B Luft

Publications (6)11.58 Total impact

• Article: Histopathology of Peromyscus leucopus naturally infected with pathogenic NY-1 hantaviruses: pathologic markers of HPS viral infection in mice.

  S Lyubsky, I Gavrilovskaya, B Luft, E Mackow
  [show abstract] [hide abstract]
  ABSTRACT: Hantavirus research is impeded by the absence of animal models of viral pathogenesis. We have studied the histopathology of mice (P. leucopus) naturally infected with the NY-1 hantavirus on Shelter Island, New York. Five mice were determined to be seropositive in Western blotting to Four Corners Virus nucleocapsid protein and had serum antibodies to Seoul and Puumala hantavirus antigens by immunofluorescence assay. Hantavirus gene segments of the NY-1 hantavirus were identified in these mice and shown to be 99% identical to hantavirus genes isolated from the Rhode Island patient with hantavirus pulmonary syndrome. In ultrastructural examinations, we identified hantavirus particles in pulmonary endothelial cells. Morphologically, these mice demonstrate lymphohistocytic infiltrates in hepatic portal zones and slightly increased numbers of immunoblasts in splenic red pulp. Additionally, the alveolar septa in the lungs of infected mice are edematous with hyperplasia of type 1 pneumocytes. Naturally infected P. leucopus may serve as potentially useful animal models of hantavirus pulmonary syndrome disease.
  Laboratory Investigation 04/1996; 74(3):627-33. · 3.64 Impact Factor
• Article: Use of third-generation cephalosporins. Spirochetes.

  B Luft, P Mariuz
  [show abstract] [hide abstract]
  ABSTRACT: Although dosing schedules are still being worked out, ceftriaxone has been shown to be effective in both primary and secondary syphilis. In our experience, ceftriaxone was the drug of choice for the treatment of Lyme disease.
  Hospital practice (Office ed.) 02/1991; 26 Suppl 4:34-9; discussion 53-4.
• Article: Suppression of newborn natural killer cell activity by prostaglandin E2.

  P O Milch, W Salvatore, B Luft, D A Baker
  [show abstract] [hide abstract]
  ABSTRACT: The effect of prostaglandin E2 on natural killer cell activity of cord blood was examined. Natural killer cell activity, determined by chromium 51 release, was significantly reduced after prostaglandin E2 (1 microgram/ml) treatment. Prostaglandin E2 has been found to enhance the cellular spread of herpesvirus. Thus prostaglandins may enhance viral infections indirectly by suppressing natural killer cell activity.
  American Journal of Obstetrics and Gynecology 11/1988; 159(4):895-6. · 3.47 Impact Factor
• Article: Massive cytomegalovirus pneumonia and myocarditis in a renal transplant recipient: successful treatment with DHPG.

  M Shabtai, B Luft, W C Waltzer, D Anaise, F T Rapaport
  Transplantation Proceedings 07/1988; 20(3):562-3. · 1.00 Impact Factor
• Article: Enhancement of maternal and neonatal natural killer cell activity with interleukin-2.

  D A Baker, P O Milch, W Salvatore, B Luft
  [show abstract] [hide abstract]
  ABSTRACT: Natural killer cell activity, which is vital to the immune surveillance against viruses and tumor cells, is significantly lower in the newborn infant than in the mother. Incubation of maternal and cord blood lymphocytes with interleukin-2 significantly increases natural killer activity in both. The increase is substantially greater in the cord blood lymphocytes.
  American Journal of Obstetrics and Gynecology 09/1987; 157(3):780-1. · 3.47 Impact Factor
• Article: A 40-year-old man with chills, fever, weight loss, and a productive cough.

  S Cantor, M Clair, S Nelson, B Luft, S Lyubsky, E L Gogel
  New York state journal of medicine 01/1986; 85(12):694-701.