Wanda Romaniuk

Publications of Wanda Romaniuk

• Indocyanine green angiography in chronic central serous chorioretinopathy.

  Authors: Urszula Gajdzik-Gajdecka, Mariola Dorecka, Ewa Nita, Anna Michalska, Joanna Miniewicz-Kurowska, Wanda Romaniuk

  Medical science monitor : international medical journal of experimental and clinical research. 02/2012; 18(2):CR51-57.

  Central serous chorioretinopathy (CSC) is a condition that originates from alterations of the choroidal circulation. The aim of this paper was to evaluate the use of indocyanine green angiographyCentral serous chorioretinopathy (CSC) is a condition that originates from alterations of the choroidal circulation. The aim of this paper was to evaluate the use of indocyanine green angiography (ICGA) in patients with chronic CSC. The analysis included 17 patients (34 eyes) with chronic CSC in at least 1 eye. The eye examination included: distance and near visual acuity, biomicroscopy, applanation tonometry, fundus examination, colored and red-free fundus photography, evaluation of autofluorescence, optical coherence tomography, and fluorescein and indocyanine green angiography. In 34 eyes (100%) involved in the ICGA study the results revealed zones of transient increased choroidal vessels permeability. In 18 eyes (52.9%) choroidal changes were accompanied by a focal serous pigment epithelial detachment. In 4 eyes (11.8%) of 3 patients' the ICGA examination confirmed the presence of occult choroidal neovascularization (CNV). In the patient with bilateral diffuse retinal pigment epitheliopathy, CNV was present in 1 eye, in the patient with unilateral chronic CSC it was also present in 1 eye, and in the third patient with bilateral chronic CSC it was detected in both eyes. ICGA is a very useful examination that enables ophthalmologists to visualize choroidal changes due to chronic CSC, as well as to diagnose occult CNV in chronic CSC.

• Results of the AcrySof Toric intraocular lenses implantation.

  Authors: Bożena Swiątek, Katarzyna Michalska-Małecka, Mariola Dorecka, Dorota Romaniuk, Wanda Romaniuk

  Medical science monitor : international medical journal of experimental and clinical research. 12/2011; 18(1):PI1-4.

  The expectations of post-removal cataract surgery patients are extremely high, and best vision acuity is expected. The best refractive results are influenced by two factors - cataract surgicalThe expectations of post-removal cataract surgery patients are extremely high, and best vision acuity is expected. The best refractive results are influenced by two factors - cataract surgical removal and the corneal astigmatism correction. Currently, the two most often applied corneal astigmatism removal methods are laser surgery and toric intraocular lens implantation, with the latter method being both more stable and more reversible. This study aimed to estimate the surgical astigmatism correction efficiency after AcrySof Toric intraocular lens implantation in patients with corneal astigmatism. We used the AcrySof Toric IOL 1-part hydrophobic acrylic lenses. The retrospective research covered 30 eyeballs in 28 cataract and corneal astigmatism patients, with the AcrySof Toric lens implanted by one surgeon. In our test group 92.31% of post-surgical patients (phacoemulsification and toric lenses implantation) gained the best uncorrected visual acuity, range 0.6-1.0; and in 7.69% of patients the acuity was 0.4-0.6. Lens rotation was examined three weeks after the surgical procedure and a 3.24 ± 3.41 degree axial displacement was observed; however, this lens rotation was clinically unimportant. Based on the analysis of post-surgical results, the corneal astigmatism was 84.2% lower than before the procedure. We noticed clinically and statistically important vision acuity improvement in the corneal astigmatism patients. The patients' high satisfaction was conditioned by proper pre-surgery qualification. Astigmatism correction by cataract removal surgery is a safe and effective surgical solution. In the future, we expect the use of toric intraocular lenses will become widespread and significant.

• Needle aspiration with surgical excision of an epithelial posttraumatic iris cyst--a case report.

