A Debby

Tel Aviv University, Tell Afif, Tel Aviv, Israel

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Publications (28)63.77 Total impact

  • Ron Sagiv · Abraham Debby · Ran Keidar · Ram Kerner · Abraham Golan ·
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    ABSTRACT: Background: Ovarian pregnancy is a rare type of ectopic pregnancy. Laparoscopic surgery is currently the cornerstone of ovarian pregnancy treatment. Few studies have analyzed the clinical outcomes of ovarian pregnancies after laparoscopic treatment, particularly subsequent pregnancies. Objective: The purpose of this study was to assess fertility outcomes subsequent to ovarian pregnancy treated by laparoscopy. Materials and Methods: A retrospective analysis was conducted of women with ovarian pregnancies that were diagnosed and successfully treated by laparoscopy at the E. Wolfson Medical Center during 1997-2009, and these women's subsequent fertility. Results: Eight of 829 women (1%) with ectopic pregnancy were diagnosed as having an ovarian pregnancy. All the patients were admitted either with abdominal pain, amenorrhea, or vaginal bleeding. Two patients (25%) carried an intrauterine device, 2 (25%) had been treated by in vitro fertilization because of male partner and tubal factors, and 1 patient (12.5%) had undergone two previous cesarean deliveries. In all patients, the sonographic results led to incorrect diagnosis of ectopic pregnancy or ruptured ovarian cyst. Additionally, in all patients, a laparoscopic wedge resection of the ovary was performed. Of the 8 patients, 2 did not desire further pregnancy. In another 6 patients, 5 reached term pregnancy and 1 had a miscarriage. Conclusions: Following an ovarian pregnancy treated by laparoscopy, there is a high rate of successful subsequent pregnancy with a good outcome. (J GYNECOL SURG 30:12)
    Journal of Gynecologic Surgery 02/2014; 30(1):12-14. DOI:10.1089/gyn.2013.0062
  • Ron Sagiv · Abraham Debby · Ran Keidar · Ram Kerner · Abraham Golan ·
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    ABSTRACT: We report on management and subsequent fertility outcome of interstitial pregnancy in a retrospective cohort study (Canadian Task Force classification II-3) at a university affiliated teaching hospital. Fourteen consecutive women with interstitial pregnancy were treated by methotrexate, laparotomy or laparoscopy between 1997 and 2007 from a total of 706 women with extrauterine pregnancy. The first four patients, with significant hemoperitoneum, were treated by laparotomy. Of the next 10 patients, four were selected for medical treatment with methotrexate. Only one case was treated successfully. The other six women had laparoscopic treatment. Of nine laparoscopies, one was converted to laparotomy due to excessive blood loss during the procedure. Of nine women desiring a child, three were infertile while six conceived with an intrauterine pregnancy. A change from diagnosis later in pregnancy and laparotomy to more conservative treatment, mainly by laparoscopy, suggests a possibly better subsequent pregnancy rate. This article is protected by copyright. All rights reserved.
    Acta Obstetricia Et Gynecologica Scandinavica 08/2013; 92(11). DOI:10.1111/aogs.12239 · 2.43 Impact Factor
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    ABSTRACT: To evaluate the efficacy of methotrexate treatment for extrauterine pregnancy and define criteria for prediction of success. Of 829 patients with an ectopic pregnancy admitted to E. Wolfson Medical Center, Holon, Israel, from January 1997 through December 2009, 238 had asymptomatic tubal pregnancies and increasing serum β-human chorionic gonadotropin (βhCG) levels. These patients were treated with a single intramuscular injection of 50mg of methotrexate (MTX) per square meter of body surface. Success was defined as undetectable βhCG levels without the need for a surgical intervention. The groups of patients successfully treated (n=167 [70%]) and unsuccessfully treated (n=71 [30%]) were compared. They were similar regarding age and gravidity. The initial serum βhCG level was significantly higher in the latter group than in the former (3798 mIU/mL vs. 1601 mIU/mL, P<0.01). The success rate was 88% when initial βhCG levels were less than 1000 mIU/mL, 71% when they were between 1000 and 2000 mIU/mL, and only 59% when they were between 2000 and 3000 mIU/mL. Methotrexate treatment is a safe and effective alternative to surgery. However, patients with initial βhCG levels higher than 2000 mIU/mL should only be offered the surgical approach.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 11/2011; 116(2):101-4. DOI:10.1016/j.ijgo.2011.09.023 · 1.54 Impact Factor
