Saudi Journal of Kidney Diseases and Transplantation. 01/2008;
ABSTRACT: We report the development of recurrent hyponatremia after intrathecal methotrexate that was not associated with elevated levels of antidiuretic hormone. We speculate that a central nervous system natriuretic peptide may be involved in the pathogenesis of the naturesis following intrathecal methotrexate.
The American Journal of the Medical Sciences 02/2006; 331(1):37-9. · 1.39 Impact Factor
ABSTRACT: Doxycycline can prevent aortic aneurysms through the inhibition of enzymes that degrade vessel walls. We investigated whether haemodialysis patients who had received one or more courses of doxycycline were at less risk for aneurysms in their vascular accesses than those who had received other antibiotics.
Three hundred and eight patients undergoing chronic maintenance hemodialysis were evaluated for aneurysm formation after exposure to doxycycline or another antibiotic. Conditional forward logistical analysis using Cox proportional hazards test (SPSS) was performed to determine the potential significance of differences of aneurysm formation between the two groups.
Patients who had received doxycycline appeared to be at lower risk than the control group, but the effect was most obvious in those patients with synthetic grafts.
Doxycycline may have the ability to reduce aneurysm formation in haemodialysis vascular accesses and a large prospective study is warranted.
Nephrology Dialysis Transplantation 06/2005; 20(5):959-61. · 3.40 Impact Factor
American Journal of Kidney Diseases 05/2003; 41(4):901; author reply 901. · 5.43 Impact Factor