  Authors: Mariola Dorecka, Joanna Miniewicz-Kurkowska, Katarzyna Michalska-Małecka, Bożena Świątek, Wanda Romaniuk

  Medical science monitor : international medical journal of experimental and clinical research. 05/2011; 17(5):CS60-2.

  The aim of this study was to report on epithelial posttraumatic iris cyst that was successfully treated with needle aspiration and surgical excision with surrounding iris tissue. A 30-year-old womenThe aim of this study was to report on epithelial posttraumatic iris cyst that was successfully treated with needle aspiration and surgical excision with surrounding iris tissue. A 30-year-old women was treated for a large fluid-filled cyst in the anterior chamber of the left eye; 25 years before, she had an open globe injury. She observed deterioration of her visual acuity 1 year before her visit to our clinic. During ophthalmological examination, an iris cyst was diagnosed. As a result, she had Nd: YAG laser puncture of the cyst in the left eye, performed 5 months before she came to our clinic. After a short time of decompression, the cyst rapidly grew in size (2/3 of the anterior chamber), and her visual acuity was getting worse due to an aggressive growth of the iris cyst. Visual acuity was 0.06. Needle aspiration with surgical excision of the cyst with surrounding iris tissue was performed. Histopathologic examination confirmed an epithelial cyst. At the 1-year follow-up, there was no evidence of recurrence of the iris cyst, and BCVA was 0.2. This case report provides evidence that needle aspiration with surgical excision of iris cyst seems to be an effective treatment method of this complication.

• [Optical coherence tomography in the imaging of the iridocorneal angle].

  Authors: Łukasz Drzyzga, Ewa Mrukwa-Kominek, Ewa Mielniczuk, Wanda Romaniuk

  Klinika oczna. 01/2011; 113(1-3):71-4.

  Anterior segment optical coherence tomography (AS OCT), enables visualization and measurements of the anterior segment of the eye. In particular, it is a valuable tool in the imaging of theAnterior segment optical coherence tomography (AS OCT), enables visualization and measurements of the anterior segment of the eye. In particular, it is a valuable tool in the imaging of the iridocorneal angle. In this paper, we reviewed parameters used for analysis of the iridocorneal angle in AS OCT and compared changes of these parameters after cataract surgery, laser iridotomy and illumination. Special attention was paid to changes of such quantitative parameters as TISA (trabecular-iris space area), AOD (angle opening distance), and ARA (angle recess area).

• Correlations in some pathogenetic factors and values of hemorheological parameters in age-related macular degeneration.

  Authors: Katarzyna Michalska-Malecka, Ludmila Slowinska, Mariola Dorecka, Wanda Romaniuk

  Clinical hemorheology and microcirculation. 02/2008; 38(3):209-16.

  The aim of this study was to correlate some pathogenetic factor with the hemorheological parameters in ills with age-related macular degeneration. The studies were performed on 52 patients sufferingThe aim of this study was to correlate some pathogenetic factor with the hemorheological parameters in ills with age-related macular degeneration. The studies were performed on 52 patients suffering from AMD. The control group consisted of 42 healthy persons. Blood samples were taken from patients immediately after ophthalmological examination from antecubital vein and anticoagulated with K3EDTA. The symptoms of macular degeneration were drusen; changes in retinal pigmentation, areolar atrophy, neovascularization. Blood viscosity measurements were performed with use of cone-plate Brookfield viscometer at sheer rate 150 s(-1) and plasma viscosity with capillary Ubbelohde's viscometer. Fibrinogen concentration has been measured according to Clauss method, and level of triglycerides was measured using coupled enzymatic reactions. Haematocrit level was measured with the help of micromethod. The viscosity of whole blood, corrected viscosity and plasma viscosity were respectively 6.9%, 14.6% and 15.7% higher in the patient group than in the control group, while fibrinogen-plasma factor was 16% higher. Aggregation amplitude and time t(1/2) were 89.3% and 28.6% lower in AMD group. Erythrocyte deformability was 18% lower. The aggregation index was 7.6% higher in the AMD group then in the control group. Summing up in people suffering from AMD rheological disturbances is observed increased blood and plasma viscosity.

