Publications (12)4.85 Total impact
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Article: Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats.
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ABSTRACT: The aim of this study was to investigate the antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of whole plant of Amaranthus viridis (MEAV) in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (140 mg/kg) in albino Wister rats. MEAV (200 and 400 mg/kg) and glibenclamide (10 mg/kg, p.o.) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. On the 15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC), total glycerides (TG) and total proteins (TP). For in vivo antioxidant activity of MEAV, liver tissues were homogenized and the assay of lipid peroxidation and was measured as Malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and total thiols (TT) were performed in control, ALX and MEAV treated rats. MEAV at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid profiles and significant improvement in MDA, GSH, CAT and TT when compared to diabetic control group. In vitro α-amylase inhibition activity of MEAV was also studied. We concluded that MEAV possess antidiabetic, antihyperlipidemic and antioxidant activities.Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie 01/2012; 64(1-2):75-9. · 1.43 Impact Factor -
Article: Evaluation of the Antioxidant Activity of Amaranthus spinosus Linn. by Non-Enzymatic Haemoglycosylation
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ABSTRACT: Amaranthus spinosus Linn. complete plant material was extracted successively by petroleum ether, chloroform, methanol, and water. All the extracts were subjected to in vitro non-enzymatic haemo-glycosylation method, i.e. an oxidation reaction. The degree of haemoglycosylation in the presence of different extracts of Amaranthus spinosus were measured colorimetrically at 520 nm. The preventive effect of haemoglobin glycosylation at the two concentration; 0.5 and 1 mg/mL was estimated as follows: pet. ether; 13.1%, 16.4%, chloroform; 5.7%, 12%, methanol: 36.91%, 56.07% and aqueous: 22.2%, 31.01 %, respectively. The α-tocopheral (Vitamin E) was used as standard.Sains Malaysiana. 01/2010; -
Article: Evaluation of Wound healing activity of Buxus wallichiana Baill
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ABSTRACT: Aim In this study, aim was to investigate the wound healing and antioxidant activities of Buxus wallichiana bark. Meterials and Methods The Methanolic extract of Buxus walliachiana Baill, was evaluated for wound healing activity by excision model at 5 and 10 % concentration. Results Methanol extract of Buxus walliachiana ointment (5 %) showed a significant reduction in the wound area from 10th day to 20th day of the experiment and 10 % produced dose depended reduction in the wound area. Nitrofurazolidine ointment (2 %) was used as standard. Methanol extract of Buxus walliachiana ointment 10 % showed significant reduction in wound area when all results were compared with standard. Different extracts of Buxus walliachiana was evaluated for antioxidant potential by; DPPH and Nitric oxide methods. Conclusion Methanol extract showed potential antioxidant activity.Journal of Pharmacokinetics and Pharmacodynamics 03/2009; 10:59-63. · 2.06 Impact Factor -
Article: Time Delay Compensation for High Speed Digital Protection
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ABSTRACT: Processing of the fault transients for eliminating the unwanted signals, is essential. for the EHV system protection. The various components which perform this function, and the filters in particular, introduce a significant delay in the operation of the protective devices. The paper investigates the various sources of time delay, and presents a digital. time delay compensation scheme, together with some test results.IEEE Transactions on Power Delivery 11/1986; · 1.35 Impact Factor -
Article: Analysis of ferro-oscillations in power systems
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ABSTRACT: The paper presents an analysis of ferro-oscillations in capacitor voltage transformers and series-compensated e.h.v. lines. The dual-input describing function is adopted to show the regions of existence and the influence of system parameters on such oscillations. A complete analytical method suitable for digital computation has been developed for determining the amplitudes of these oscillations.Electrical Engineers, Proceedings of the Institution of. 08/1974; -
Article: Computer-aided analysis of high-speed protective relays
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ABSTRACT: Most of the modern distance relays are designed to avoid overreaching due to the transient d.c. component of the fault current, whereas a more likely source of transients in e.h.v. systems is the oscillatory discharge of the system charging current into the fault. Until now attempts have not been made to reproduce these transients in the laboratory. This paper describes an analogue and an accurate digital simulation of these harmonic transients. The dynamic behaviour of a typical polarised mho-type relay is analysed, and results are presented. The paper also advocates the use of active filters for filtering the harmonics associated with e.h.v. system, and hence, to improve the speed of response and accuracy of the protective relays.Electrical Engineers, Proceedings of the Institution of. 08/1974; -
Article: Hybrid Comparison Technique for Distance Relays
