Xiaoxiang Wang

Publications of Xiaoxiang Wang

• Enhanced initial proliferation and differentiation of MC3T3-E1 cells on HF/HNO3 solution treated nanostructural titanium surface.

  Authors: Fuming He, Feng Zhang, Guoli Yang, Xiaoxiang Wang, Shifang Zhao

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 10/2010; 110(4):e13-22.

  The aim of this study was to investigate the effects of nano- or submicro topography and fluoride ion on the biology of osteoblasts. Pure Ti plates were sandblasted, etched with an HCl/H(2)SO(4)The aim of this study was to investigate the effects of nano- or submicro topography and fluoride ion on the biology of osteoblasts. Pure Ti plates were sandblasted, etched with an HCl/H(2)SO(4) solution (control surface) and then etched in a diluted HF/HNO(3) solution (test surface). MC3T3-E1 cells attached, spread, and proliferated on both surfaces. The alkaline phosphatase activity was evidently higher for the test surface than for control surface after 4 and 7 days of cell culture. Real-time PCR showed significant increases in type I collagen and osteocalcin gene expression in osteoblast growth on the test surface after 4 days of culture compared with the control surface. With nanotopography and fluoride, hydrogen ions might improve MC3T3-E1 cell proliferation and differentiation during the early stages of cell culture.

• Bone responses to rough titanium implants coated with biomimetic Ca-P in rabbit tibia.

  Authors: Fuming He, Guoli Yang, Xiaoxiang Wang, Shifang Zhao

  Journal of biomedical materials research. Part B, Applied biomaterials. 04/2009;

  A new technique to biomimetic deposition calcium phosphate (BDCaP) coating onto rough titanium substrates has been developed recently. This biomimetic deposition technique seems to be promising. ItA new technique to biomimetic deposition calcium phosphate (BDCaP) coating onto rough titanium substrates has been developed recently. This biomimetic deposition technique seems to be promising. It appears to have some advantages such as an inexpensive and simple set-up, and the possibility to synthesize layers with a defined surface morphology. The aim of this study was to examine the bone responses to BDCaP-coated implants in a rabbit model. Thirty one implants (16 BDCaP and 15 rough) were inserted into both tibia of 15 rabbits. After 2, 4, and 8 weeks following the implantation, the tibias were retrieved and prepared for histological evaluation. After 2 weeks, BDCaP-coated implant showed more bone ingrowth inside threads than the rough implants in medullary region (31.43% vs. 24.38%). Histological and quantitative histomorphometrical measurements demonstrated no more bone ingrowth and bone-implant contact for coated implant as compared with uncoated implant in cortical region at all experiment periods. From the histological viewpoint, the BDCaP coating did not have any positive effect on new bone formation. (c) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009.

• [Fast formation of biomimetic apatite coatings on pure porous titanium implant's surface]

  Authors: Fuming He, Li Lin, Shifang Zhao, Shanshan Zhao, Song Chen, Xiaoxiang Wang

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 09/2007; 24(4):806-11.

  The aim of this study was to elaborate a dense, strong and thin calcium-phosphate coating on commercial porous pure titanium implant surface in the light of a fast biomimetic procedure. After beingThe aim of this study was to elaborate a dense, strong and thin calcium-phosphate coating on commercial porous pure titanium implant surface in the light of a fast biomimetic procedure. After being polished, sandblasted, cleaned and treated with the mixture of HF and HNO3, the titanium plates were divided into two groups, namely group A and group B. The specimens of group A were free from any treatment. The specimens of group B were treated with the mixture of 48% H2SO4 and 18% HCl. All specimens soaked in SBF-A solution for 1d. Then the specimens were immersed in the SBF-B solution for 2 d. A thin calcium-phosphate coating was deposited on all the specimens of the two groups, the surface consisted of well-formed crystals, which were proved to be the mixture of hydroxycarbonated apatite (HCA) and octacalcium phosphate (OCP); the coating's Ca/P rate was 1.51. A thin carbonated calcium-phosphate coating was deposited on porous pure titanium by the use of the fast biomimetic procedure.

• Effect of electrochemically deposited nanohydroxyapatite on bone bonding of sandblasted/dual Acid-etched titanium implant.

  Authors: Fuming He, Guoli Yang, Xiaoxiang Wang, Shifang Zhao

  The International journal of oral & maxillofacial implants. 24(5):790-9.

  Purpose: The aim of this study was to evaluate the effect of an electrochemically deposited nanohydroxyapatite (EDHA) coating on the bone bonding of sandblasted and dual acid-etched titaniumPurpose: The aim of this study was to evaluate the effect of an electrochemically deposited nanohydroxyapatite (EDHA) coating on the bone bonding of sandblasted and dual acid-etched titanium implants. Materials and Methods: One hundred EDHA-coated and uncoated sandblasted/dual acid-etched implants (3 mm in diameter, 10 mm long) were inserted into the femoral condyles of 50 rabbits. The osteotomy sites were enlarged to 3 mm in diameter via a sequence of drills. After 2, 4, 6, 8, and 12 weeks of bone healing, removal torque testing was performed to evaluate the interfacial shear strength of each implant type. The removed implants were prepared and observed with an electron microscope equipped with an energy dispersive electron probe x-ray microanalyzer. Results: The mean removal torque values for the EDHA-coated implants were 39.6 Ncm at 2 weeks and 40.4 Ncm at 4 weeks; corresponding values for the control implants were 21.1 Ncm and 24.1 Ncm. Removal torque values of the EDHA-coated implants were 87% higher than those of control implants after 2 weeks of healing (P = .015). However, the mean removal torque values for both types of implants were similar after 6, 8, or 12 weeks of healing (no significant differences between the implant surfaces; P > .05). Conclusions: The EDHA nanocrystal coating had a beneficial effect on interfacial shear strength during the early stages of bone healing. Int J Oral Maxillofac Implants 2009;24:790-799.