• [Posterior chamber phacic intraocular lens implantation in patients with medium or high myopia--own experiments]

  Authors: Katarzyna Michalska-Małecka, Wanda Romaniuk

  Klinika oczna. 02/2007; 109(7-9):272-5.

  PURPOSE: To evaluate the results of the PCPIOL implantation (Posterior Chamber Phacic Intaocular Lens) in patients with medium or high myopia. MATERIAL AND METHODS: The posterior chamber phacicPURPOSE: To evaluate the results of the PCPIOL implantation (Posterior Chamber Phacic Intaocular Lens) in patients with medium or high myopia. MATERIAL AND METHODS: The posterior chamber phacic lenses were implanted by means of an 3.2 mm (or smaller) incision in a clear cornea. The studied group consisted of 6 patients (4 women and 2 men; age range 28-45 years). Mean preoperative spherical equivalent was from -10.0 to 17.0 D. Preoperative uncorrected visual acuity was worse than 0.04 in all the eyes. Preoperative spectacle corrected visual acuity was 0.42 or better. RESULTS: 4 patients after the posterior chamber phacic lens implantation gained full visual acuity without spectacle correction, the remaining 2 achieved postoperative visual acuity equal to preoperative best spectacle-corrected visual acuity. CONCLUSIONS: The posterior chamber phacic intraocular lens implantation is an effective, safe, reversible procedure and it offers an alternative to laser refractive surgery.

• [Phacoemulsification of subluxated lens with capsular tension ring implantation]

  Authors: Mariola Dorecka, Wojciech Rokicki, Malgorzata Nita, Katarzyna Krysik, Ewa Nita, Aleksandra Sikorska, Wanda Romaniuk

  Klinika oczna. 02/2007; 109(7-9):280-2.

  PURPOSE: To evaluate long term results of phacoemulsification with PC IOL and capsular tension ring (CTR) implantation in lens subluxation. MATERIAL AND METHODS: The study comprised of 134PURPOSE: To evaluate long term results of phacoemulsification with PC IOL and capsular tension ring (CTR) implantation in lens subluxation. MATERIAL AND METHODS: The study comprised of 134 patients--146 eyes with subluxated lens. In all cases phacoemulsification with PC IOL and CTR implantation was performed. RESULTS: No intaroperative complications has occured. Postoperative complications included: inflammation in the anterior chamber in 3 eyes (2.1%), retinal detachment in 2 eyes (1.4%). In all cases there was no PC IOL decentration. CONCLUSIONS: (1) CTR facilitates phacoemulsification with PC IOL implantation in lens subluxation. (2) Phacoemulsification of subluxated lens with PC IOL and CTR implantation seems to be safe and effective procedure.

• [Retinal ganglion cells death in glaucoma--mechanism and potential treatment. Part II]

  Authors: Wojciech Rokicki, Mariola Dorecka, Wanda Romaniuk

  Klinika oczna. 02/2007; 109(7-9):353-5.

  Glaucoma is a kind of optic neuropathy where selective retinal ganglion cell loss is the major hallmark. Frequently glaucoma is associated with elevated intraocular pressure, but this condition isGlaucoma is a kind of optic neuropathy where selective retinal ganglion cell loss is the major hallmark. Frequently glaucoma is associated with elevated intraocular pressure, but this condition is neither necessary nor sufficient for onset and progression of the disease. The exact mechanism(s) of ganglion cell death in glaucoma and fully effective treatment of glaucomatous neuropathy still remain unknown. This article reviews the recent researches relevant to IOP-independent risk factors, mechanisms of RGC death and modern potential therapeutic strategies in glaucoma. Part two includes review of ionic derangements, reactive oxygen species cytotoxicity, role of nitric oxide and immunity disorder findings in glaucoma.

