Burak Tatlı

Istanbul Medical University, İstanbul, Istanbul, Turkey

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Publications (28)19.6 Total impact

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    ABSTRACT: To evaluate demographic and prognostic features of febrile seizures in a tertiary center in Turkey. A retrospective study of 632 children with febrile seizure was conducted from January 1995 to January 2002 in the pediatric neurology and general pediatrics departments of İstanbul University, İstanbul Medical School. Patients data was collected and eligible patients were included in the study. There were 386 male (61.1%) and 246 female (38.9%) patients, with a male-to-female ratio of 1.57. Twenty six (% 4.1) patients had prenatal, 104 (%16,5) patients had perinatal-neonatal problems. Age at first seizure was 3-72 months with an average of 20.1 months. While 193 patients (30%) were admitted with two seizures, 246 (39%) were admitted with three or more. Out of 632 patients, 501 (79.2%) had recurrences. In an average of 5.8 years (4-8.8), 30 out of 632 patients (4.7%) were diagnosed with epilepsy. First degree relative with febrile seizure, age at first febrile seizure less than 18 months, height of peak temperature (< 38.5 °C), less than 1 or 3 hours between onset of fever and seizure, complex first seizure, complex febrile seizure were all related to febrile seizure recurrence in a statistically significant way. Some risk factors for subsequent epilepsy development included complex febrile seizures and less than 1 hour of fever before febrile seizure. No patient with febrile seizure had died. Complex febrile seizures and less than 1 hour of fever before febrile seizure are common risk factors for both epilepsy and febrile seizure recurrence.
    Minerva pediatrica 06/2015; · 0.43 Impact Factor
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    ABSTRACT: Background: Pharyngeal-cervical-brachial (PCB) variant is a rare form of Guillan-Barre Syndrome (GBS). Antibodies against other membrane proteins like GM1b and GD1a have been found only in a small number of patients with Guillan Barre syndrome variant. Case report: Here, we report a 5.5 year-old boy diagnosed early with positive GD1a and GD1b gangliosides of Guillan-Barre syndrome pharyngeal cervical-Brachial variant, who improved and recovered fully in a short period. This is in contrast to those whose recovery period prolongs in spite of early diagnosis and appropriate treatment and/or those who experience incomplete recovery. Conclusion: In summary, diagnosis of PCB variant of GBS should be considered in infants with sudden onset bulbar symptoms and muscle weakness, and it should be kept in mind that early diagnosis and appropriate treatment can give successful outcomes.
    Balkan Journal of Medical Genetics 09/2013; 30(3):337-41. DOI:10.5152/balkanmedj.2013.8334 · 0.50 Impact Factor
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    ABSTRACT: The purpose of this study was to evaluate positron emission tomography (PET) findings in patients diagnosed with infantile spasms and autism. This study includes 90 patients who were diagnosed with infantile spasms at the Department of Pediatric Neurology in the Istanbul University Medical Faculty between 1995 and 2007. Of the 90 patients, 15 patients who were diagnosed with autism using the Autism Behaviour Checklist and Childhood Autism Rating Scale and a control group of nine patients without autism but with infantile spasms underwent PET examination. Mean patient age (± standard error, SE) varied between 3years and 16years (7.8±4years), while the mean follow-up time (±SE) varied between 2years and 16years (average: 7.1±4years). Autism was present in 11 patients with symptomatic spasms and in four patients with cryptogenic spasms (p=0.009). On the PET scans of the 15 patients with autism, 13 (86.7%) had significantly decreased metabolic activity in the temporal lobe (p<0.001), nine (60%) had significantly decreased activity in the frontal lobe (p=0.004), and seven (46.7%) had significantly decreased activity in the parietal lobe (p=0.022). In our opinion, hypometabolism in the frontal and parietal lobes, in addition to that previously reported in the temporal lobe, plays a role in the development of autism in patients with infantile spasms.
    Journal of Clinical Neuroscience 12/2012; 20(3). DOI:10.1016/j.jocn.2012.03.034 · 1.38 Impact Factor
  • Barış Ekici · Yeliz Yıldırım · Didar Uçar · Burak Tatlı ·

