Y Manor

Tel Aviv University, Tell Afif, Tel Aviv, Israel

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Publications (47)97.46 Total impact

  • The Journal of craniofacial surgery 09/2015; 26(6). DOI:10.1097/SCS.0000000000001956 · 0.68 Impact Factor
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    ABSTRACT: Objective: To determine and investigate the effect of bacterial contamination on implant survival rate. Method: A prospective cohort study was conducted on patients planned for dental implantation who agreed to participate in the study. Levels of bacterial contamination was estimated before and after saline rinses in immediate implantation/augmentation (study) and late implantation (control) sites. Samples from the socket were plated onto appropreate agar plates for total bacterial counts and on selective agar plates for Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) counts. The clinical situation of the augmented / implanted area was followed up for 1-3 years. Results: Thirty two patients participated in the study and were devided to either experimental (N=17) or control group (N=15). Significant differences were found between the two groups before and after the saline rinse (P<0.005). Significant positive correlations were found between prevalence of the periopathogens Aa and Pg and bleeding on probing and presence of oral malodor. None of the cases has revealed evidence for late infection of the graft/implant. All augmentations and dental implantations have survived during the follow up period (3 years). Conclusions: A high level of bacterial contaminationwas found in clinically infected extraction sockets, with higher levels in the mandible. Meticulous debridment and saline rinse can lower the contamination level. Immediate implantation or augmentation in clinically and microbiologically infected sites can be treatment of choice, without engdangaring survival rates, as long as debridment and rinses are performed.
    IADR Israeli Division Meeting 2013; 06/2013
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    ABSTRACT: Objectives : to evaluate the survival rate of dental implants replacing failed implants in grafted maxillary sinuses by lateral approach compared to replacing failed implants in non grafted posterior maxillae. Methods: retrospective analysis of 75 patients undergone re-implantation in posterior maxillae. The study group composed of 40 patients who had failed and replaced implant in grafted posterior maxilla by lateral approach sinus floor augmentation sites, and a control group composed of 35 patients who had failed and replaced implant in pristine sites of posterior maxilla. The collected date were analyzed for mean ± standard deviation (SD) using SPSS 10.0, SPSS Chicago IL, with a significant level of 5% using T-Test, Mann Whitney, Chi-Square test and survival with Kaplan-Meier. Results: In a follow up period of 5 years in average, there were no failure of the secondary implants, so 100% survival in the replacing implants (75 implant). The main reason for failure was lack of osseointegration, and it was more pronounced in the study group. (p=0.027) A higher rate of early failure was found in the study group. (p=0.038) Conclusions: According to the current research, the high survival rates of dental implants replacing failed implants in posterior maxilla with or without sinus floor augmentation- 100% survival for 5 year follow up- leads to the conclusion that the maturation level of bone graft may play a role in the early failure of the dental implant and leads to higher survival rate in the replacing implant. With the limitations of this research, we can conclude that dental implant failure after sinus floor augmentation should not prevent the practicioner from second attempt.
    IADR Israeli Division Meeting 2013; 06/2013
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    ABSTRACT: Overall first-year failure rate for dental implants may reach 3%-8% as the result of various complications. Accordingly, reimplantation accounts for an ever-growing portion of clinic's practice. The purpose of the present study was to evaluate the survival rate of dental implants that were performed in sites where failed implants were previously removed and to evaluate the factors affecting outcome. Three certified oral and maxillofacial surgeons inserted 144 implant replacement in previously failed sites in 144 patients (1994-2009). Clinical and epidemiologic data were collected retrospectively and analyzed regarding survival rates. Survival rate of the implants replacing previously failed ones was 93% (133/144). A third placement in the same site was performed in 7 of 11 patients with a survival rate of 85% (6/7) up to the last follow-up. No correlations were found between replaced implant failures with any of the parameters examined. Within the limits of the present study, it can be concluded that a previous implant failure should not discourage practitioners from a second or even a third attempt.