• [Phacoemulsification in patients with cataract and pseudoexfoliation syndrome--own experience]

  Authors: Wanda Romaniuk, Bogumiła Wójcik-Niklewska, Joanna Markowska, Katarzyna Michalska-Małecka, Mariola Dorecka

  Klinika oczna. 02/2004; 106(4-5):593-5.

  The aim of the study was the assesment of effectivness of phacoemulsification procedure in patients with cataract and pseudoexfoliation syndrome. Analysed group consisted of 72 eyes (8 patients), ageThe aim of the study was the assesment of effectivness of phacoemulsification procedure in patients with cataract and pseudoexfoliation syndrome. Analysed group consisted of 72 eyes (8 patients), age 53 - 93 years with PEX and 50 eyes (50 patients), age 49-82 without PEX. All cases have performed the phacoemulsification with implantation of artificial posterior chamber lens using small incision procedure. In more than 50% of patients marked postoperative improvement of visual acuity up to 0,6. Year after operation significant decrease of intrabulbar pressure was observed. We conclude that phacoemulsification in cataract treatment is an efficient and save procedure with improvement of patient's visual acuity and with low number of postoperative complications.

• [Implantation of Ahmed-type valve in the treatment of glaucoma, following penetrating keratoplasty]

  Authors: Wanda Romaniuk, Mariusz Fronczek, Paweł Szkaradek, Mariola Dorecka

  Klinika oczna. 02/2004; 106(1-2 Suppl):170-2.

  PURPOSE: To evaluate the outcomes of Ahmed glaucoma valve implantation for therapy of glaucoma after penetrating keratoplasty. MATERIAL AND METHODS: 17 Ahmed glaucoma valve implants were placed in 17PURPOSE: To evaluate the outcomes of Ahmed glaucoma valve implantation for therapy of glaucoma after penetrating keratoplasty. MATERIAL AND METHODS: 17 Ahmed glaucoma valve implants were placed in 17 eyes with glaucoma after penetrating keratoplasty. The follow up was 1 year. V.A., IOP and index medication were observed before and 1 year after surgery. RESULTS: The mean preoperative IOP was 29.1 mmHg (+/-6.5) with average medication 2.65 +/- 0.5, 1 year after surgery the mean IOP decreased to 18.4 mmHg +/- 4.7 with 0.7 +/- 0.8 medication. The tube implant successfully controlled glaucoma in 13 eyes (73.5%) at 1 year. The corneal grafts remain clear in 11 eyes (64.7%). CONCLUSIONS: Implantation of Ahmed glaucoma valve successfully controlled IOP in difficult cases of glaucoma after penetrating keratoplasty.

• [Confocal laser scanning tomography (HRT) in diagnosis and monitoring glaucomatous optic nerve damage in primary open angle glaucoma]

  Authors: Joanna Markowska, Wanda Romaniuk, Henryk Kozioł

  Klinika oczna. 02/2004; 106(3):312-7.

  PURPOSE: The aim of this study was to estimate HRT usefulness in quantitative evaluation of structural glaucomatous optic nerve head damage and in monitoring this atrophy in POAG patients and normalPURPOSE: The aim of this study was to estimate HRT usefulness in quantitative evaluation of structural glaucomatous optic nerve head damage and in monitoring this atrophy in POAG patients and normal subjects, during 18-monthly follow up. MATERIAL AND METHODS: 130 eyes of 84 patients with primary open angle glaucoma, 52 women (79 eyes) and 32 men (51 eyes) in age 45-70 (mean = 54.69 yrs) and 96 eyes of 48 normal subjects, 33 women (66 eyes) and 15 men (30 eyes) in age 40-70 (mean=51.90 yrs). The ONH-stereometric parameters were examined using confocal laser scanning tomography--HRT (version 2.01). RESULTS: All of ONH stereometric parameters (except: HVC) statistically significant distinguish glaucoma and normal eyes. The most marked of ONH-parameters are: C/D area ratio, CA, CSM, RA, RV, Mean cup depth, CV, Max cup depth, Mean RNFL thickness, RNFL-csa and DA. Statistically significant changes of all ONH stereometric parameters in primary open angle glaucoma were found during follow up (except: HVC, CV and CSM). CONCLUSIONS: HRT is precise method for ONH-parameters evaluation. All of ONH-stereometric parameters (except HVC) are good markers of quantitative ONH-glaucomatous damage. HRT is valuable and precise method of quantitative monitoring progression of glaucomatous neuropathy.

