-
A J Cooper,
N G Forouhi,
Z Ye,
B Buijsse,
L Arriola,
B Balkau,
A Barricarte,
J W J Beulens,
H Boeing,
F L Büchner, [......],
I Sluijs,
A M W Spijkerman,
B Teucher, A Tjonneland,
R Tumino,
S J Sharp,
C Langenberg,
E J M Feskens,
E Riboli,
N J Wareham
[show abstract]
[hide abstract]
ABSTRACT: Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.
European journal of clinical nutrition 08/2012; 66(10):1082-1092. · 3.07 Impact Factor
-
C A González,
F Megraud,
A Buissonniere,
L Lujan Barroso,
A Agudo,
E J Duell,
M C Boutron-Ruault,
F Clavel-Chapelon,
D Palli,
V Krogh, [......],
K Bakken,
V Dumeaux,
E Lund,
M Jenab,
I Romieu,
D Michaud,
T Mouw,
F Carneiro,
C Fenge,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: In epidemiological studies, Helicobacter pylori infection is usually detected by enzyme-linked immunosorbent assay (ELISA). However, infection can spontaneously clear from the mucosa during the progression of atrophy and could lead to substantial under-detection of infection and underestimation of its effect on gastric cancer (GC) risk. Antibodies detected by western blot are known to persist longer after the loss of the infection.
In a nested case-control study from the Eurogast-EPIC cohort, including 88 noncardia GC cases and 338 controls, we assessed the association between noncardia GC and H. pylori infection comparing antibodies detected by western blot (HELICOBLOT2.1) to those detected by ELISA (Pyloriset EIA-GIII(®)).
By immunoblot, 82 cases (93.2%) were H. pylori positive, 10 of these cases (11.4%) were negative by ELISA and only 6 cases (6.8%) were negative by both ELISA and immunoblot. Multivariable odds ratio (OR) for noncardia GC comparing immunoglobulin G positive versus negative by ELISA was 6.8 [95% confidence interval (CI) 3.0-15.1], and by immunoblot, the OR was 21.4 (95% CI 7.1-64.4).
Using a western blot assay, nearly all noncardia GC were classified as H. pylori positive and the OR was more than threefold higher than the OR assessed by ELISA, supporting the hypothesis that H. pylori infection is a necessary condition for noncardia GC.
Annals of Oncology 09/2011; 23(5):1320-4. · 6.43 Impact Factor
-
S S M Chan,
R Luben,
M M Bergmann,
H Boeing,
A Olsen, A Tjonneland,
K Overvad,
R Kaaks,
H Kennedy,
K-T Khaw,
E Riboli,
A R Hart
[show abstract]
[hide abstract]
ABSTRACT: Aspirin has detrimental effects on the gastrointestinal tract mucosa and may play a role in the aetiology of inflammatory bowel disease.
To investigate if the regular use of aspirin is associated with the development of Crohn's disease (CD) and ulcerative colitis (UC) using, for the first time, a prospective cohort study design.
A total of 135,780 men and women in Europe, aged 30-74years, were recruited into the European Prospective Investigation into Cancer and Nutrition study. Participants completed questionnaires at baseline detailing their regular aspirin use and were then followed up to identify those who developed either incident CD or UC. Each case was matched with four controls and odds ratios (OR) were calculated, adjusting for cigarette smoking. Potential interactions between aspirin and smoking were assessed.
A total of 35 participants developed CD and a further 84 were diagnosed with UC. Regular aspirin intake was positively associated with the risk of developing CD (OR=6.14, 95% CI=1.76-21.35). In those who took aspirin and smoked there was no detectable increased risk of CD (OR=0.30, 95% CI=0.03-3.08). No association was found between regular aspirin use and UC (OR=1.29, 95% CI=0.67-2.46).
A strong positive association between regular aspirin use and CD, but not UC, was observed. The data suggest that regular aspirin use should be measured in epidemiological work on CD. If such findings are consistent in other work then aspirin may affect the development of CD in a middle-aged to elderly population.
