M Coudurier

Publications (9)5.03 Total impact

• Source

  Available from: Alban Deroux

  Article: [A case of mediastinal angiosarcoma].

  A Deroux, M Destors, M Coudurier, S Lantuejoul, M Aubert, N Girard, D Moro-Sibilot
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  ABSTRACT: Mediastinal angiosarcoma is a rare intrathoracic tumour and the therapeutic approach remains poorly codified. We report the case of a 65-year-old female patient presenting with chest pain. Further exploration revealed an anterior mediastinal mass with pericardial invasion. Transthoracic biopsy gave the diagnosis of angiosarcoma. Multimodal treatment with neoadjuvant chemotherapy (doxorubicin 20mg/m(2), Ifosfamide 2500mg/m(2), Uromitexan(®) 2500mg/m(2)) and surgery followed by adjuvant radiotherapy has led to remission of the tumour that has persisted for 12 months. Systematic recording of such conditions in dedicated registries could contribute to enhance the description of the clinical and pathological characteristics, thus helping define the principles of specific management.
  Revue des Maladies Respiratoires 11/2012; 29(9):1120-3. · 0.59 Impact Factor
• Article: [Targeting insulin-like growth factors in the treatment of cancer].

  D Moro-Sibilot, M Coudurier, S Lantuejoul
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  ABSTRACT: The insulin-like growth factor I receptor (IGF-IR) pathway plays a major role in cancer growth, tumor cell survival and resistance to therapy. Preclinical evidence that targeting the IGF-IR is effective in cancer treatment has been accumulating for almost 2 decades. Early clinical trials revealed an acceptable safety profile together with pharmacodynamic evidence that the receptor can be targeted successfully. It is premature to draw conclusions regarding the therapeutic potential of this class of compounds but well-documented single-agent activity was noted during phase I evaluations, and recent evidence from a phase-II study suggests that co-administration of an anti-IGF-1R antibody with chemotherapy for non-small-cell lung cancer (NSCLC) improves objective response rate and progression-free survival. These early results are a strong indication for continued research on the targeting of IGF-R, particularly in the treatment of NSCLC. Today, IGF-1R targeting appears a promising approach, more than two dozen compounds have been developed and clinical trials are underway.
  Revue des Maladies Respiratoires 10/2010; 27(8):959-63. · 0.59 Impact Factor
• Article: [Interstitial lung disease and anti-TNF-alpha therapy in rheumatoid arthritis: Two different patterns?].

  A Schuller, M Coudurier, J-C Lega, C Khouatra, V Cottin, J-F Cordier
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  ABSTRACT: The first lung complications of anti-TNF-alpha therapy in rheumatoid arthritis (RA) that were reported were infections. Recently, interstitial lung disease (ILD) has been described as a consequence of this treatment. We report two cases of women treated with anti-TNF-alpha therapy for RA who both developed exacerbations of their preexisting ILD thought to be due to the treatment. In one case, this complication occurred 2 months after anti-TNF-alpha therapy, whereas the delay of occurrence was 26 months in the second case. Based on these two cases and on the first 40 observations in the literature, we hypothesize that ILD may be exacerbated according to two distinct patterns during anti-TNF-alpha treatment for RA, occurring early (most frequently) or late after treatment was started, with a mean of 4 and 26 months, respectively. Other features that may differ between these two presentations include the risk factors, the anti-TNF-alpha molecule used, the histopathological pattern, and the prognosis.
  Revue des Maladies Respiratoires 03/2010; 27(3):232-7. · 0.59 Impact Factor
• Article: [Targeting of the IGF (Insulin-like Growth Factor) route in pulmonary oncology.]

  D Moro-Sibilot, M Coudurier
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  ABSTRACT: The pathway of Insulin-like Growth Factor (IGF-1) and its receptor (IGF-1R) is preponderant in solid tumours, and particularly in non small cell lung cancer (NSCLC). Several anticancer therapeutics, targeting this pathway, have been developed, whether it is monoclonal antibodies or small molecules (tyrosine kinase inhibitors, TKI). The results of phase II and III in stage IV NSCLC are promising, with response rate around 78% in non squamous cell carcinomas, that seem to be the histological type benefiting the most of anti-IGF-R therapies. Adverse effects are acceptable, essentially neutropenia or hyperglycaemia, with an interesting effect of metformin in this indication. Some other studies have underlined a synergic effect of EGFR (Epidermal Growth Factor Receptor) TKI and anti-IGF-1R antibodies. These promising results must be confirmed in phase III trials, currently opened or planned.
  Revue de Pneumologie Clinique 12/2009; 65S2:S80-S83. · 0.24 Impact Factor
• Article: Near-fatal haemorrhage from pulmonary arteriovenous malformation in HHT with increased cardiac output.