• [Phacoemulsification of subluxated opacified lens in pseudoexfoliation glaucoma patients, performed with the use of a capsular tension ring and iris retractors]

  Authors: Bogumiła Wójcik-Niklewska, Katarzyna Michalska-Małecka, Joanna Markowska, Witold Korzekwa, Wanda Romaniuk

  Klinika oczna. 02/2004; 106(1-2 Suppl):185-6.

  PURPOSE: To evaluate results of phacoemulsification of subluxated lens in patients suffering from pseudoexfoliation-related cataract and glaucoma, performed with the use of a capsular tension ringPURPOSE: To evaluate results of phacoemulsification of subluxated lens in patients suffering from pseudoexfoliation-related cataract and glaucoma, performed with the use of a capsular tension ring (CTR) and iris retractors and implantation of artificial intracapsular lens. PATIENTS AND METHODS: The retrospective covered 15 patients (15 eyes) at the average age of 75 years, with a subluxated, cloudy lens and pseudoexfoliation glaucoma with IV PEX. Due to poor mydriasis resulting from the course of the pseudoexfoliation syndrome, it was necessary with all the patients to apply iris retractors in order to enlarge the pupil. The opacified lens were removed by means of phacoemulsification. In order to provide additional peripheral support and to maintain the artificial lens in the central position after the surgery, a tension ring was implanted into the lenticular capsule. A foldable intraocular lens was implanted inside the capsule. RESULTS: The observation period was 12 months. The average visual acuity prior the surgery was 0.18+/-0.2, while after a year after the surgery it was 0.56+/-0.32 (p<0.001). Besides, the intraocular pressure was observed to decrease from 18.2+/-5.02 mm Hg before the surgery to 15.8+/-0.84 mmHg (p<0.001) after the surgery. The anti-glaucoma medication ratio was also reduced from 2.1 to 1.3 in the post-surgery period. Inflammatory reaction of the anterior chamber was observed in 7 eyes. CONCLUSIONS: Application of a CTR and iris retractors during a surgery of cataract in patients with subluxated opacified lens considerably facilitates the implantation procedure of an artificial lens into the capsule, and it allows to improve the visual acuity and stabilize the intraocular pressure while reducing the quantity of the applied anti-glaucoma drugs.

• [Phacotrabeculectomy in patients with cataract and chronic open angle glaucoma, and patients with cataract and pseudoexfoliation glaucoma]

  Authors: Bogumiła Wójcik-Niklewska, Katarzyna Michalska-Małecka, Joanna Markowska, Witold Korzekwa, Wanda Romaniuk

  Klinika oczna. 02/2004; 106(1-2 Suppl):190-1.