Alimentary Pharmacology & Therapeutics 09/2011; 34(6):649-55. · 3.77 Impact Factor
-
S. S. M. Chan,
R. Luben,
M. M. Bergmann,
H. Boeing,
A. Olsen, A. Tjonneland,
K. Overvad,
R. Kaaks,
H. Kennedy,
K.-T. Khaw,
E. Riboli,
A. R. Hart
[show abstract]
[hide abstract]
ABSTRACT: Aliment Pharmacol Ther 2011; 34: 649–655SummaryBackground Aspirin has detrimental effects on the gastrointestinal tract mucosa and may play a role in the aetiology of inflammatory bowel disease.Aim To investigate if the regular use of aspirin is associated with the development of Crohn’s disease (CD) and ulcerative colitis (UC) using, for the first time, a prospective cohort study design.Methods A total of 135 780 men and women in Europe, aged 30–74 years, were recruited into the European Prospective Investigation into Cancer and Nutrition study. Participants completed questionnaires at baseline detailing their regular aspirin use and were then followed up to identify those who developed either incident CD or UC. Each case was matched with four controls and odds ratios (OR) were calculated, adjusting for cigarette smoking. Potential interactions between aspirin and smoking were assessed.Results A total of 35 participants developed CD and a further 84 were diagnosed with UC. Regular aspirin intake was positively associated with the risk of developing CD (OR = 6.14, 95% CI = 1.76–21.35). In those who took aspirin and smoked there was no detectable increased risk of CD (OR = 0.30, 95% CI = 0.03–3.08). No association was found between regular aspirin use and UC (OR = 1.29, 95% CI = 0.67–2.46).Conclusions A strong positive association between regular aspirin use and CD, but not UC, was observed. The data suggest that regular aspirin use should be measured in epidemiological work on CD. If such findings are consistent in other work then aspirin may affect the development of CD in a middle-aged to elderly population.
Alimentary Pharmacology & Therapeutics 07/2011; 34(6):649 - 655. · 3.77 Impact Factor
-
B Schlehofer,
B Siegmund,
J Linseisen,
J Schüz,
S Rohrmann,
S Becker,
D Michaud,
B Melin,
H Bas Bueno-de-Mesquita,
P H M Peeters, [......],
M-D Chirlaque,
A Barricarte,
S Borgquist,
J Manjer,
V Gallo,
N E Allen,
T J Key,
E Riboli,
R Kaaks,
J Wahrendorf
[show abstract]
[hide abstract]
ABSTRACT: Case-control studies suggest that patients with allergic diseases have a lower risk of developing glioma but not meningioma or schwannoma. However, those data can be differentially biased. Prospective studies with objective measurements of immunologic biomarkers, like immunoglobulin E (IgE), in blood obtained before cancer diagnosis could help to clarify whether an aetiological association exists.
The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. Subjects with an IgE level ≥0.35 kUA/l (kilo antibody units per litre) were classified as sensitized by allergens. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by adjusted conditional logistic regression models for each tumour subtype. The effect of dose-response relationship was assessed in five increasing IgE level categories to estimate P-values for trend.
The risk of glioma was inversely related to allergic sensitization (OR = 0.73; 95% CI 0.51-1.06), especially pronounced in women (OR = 0.53; 95% CI 0.30-0.95). In dose-response analyses, for high-grade glioma, the lowest OR was observed in sera with the highest IgE levels (P for trend = 0.04). No association was seen for meningioma and schwannoma.
The results, based on serum samples prospectively collected in a cohort study, provide some support for the hypothesis that individuals with allergic sensitization are at reduced risk of glioma and confirm results from previous case-control studies.
Allergy 07/2011; 66(11):1434-41. · 6.27 Impact Factor
-
C Langenberg,
S Sharp,
N G Forouhi,
P W Franks,
M B Schulze,
N Kerrison,
U Ekelund,
I Barroso,
S Panico,
M J Tormo, [......],
B Teucher, A Tjonneland,
R Tumino,
D L van der A,
W M M Verschuren,
J Tuomilehto,
E Feskens,
M McCarthy,
E Riboli,
N J Wareham
[show abstract]
[hide abstract]
ABSTRACT: Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes.
Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and verified. Prentice-weighted Cox regression and random-effects meta-analyses were used to investigate differences in diabetes incidence by age and sex.
A total of 12,403 verified incident cases of type 2 diabetes occurred during 3.99 million person-years of follow-up of 340,234 EPIC participants eligible for InterAct. We defined a centre-stratified subcohort of 16,154 individuals for comparative analyses. Individuals with incident diabetes who were randomly selected into the subcohort (n = 778) were included as cases in the analyses. All prevalent diabetes cases were excluded from the study. InterAct cases were followed-up for an average of 6.9 years; 49.7% were men. Mean baseline age and age at diagnosis were 55.6 and 62.5 years, mean BMI and waist circumference values were 29.4 kg/m(2) and 102.7 cm in men, and 30.1 kg/m(2) and 92.8 cm in women, respectively. Risk of type 2 diabetes increased linearly with age, with an overall HR of 1.56 (95% CI 1.48-1.64) for a 10 year age difference, adjusted for sex. A male excess in the risk of incident diabetes was consistently observed across all countries, with a pooled HR of 1.51 (95% CI 1.39-1.64), adjusted for age.
InterAct is a large, well-powered, prospective study that will inform our understanding of the interplay between genes and lifestyle factors on the risk of type 2 diabetes development.
Diabetologia 06/2011; 54(9):2272-82. · 6.81 Impact Factor
-
M M Bergmann,
M Schütze,
A Steffen,
H Boeing,
J Halkjaer, A Tjonneland,
N Travier,
A Agudo,
N Slimani,
S Rinaldi, [......],
D Palli,
S Grioni,
P Vineis,
S Panico,
R Tumino,
E Riboli,
N J Wareham,
B Bueno-de-Mesquita,
A May,
P H M Peeters
[show abstract]
[hide abstract]
ABSTRACT: The relation between lifetime use of alcohol and measures of abdominal and general adiposity is unknown.
Among 99,381 men and 158,796 women of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, means of waist circumference (WC), waist-to-hip-ratio (WHR) and body mass index (BMI), and odds ratios (OR) for a larger WC than predicted for a given BMI (WClp=positive residuals of gender specific linear regression of BMI on WC) across categories of average lifetime use of alcohol (total, from wine and from beer) were calculated, all adjusted for socio-demographic, lifestyle and health factors.
WC, WHR and BMI in men using lifetime ≤6 g/d alcohol were 95.1 cm, 0.942 and 27.3 kg/m(2), and 96.2 cm, 0.961 and 28.3 kg/m(2) when using >96 g/d. WC and WHR in women was 83.2 cm and 0.813 for ≤6 g/d, and 84.6 cm and 0.830 for >60 g/d, whereas BMI deviated only slightly with the lowest BMI (26.7 kg/m(2)) observed for >6-24 g/d. Compared with ≤6 g/d, OR for a WClp in both genders increased steadily across categories of alcohol use (up to 1.40 (95% confidence interval 1.32, 1.49) in men using >60 g/d and 1.63 (1.54, 1.73) in women using >24 g/d), though increase was higher for alcohol from beer than from wine (P for difference between beer and wine<0.001 (men) and=0.002 (women)).
Lifetime alcohol use is positively related to abdominal and general adiposity in men, possibly following the male weight gain pattern; in women, it is positively related only to abdominal adiposity. In this context, beer may contribute additionally to abdominal adiposity.
European journal of clinical nutrition 05/2011; 65(10):1079-87. · 3.07 Impact Factor
-
M M Bergmann,
M Sch|[uuml]|tze,
A Steffen,
H Boeing,
J Halkjaer, A Tjonneland,
N Travier,
A Agudo,
N Slimani,
S Rinaldi, [......],
D Palli,
S Grioni,
P Vineis,
S Panico,
R Tumino,
E Riboli,
N J Wareham,
B Bueno-de-Mesquita,
A May,
P H M Peeters
[show abstract]
[hide abstract]
ABSTRACT: Background/Objectives: The relation between lifetime use of alcohol and measures of abdominal and general adiposity is unknown.
