Liangrong Zheng

Publications (12)30.38 Total impact

• Article: No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: A tract-based spatial statistics study.

  Qinling Wei, Zhuang Kang, Feici Diao, Arnaud Guidon, Xiaoli Wu, Liangrong Zheng, Leijun Li, Xiaofeng Guo, Maorong Hu, Jinbei Zhang, Chunlei Liu, Jingping Zhao
  [show abstract] [hide abstract]
  ABSTRACT: Altered brain connectivity has been widely considered as a genetic risk mechanism for schizophrenia. Of the many susceptibility genes identified so far, ZNF804A (rs1344706) is the first common genetic variant associated with schizophrenia on a genome-wide level. Previous fMRI studies have found that carriers of rs1344706 exhibit altered functional connectivity. However, the relationship between ZNF804A and white matter structural connectivity in patients of schizophrenia remains unknown. In this study, 100 patients with schizophrenia and 69 healthy controls were genotyped at the single nucleotide polymorphism rs1344706. Diffusion tensor imaging (DTI) was conducted and analyzed with tract-based spatial statistics. Systematic statistical analysis was conducted on multiple diffusion indices, including fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity. Unpaired two-sample t-test revealed significant differences in fractional anisotropy and diffusivity between schizophrenia and control groups. A two-way ANOVA analysis was conducted to assess the main effects of and the interaction between schizophrenia and ZNF804A. Although significant main effects of the diagnosis of schizophrenia were found on radial diffusivity, no association between the ZNF804A (rs1344706) and white matter connectivity was found in the entire group of subjects or in a selected subgroup of age-matched subjects (n=72).
  Neuroscience Letters 11/2012; · 2.11 Impact Factor
• Article: The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.

  Qinling Wei, Feici Diao, Zhuang Kang, Zhaoyu Gan, Zili Han, Liangrong Zheng, Leijun Li, Xiaofeng Guo, Baoci Shan, Chunlei Liu, Jingping Zhao, Jinbei Zhang
  [show abstract] [hide abstract]
  ABSTRACT: Schizophrenia is thought to arise in part from abnormal gray matter (GM), which are partly shared by the relatives of the probands. DISC1 is one of the most promising susceptibility genes of schizophrenia and a SNP rs821597 (A) in the gene was associated with schizophrenia in Han Chinese population. In this study, 61 healthy controls and 72 with schizophrenic patients were genotyped at rs821597, and underwent T1-weighted MRI for the density of GM. The results showed that the risk allele (A) carriers had higher GM density in regional left parahippocampal gyrus and right orbitofrontal cortex in schizophrenic patients, but had reduced GM density of these brain regions in healthy controls. The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional GM in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia.
  Neuroscience Letters 04/2012; 517(1):21-4. · 2.11 Impact Factor
• Article: Serum uric acid levels and the clinical characteristics of depression.

  Shenglin Wen, Minfeng Cheng, Houliang Wang, Jihui Yue, Hong Wang, Guanying Li, Liangrong Zheng, Zhiyong Zhong, Fuhua Peng
  [show abstract] [hide abstract]
  ABSTRACT: This study was designed to investigate the correlation between serum uric acid (UA) levels and the clinical characteristics of depression. The serum UA levels were measured in 124 patients with depression, 660 patients with different types of other mental disorders (OMD) and 42 healthy subjects. Clinical characteristics of depression and OMD were also investigated. Depressive patients (271.97 ± 77.50 μmol/L) had significantly lower UA levels than those with delirium, dementia, amnesia and other cognitive disorders (339.95 ± 141.74 μmol/L, P=0.004), substances related disorders (359.61 ± 125.02 μmol/L, P=0.022), schizophrenia (341.03 ± 106.84 μmol/L, P=0.000), schizoaffective disorder (336.78 ± 155.49 μmol/L, P=0.024), bipolar disorder (323.04 ± 108.70 μmol/L, P=0.008) and the healthy control group (315.76 ± 87.50 μmol/L, P=0.012). We also found that the UA levels of depressive patients normalised after a five week treatment with antidepressants. Our data suggested that a lowered UA level is another characteristic of depression.
  Clinical biochemistry 01/2012; 45(1-2):49-53. · 2.02 Impact Factor
• Article: Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.