    09/2012; 114(3):290-3. DOI:10.1016/j.tripleo.2011.07.010
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    ABSTRACT: The aim of this study was to assess the incidence of late signs and symptoms of acute and chronic maxillary sinusitis after sinus augmentation and to correlate them with predisposing factors. A total of 137 individuals (54 male and 83 female; 153 sinus augmentation procedures) were evaluated retrospectively for signs and symptoms of maxillary sinusitis, 12-80 months after surgery, using a questionnaire and clinical and radiographic examinations. The incidence of acute and chronic sinusitis after sinus augmentation was low (<5%). History of preoperative sinusitis (P = .001) and sinuses with thick mucosa (P < .0001) were statistically significant factors correlated with late signs and symptoms of sinusitis. There was a slight correlation between chronic sinusitis and women (P = .079) or 2-stage procedures (P = .098). There was no statistical correlation to intraoperative complications, such as membrane perforation and excessive bleeding. The occurrence of postoperative chronic sinusitis appears to be limited to patients with history of preoperative sinusitis and sinuses with thick mucosa, despite control of the disease before sinus augmentation. Intraoperative surgical complications have negligible effect. Patients presenting with preoperative sinusitis and sinuses with thick mucosa need to be informed of the increased risk. They require a close follow-up and prompt treatment in the event of signs and symptoms of sinusitis.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 07/2010; 110(1):e1-4. DOI:10.1016/j.tripleo.2010.02.038 · 1.46 Impact Factor
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    ABSTRACT: This study was a retrospective assessment of reentry sinus augmentation compared with sinus augmentation performed for the first time. There were 38 subjects who required sinus augmentation. The study group (17 patients, 21 sinuses) included subjects following failure of a previous sinus augmentation procedure that required reentry augmentation. The control group (21 patients, 21 sinuses) included subjects in which sinus augmentation was performed for the first time. Patients' medical files were reviewed. A preformed questionnaire was used to collect data regarding demographic parameters, medical and dental health history, habits, and intra- and postoperative data. Operative challenges in the study group included adhesions of the buccal flap to the Schneiderian membrane (62%, 13/21, P<.001), bony fenestration of the lateral wall with adhesions (71%, 15/21, P<.001), limited mobility of a clinical fibrotic Schneiderian membrane (71%, 15/21, P<.001), and increased incidence of membrane perforations (47%, 10/21, versus 9.5%, 2/21, P=.03). In the control group the Schneiderian membrane was thin and flexible. Sinus augmentation succeeded in all cases of both groups. Implant failure was significantly higher in the study group (11% versus 0%, P<.001). Clinical success of reentry sinus augmentation is predictable despite its complexity. Clinicians should be aware of anatomical changes caused by previous failure of this procedure. Patients should be informed about the lower success rate of implants when reentry sinus augmentation is required.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 04/2010; 110(3):287-91. DOI:10.1016/j.tripleo.2010.01.022 · 1.46 Impact Factor
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    ABSTRACT: Implant failures can be divided into early and late according to the timing of failure. The purpose of this study was to characterize and compare both types. A retrospective cohort study was conducted in 194 patients (98 men and 96 women) who presented after dental implant failures during a 6-year period (2000 to 2006). The patient served as the unit of analysis. A history of at least 1 failed and removed dental implant served as the inclusion criterion. Patients were excluded from this study whenever their files had missing data. The collected data included a patient's characteristics, failure characteristics, and the anatomic status of the alveolar ridge after failure. Late failures were associated with moderate to severe bone loss, a larger number of failed implants per patient, a higher incidence in men, and mostly in posterior areas. Early failures were associated with minimal bone loss, occurred more in women, at a younger age, and in most cases the implants were intended to support single crowns. Meticulous follow-up is needed to reveal and treat failing or ailing implants. Once established as hopeless, they should be removed as soon as possible to prevent further bone loss.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 12/2009; 67(12):2649-52. DOI:10.1016/j.joms.2009.07.050 · 1.43 Impact Factor
  • M Szyper-Kravitz · R Lang · Y Manor · M Lahav
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    ABSTRACT: 46-year-old patient with acute myeloid leukemia (AML) whose disease manifested as fever, chills and dry cough is reported here. Despite broad antibiotic coverage he remained acutely ill with spiking fever, shaking chills, and hypoxemia. His initial chest radiograph was normal but chest computed tomography (CT) scan disclosed bilateral focal infiltrates. Hypoxemia and severe thrombocytopenia precluded invasive diagnostic procedures. A thorough epidemiological investigation revealed that before becoming acutely ill the patient smoked daily tobacco mixed with marijuana from a "hookah bottle". While waiting for tobacco and "hookah water" cultures, we started antifungal therapy. Resolution of fever and hypoxemia ensued after 72 hours. Tobacco cultures yielded heavy growth of Aspergillus species. We suggest that habitual smoking of Aspergillus-infested tobacco and marijuana caused airway colonization with Aspergillus. Leukemia rendered the patient immunocompromised, and allowed Aspergillus to infest the lung parenchyma with early occurrence of invasive pulmonary aspergillosis. Physicians should be aware of this potentially lethal complication of "hookah" and marijuana smoking in immunocompromised hosts.
