JALILIAN, AMIR R,
Nuclear Medicine Research Group,
Agricultural,
Medical and Industrial Research School (AMIRS,
Karaj,
Iran,
ajalilian@nrcam.org,
GAROUSI,
JAVAD,
YOUSEFNIA,
HASSAN,
RAJABIFAR,
SAEED
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ABSTRACT: -human chorionic gonadotropin (-hCG) was successively labeled with [67Ga] gallium chloride after conjugation with freshly prepared diethylenetriaminepentaacetic acid dianhydride (ccDTPA). After solid phase purification of the radiolabeled hormone, high performance liquid chromatography showed radiochemical purity higher than 95 % under optimized conditions (specific activity = 2223 TBq mM1, labeling efficiency 80 %). Preliminary in vivo studies (ID g1, %) in male wild-type rats showed marked gonadal uptake of the tracer after 240 minutes in agreement with the biodistribution studies and reported -hCG receptors. Target to blood ratios were 5.1 and 15.2 after 3 and 24 hours, respectively, while target to muscle ratios were 35 and 40 after 3 and 24 hours, respectively.
Acta pharmaceutica (hfd-fg-ap@zg.htnet.hr); Vol.59 No.4.