  PURPOSE: To compare the results obtained after phacotrabeculectomy followed by implantation of an intracapsular lens in patients with cataract and chronic open angle glaucoma, and patients withPURPOSE: To compare the results obtained after phacotrabeculectomy followed by implantation of an intracapsular lens in patients with cataract and chronic open angle glaucoma, and patients with cataract and pseudoexfoliation open angle glaucoma. MATERIAL AND METHODS: The retrospective study covered 55 eyes with cataract and glaucoma. In 28 eyes, chronic open angle glaucoma was diagnosed, and in 27--pseudoexfoliation glaucoma. In all cases, phacoemulsification of the opacified lens was carried out, a foldable intraocular lens was implanted in the capsule, and the trabeculum was removed by means of a punch. Visual acuity, intraocular pressure and the ratio of applied anti-glaucoma drugs were subject to the assessment. RESULTS: The observation period was 12 months. Within the COAG patient group, the average visual acuity prior to the surgery was 0.2+/-0.24, and after one year from the surgery it increased to 0.82+/-0.22. For PEX glaucoma patients, the values were respectively 0.3+/-0.25 before the surgery and 0.75+/-0.29 a year after it. Considerable reduction of the intraocular pressure was also achieved: in the COAG patients--from 19.51+/-3.8 mm Hg to 16.6+/-1.6 mm Hg, and in PEX glaucoma patients--from 22.28+/-5.18 mm Hg to 17.6+/-2.33 mm Hg one year after the surgery. Also, the quantity of anti-glaucoma drugs applied in the study groups was significantly reduced. The anti-glaucoma drug ratio in the COAG patients dropped from 1.8 to 0 after the surgery, and in the PEX glaucoma patients--from 2.3 to 0.3. CONCLUSIONS: Phacotrabeculectomy is an efficient and safe surgical method, to be recommended for patients both with primary open angle glaucoma and with pseudoexfoliation glaucoma.

• [The estimation of efficacy of the phacotrabeculectomy procedure in patient with cataract and pseudoexfoliation glaucoma]

  Authors: Wanda Romaniuk, Bogumiła Wójcik-Niklewska, Joanna Markowska, Katarzyna Michalska-Małecka, Aleksandra Sikorska

  Klinika oczna. 02/2004; 106(6):753-5.

  PURPOSE: The aim of the study was the estimation of phacotrabeculectomy effectiveness in patient with pseudoexfoliation syndrome. MATERIAL AND METHODS: The analyzed group consisted of 72 eyes of 65PURPOSE: The aim of the study was the estimation of phacotrabeculectomy effectiveness in patient with pseudoexfoliation syndrome. MATERIAL AND METHODS: The analyzed group consisted of 72 eyes of 65 patients in the range of 61-92 years old. 32 patients have phacoemulsification procedure (gr. I) and 40 patients have performed the procedure of the phacotrabeculectomy (gr. II). RESULTS: In 60% of the eyes marked postoperative improvement of visual acuity to more than 0.6 was observed. We noticed significant decrease of mean intraocular pressure (from 22.45 mmHg-17.88 mmHg), only in group II. CONCLUSIONS: We have concluded that the polyprocedular operation of phacotrabeculectomy in cataract with pseudoexfolation syndrome is an efficient procedure lowering mean intraocular pressure and improving visual acuity.

• [Non-proliferative diabetic retinopathy and red blood cell aggregation]

  Authors: Bolesław Turczyński, Katarzyna Michalska-Małecka, Ludmiła Słowińska, Stanisław Szczesny, Wanda Romaniuk

  Wiadomości lekarskie (Warsaw, Poland : 1960). 01/2004; 57(11-12):634-40.

  The pathogenesis of diabetic retinopathy is not clear, but it is generally agreed, that in addition to vascular components hemorheological disturbances can play a role in the impairment ofThe pathogenesis of diabetic retinopathy is not clear, but it is generally agreed, that in addition to vascular components hemorheological disturbances can play a role in the impairment of microvascular flow. The aim of this study was to correlate the severity of retinopathy in diabetic patients with red blood aggregation and some parameters of aggregation. The study was carried out on 52 patients suffering from type 2 diabetes mellitus with non-proliferative retinopathy--25 men and 27 women (mean age 63.8 +/- 6.5 years) and 43 healthy--20 men and 23 women (mean age 55.5 +/- 9.6 years). The fundus appearance of patients showed non-proliferative diabetic retinopathy. Red blood cell aggregation was determined by LORCA aggregometer. Aggregation index (AI), disaggregation shear rate (gamma(p)), time to the half of the disaggregation (t1/2), time constant of fast component in syllectogram (T1), time constant of slow component (T2) and amplitude (total extent of aggregation Am) were measured. In diabetics with non-proliferative retinopathy we observed the increase of AI (66.5 +/- 7.2 vs 59.4 +/- 5.8; p < 0.001), decrease of Am (19.8 +/- 3.3 vs 21.2 +/- 2.7; p < 0.05), decrease of T1 (2.4 +/- 0.5 vs 2.75 +/- 0.42; p < 0.005), increase of T2 (27.6 +/- 4.7 vs 25.75 +/- 4.11; p < 0.05), decrease of t1/2 (1.98 +/- 0.72 vs 2.7 +/- 0.77; p < 0.001) and increase of gamma(p) (215.6 +/- 23.3 vs 98.1 +/- 8.7; p < 0.001). The parameters of erythrocytes aggregation were correlated with intensification of diabetic retinopathy symptoms. Our results show the importance of red blood cell aggregation parameters in the development of diabetic microangiopathy.