    Leukemia and Lymphoma 07/2009; 42(6):1433-7. DOI:10.3109/10428190109097776 · 2.89 Impact Factor
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    ABSTRACT: The purpose of the present study was to explore the major factors that can affect the decision to replace failed implants. A retrospective cohort study was conducted on 194 patients who presented following dental implant failure during a 6-year period (2000 to 2006). The collected data included patient characteristics, failed implant characteristics, the anatomic status of the alveolar ridge after failure, and factors affecting the decision to avoid reimplantation. The study group included patients in whom the failed dental implants were replaced, whereas there was no reimplantation in the control group. Seventy-four patients (135 implants) made up the control group, and 120 patients (157 implants) made up the study group. The mean patient age was higher and the medical status was worse in the control group. The number of failed implants per patient was higher in the control group. The time between the diagnosis of failure and removal and between implant placement and removal were greater in the control group. The chances of a patient with minor bone loss undergoing reimplantation was 20 times greater (odds ratio, 20.4) than a patient with severe bone loss. The main patient-related reasons for avoiding reimplantation were the additional costs (27%), fear of additional pain (17.7%), and fear of a second failure (16.2%). The removal of a failing implant as soon as it is diagnosed as hopeless will improve the chances for reimplantation.
    Journal of Periodontology 01/2009; 79(12):2262-6. DOI:10.1902/jop.2008.080255 · 2.71 Impact Factor
  • N Gronich · J Radnay · H Shapiro · Y Manor · M Lahav · M Lishner
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    ABSTRACT: Bone marrow (BM) involvement in low-grade non-Hodgkin's lymphoma (NHL) has a clear impact on patients' survival. The standard practice is morphological examination of BM biopsy at diagnosis. The clinical significance of flow cytometry (FC) analysis of BM aspirates is largely unknown. The medical charts of 70 low-grade NHL patients, who underwent BM biopsy and FC analysis between 1994 and 2004, were reviewed. Forty-three patients (61.4%) were BM+ by morphology, while in those without morphological involvement by lymphoma FC was positive in 9 (BM-FC+, 12.9%) and negative in 18 (BM-FC-, 25.7%). The median treatment-free period was shorter in the BM+ and BM-FC+ groups compared with the BM-FC- group (1 and 4 months vs. 31 months, respectively) (log-rank test, P = 0.0195). The median survival time was not reached for the BM-FC- patients, whereas for BM+ and BM-FC+ patients it was 129 and 89 months, respectively, with no significant difference between them [the difference between the BM-FC- and the two other groups was statistically significant (log-rank test, P = 0.029)]. The outcome of low grade NHL in patients who had BM involvement by FC alone or by morphology was similar. If confirmed, these findings suggest a modification in the workup and management of localized low grade NHL.