    Annals of Indian Academy of Neurology 10/2012; 15(4):350-1. DOI:10.4103/0972-2327.104359 · 0.60 Impact Factor
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    ABSTRACT: This study evaluated etiologic and risk factors affecting long-term prognoses of neurologic outcomes in newborns with neonatal seizures. We enrolled patients at chronologic ages of 23-44 months, referred to the Department of Pediatric Neurology, Istanbul Medical Faculty, from January 1, 2007-December 31, 2009, after manifesting seizures in their first postnatal 28 days. Of 112 newborns, 41 were female, 71 were male, 33 were preterm, and 79 were full-term. Perinatal asphyxia (28.6%) and intracranial hemorrhage (17%) were the most common causes of neonatal seizures. Cerebral palsy developed in 27.6% of patients during follow-up. The incidence of epilepsy was 35.7%. Almost 50% of patients manifested developmental delay in one or more areas. Global developmental delay was the most common (50.8%) neurologic disorder. The correlation between gestational age or birth weight and adverse outcomes was nonsignificant. Etiology, Apgar score, need for resuscitation at birth, background electroencephalogram, neonatal status epilepticus, cranial imaging findings, type/duration of antiepileptic treatment, and response to acute treatment were all strong prognostic factors in neurologic outcomes. Neonatal seizures pose a threat of neurologic sequelae for preterm and full-term infants. Although the number of recognized etiologic factors in neonatal seizures has increased because of improvements in neonatology and diagnostic methods, perinatal asphyxia remains the most common factor.
    Pediatric Neurology 09/2012; 47(3):186-92. DOI:10.1016/j.pediatrneurol.2012.05.015 · 1.70 Impact Factor
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    ABSTRACT: The main object of the present study is to assess neuromotor development of high-risk infants by using three tests, and to determine inter-test concordance and the feasibility of these tests. One-hundred and nine patients aged between 0 and 6 months and identified as "high-risk infant" according to the Kliegman's criteria were enrolled to the study. Three different tests were used to assess neuromotor development of the patients: Bayley scales of infant development-II (BSID-II), Alberta infant motor scale (AIMS), and Milani Comparetti Motor Development Screening Test (MCMDST). Correlation analysis was performed between pure scores of BSID-II motor scale and total scores of AIMS. These two tests were highly correlated (r:0.92). Moderate concordance was found between BSID-II and AIMS (k:0.35). Slight concordance was found between BSID-II and MCMDST; and the concordance was slight again for AIMS and MCMDST (k:0.11 and k:0.16, respectively) too. AIMS has a high correlation and consistency with BSID-II and can be used with routine neurological examination as it is based on observations, has few items, and requires less time to complete.
    Annals of Indian Academy of Neurology 07/2012; 15(3):196-9. DOI:10.4103/0972-2327.99714 · 0.60 Impact Factor
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    ABSTRACT: The aim of this study was to elucidate the clinical features, prothrombotic risk factors, and outcome of pediatric Moyamoya patients. Patients diagnosed with Moyamoya disease at a tertiary center between January 2000 and December 2006 were enrolled in this study. The clinical presentations, underlying diseases, prothrombotic risk factors, family history of thrombosis, radiological findings, treatment, and outcome of the patients were reviewed retrospectively. Eight patients with angiographically proven Moyamoya disease were identified, one of whom had neurofibromatosis type I and one had Down syndrome. The age at diagnosis varied between 19 months and 11 years (73.4±41.8 months, mean±SD). The follow-up period after diagnosis was 52.5±14.8 months. In six patients, the initial clinical presentation was hemiparesis. None of the patients had any identifiable prothrombotic factors. Despite medical and surgical treatment, three patients had recurrences and one died. Only two patients recovered without sequelae. The value of prothrombotic risk factor evaluation appears to be limited in Moyamoya patients; the outcome for pediatric patients remains dismal.
    Journal of Clinical Neurology 06/2012; 8(2):100-3. DOI:10.3988/jcn.2012.8.2.100 · 1.70 Impact Factor
  • Barış Ekici · Mine Calışkan · Burak Tatlı ·

    Journal of Pediatric Neurosciences 05/2012; 7(2):160-1. DOI:10.4103/1817-1745.102597
  • Barış Ekici · Burak Tatlı · Meral Özmen ·