  Qinling Wei, Zhuang Kang, Feici Diao, Baoci Shan, Leijun Li, Liangrong Zheng, Xiaofeng Guo, Chunlei Liu, Jinbei Zhang, Jingping Zhao
  [show abstract] [hide abstract]
  ABSTRACT: ZNF804A gene polymorphism rs1344706, the first genetic risk variant to achieve genome wide significance for schizophrenia, has been linked to neural functional connectivity. Dysconnectivity of WM may be the primary pathological mechanism of schizophrenia. Association of this variant with regional WM density has not been investigated in schizophrenic patients. 69 healthy controls and 80 patients with schizophrenia underwent genotyping of rs1344706 SNPs, and were examined for WM density (T1-weighted MRI). The association of rs1344706 with WM changes in schizophrenia patients and healthy controls was analyzed using a full-factorial 2×2 analysis of variance. 1. There was an interaction on WM density in the left prefrontal lobe between the rs1344706 genotype and schizophrenic diagnosis, where the risk T allele carriers presented higher WM density in the schizophrenia patients and lower WM density in healthy controls in comparison with the non-risk allele carriers. 2. The risk allele was associated with an increased WM density of the bilateral hippocampus in both the patients and the healthy group. The influence of antipsychotics to the white matter in schizophrenic patients was not fully eliminated. The ZNF804A variant may confer risk for schizophrenia by exerting its effects on the WM in the left prefrontal lobe together with other risk factors for schizophrenia.
  Progress in Neuro-Psychopharmacology and Biological Psychiatry 09/2011; 36(1):122-7. · 3.25 Impact Factor
• Article: Heart failure patients selection for cardiac resynchronization therapy.

  Junchao Geng, Bifeng Wu, Liangrong Zheng, Jianhua Zhu
  [show abstract] [hide abstract]
  ABSTRACT: Cardiac resynchronization therapy (CRT) is an established treatment for refractory chronic heart failure (CHF) patients with ventricular dyssynchrony. The patient selection for this therapy remains the basis for response improvement. Various parameters, methods and technology for identification of appropriate patient are under research. The influences of age and gender, disease progress stage such as mild and late stage CHF including right ventricular dysfunction, dyssynchrony and scar identified by imaging techniques like echocardiography, magnetic resonance and nuclear imaging, and atrial fibrillation on CRT benefits were respectively discussed. This review summarizes the current advancement in these areas.
  European Journal of Internal Medicine 02/2011; 22(1):32-8. · 2.00 Impact Factor
• Article: The influence of influenza A (H1N1) virus on creatinine and cystatin C.

  Zhidong Guo, Qiqi Wang, Zhangying Wu, Jianhua Zhu, Yuangang Qiu, Liangrong Zheng, Lifeng Qiu
  [show abstract] [hide abstract]
  ABSTRACT: In March 2009, the novel 2009 influenza A (H1N1) virus was first reported in the southwestern USA and Mexico. It rapidly spread to China and worldwide. We investigated possible kidney injury in patients with the 2009 influenza A (H1N1) virus in China. This study was a retrospective cohort investigation of the potential renal injury in patients of influenza. One hundred and seventy-two patients confirmed to have the 2009 influenza A (H1N1) virus but who had different levels of severity (non-severe, severe, and critically severe) and 21 cases who were influenza A (H1N1)-negative but who had an influenza-like illness were investigated. Blood samples were obtained for the measurement of creatinine (Cr) and cystatin C (Cy-C). The influenza A (H1N1) virus caused more illness in middle-aged people in all groups. The patients in the non-severe group were younger than those in the severe group (p<0.05) and the non-influenza A (H1N1) group (p<0.01). Four subjects in the critically severe group died (3 due to respiratory failure, 1 heart injury). A significant difference in the levels of Cr and Cy-C between the groups was not observed (p>0.05). The 2009 influenza A (H1N1) virus did not cause severe kidney injury in the acute phase in adult patients.
  Clinica chimica acta; international journal of clinical chemistry 12/2010; 411(23-24):2040-2. · 2.54 Impact Factor
• Source

  Available from: Peikuan Cong

  Article: LQTS gene LOVD database.