    European Journal of Clinical Investigation 05/2007; 37(4):305-9. DOI:10.1111/j.1365-2362.2007.01782.x · 2.73 Impact Factor
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    ABSTRACT: To describe the anatomy of the lingual perimandibular vessels and emphasize the distance to the bone. The hemifacial lower third was dissected in 12 human cadavers. The blood vessels in the floor of the mouth were exposed using sagittal incisions at the canine, mental foramen, and second molar areas. The diameter of the dissected vessels ranged from 0.5 to 3 mm (mean, 1.5 mm). Most vessels were found superior to the mylohyoid muscle in the canine area and beneath the muscle in the mental and second molar areas. The smallest median vertical distance from blood vessel to bone was in the canine area (14.5 mm), followed by the mental foramen area (15.5 mm) and the second premolar area (19 mm). The median horizontal distance of the vessels from the lingual plate was 2 mm at the canine and second molar areas and 4 mm at the mental area. Lingual plate perforation, especially anterior to the canine area, can easily injure blood vessels in the floor of the mouth and cause life-threatening hemorrhage following implant placement. Bleeding can occur when the mandibular lingual plate is perforated. Care should be taken to recognize situations where this complication may occur. Based on the study of human cadavers, it appears that vessels in the floor of the mouth are sometimes in close proximity to the site of implant placement. Caution should be exercised when placing implants in this area.
    The International journal of oral & maxillofacial implants 01/2007; 22(1):127-31. · 1.45 Impact Factor
  • Yifat Manor · Danielle Blinder · Shlomo Taicher
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    ABSTRACT: Intraoral vertical ramus osteotomy (IVRO) and advancement genioplasty are effective and predictable methods of treating selective individuals with mandibular prognathism. The sequence of performing these procedures does have a clinical effect, but this is not found in the literature. The purpose of this article is to introduce the clinical implication of the sequence of procedures and to recommend the preferred sequence based on experience. A retrospective study was conducted on 75 patients treated by IVRO with or without genioplasty. In 31 patients, IVRO was performed without genioplasty; only one patient suffered from transient hypoesthesia. When IVRO was performed before genioplasty (sequence I) in 20 patients, nine suffered from mental nerve hypoesthesia. However, when IVRO was performed after genioplasty (sequence II) in 24 patients, permanent mental nerve anesthesia occurred in five patients and mental nerve hypoesthesia in 15 patients. Based on these results, it is recommended that IVRO be performed before genioplasty.
    Cranio: the journal of craniomandibular practice 05/2006; 24(2):95-7. DOI:10.1179/crn.2006.015 · 0.68 Impact Factor
  • A Amiel · M Yukla · S Yogev · Y Manor · M D Fejgin · M Lishner
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    ABSTRACT: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone. It is well known that alkylating agents are capable of inducing myelodysplastic syndromes (MDS) and acute myelocytic leukemias (AML). This risk of both diseases in patients with multiple myeloma has been estimated to be 10-20% after 10 years. We aimed to evaluate the time course and the type of genetic abnormalities in melphalan-treated patients in the chronic stage of the disease. We applied fluorescence in situ hybridization methods with probes to 5q31 and 7q31 to mononuclear peripheral blood leukocytes of 18 melphalan-treated patients and compared the results to those of 8 untreated myeloma patients. We found three patients (17%) with a 5q31 deletion in their peripheral white blood cells, but no 7q31 deletion. These findings suggest that 5q- occurs before the overt development of MDS/AML and raise important concerns regarding long-term treatment of myeloma patients with alkylating agents. Also, the performance of cytogenetic evaluation should be considered before autologous transplantation. The clinical and biological implications of these findings should be evaluated in larger clinical and laboratory studies.
    Cancer Genetics and Cytogenetics 08/2004; 152(1):84-7. DOI:10.1016/j.cancergencyto.2003.10.015 · 1.93 Impact Factor
  • Y Manor · O Mardinger · J Katz · S Taicher · A Hirshberg
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    ABSTRACT: Peripheral odontogenic tumours (POT) are rare benign focal overgrowths of the oral soft tissue, usually occurring in the gingiva. Between 1996-2000, 6 out of 406 excised gingival lesions were diagnosed as POT (1.5%). Tumours included peripheral odontogenic fibroma (2 patients), peripheral calcifying odontogenic cyst (2 patients), peripheral ameloblastoma (1 patient), and peripheral calcifying epithelial odontogenic tumour (1 patient). Review of the literature reveals that peripheral odontogenic fibroma and peripheral ameloblastoma were the most common POT. The purpose of this article was to analyse the clinical data of these tumours according to the presented cases and the literature review, to elucidate typical features of each tumour type and enhance easy identification.