    Turk Pediatri Arsivi 03/2012; 47(1):64-66. DOI:10.4274/tpa.125 · 0.06 Impact Factor
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    ABSTRACT: We present the neurodevelopmental outcome of patients with isolated borderline fetal ventriculomegaly. The present study was carried out at the Department of Pediatric Neurology, Istanbul Medical Faculty, Istanbul University in July-December 2010. Prenatal second trimester detailed ultrasound examinations were performed by obstetricians at the Prenatal Diagnosis Department of Istanbul Medical School, and 31 consecutive patients aged 8-33 months have been included in the study. Four patients with atrial diameters of over 15 mm and three patients with central nervous system development anomalies were excluded from the study. In order to assess the neuromotor development of patients, neurologic examinations and the Bayley Scales of Infant Development (BSID-III) were used. Nine patients were female (29%) and 22 were male (71%). In the postnatal period, tuberous sclerosis was found in one patient, Down syndrome in one, and equinovarus foot deformity in one. Atrial diameter was <12 mm in 18 patients and >12 mm in 13. Cranial ultrasounds done in the first postnatal month revealed persisting ventriculomegaly in nine patients. The two patients who scored significantly low in all areas on the Bayley Scales of Infant Development were the patients with Down syndrome and tuberous sclerosis. The one scoring low in the motor area was the patient with the equinovarus foot deformity. The BSID-III scores of the patients whose prenatal ventricle diameter was <12 mm were within normal limits. The four patients showing slight developmental delay were the ones whose cranial ultrasound in the first postnatal month showed persisting ventriculomegaly. In patients with borderline fetal ventriculomegaly, atrial diameter being more than 12 mm, the condition persisting in the first postnatal month and the presence of accompanying syndromes and malformations all constitute clear risk factors for neurodevelopmental outcome.
    Clinical neurology and neurosurgery 03/2012; 114(7):969-71. DOI:10.1016/j.clineuro.2012.02.025 · 1.13 Impact Factor
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    ABSTRACT: Aim: The aim of this study was to evaluate the application of complementary and alternative medicine (CAM) in pediatric epilepsy patients. Methods: The parents of 202 epilepsy patients being followed at the Pediatric Neurology outpatient clinic of the Istanbul Medical Faculty were interviewed face-to-face between November 2010 and February 2011. Results: At least one CAM method had been used by 95% of interviewed families. Religious practices were used by 94.1% of families. Non-religious spiritual practices were used by 9.9% and other alternative treatment methods by 27.7%. Families had started to use CAM at the suggestion of their doctor in 6.9% of the cases. Compared to the medium and high-income group, religious practices (96.8% vs 64.7%, p: 0.000) and regular prayer (92.4% vs 58.8%, p: 0.000) were significantly more prevalent in the low-income group. Regular prayer was more common in families where patients had moderately frequent or frequent seizures, while families of patients with rare seizures more commonly used religious practices other than regular prayer (p: 0.038, 0.027). The number of antiepileptics used and special education were found to correlate with the use of other alternative treatment methods (p: 0.002, 0.000). Families of patients with rare seizures are more inclined to see benefit in CAM (p = 0.043). Conclusion: Religious practices are the most frequently used type of CAM in families with epileptic children. The economic status of the parents and the course of the disease are the main factors that influence the choice between religious, spiritual and other CAM practices and the perception of benefit from them.
    European Journal of Integrative Medicine 03/2012; 4(1). DOI:10.1016/j.eujim.2011.10.005 · 0.78 Impact Factor
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    ABSTRACT: The aim of this study was to demonstrate demographics of 39 consecutive Spinal Muscular Atrophy (SMA) type 1 patients diagnosed genetically in a tertiary center between June 2006 and June 2009. There was history of consanguineous marriage in 27 (69%) patients. The average patient lifespan was 251 days (30-726 days). The average patient age at diagnosis was 129 days (33-297 days). A statistically significant correlation was found between the age at diagnosis and the lifespan (p = 0.00). No significant correlation was found between the time spent in intensive care and the lifespan (p = 0.43). Routine physical therapy was found to have no significant impact on the lifespan average (p = 0.17). The cause of death in all of our patients was respiratory issues. Genetic counseling was given to 35 families. A second child with SMA was born in three out of the 14 families who declined prenatal diagnosis. CONCLUSION: A national program is needed in Turkey for SMA prevention and creation of expert teams for the management of these patients.
    European Journal of Pediatrics 03/2012; 171(3):549-52. DOI:10.1007/s00431-011-1607-2 · 1.89 Impact Factor

