Ali Bakhtiari

Publications (3)0 Total impact

• Source

  Available from: Ali Karami

  Dataset: H pylori Genotypes

  Hossein Khedmat, Ali Karami, Zahra Safiri, Mohsen Amini, Ali Bakhtiari, Ashraf Karbasi, Mojgan Jayhounian, Hamidreza Jalalian, Saeed Taheri
• Source

  Available from: Ali Karami

  Article: Helicobacter pylori genotypes can predict gastric tissue histopathology: a longitudinal study of Iranian patients.

  Hossein Khedmat, Ali Karami, Zahra Safiri, Mohsen Amini, Ali Bakhtiari, Ashraf Karbasi, Mojgan Jayhounian, Hamidreza Jalalian, Saeed Taheri
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  ABSTRACT: Several factors have been suggested to account for differences in the virulence of Helicobacter pylori infections in various populations. Evidence suggests the existence of different strains of H. pylori with different degrees of virulence. The present study aimed to investigate the gastric histopathology in Iranian patients infected with H. pylori and to investigate the relationship between the severity of gastritis and four different bacterial virulence-associated genotypes. All of the patients with positive results from a pathological examination, a rapid urease test, and PCR analysis for H. pylori infection were consecutively included into the study. The classification and grading of gastritis were performed according to the Sydney System. Esophagitis was classified endoscopically according to the Savary-Miller grading system. The primers used in this study targeted 16S rRNa (521 bp), Urease A (411 bp), Cag A (400 bp), and 26 kDa (303 bp). Twenty-eight patients were included in the study. The presence of Cag A showed a significant relationship with higher gastritis grades (3.0±0.7 vs. 2.3±0.9, p=0.024) and higher scores for H. pylori infection (3.0±0.7 vs. 2.3±0.7, p=0.027). The patients infected with 26 kDa-positive H. pylori had significantly higher infection scores (3.5±0.6 vs. 2.5±0.6, p=0.020). This study showed that CagA-positive H. pylori infection is associated with more severe gastritis and with increased bacterial density and inflammation in the biopsy specimens. The 303-bp positive genotype was also significantly associated with higher grades of esophagitis. Additional in-depth trials will be helpful in extending our findings.
  Journal of infection and public health. 04/2012; 5(2):153-8.
• Source

  Available from: Ali Karami

  Article: Diagnostic accuracy of PCR based method using four gene primers to detect Helicobacter pylori infection in gastric tissues: report from Iran.

  Hossein Khedmat, Ali Karami, Zahra Safiri, Mohsen Amini, Ali Bakhtiari, Ashraf Karbasi, Mojgan, Jayhounian, Hamidreza Jalalian, Saeed Taheri
  Tropical gastroenterology: official journal of the Digestive Diseases Foundation 01/2010; 31(2):116-8.