S Borrelli,
R Minutolo,
L De Nicola,
P Zamboli,
C Iodice,
A De Paola,
E De Simone,
B Zito,
P Guastaferro,
F Nigro, [......],
G Iacono, A Di Serafino,
L D'Apice,
C Saviano,
A Sarti,
M Capuano,
R Genualdo,
M Auricchio,
M Merola,
G Conte
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ABSTRACT: During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free biofiltration (AFB). 48 patients chronically treated with HFR or AFB were matched 1:1 for age, gender, Kt/V and diabetes. Blood samples were collected at the beginning and the end of dialysis. Baseline plasma levels (μmol/l) of total AA (3,176 ± 722), essential AA (889 ± 221), and branched chain AA (459 ± 140) levels in HFR were similar to those in AFB (3,399 ± 621, 938 ± 277, and 463 ± 71, respectively). Plasma intradialytic AA levels did not change in HFR, while in AFB there was a reduction by about 25%. In conclusion, as compared with AFB, HFR has a sparing effect on AA loss due to the lack of adsorption by cartridge and to their complete reinfusion in blood.
Blood Purification 10/2010; 30(3):166-71. · 2.10 Impact Factor
