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Carla Perrotta,
Silke Kleefeld,
Anthony Staines,
Prerna Tewari,
Anneclaire J De Roos,
Dalsu Baris, Brenda Birmann,
Brian Chiu,
Wendy Cozen,
Nikolaus Becker,
Lenka Foretova,
Marc Maynadié,
Alexandra Nieters,
Silvia de Sanjosé,
Lucia Miligi,
Adele Seniori Costantini,
Mark Purdue,
John Spinelli,
Pierluigi Cocco
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ABSTRACT: Objective: We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case-control studies. Methods: We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM). Results: Gardeners and nursery workers combined, most likely exposed to pesticides, showed a 50% increase in risk (OR=1.50, 95% CI 0.9-2.3), while other farming jobs did not. Metal processors (OR=1.55, 95% CI 0.9-2.3), female cleaners (OR=1.32, 95% CI 1.0-1.8), and high level exposure to organic solvents (OR=1.38, 95% CI 0.96-1.8) also showed moderately increased risks. Conclusions: Additional case-control studies of MM aetiology are warranted to further investigate the nature of the repeatedly reported increase in MM risk in several occupational groups.
Cancer epidemiology. 02/2013;
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Nikolaus Becker,
Michael O Falster,
Claire M Vajdic,
Silvia de Sanjose,
Otoniel Martínez-Maza,
Paige M Bracci,
Mads Melbye,
Karin Ekström Smedby,
Eric A Engels,
Jennifer Turner, [......],
Anthony Staines,
Paul Brennan,
Scott Davis,
Richard Severson,
James R Cerhan,
Elizabeth C Breen, Brenda Birmann,
Wendy Cozen,
Andrew E Grulich,
Robert Newton
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ABSTRACT: We performed a pooled analysis of data on self-reported history of infections in relation to the risk of non-Hodgkin lymphoma (NHL) from 17 case-control studies that included 12,585 cases and 15,416 controls aged 16-96 years at recruitment. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were estimated in two-stage random-effect or joint fixed-effect models, adjusting for age, sex and study centre. Data from the 2 years before diagnosis (or date of interview for controls) were excluded. A self-reported history of infectious mononucleosis was associated with an excess risk of NHL (OR = 1.26, 95% CI = 1.01-1.57 based on data from 16 studies); study-specific results indicate significant (I(2) = 51%, p = 0.01) heterogeneity. A self-reported history of measles or whooping cough was associated with an approximate 15% reduction in risk. History of other infection was not associated with NHL. We find little clear evidence of an association between NHL risk and infection although the limitations of data based on self-reported medical history (particularly of childhood illness reported by older people) are well recognized.
International Journal of Cancer 01/2012; 131(10):2342-8. · 5.44 Impact Factor
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Andrew E Grulich,
Claire M Vajdic,
Michael O Falster,
Eleanor Kane,
Karin Ekstrom Smedby,
Paige M Bracci,
Silvia de Sanjose,
Nikolaus Becker,
Jenny Turner,
Otoniel Martinez-Maza, [......],
Marc Maynadié,
Lenka Foretova,
Anthony Staines,
Paul Brennan,
Scott Davis,
Richard K Severson,
James R Cerhan,
Elizabeth C Breen, Brenda Birmann,
Wendy Cozen
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ABSTRACT: There is inconsistent evidence that increasing birth order may be associated with risk of non-Hodgkin lymphoma (NHL). The authors examined the association between birth order and related variables and NHL risk in a pooled analysis (1983-2005) of 13,535 cases and 16,427 controls from 18 case-control studies within the International Lymphoma Epidemiology Consortium (InterLymph). Overall, the authors found no significant association between increasing birth order and risk of NHL (P-trend = 0.082) and significant heterogeneity. However, a significant association was present for a number of B- and T-cell NHL subtypes. There was considerable variation in the study-specific risks which was partly explained by study design and participant characteristics. In particular, a significant positive association was present in population-based studies, which had lower response rates in cases and controls, but not in hospital-based studies. A significant positive association was present in higher-socioeconomic-status (SES) participants only. Results were very similar for the related variable of sibship size. The known correlation of high birth order with low SES suggests that selection bias related to SES may be responsible for the association between birth order and NHL.
American journal of epidemiology 09/2010; 172(6):621-30. · 5.59 Impact Factor
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Claire M Vajdic,
Michael O Falster,
Silvia de Sanjose,
Otoniel Martínez-Maza,
Nikolaus Becker,
Paige M Bracci,
Mads Melbye,
Karin Ekström Smedby,
Eric A Engels,
Jennifer Turner, [......],
Lenka Foretova,
Anthony Staines,
Paul Brennan,
Scott Davis,
Richard Severson,
James R Cerhan,
Elizabeth C Breen, Brenda Birmann,
Wendy Cozen,
Andrew E Grulich
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ABSTRACT: We performed a pooled analysis of data on atopic disease and risk of non-Hodgkin lymphoma (NHL) from 13 case-control studies, including 13,535 NHL cases and 16,388 controls. Self-reported atopic diseases diagnosed 2 years or more before NHL diagnosis (cases) or interview (controls) were analyzed. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were computed in two-stage random-effects or joint fixed-effects models, and adjusted for age, sex, and study center. When modeled individually, lifetime history of asthma, hay fever, specific allergy (excluding hay fever, asthma, and eczema), and food allergy were associated with a significant reduction in NHL risk, and there was no association for eczema. When each atopic condition was included in the same model, reduced NHL risk was only associated with a history of allergy (OR, 0.80; 95% CI, 0.68-0.94) and reduced B-cell NHL risk was associated with history of hay fever (OR, 0.85; 95% CI, 0.77-0.95) and allergy (OR, 0.84; 95% CI, 0.76-0.93). Significant reductions in B-cell NHL risk were also observed in individuals who were likely to be truly or highly atopic-those with hay fever, allergy, or asthma and at least one other atopic condition over their lifetime. The inverse associations were consistent for the diffuse large B-cell and follicular subtypes. Eczema was positively associated with lymphomas of the skin; misdiagnosis of lymphoma as eczema is likely, but progression of eczema to cutaneous lymphoma cannot be excluded. This pooled study shows evidence of a modest but consistent reduction in the risk of B-cell NHL associated with atopy.
Cancer Research 09/2009; 69(16):6482-9. · 7.86 Impact Factor
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Karin Ekström Smedby,
Claire M Vajdic,
Michael Falster,
Eric A Engels,
Otoniel Martínez-Maza,
Jennifer Turner,
Henrik Hjalgrim,
Paolo Vineis,
Adele Seniori Costantini,
Paige M Bracci, [......],
Lenka Foretova,
Anthony Staines,
Paul Brennan,
Scott Davis,
Richard Severson,
James R Cerhan,
Elizabeth C Breen, Brenda Birmann,
Andrew E Grulich,
Wendy Cozen
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ABSTRACT: Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis.
Blood 05/2008; 111(8):4029-38. · 9.90 Impact Factor