    International Journal of Oral and Maxillofacial Surgery 05/2004; 33(3):268-73. DOI:10.1006/ijom.2003.0508 · 1.57 Impact Factor
  • D Blinder · Y Manor · U Martinowitz · S Taicher
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    ABSTRACT: The purpose of this study was to evaluate the incidence of postoperative bleeding in patients treated with oral anticoagulant medication who underwent dental extractions without interruption of the treatment and to analyze the incidence of postoperative bleeding according to the International Normalized Ratio (INR) value. The 249 patients who underwent 543 dental extractions were divided into five groups: Group 1 with INRs of 1.5-1.99, Group 2 with INRs of 2-2.49, Group 3 with INRs of 2.5-2.99, Group 4 with INRs of 3-3.49 and Group 5 with INRs>3.5. The INR was measured on the day of the procedure. Local haemostasis was carried out with gelatin sponge and multiple silk sutures. Of the 249 patients, 30 presented with postoperative bleeding (12%): Group 1, three patients presented with bleeding (5%), Group 2, 10 patients (12.8%), Group 3, nine patients (15.2%), Group 4, five patients (16.6%) and Group 5, three patients (13%). The incidence of postoperative bleeding was not significantly different among the five groups. The value of the INR at the therapeutic dose did not significantly influence the incidence of postoperative bleeding. Thus, dental extractions can be performed without modification of oral anticoagulant treatment. Local haemostasis with gelatin sponge and sutures appears to be sufficient to prevent postoperative bleeding.
    International Journal of Oral and Maxillofacial Surgery 12/2001; 30(6):518-21. DOI:10.1054/ijom.2001.0172 · 1.57 Impact Factor
  • Yifat Manor · Danielle Blinder · Shlomo Taicher
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    ABSTRACT: Intra-oral vertical ramus osteotomy is a useful procedure for correction of mandibular prognathism. However, a major disadvantage is poor visibility of the operating field. A modified technique that improves visibility without higher morbidity is described.
    International Journal of Oral and Maxillofacial Surgery 11/2001; 30(5):443-4. DOI:10.1054/ijom.2001.0117 · 1.57 Impact Factor
  • A Kesler · M H Ellis · Y Manor · N Gadoth · M Lishner
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    ABSTRACT: To evaluate the prevalence of neurological abnormalities in patients with ET and attempt to identify risk factors for neurological complications. Ninety-five patient charts were reviewed from January 1983-July 1999. Seventy patients fulfilled the Polycythemia Vera Study Group criteria for diagnosing ET. Eighteen patients (25.7%) had episodes of neurological impairment, 52 (74.3%) had none. Neurological features-- occlusive cerebrovascular event-9; chronic headache-3 and dizziness-3, mononeuritis multiplex, sinus vein thrombosis and epilepsy-1 each. The interval between diagnosis of ET and occurrence of neurological events ranged from time of presentation (10 patients) to 13 years (1 patient) with a high predominance of females, 88.8% and 55%, respectively. Neurological complications occurred at presentation or during follow-up in approximately 25% of patients with ET. Our observation suggests that further investigation focusing on the possible mechanisms for neurological deficits in females with ET should be considered.
    Acta Neurologica Scandinavica 12/2000; 102(5):299-302. DOI:10.1034/j.1600-0404.2000.102005299.x · 2.40 Impact Factor
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    ABSTRACT: Recently, a working-model of a stepwise malignant transformation in the molecular pathogenesis of multiple myeloma (MM) was proposed, involving the tumor suppressor gene TP53 and retinoblastoma gene (RB1) as prominent components of cell cycle control. To further define the role of TP53 and RB1 in disease progression, we retrospectively analyzed by fluorescence in situ hybridization (FISH) cytological material from 16 patients who underwent sequential bone marrow biopsies during the course of their disease. For TP53, no deletions were detected at presentation or during follow-up. It is possible that the patients reported here represent a subset with relatively long survival, and therefore did not demonstrate the TP53 deletions that had been reported in patients with a very poor prognosis. For RB1, monoallelic deletion was demonstrated in nine patients. In each case, the deletion appeared already in the first biopsy analyzed. The presence of a deletion did not affect the rate of tumor progression or the length of follow-up, and thus prognosis. Monoallelic deletions of RB1 appear to be a frequent and early event in the pathogenesis of MM, without obvious relevance for disease progression.