European Journal of Clinical Nutrition 05/2011; 65(10):1079-1087. · 2.46 Impact Factor
-
Valerie A McCormack,
Antonio Agudo,
Christina C Dahm,
Kim Overvad,
Anja Olsen, Anne Tjonneland,
Rudolf Kaaks,
Heiner Boeing,
Jonas Manjer,
Martin Almquist, [......],
Aurelio Barricarte,
Miren Dorronsoro,
Laudina Rodriguez,
Maria Luisa Redondo,
Kay-Tee Khaw,
Nick Wareham,
Naomi Allen,
Tim Key,
Elio Riboli,
Paolo Boffetta
[show abstract]
[hide abstract]
ABSTRACT: The carcinogenicity of cigar and pipe smoking is established but the effect of detailed smoking characteristics is less well defined. We examined the effects on cancer incidence of exclusive cigar and pipe smoking, and in combination with cigarettes, among 102,395 men from Denmark, Germany, Spain, Sweden and the United Kingdom in the EPIC cohort. Hazard ratios (HR) and their 95% confidence intervals (CI) for cancer during a median 9-year follow-up from ages 35 to 70 years were estimated using proportional hazards models. Compared to never smokers, HR of cancers of lung, upper aerodigestive tract and bladder combined was 2.2 (95% CI: 1.3, 3.8) for exclusive cigar smokers (16 cases), 3.0 (2.1, 4.5) for exclusive pipe smokers (33 cases) and 5.3 (4.4, 6.4) for exclusive cigarette smokers (1,069 cases). For each smoking type, effects were stronger in current smokers than in ex-smokers and in inhalers than in non-inhalers. Ever smokers of both cigarettes and cigars [HR 5.7 (4.4, 7.3), 120 cases] and cigarettes and pipes [5.1 (4.1, 6.4), 247 cases] had as high a raised risk as had exclusive cigarette smokers. In these smokers, the magnitude of the raised risk was smaller if they had switched to cigars or pipes only (i.e., quit cigarettes) and had not compensated with greater smoking intensity. Cigar and pipe smoking is not a safe alternative to cigarette smoking. The lower cancer risk of cigar and pipe smokers as compared to cigarette smokers is explained by lesser degree of inhalation and lower smoking intensity.
International Journal of Cancer 02/2010; 127(10):2402-11. · 5.44 Impact Factor
-
F L Büchner,
H B Bueno-de-Mesquita,
J Linseisen,
H C Boshuizen,
L A L M Kiemeney,
M M Ros,
K Overvad,
L Hansen, A Tjonneland,
O Raaschou-Nielsen, [......],
T J Key,
A W Roddam,
S Bingham,
K-T Khaw,
N Slimani,
P Bofetta,
G Byrnes,
T Norat,
D Michaud,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study.
Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors.
During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes.
We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas.
Cancer Causes and Control 11/2009; 21(3):357-71. · 2.88 Impact Factor
-
A Tjonneland,
K Overvad,
M M Bergmann,
G Nagel,
J Linseisen,
G Hallmans,
R Palmqvist,
H Sjodin,
G Hagglund,
G Berglund,
S Lindgren,
O Grip,
D Palli,
N E Day,
K-T Khaw,
S Bingham,
E Riboli,
H Kennedy,
A Hart
[show abstract]
[hide abstract]
ABSTRACT: Dietary linoleic acid, an n-6 polyunsaturated fatty acid, is metabolised to arachidonic acid, a component of colonocyte membranes. Metabolites of arachidonic acid have pro-inflammatory properties and are increased in the mucosa of patients with ulcerative colitis. The aim of this investigation was to conduct the first prospective cohort study investigating if a high dietary intake of linoleic acid increases the risk of developing incident ulcerative colitis.
Dietary data from food frequency questionnaires were available for 203 193 men and women aged 30-74 years, resident in the UK, Sweden, Denmark, Germany or Italy and participating in a prospective cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC). These participants were followed up for the diagnosis of ulcerative colitis. Each case was matched with four controls and the risk of disease calculated by quartile of intake of linoleic acid adjusted for gender, age, smoking, total energy intake and centre.
