM-PONs). In our measurements, a broadband light source (BLS) was used as a seeding source for the cost-effective implementation of R-EAM based optical source. At first, a bit-error rate (BER) floor at 10<sup>-6</sup> was observed even in a back-to-back configuration with the BLS seeded R-EAM source. This is mainly because of the excess intensity noise (EIN) within BLS and the signal-to-noise ratio (SNR) degradation induced by a high insertion loss of R-EAM. To mitigate both effects of EIN and SNR degradation, a reflective semiconductor optical amplifier (RSOA) was also used for the implementation of our BLS seeded R-EAM source. Then, we have evaluated the impact of various noises, such as EIN, chromatic dispersion of transmission fiber and in-band crosstalk, on the system's performance using our BLS seeded R-EAM optical source. From the results, we have found that a 3-dB bandwidth of the BLS seeded R-EAM optical source should be wider than ~0.8 nm to achieve an error-free transmission of 1.25 Gb/s signal. We have also confirmed that there was a trade-off between the dispersion- and the in-band crosstalk-induced penalties due to the wide source bandwidth of our BLS seeded R-EAM source, like the cases of BLS seeded RSOA and Fabry-Perot laser diode (FP-LD) sources.
    Optics Express 05/2013; 21(10):12914-9. · 3.55 Impact Factor
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    Chul Han Kim
    Archives of plastic surgery. 05/2013; 40(3):285-7.
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    Chul Han Kim
    Archives of plastic surgery. 01/2013; 40(1):79-81.
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    Archives of plastic surgery. 11/2012; 39(6):675-8.
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    Archives of plastic surgery. 11/2012; 39(6):669-71.
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    Chul Han Kim
    Archives of plastic surgery. 11/2012; 39(6):678-80.
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    Chul Han Kim
    Archives of plastic surgery. 11/2012; 39(6):680-2.
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    ABSTRACT: We propose and experimentally demonstrate a novel wavelength-division-multiplexed passive optical network (WDM-PON) scheme for providing broadcasting service by using an inverted amplified spontaneous emission (ASE) from a semiconductor optical amplifier (SOA). In this scheme, single pump signal is converted into multiple wavelengths signal by spectrum sliced wavelength conversion. We expect it could be very practical and cost-effective solution for broadcasting in WDM-PON due to its simplicity.
    Optical Fiber Technology 03/2012; 18(2):112–116. · 1.19 Impact Factor
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    Chul Han Kim
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    ABSTRACT: The maximum reach in a WDM-PON using a broadband light source (BLS) seeded optical source has been experimentally evaluated by taking into account both effects of dispersion-induced pulse broadening and excess intensity noise (EIN) increase. In order to investigate the impact of BLS seed source power on the dispersion-limited performance, the system's performance has been measured and compared as a function of the spectrum-sliced BLS seed power into a reflective semiconductor optical amplifier (RSOA). From the results, we confirmed that the maximum reach in a RSOA based WDM-PON was mainly degraded by the dispersion-induced EIN increase. Therefore, by mitigating the effect of dispersion-induced EIN increase with a high seed power into a RSOA, the maximum reach in the WDM-PON using a BLS seeded RSOA source could be achieved to be ~60 km of single-mode fiber at the spectrum-sliced BLS seed power of >-10 dBm and a 1.25 Gb/s signal without using any dispersion-compensating techniques.
    Optics Express 02/2012; 20(4):3473-8. · 3.55 Impact Factor
  • Chul Han Kim
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    ABSTRACT: We have investigated the dependence of in-band incoherent crosstalk-induced power penalties on seed source in reflective semiconductor optical amplifier (RSOA)-based wavelength-division-multiplexed passive optical networks (WDM-PONs). The in-band crosstalk penalties in an RSOA-based WDM-PON were measured with two different seed sources; a broadband light source (BLS) and a distributed feedback laser diode (DFB-LD). The 1-dB power penalties with a BLS seeded and a DFB-LD seeded RSOA source were observed when the crosstalk-to-signal ratios were ${\sim}{-}{\rm 14}$ and ${-}{\rm 16}~{\rm dB}$, respectively. From the results, we found that the directly-modulated RSOA sources with a BLS or a DFB-LD seed source were more tolerant to the in-band crosstalk than an externally-modulated DFB-LD source. In addition, we confirmed that the in-band crosstalk-induced power penalty in the RSOA-based WDM-PONs could be calculated with a proper estimation of an equivalent optical source bandwidth.
    IEEE Photonics Technology Letters 01/2012; 24(7):581-583. · 2.04 Impact Factor
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    ABSTRACT: We have evaluated the performance of fiber Bragg grating (FBG) based dispersion compensators for an amplified wavelength-division multiplexed passive optical network (WDM-PON) implemented using broadband light source (BLS) seeded optical sources.
    Opto-Electronics and Communications Conference (OECC), 2012 17th; 01/2012
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    ABSTRACT: TC21 plays an important role in highly aggressive tumor formation, and it was overexpressed in several human cancers, including breast cancer, oral squamous cell carcinoma (SCC), and esophageal SCC. In light of this, we explored the expression of TC21 in overall skin cancers in order to evaluate the relationship between TC21 and malignant skin tumors. We examined six normal skin tissues and 18 malignant skin tumor tissues, including six malignant melanomas (MM), six SCCs, and six basal cell carcinomas (BCCs) using western blotting for the expression of TC21. In another set, 16 specimens of MM, 16 SCC, and 16 BCC were analyzed for the expression of TC21 using immunohistochemical staining. To evaluate the amount of expression of TC21, the Raytest TINA software was used for western blotting and a histochemical score (HSCORE) was used for immunohistochemical evaluation. The western blotting and immunohistochemistry showed that TC21 was expressed in all malignant skin tumors and not in normal skin tissues. The relative protein expression was an average of 0.004 in normal skin, 1.042 in MM, 0.621 in SCC, and 0.485 in BCC. In immunohistochemistry, HSCORE for normal skin was an average of 0.05, MM was 2.42, SCC was 2.11, and BCC was 1.22. This article is the first study demonstrating expression of TC21 in human skin malignant tumors and suggests that TC21 is more expressed in highly aggressive skin tumors.
    International journal of dermatology 08/2011; 50(8):956-60. · 1.18 Impact Factor

Publication Stats

101 Citations
51.95 Total Impact Points

Institutions

  • 2010–2014
    • Soonchunhyang University
      • College of Medicine
      Onyang, South Chungcheong, South Korea
  • 2005–2012
    • University of Seoul
      • School of Electrical and Computer Engineering
      Seoul, Seoul, South Korea
  • 2006
    • Institute of Electrical and Electronics Engineers
      Washington, Washington, D.C., United States