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ABSTRACT: A new hybrid comparison technique for transmission line protection, providing polar characteristics marked by sharp discontinuities, has been developed. The comparator models, described in block schematic form, accompany a steady state theoretical basis for comparison. Dynamic test results are indicated for a directional quadrilateral characteristic which closely corresponds to the probable fault area of a transmission line.IEEE Transactions on Power Apparatus and Systems 04/1971; -
Article: Effectiveness of Series Capacitors in Long Distance Transmission Lines
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ABSTRACT: The effectiveness of series capacitors used with long distance transmission lines in improving system stability is analyzed. Compensation efficiency is defined as the effectiveness of series capacitors. The influence of various factors on compensation efficiency such as capacitor location, line length, and degree of series compensation is investigated. Proper use of shunt reactors with series capacitors, in addition to limiting power frequency over- voltages, increases the maximum power transfer. Analytical expressions are included to aid in the calculation of compensation efficiency for a few typical cases. Curves are also presented indicating the critical value of shunt Mvar required for various degrees of series compensation and line lengths.IEEE Transactions on Power Apparatus and Systems 06/1970; -
Article: In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats
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ABSTRACT: Amaranthus spinosus Linn. (Amaranthaceae), commonly known as “Mulluharivesoppu” in Kannada, is used in the Indian traditional system of medicine for the treatment of diabetes. The present study deals with the scientific evaluation of alpha amylase and the antioxidant potential of methanol extract of A. spinosus (MEAS). The aim of this study was to investigate in vitro alpha-amylase enzyme inhibition by CNPG3 (2-chloro-4-nitrophenol α-d-maltotrioside) and in vivo antioxidant potential of malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and total thiols (TT) in alloxan-induced diabetic rats of a methanolic extract of A. spinosus. Blood sugar was also determined in MEAS-treated alloxan-induced diabetic rats. MEAS showed significant inhibition of alpha-amylase activity and IC50 46.02 μg/ml. Oral administration of MEAS (200 and 400 mg/kg) for 15 days showed significant reduction in the elevated blood glucose, MDA and restores GSH, CAT and TT levels as compared with a diabetic control. The present study provides evidence that the methanolic extract of A. spinosus has potent alpha amylase, anti-diabetic and antioxidant activities.Saudi Journal of Biological Sciences 18(1):1-5. -
Article: Laxative Property of Safoof-E-Sana, a Unani Formulation
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ABSTRACT: An investigation was carried out to study the laxative property of aqueous extract Safoof-ESana in the unani formulation. Aqueous extract of Safoof-E-Sana was evaluated for laxative property and was measured by weighing the fecal out at 8th and 16th hour of drug administration. Safoof-E-Sana at 50, and 100 mg/kg showed dose dependent laxative effect. The results are compared with standard Senna. Safoof-E-Sana was showed significant laxative activity.Ethnobotanical Leaflets. -
Article: Estimation of Rutin and Quercetin in Amaranthus viridis L by High Performance Layer Chromatography (HPLC)
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ABSTRACT: Flavonoids are a group of polyphenolic compounds, which are widely distributed through out the plant kingdom. Flavonoids like Rutin and quercetin possess many biochemical effects like inhibition of enzymes, regulatory role on different hormones and pharmacological activities like antimicrobial, antioxidant, and anticancer, antihepatotoxic, protection of cardio vascular system. An HPLC method was developed for the estimation of rutin and quercetin from methanol herbal extract of Amaranthus viridis. Amaranthus viridis is traditionally used for treatment of constipation, inflammation, eczema, bronchitis, anemia, and leprosy.Ethnobotanical Leaflets. -
Article: Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats
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ABSTRACT: The aim of this study was to investigate the antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of whole plant of Amaranthus viridis (MEAV) in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (140 mg/kg) in albino Wister rats. MEAV (200 and 400 mg/kg) and glibenclamide (10 mg/kg, p.o.) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. On the 15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC), total glycerides (TG) and total proteins (TP). For in vivo antioxidant activity of MEAV, liver tissues were homogenized and the assay of lipid peroxidation and was measured as Malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and total thiols (TT) were performed in control, ALX and MEAV treated rats. MEAV at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid profiles and significant improvement in MDA, GSH, CAT and TT when compared to diabetic control group. In vitro α-amylase inhibition activity of MEAV was also studied. We concluded that MEAV possess antidiabetic, antihyperlipidemic and antioxidant activities.Experimental and Toxicologic Pathology.
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Institutions
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1986
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The University of the West Indies, Trinidad and Tobago
Port-of-Spain, Port-of-Spain, Trinidad and Tobago
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