A total of 126 participants developed ulcerative colitis (47% women) after a median follow-up of 4.0 years (range, 1.7-11.3 years). The highest quartile of intake of linoleic acid was associated with an increased risk of ulcerative colitis (odds ratio (OR) = 2.49, 95% confidence interval (CI) = 1.23 to 5.07, p = 0.01) with a significant trend across quartiles (OR = 1.32 per quartile increase, 95% CI = 1.04 to 1.66, p = 0.02 for trend).
The data support a role for dietary linoleic acid in the aetiology of ulcerative colitis. An estimated 30% of cases could be attributed to having dietary intakes higher than the lowest quartile of linoleic acid intake.
Gut 08/2009; 58(12):1606-11. · 10.11 Impact Factor
-
B Lumbreras,
S Garte,
K Overvad, A Tjonneland,
F Clavel-Chapelon,
J P Linseisen,
H Boeing,
A Trichopoulou,
D Palli,
M Peluso, [......],
T J Key,
R Saracci,
R Kaaks,
C Malaveille,
P Ferrari,
P Boffetta,
T Norat,
E Riboli,
C A Gonzalez,
P Vineis
[show abstract]
[hide abstract]
ABSTRACT: The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require host-mediated metabolic activation before inducing DNA mutations. The role of SULT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants can have an effect on HAA carcinogenicity.
Data were collected as part of a case-control study nested within the EPIC cohort, the Gen Air investigation. EPIC is a prospective study designed to investigate the relationship between nutrition and cancer. Information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire. The subjects were restricted to non-smokers. We calculated the matched odds ratio for bladder cancer risk using logistic regression, controlling for potential confounders.
There were 227 bladder cases and 612 controls matched 1:3. Meat intake and NAT2 genotype were not independently associated with bladder cancer risk. A significant relationship was observed between bladder cancer risk and consumption of meat only among subjects with the rapid NAT2 genotype (odds ratios [OR] 2.9, 95% CI 1.0-7.9 for the 2nd quartile of meat intake; 3.6, 95% CI 1.3-9.7 for the 3rd quartile; and 3.5, 95% CI 1.2-9.7 for the 4th quartile), and was not present among subjects with the slow genotype. An interaction between NAT2 and meat intake was found in logistic regression (P = 0.034). No association was observed for SULT1A *1/2 genotype (1.0; 95% CI 0.7-1.5) and for SULT1A1 *2/2 genotype (0.9; 95% CI 0.5-1.7).
These results are suggestive of a role of meat intake and NAT2 on bladder cancer risk. They support the hypothesis that among subjects with the rapid NAT2 acetylation genotype higher levels of HAAs exposure are a bladder cancer risk factor. We did not observe an effect of SULT1A1 allele variants on this cancer. The present study adds new information on the possible long-term adverse effects of diets with high meat intake.
Cancer Causes and Control 09/2008; 19(6):649-56. · 2.88 Impact Factor
-
S Rinaldi,
P H M Peeters,
I D Bezemer,
L Dossus,
C Biessy,
C Sacerdote,
F Berrino,
S Panico,
D Palli,
R Tumino, [......],
M Koliva,
G Kyriazi,
A Thrichopoulou,
M C Boutron-Ruault,
F Clavel-Chapelon,
P Ferrari,
N Slimani,
R Saracci,
E Riboli,
R Kaaks
[show abstract]
[hide abstract]
ABSTRACT: Women with a moderate intake of alcohol have higher concentrations of sex steroids in serum, and higher risk of developing breast cancer, compared to non-drinkers. In the present study, we investigate the relationships between alcohol consumption and serum levels of sex steroids and sex-hormone binding globulin (SHBG) in 790 pre- and 1,291 post-menopausal women, who were part of the European Prospective Investigation into Cancer and Nutrition (EPIC).
Serum levels of testosterone (T), androstenedione (Delta4), dehydroepiandrosterone sulphate (DHEAS), estrone (E1), estradiol (E2) and SHBG were measured by direct immunoassays. Free T (fT) and free E2 (fE2) were calculated according to mass action laws. Current alcohol intake exposure to alcohol was assessed from dietary questionnaires.
