[show abstract][hide abstract] ABSTRACT: To find any association of white blood cells, haemoglobin and ESR with ischemic heart disease in high risk native population.
The study included 93 male patients with Ischemic heart disease, between 40 and 60 years of age; 96 age and gender matched subjects. All study participants were non-diabetics. Complete blood cells count, haemoglobin and ESR levels were compared between the patient and control groups.
Total leukocyte counts along with neutrophils were significantly higher in the test group compared to the control population (p < 0.001) and lymphocytes were significantly lower (p < 0.001) in the patient group as compared to the control group. Haemoglobin levels were significantly lower (p < 0.001) and ESR was higher (p = 0.030) in the patient group as compared to the control group.
Although, our findings of the study variables extend previous reports, the prevalence and prognostic importance of theses variables in IHD should be assessed in future experimental studies. These parameters could be important in public health because they are routinely measured by clinicians and may be helpful to predict the risk of future and secondary ischemic events in a high risk population.
Journal of Ayub Medical College, Abbottabad: JAMC 21(3):59-62.
[show abstract][hide abstract] ABSTRACT: Staphylococcus aureus is a gram positive bacterium that causes a number of diseases such as abscesses, infective endocarditis, septic arthritis, etc. It is acquiring resistance against many antibiotics like methicillin; therefore its control is becoming increasingly difficult. Peripheral blood phagocytes particularly polymorphonuclear leucocytes play an important role in the protective mechanisms against these organisms. Phagocytes interact with bacteria and phagocytose these microorganisms to kill them.
Phenotypically different isolates of Staphylococcus aureus including methicillin resistant Staphylococcus aureus (MRSA) and methicillin sensitive Staphylococcus aureus (MSSA) were collected from various hospitals of Lahore, Pakistan. Fresh polymorphonuclaer leucocytes were obtained from healthy individuals by centrifugation using Ficol-Hypaque gradient combined with dextran sedimentation. Microbiological method was used for the determination of phagocytic index of phenotypic variants of Staphylococcus aureus.
A significant difference was observed between the phagocytic index of both bacterial groups. MSSA group showed the Mean +/- SD of 79.46% +/- 3.9 while MRSA group showed 72.350% +/- 2.5.
Significant difference in phagocytic index indicates that it can be one of the mechanisms of MRSA to evade host immune system as compare to MSSA.
Journal of Ayub Medical College, Abbottabad: JAMC 21(2):49-52.