  Tao Zhang, Arthur Moss, Peikuan Cong, Min Pan, Bingxi Chang, Liangrong Zheng, Quan Fang, Wojciech Zareba, Jennifer Robinson, Changsong Lin, Zhongxiang Li, Junfang Wei, Qiang Zeng, Ming Qi
  [show abstract] [hide abstract]
  ABSTRACT: The Long QT Syndrome (LQTS) is a group of genetically heterogeneous disorders that predisposes young individuals to ventricular arrhythmias and sudden death. LQTS is mainly caused by mutations in genes encoding subunits of cardiac ion channels (KCNQ1, KCNH2,SCN5A, KCNE1, and KCNE2). Many other genes involved in LQTS have been described recently(KCNJ2, AKAP9, ANK2, CACNA1C, SCNA4B, SNTA1, and CAV3). We created an online database(http://www.genomed.org/LOVD/introduction.html) that provides information on variants in LQTS-associated genes. As of February 2010, the database contains 1738 unique variants in 12 genes. A total of 950 variants are considered pathogenic, 265 are possible pathogenic, 131 are unknown/unclassified, and 292 have no known pathogenicity. In addition to these mutations collected from published literature, we also submitted information on gene variants, including one possible novel pathogenic mutation in the KCNH2 splice site found in ten Chinese families with documented arrhythmias. The remote user is able to search the data and is encouraged to submit new mutations into the database. The LQTS database will become a powerful tool for both researchers and clinicians.
  Human Mutation 11/2010; 31(11):E1801-10. · 5.69 Impact Factor
• Article: Ablation of atrial tachycardia originating from the noncoronary sinus: case report and literature review.

  Yao Chen, Shudong Xia, Qianming Tao, Liangrong Zheng
  [show abstract] [hide abstract]
  ABSTRACT: This report describes a patient with atrial tachycardia who underwent radiofrequency catheter ablation. Two applications of radiofrequency energy were received at different sites within 1 week. Initially, right atrium mapping indicated that the earliest activation site was located at the His-bundle region (HBR). However, the first application of radiofrequency near HBR appeared to be ineffective. Moreover, a degree III atrioventricular block and inferior ST-segment elevation was temporally observed during the therapy, which recovered after drug treatment. As later aortic sinus mapping showed that the activation site located at the noncoronary sinus (NCS) preceded the one at HBR, and this activation terminated at atrial tachycardia, a second application of radiofrequency was performed at NCS without any complications. In addition, a literature review of the clinical features of atrial tachycardia at the NCS is also summarized in the present report.
  Journal of Cardiovascular Medicine 10/2009; 11(5):389-93. · 1.51 Impact Factor
• Article: Decreased expression of transient receptor potential vanilloid 1 impaires the postischemic recovery of diabetic mouse hearts.

  Zhonghai Wei, Lihong Wang, Jie Han, Junxian Song, Lei Yao, Lei Shao, Zhihui Sun, Liangrong Zheng
  [show abstract] [hide abstract]
  ABSTRACT: We hypothesized that the transient receptor potential vanilloid type 1 (TRPV1), which is found in the sensory nerve fibers, could modulate the cardiac function, be impaired by diabetes and could contribute to further severe postischemic heart injury. Diabetes was induced in ICR mice by an intraperitoneal injection of streptozotocin. The expression of both TRPV1 and calcitonin gene-related peptide (CGRP) in diabetes mellitus (DM) hearts was significantly lower, as determined by Western blot and radioimmunoassay, respectively. During the ischemia/reperfusion, the cardiac function was measured by a Medlab system and the lactate dehydrogenase (LDH) in the effluents was measured by an ELISA kit. Compared with the non-DM hearts, the DM hearts demonstrated increased left ventricular end-diastolic pressure and decreased left ventricular developed pressure, heart rate and coronary flow, and also released more LDH in the effluents. Pretreatment with capsaicin attenuated the postischemic injury significantly in non-DM hearts, but not in DM hearts. Pretreatment with CGRP in both non-DM and DM hearts protected hearts against ischemic injury. The alteration of TRPV1 caused by diabetes is related to the poor recovery of cardiac function after myocardial ischemia.
  Circulation Journal 05/2009; 73(6):1127-32. · 3.77 Impact Factor
• Article: Reduced testosterone levels in males with lone atrial fibrillation.