Pre-menopausal women who consumed more than 25 g/day of alcohol had about 30% higher DHEAS, T and fT, 20% higher Delta4 and about 40% higher E1, concentrations compared to women who were non-consumers. E2, fE2 and SHBG concentrations showed no association with current alcohol intake. In post-menopausal women, DHEAS, fT, T, Delta4, and E1 concentrations were between 10% and 20% higher in women who consumed more than 25 g/day of alcohol compared to non-consumers. E2 or fE2 were not associated with alcohol intake at all. SHBG levels were about 15% lower in alcohol consumers compared to non-consumers.
This study supports the hypothesis of an influence of alcohol intake on sex hormone concentrations in blood.
Cancer Causes and Control 11/2006; 17(8):1033-43. · 2.88 Impact Factor
-
S Rinaldi,
P H M Peeters,
F Berrino,
L Dossus,
C Biessy,
A Olsen, A Tjonneland,
K Overvad,
F Clavel-Chapelon,
M C Boutron-Ruault, [......],
J R Quiros,
S Bingham,
K T Khaw,
T Key,
N E Allen,
A Lukanova,
N Slimani,
R Saracci,
E Riboli,
R Kaaks
[show abstract]
[hide abstract]
ABSTRACT: Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI 1.04-1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57-1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women.
Endocrine Related Cancer 07/2006; 13(2):593-605. · 4.36 Impact Factor
-
W K Al-Delaimy,
N Slimani,
P Ferrari,
T Key,
E Spencer,
I Johansson,
G Johansson,
I Mattisson,
E Wirfalt,
S Sieri, [......],
C Martinez-Garcia,
G Nagel,
J Linseisen,
J R Quirós,
P H M Peeters,
C H van Gils,
H Boeing,
A L van Kappel,
J-P Steghens,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: The aim of this study was to assess the ability of a single 24-h dietary recall (24HDR) and food questionnaires (FQ) to predict plasma carotenoid levels at the ecological level by assessing the relationship between mean plasma carotenoid levels and mean intake of fruit and vegetables measured by 24HDR and FQ across 16 European regions.
A random subsample of 3089 subjects was included, stratified by age and gender. They provided blood samples and dietary information between 1992 and 2000 as part of the European Prospective Investigation into Cancer and Nutrition.
Using Spearman's correlation coefficients, the correlations between mean regional 24HDR fruit and vegetable variables and corresponding mean plasma carotenoid levels were generally higher than the correlations using FQ means. The highest correlation was between the 24HDR citrus fruit variable and beta-cryptoxanthin (r = 0.90). For 24HDR, total fruits and vegetables were highly correlated with lutein, zeaxanthin, and beta-cryptoxanthin (r = 0.83-0.87), while vegetables were more closely related with lutein (r = 0.69) and zeaxanthin (r = 0.68), and fruits correlated with zeaxanthin (r = 0.87) and beta-cryptoxanthin (r = 0.84). Root vegetables (r = 0.81) and total carrots (r = 0.71) were well correlated with alpha-carotene. In the multivariate models adjusting for age, body mass index, and season, and using observations of means stratified by sex and region, the association was generally higher for 24HDR compared to FQ.
Mean regional intakes of fruits and vegetables in several European countries were closely correlated with corresponding mean plasma levels of individual carotenoids. Fruits and vegetables measured by 24HDR were generally better able to predict plasma carotenoids at the ecological level.
European Journal of Clinical Nutrition 01/2006; 59(12):1397-408. · 2.46 Impact Factor
-
W K Al-Delaimy,
N Slimani,
P Ferrari,
T Key,
E Spencer,
I Johansson,
G Johansson,
I Mattisson,
E Wirfalt,
S Sieri, [......],
C Martinez-Garcia,
G Nagel,
J Linseisen,
J R Quir|[oacute]|s,
P H M Peeters,
C H van Gils,
H Boeing,
A L van Kappel,
J-P Steghens,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: Objective: The aim of this study was to assess the ability of a single 24-h dietary recall (24HDR) and food questionnaires (FQ) to predict plasma carotenoid levels at the ecological level by assessing the relationship between mean plasma carotenoid levels and mean intake of fruit and vegetables measured by 24HDR and FQ across 16 European regions.