• [Evaluation stereometric parameters of the optic nerve head in the III and IV stage of pseudoexfoliation syndrome].

  Authors: Wanda Romaniuk, Katarzyna Krysik, Mariola Dorecka, Joanna Markowska

  Klinika oczna. 01/2004; 106(1-2 Suppl):201-2.

  Pseudoexfoliation syndrome (PEX) often coexists with glaucomatous optic nerve head damage. Confocal scanning laser tomography Heidelberg Retina Tomograph (HRT) is the most competent and accuratePseudoexfoliation syndrome (PEX) often coexists with glaucomatous optic nerve head damage. Confocal scanning laser tomography Heidelberg Retina Tomograph (HRT) is the most competent and accurate technique of monitoring of glaucomatous optic nerve head damage. Our aim was to determine correlation between stage of PEX and glaucomatous optic nerve head damage, by using HRT system. Two groups of patients underwent examination. The examined PEX-group with 35 eyes with III stage and 35 eyes with IV stage of PEX. The control group (POAG patients) of 44 eyes. Stereometric parameters Disc Area, Cup Area, Cup/Disc Area Ratio, Rim Area, Height Variation Contour, Cup Volume, Rim Volume, Mean Cup Depth, Max Cup Depth, Cup Shape Measure, Mean RNFL Thickness, RNFL Cross Section Area were obtained by HRT. No statistical differences were noted between III and IV stage of PEX for DA, HVC, RV, Mean RNFL Thickness and RNFL Cross Section Area parameters. Between III stage of PEX and control group no statistical differences were confirmed for HVC. Between IV stage of PEX and control group no statistical differences have respect to: CSM, Mean RNFL Thickness and RNFL Cross Section Area stereometric parameters. IV stage of PEX syndrome is the serious risk for glaucomatous neuropathy and requires precise monitoring.

• [Frequency doubling perimetry in diagnosis of early glaucomatous optic nerve fiber damage].

  Authors: Witold Korzekwa, Małgorzata Korzekwa, Joanna Markowska, Bogumiła Wójcik-Niklewska, Wanda Romaniuk, Anna Korzekwa, Katarzyna Michalska-Małecka

  Klinika oczna. 01/2004; 106(1-2 Suppl):222-4.

  The comparative evaluation results of frequency doubling technology (FDT) in healthy subjects, in patients with glaucoma suspected and glaucoma, as well as analysis influences of selected riskThe comparative evaluation results of frequency doubling technology (FDT) in healthy subjects, in patients with glaucoma suspected and glaucoma, as well as analysis influences of selected risk factors onset, and progression of glaucoma (age, gender, intraocular pressure, refractive errors, circulation system disease, diabetes mellitus, vasospastic vascular disease) on FDT-parameters. Sixty four patients (128 eyes), in age between 13-80, with refraction error from -14.5 to +6.5 D sph and average intraocular pressure 19.8 +/- SEM were included in this study. All patients were previously diagnosed towards glaucoma. The visual field testing with help of FDT Visual Field Instrument were made at least triple at all patients, with capitalize on the THR N-30 threshold program. Global indices: mean deviation (MD) and pattern standard deviation (PSD) and numerical value of mean retinal sensitivity for central visual field 5 degree sector (mean sensitivity to central 5 degrees--MS 5 degrees) come in comparative analysis. All data were analyzed by chi2 and Kruskal-Wallis tests. Comparative analysis examined groups of healthy persons, patients with glaucoma suspect and glaucoma, it proves statistically significant difference between MD, PSD and MS 5 degrees. Statistically no significant difference between PSD and MS 5 degrees at groups of healthy and glaucoma suspect patients was detected. In glaucoma group there did not reveal an influence on selected risk factors on FDT parameters. However, in glaucoma suspect group revealed an influence on most risk factors on perimetry parameters. FDT is useful for detection of glaucomatous nerve fiber damage. There should be taken precautions of interpretation FDT results at glaucoma suspect patients.

