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ABSTRACT: It is generally accepted that peak bone mass affects later fracture risk in the elderly. The extent to which early nutrition and growth can program later bone health has been examined in only a few studies. In the Copenhagen Cohort Study we showed that breastfed infants had significantly higher serum (s)-osteocalcin concentration than did formula-fed infants.
We investigated whether early nutrition and early growth are associated with later bone mass in adolescence.
Participants were examined at birth; at ages 2, 6, and 9 mo (n = 143); and at age 17 y (n = 109) with anthropometric and s-osteocalcin measures and whole-body dual-energy X-ray absorptiometry (DXA) scanning (age 17 y only). Total body (T) and lumbar spine (LS) DXA values were used.
The duration of exclusive breastfeeding was positively correlated with the sex-adjusted LS bone mineral content (BMC), LS bone area (BA), and LS bone mineral density (BMD) (all P < 0.03) and with size-adjusted LS-BMC (P = 0.075) at 17 y of age. s-Osteocalcin at 6 mo was positively correlated with sex-adjusted LS-BMC and LS-BMD (both P < 0.04) and with size-adjusted LS-BMC (P = 0.047) at 17 y of age. Weight and length at 9 mo and increase in weight and length during the first 9 mo of life were positively correlated with sex-adjusted T-BMC and T-BA at age 17 y (all P < 0.04).
Early body size and growth in infancy are related to bone mass in late adolescence. Furthermore, the duration of exclusive breastfeeding and the markers of bone turnover at 6 mo seem to be positively related to LS bone mass at age 17 y.
American Journal of Clinical Nutrition 08/2011; 94(6 Suppl):1865S-1869S. · 6.67 Impact Factor
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ABSTRACT: The demand for organic food products has increased during the last decades due to their probable health effects, among others. A higher content of secondary metabolites such as carotenoids in organic food products has been claimed, though not documented, to contribute to increased health effects of organic foods. The aim was to study the impact of organic and conventional agricultural systems on the content of carotenoids in carrots and human diets. In addition, a human cross-over study was performed, measuring the plasma status of carotenoids in humans consuming diets made from crops from these agricultural systems.
Journal of the Science of Food and Agriculture 03/2011; 91(4):767-75. · 1.44 Impact Factor
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ABSTRACT: We have previously shown that at equal protein content, milk, but not meat, decreased bone turnover in boys. This suggested that milk-derived components are important for bone metabolism. In the present study, we hypothesized that milk-derived proteins (whey and casein) affect bone turnover during growth depending on the content of milk minerals (calcium and phosphorus). This was a randomized, parallel, double-blind study. Eight-year-old boys (n = 57) received 1 of 4 milk drinks: whey protein with low or high content of minerals, or casein protein with low or high content of minerals. The amount of whey and casein was identical to their content in 1.5 L of milk. We measured serum osteocalcin (sOC), bone-specific alkaline phosphatase, and C-terminal telopeptides of type I collagen (immunoassay) and estimated dietary intake (3-day weighed food record) at baseline and after 7 days. Only sOC was significantly affected by the treatments (P < .05). There was a significant interaction between milk-derived proteins and minerals with regard to sOC (P = .01). The intake of milk drinks containing whey increased sOC at the low content of minerals, whereas it decreased sOC at the high content of minerals (P < .05). In contrast, milk drinks containing casein increased sOC both at the low and at the high contents of minerals. In conclusion, whey and casein (corresponding to their content in 1.5 L of milk) differently affect sOC in 8-year-old boys depending on the content of milk minerals, but do not seem to affect other markers for bone turnover.
Nutrition research (New York, N.Y.) 08/2010; 30(8):558-64. · 1.20 Impact Factor