  • Clinical neurology and neurosurgery 02/2012; 114(7):1033-4. DOI:10.1016/j.clineuro.2012.01.049 · 1.13 Impact Factor
  • Barış Ekici · Erhan Aygün · Burak Tatlı ·

    Turk Pediatri Arsivi 12/2011; 46(4):353-353. DOI:10.4274/tpa.46.692 · 0.06 Impact Factor
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    ABSTRACT: Adverse events were reported in various patients treated with etanercept, including infections (sepsis and tuberculosis), malignancies (e.g., lymphoma), demyelinating disorders, and autoimmune diseases. Only two adult patients with etanercept-related encephalopathy were previously reported. We describe a 7-year-old patient who developed encephalopathy immediately after his third dose of etanercept. To the best of our knowledge, ours is the first report of a pediatric patient with a diagnosis of systemic arthritis and who developed etanercept-related encephalopathy.
    Pediatric Neurology 10/2011; 45(4):271-3. DOI:10.1016/j.pediatrneurol.2011.06.013 · 1.70 Impact Factor

  • Turk Pediatri Arsivi 09/2011; 46(3):259-260. DOI:10.4274/tpa.46.85 · 0.06 Impact Factor
  • Meral Özmen · Burak Tatlı · Barış Ekici ·

    Turk Pediatri Arsivi 09/2011; 46(3):191-195. DOI:10.4274/tpa.46.73 · 0.06 Impact Factor
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    ABSTRACT: Mutations of the α-1 subunit sodium channel gene (SCN1A) cause severe myoclonic epilepsy of infancy (SMEI). To date, over 300 mutations related to SMEI have been described. In the present study, we report new SCN1A mutations and the clinical features of SMEI cases. We studied the clinical and genetic features of nine patients diagnosed with SMEI at the Pediatric Neurology Department of Istanbul Medical Faculty. Five patients had nonsense mutations, two had missense mutations, one had a splice site mutation and one had a deletion mutation of the SCN1A gene. Mutations at c.3705+5G splice site, p.trip153X nonsense mutation and deletion at c.2416_2946 have not been previously described. The seizures started following whole cell pertussis vaccination in all patients. The seizures ceased in one patient and continued in the other eight patients. Developmental regression was severe in three patients, with frequent status epilepticus. The type of mutation was not predictive for the severity of the disease. Two of the three patients with severe regression had nonsense and missense mutations. Dravet syndrome can be result of several different types of mutation in SCN1A gene. Onset of the seizures after pertussis vaccination is an important clue for the diagnosis and neuro- developmental delay should be expected in all patients.
    Annals of Indian Academy of Neurology 07/2011; 14(3):178-81. DOI:10.4103/0972-2327.85879 · 0.60 Impact Factor
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    ABSTRACT: The aim of this work was to assess the respiratory functions of ambulatory Duchenne patients and to propose an earlier time period for intervention. Lung functions and North Star Ambulatory Assessment (NSAA) scores of Duchenne patients were evaluated simultaneously. Thirty ambulatory Duchenne patients were included in this study. NSAA scores of the patients were directly correlated with arm abduction, arm adduction, and shoulder flexion strengths. Forced expiratory volume in 1 second percent predicted and forced vital capacity (FVC) percent predicted correlated inversely to age and to the NSAA score. Twelve of 13 patients with FVC values lower than 80% of predicted had NSAA scores below 24 points. None of the patients who were younger than 7 years had FVC values lower than 80% of predicted. Annual spirometry is necessary for Duchenne patients older than 6 years regardless of the ambulatory status.
    Annals of Indian Academy of Neurology 07/2011; 14(3):182-4. DOI:10.4103/0972-2327.85889 · 0.60 Impact Factor
  • Article: Response.

    Pediatric Neurology 07/2011; 45(1):63-4. DOI:10.1016/j.pediatrneurol.2011.03.010 · 1.70 Impact Factor