• Correlations between the severity of retinopathy in diabetic patients and whole blood and plasma viscosity.

  Authors: Bolesław Turczyński, Katarzyna Michalska-Małecka, Ludmiła Słowińska, Stanisław Szczesny, Wanda Romaniuk

  Clinical hemorheology and microcirculation. 01/2003; 29(2):129-37.

  The aim of this study was to correlate the severity of retinopathy in diabetic patients with the whole blood and plasma viscosity. The studies were performed on 52 patients suffering from type IIThe aim of this study was to correlate the severity of retinopathy in diabetic patients with the whole blood and plasma viscosity. The studies were performed on 52 patients suffering from type II diabetes mellitus with non-proliferative retinopathy (25 men and 27 females, mean age of patients 64+/-6.5 years). The mean duration of diabetes treatment was 13.7 years. The control group consisted of 43 healthy persons (20 men and 23 women, the mean age of controls was 55.9+/-9.2 years). Blood samples were taken from patients immediately after ophthalmological examination from anticubital vein and anticoagulated with K2EDTA. The symptoms of retinopathy were: macular edemas, microaneurysms, hard and soft exudates and hemorrhagic focuses. The severity of particular signs of retinopathy was expressed in a three point scale. The total number of rank points was correlated with blood and plasma viscosity, moreover with eyes acuity. Blood viscosity measurements were performed with the use of cone-plate Brookfield's viscometer at shear rate 150 s(-1), and plasma viscosity with capillary Ubbelohd's viscometer. Besides the viscometric examinations hematocrit, fibrinogen, blood morphology, total cholesterol concentration, LDL-cholesterol, HDL-cholesterol, triglycerides, blood glucose concentration and glycosylated hemoglobin were examined. The whole blood viscosity, the corrected blood viscosity adjusted to 45% of hematocrit were significantly higher in diabetics (p<0.001). The whole blood relative viscosity was also significantly elevated in diabetic patients (p<0.002). The correlation between visual acuity and rank point of retinopathy severity was negative (r= -0.91, p<0.001). The retinopathy severity was positively correlated with whole blood and plasma viscosity (r=0.51; p<0.001 and r=0.4; p<0.005, respectively). CONCLUSION: Elevated blood and plasma viscosity may play an additional and significant role in the development of diabetic retinopathy.

• A unique case of primary corneal melanoma.

  Authors: Wanda Romaniuk, Henryk Koziol, Krzysztof Muskalski, Mariola Dorecka, Dorota Tarnawska, Daniel Sabat

  Japanese journal of ophthalmology. 46(1):114-6.

  PURPOSE: To report a unique case of primary corneal melanoma. METHODS: A 59-year-old white woman underwent keratectomy to remove a pigmented rapidly enlarging growth on the corner of her left eye.PURPOSE: To report a unique case of primary corneal melanoma. METHODS: A 59-year-old white woman underwent keratectomy to remove a pigmented rapidly enlarging growth on the corner of her left eye. The specimen was submitted for histopathologic examination. RESULTS: Ophthalmic examination disclosed no association with limbal or conjunctival melanocytic abnormalities. Histopathologic studies demonstrated nodular malignant melanoma. CONCLUSION: Possible development of primary corneal melanoma should be considered in diagnosing all cases with a past history of corneal melanin pigmentation.