European Journal of Clinical Nutrition 09/2005; 59(12):1397-1408. · 2.46 Impact Factor
-
P Vineis,
L Airoldi,
F Veglia,
L Olgiati,
R Pastorelli,
H Autrup,
A Dunning,
S Garte,
E Gormally,
P Hainaut, [......],
V Krogh,
D Palli,
S Panico,
R Tumino,
B Bueno-De-Mesquita,
P Peeters,
G Berglund,
G Hallmans,
R Saracci,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: To investigate the association between environmental tobacco smoke, plasma cotinine concentration, and respiratory cancer or death.
Nested case-control study within the European prospective investigation into cancer and nutrition (EPIC).
303,020 people from the EPIC cohort (total 500,000) who had never smoked or who had stopped smoking for at least 10 years, 123,479 of whom provided information on exposure to environmental tobacco smoke. Cases were people who developed respiratory cancers or died from respiratory conditions. Controls were matched for sex, age (plus or minus 5 years), smoking status, country of recruitment, and time elapsed since recruitment.
Newly diagnosed cancer of lung, pharynx, and larynx; deaths from chronic obstructive pulmonary disease or emphysema. Plasma cotinine concentration was measured in 1574 people.
Over seven years of follow up, 97 people had newly diagnosed lung cancer, 20 had upper respiratory cancers (pharynx, larynx), and 14 died from chronic obstructive pulmonary disease or emphysema. In the whole cohort exposure to environmental tobacco smoke was associated with increased risks (hazard ratio 1.30, 95% confidence interval 0.87 to 1.95, for all respiratory diseases; 1.34, 0.85 to 2.13, for lung cancer alone). Higher results were found in the nested case-control study (odds ratio 1.70, 1.02 to 2.82, for respiratory diseases; 1.76, 0.96 to 3.23, for lung cancer alone). Odds ratios were consistently higher in former smokers than in those who had never smoked; the association was limited to exposure related to work. Cotinine concentration was clearly associated with self reported exposure (3.30, 2.07 to 5.23, for detectable/non-detectable cotinine), but it was not associated with the risk of respiratory diseases or lung cancer. Frequent exposure to environmental tobacco smoke during childhood was associated with lung cancer in adulthood (hazard ratio 3.63, 1.19 to 11.11, for daily exposure for many hours).
This large prospective study, in which the smoking status was supported by cotinine measurements, confirms that environmental tobacco smoke is a risk factor for lung cancer and other respiratory diseases, particularly in ex-smokers.
BMJ (Clinical research ed.). 03/2005; 330(7486):277.
-
M Saadatian-Elahi,
T Norat,
H B Bueno-de-Mesquita,
F Clavel,
C A Gonzalez,
G Hallmans,
T J T Key,
V Krogh,
A B Miller, A Tjonneland,
A Trichopoulou,
E Riboli
IARC scientific publications 02/2002; 156:215-8.
-
A Steffen,
M B Schulze,
T. Pischon,
T. Dietrich,
E. Molina,
M.D. Chirlaque,
A. Barricarte,
P Amiano,
J.R. Quiros,
R. Tumino, [......],
K. Overvad,
J. Stegger,
J. Manjer,
B. Lindkvist,
G. Hallmanns,
R Stenling,
E Lund,
E Riboli,
C.A. Gonzalez,
H Boeing
-
C M Friedenreich,
A. Cust,
P.H. Lahmann,
K. Steindorf,
M.C. Boutron-Ruault,
F. Clavel-Chapelon,
S Mesrine,
J. Linseisen,
S. Rohrmann,
T. Pischon, [......],
P Vineis,
H.B. Bueno-de-Mesquita,
P.H.M. Peeters,
E.M. Monninkhof,
G Berglund,
J. Manjer,
N. Slimani,
P Ferrari,
R. Kaaks,
E Riboli
