A Varghese

Publications (2)3.13 Total impact

• Article: Protective action of aspirin in experimental myocardial infarction induced by isoproterenol in rats and its effect on lipid peroxidation.

  S Sushama Kumari, A Varghese, D Muraleedharan, V P Menon
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  ABSTRACT: The protective action of aspirin in experimental myocardial infraction induced by isoproterenol was studied in rats. Aspirin treated rats showed lower mortality rate and smaller changes in the myocardium on histopathological examination when compared to corresponding animals given isoproterenol alone. Changes were also observed in the different lipid fractions studied. The ratio of cholesterol to phospholipids decreased in the heart in aspirin treated animals when compared to control rats given isoproterenol alone. The levels of lipid peroxide also showed a decrease while the activity of superoxide dismutase (SOD) and catalase registered an increase in the aspirin treated animals given isoproterenol when compared to corresponding animals given isoproterenol alone.
  Indian journal of experimental biology 06/1990; 28(5):480-5. · 1.29 Impact Factor
• Article: Effect of vitamin E on the severity of myocardial infarction induced by isoproterenol.

  S S Kumari, A Varghese, D Muraleedharan, V P Menon
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  ABSTRACT: The effect of vitamin E administration on the severity of myocardial infarction induced by isoproterenol on rats was studied. Judging from serum enzyme activity (CPK 714 micromoles; GOT 291.7 micromoles; and GPT 155.5 micromoles), mortality rate (60 to 65% survived) and histopathological observation, vitamin E has been observed to offer very little protection to the myocardium during experimental myocardial infarction when compared to control animals given isoproterenol alone (CPK 775.8 micromoles; GOT 336.2 micromoles; and GPT 168 micromoles), mortality rate (60 to 65% survived) and histopathological observation (more or less similar). The level of lipid peroxides namely hydroperoxides (control 3.15; vitamin E + iso. 14.8); conjugated diene (4.45 and 6.85) and malondialdehyde (1.22 and 2.55) in the heart were higher in the vitamin E treated animals given isoproterenol when compared to control animals given vitamin E alone. The level of cholesterol and phospholipid was more or less similar in the control animals given vitamin E alone (183.6 and 3.12) and vitamin E treated animals given isoproterenol (170.25 and 2.49), but the ratio of cholesterol to phospholipid was higher in the vitamin E treated animals given isoproterenol when compared to control animals given vitamin E alone.
  The Indian journal of medical research 01/1990; 90:468-71. · 1.84 Impact Factor