  Jiangtao Lai, Dongchen Zhou, Shudong Xia, Yunpeng Shang, Lihong Want, Liangrong Zheng, Jianhua Zhu
  [show abstract] [hide abstract]
  ABSTRACT: Sex hormones play an important role in the development of cardiovascular disease. Testosterone and estradiol have been reported to be down-regulated in subjects with coronary artery disease and heart failure, but has not been studied in atrial fibrillation (AF). Levels of sex hormones may be associated with susceptibility to lone AF in men. Fifty-eight male subjects who had electrocardiographic evidence of paroxysmal or chronic AF and a structurally normal heart on echocardiography were enrolled. Subjects were excluded if they had been taking angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or statins within 3 mo or had a history of coronary artery disease, rheumatic heart disease, cardiomyopathy, significant valvular disease, hyperthyroidism, or hypertension. Fifty-eight controls were recruited from a healthy outpatient population. Serum total testosterone and estradiol levels were determined using a commercially available radioimmunoassay. Mean levels of testosterone were significantly lower in subjects with lone AF when compared with controls (476 ng/dl versus 514 ng/dl, p = 0.005). No significant differences were found in the estradiol levels between the 2 groups (31.9 pg/ml versus 32.4 pg/ml, p = 0.789). Reduced testosterone levels may be associated with susceptibility to lone AF in men.
  Clinical Cardiology 02/2009; 32(1):43-6. · 2.15 Impact Factor
• Article: Low dose cyclophosphamide rescues myocardial function from ischemia-reperfusion in rats.

  Jianhua Zhu, Yuangang Qiu, Qiqi Wang, Yujuan Zhu, Shenjiang Hu, Liangrong Zheng, Lihong Wang, Yun Zhang
  [show abstract] [hide abstract]
  ABSTRACT: The effect of low dose of cyclophosphamide (CP) protecting cardiac function from ischemia-reperfusion injury was studied on rats. The premise is that CP inhibits immune and inflammatory process, thereby limits I/R injury and improves myocardial function. Open chest rats were submitted to 30 min of ischemia followed by 3h, 12h or 24h of reperfusion. Rats were divided into sham group, I/R group and CP group, and each group included 3 time-point subgroups (3h, 12h and 24h; n=8 for each subgroup). A total of 750 mg/m(2) cyclophosphamide was intraperitoneally administrated in CP group and saline was given to I/R group. A polyethylene tube was inserted into the left ventricular cavity to detect left ventricular systolic pressure (LVSP) and +/-dp/dt(max). At the end of the experiment, hearts were harvested for histopathological assessment and infarct size determination. Compared with I/R group, rats treated with low dose CP showed a significant recovery in myocardial function with improved LVSP (88+/-11 vs 69+/-11 mmHg of 3h; 92+/-11 vs 64+/-14 mmHg of 12h; 90+/-11 vs 64+/-14 mmHg of 24h; p<0.01 respectively). The +/-dp/dt(max) also had the similar trends. The myocardial infarct size was reduced in CP group compared to that in I/R group; the infiltration of polymorph nuclear leukocytes (PMNs) in myocardium was decreased in CP group. The histopathological damage score was also attenuated. These findings suggest that low dose CP rescues cardiac function from ischemia-reperfusion injury by alleviating histopathological damage in rat myocardium.
  European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 06/2008; 34(3):661-6. · 2.40 Impact Factor
• Article: Deceleration injury of concomitant coronary artery and thoracic aorta: a case report.

  Qianmin Tao, Junzhu Chen, Furong Zhang, Yuangang Qiu, Jianhua Zhu, Liangrong Zheng
  Chinese medical journal 12/2002; 115(11):1741-2. · 0.86 Impact Factor