  V Cottin, D Gamondes, A Schuller, M Coudurier, S Dupuis-Girod, F Tronc, J-F Cordier
  European Respiratory Review 09/2009; 18(113):190-2.
• Source

  Available from: sarcoidosis.it

  Article: Homozygous variant rs2076530 of BTNL2 and familial sarcoidosis.

  M Coudurier, N Freymond, S Aissaoui, A Calender, Y Pacheco, G Devouassoux
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  ABSTRACT: Despite extensive studies, the pathogenesis of sarcoidosis is largely unknown. Although multiple environmental and putative infectious agents have been proposed, none was retained as a major contributor to the disease occurrence. Genetic predisposition to sarcoidosis was considered as a significant factor and numerous candidate genes have been reviewed. This last point was reinforced since the discovery of a pathogenic polymorphism (rs2076530 or G > A) of the BTNL2 gene, leading to an early truncation of the protein, which increases the relative risk of the disease. BTNL2 is known to act as a co-stimulatory molecule, inducing a negative signal to T-lymphocyte activation and the mutated gene is responsible for a truncated protein and disruption of membrane localization. Our work attempted to confirm this observation in a highly penetrant familial form of sarcoidosis. In this family, the disease was diagnosed in 5 members through 3 generations. Despite individual clinical specificities, all displayed severe forms of the disease. Peripheral blood samples were collected from 3 patients and 2 additional healthy children of the fourth generation. Analysis of the BTNL2 gene confirmed the presence of the pathogenic variant of BTNL2 on both alleles (A/A homozygous genotype) in all subjects tested. Our data suggest that the absence of a membrane anchored BTNL2 protein may increase genetic susceptibility to sarcoidosis and familial occurrence of the disease. This observation assessed the putative pathogenic involvement of the rs2076530 variant of BTNL2 in the development of this granulomatosis disease.
  Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 07/2009; 26(2):162-6. · 1.27 Impact Factor
• Article: [Thymic tumours, autoimmune neutropaenia and autoimmune haemolytic anaemia].

  M Coudurier, R Houot, L Geriniere, S Blandin, G Salles, T Lamy, P-J Souquet
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  ABSTRACT: Although an association between thymic tumour and autoimmune disease (including autoimmune cytopenia) has been established, the association between thymic tumour and autoimmune neutropenia has rarely been reported, with only 13 cases described in the literature. We report on a 30 year old man diagnosed with autoimmune neutropenia who had been treated for invasive thymic tumour one year previously. He successfully responded to cyclosporin and steroids therapy. A few months later, the patient presented with autoimmune haemolytic anaemia after prematurely halting his own immunosuppressive treatment. This observation brings additional insights about the clinical features, biology and treatment of autoimmune neutropenia associated with thymic tumours and underlines the potential severity of such an association. Furthermore, the association of a thymic tumour with both autoimmune neutropaenia and autoimmune haemolytic anaemia has not been reported previously.
  Revue des Maladies Respiratoires 06/2008; 25(5):605-9. · 0.59 Impact Factor
• Article: [Multiple cavitating pulmonary nodules in a virology laboratory assistant].

  M Coudurier, S Couraud, Y Duval, L Geriniere, S Isaac, P J Souquet
  Revue des Maladies Respiratoires 04/2007; 24(3 Pt 1):371-3. · 0.59 Impact Factor
• Article: [Nocardial pulmonary infection].

  S Couraud, R Houot, M Coudurier, A C Ravel, B Coiffier, P J Souquet
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  ABSTRACT: Nocardial pneumonias are due to a genus of aerobic, filamentous, partly acid-alcohol fast, mainly Gram positive, actinomycetes. We report here two cases of nocardial pneumonia. The first was a 62 year old man with a history of fludaribine treatment and bone marrow transplant for lymphocytic leukaemia. During the investigation of pyrexia evidence of N. farcinica infection was found in the bronchial secretions. The second case was a man of 61 receiving long term corticosteroids and cytotoxic chemotherapy. Investigation of a pneumonia with pleural effusion found evidence, on culture of blood and pleural fluid, of disseminated infection with N. nova (cerebral, pleural, pulmonary and splenic). Nocardiosis is a rare cause of pneumonia mainly occurring in immuno-compromised adults (corticosteroid therapy, HIV infection, transplantation, cancer or leukaemia). It should be suspected in the presence of pleuro-pulmonary symptoms associated with neurological and cutaneous signs, general deterioration and weight loss. The microbiology laboratory should be advised of this eventuality as soon as possible in order to optimise the search for the organism.
  Revue des Maladies Respiratoires 04/2007; 24(3 Pt 1):353-7. · 0.59 Impact Factor