    Cancer Genetics and Cytogenetics 03/2000; 117(1):57-60. DOI:10.1016/S0165-4608(99)00144-2 · 1.93 Impact Factor
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    ABSTRACT: This study analyzed the fate of plates used to correct maxillofacial injuries and defined risk factors that eventually resulted in plate removal. The outpatient clinic files of 108 patients treated with rigid internal fixation after maxillofacial trauma were reviewed. Study variables included age, sex, trauma circumstances, diagnosis, type of fracture, approach to the facial skeleton, presence of teeth in the line of fracture, plate material, site of plates, and reasons for plate removal. Of 204 plates used for fixation, 44 plates (22 percent) were removed. When all factors were considered together, only fracture diagnosis (mandibular body and angle) and plate location (mandibular body and angle) were statistically significant. Only when each factor was considered separately, the approach to the facial skeleton (intraoral) and the type of fracture (comminuted and compound fractures) were statistically associated with plate removal. Selection of favorable plate location, the extraoral approach, and vigilant infection control may reduce plate removal in patients with maxillofacial injuries. Special attention should be given to compound and comminuted fractures of the mandibular body and angle.
    Plastic &amp Reconstructive Surgery 03/2000; 105(2):521-5. DOI:10.1097/00006534-200002000-00006 · 2.99 Impact Factor
  • M H Ellis · Y Manor · M Witz
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    ABSTRACT: To determine the prevalence of endogenous and exogenous risk factors for venous thrombosis in patients with upper limb deep vein thrombosis (DVT), and to evaluate the risk of clinically detectable pulmonary embolus, recurrent DVT, and postphlebitic symptoms in these patients. A combined prospective and retrospective descriptive analysis of a cohort of patients with upper limb DVT compared with age- and sex-matched patients with lower limb DVT. Internal medicine departments, and hematology and vascular surgery outpatient clinics at a tertiary-care university hospital. Consecutive patients with "spontaneous" upper limb DVT diagnosed between 1989 and 1997 were studied. Twenty age- and sex-matched patients with lower limb DVT admitted to the hospital via the emergency department served as control patients. Eighteen patients with upper limb DVT were studied. An endogenous risk factor (thrombophilia) was present in 11 of 18 patients vs 8 of 20 control patients (p = not significant). In the upper limb group, nine patients had activated protein C resistance, four patients had anticardiolipin antibodies, and two patients had both forms of thrombophilia. Furthermore, 14 of the upper limb DVT patients were found to have an exogenous risk factor for thrombosis compared with 7 of the patients with lower limb DVT (p = 0.01), and 66.6% of patients with upper limb DVT had both an exogenous and an endogenous risk factor for thrombosis vs 15% of patients with lower limb DVT (p < 0.002). No clinically detectable pulmonary emboli occurred among the upper limb DVT patients. Three patients have minor postphlebitic symptoms. Two patients experienced recurrent DVT. In the majority of patients with upper limb DVT that we studied in this relatively small study, exogenous (environmental) or endogenous risk factors for venous thrombosis, or a combination of both, were found. Furthermore, in our patients, these thromboses had a low propensity to cause clinically significant pulmonary embolus and did not cause significant postphlebitic symptoms. Finally, we suggest that anticoagulant therapy for these thromboses may be adequate and that thrombolytic agents and surgical intervention are not routinely indicated.
    Chest 02/2000; 117(1):43-6. DOI:10.1378/chest.117.1.43 · 7.48 Impact Factor

Publication Stats

692 Citations
97.46 Total Impact Points


  • 1995–2013
    • Tel Aviv University
      • • Department of Oral and Maxillofacial Surgery
      • • Faculty of Medicine
      Tell Afif, Tel Aviv, Israel
  • 1993–2009
    • Meir Medical Center
      • Department of Obstetrics and Gynecology
      Kafr Saba, Central District, Israel
  • 2006
    • Center For Oral & Maxillofacial Surgery
      Georgia, United States
  • 1999
    • Sheba Medical Center
      • Department of Pathology
      Gan, Tel Aviv, Israel