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    ABSTRACT: The postoperative analgesic effects of rectal indomethacin and tramadol were compared in patients undergoing elective termination of first trimester pregnancy and diagnostic dilatation and curettage. Eighty-one American Society of Anesthesiologists class I and II women undergoing first trimester termination of pregnancy or diagnostic dilation and curettage were randomly allocated to receive rectal suppositories of either tramadol 100 mg (n=41) or indomethacin 100 mg (n=40) 90 min before induction of anesthesia. Pain scores and side effects were evaluated until discharge. Intraoperative anesthetic and postoperative analgesic consumption was also recorded. Intravenous metamizole 1 g was employed for postoperative rescue analgesia. When compared to the indomethacin group, the tramadol group required less intraoperative propofol [136 mg ±28 vs. 160 mg ±35 (P=0.001)], less rescue analgesia [2.4% vs. 22% (P=0.005)] and lower visual analogue pain scores [2.4 ±8 vs. 23 ±22 (P=0.005)]. The incidence of postoperative nausea and vomiting was similar in both groups. When compared to indomethacin 100 mg, preoperative administration of tramadol 100 mg provides superior postoperative analgesia with minimal adverse effects.
    International journal of obstetric anesthesia 07/2011; 20(3):236-9. DOI:10.1016/j.ijoa.2011.03.002 · 1.60 Impact Factor
  • Abraham Debby · Abraham Golan · Oscar Sadan · Marek Glezerman · Haim Shirin ·
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    ABSTRACT: To determine the impact of esophagogastroduodenoscopy (EGD) on the clinical management of pregnancy women with recurrent vomiting and their pregnancy outcome. Retrospective evaluation of 60 pregnant women who underwent diagnostic EGD in the first trimester of pregnancy. Pregnant women were divided into 2 groups according to the indications for EGD: group 1, intractable vomiting with or without epigastric pain (n = 49) and group 2, vomiting and gastrointestinal bleeding (n = 11). The endoscopic findings found in both groups were esophagitis (43%), gastritis (17%), diaphragmatic hernia (17%) and normal EGD (28%). The diagnostic yield for EGD was 69% for group 1 and 82% for group 2. EGD was helpful for clinical management when performed for suspected gastrointestinal bleeding rather than for other indications. Mean gestational age at delivery, fetal weight and mean Apgar score did not differ by groups. No fetal malformations were observed. Recurrent intractable vomiting in pregnancy may be accompanied by esophagitis or peptic disease in a significant proportion of patients. Based on the significant pathologies amenable to medical therapy, a therapeutic trial with a proton pump inhibitor during hyperemesis gravidarum seems warranted. EGD can be safely performed in pregnancy with no maternal or fetal complications.
    The Journal of reproductive medicine 06/2008; 53(5):347-51. · 0.70 Impact Factor
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    A Debby · A Golan · O Sadan · S Rotmensch · G Malinger ·
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    ABSTRACT: To characterize the sonographic appearance of the uterine cavity after first-trimester uterine evacuation and to follow the evolution of these findings in an attempt to reduce the number of unnecessary surgical interventions following evacuation. We studied retrospectively the sonographic characteristics of the uterine cavity in 599 women, 5-8 days after first-trimester uterine evacuation. The patients were grouped according to the sonographic appearance of the uterine cavity. Patients with abnormal sonographic patterns were followed weekly until sonographic resolution. Group 1 included 351 (58.6%) women with normal endometrium; Group 2 included 130 (21.7%) women with hypoechoic endometrial content only; Group 3 included 69 (11.5%) patients with mixed type (hypoechoic and hyperechoic) endometrial content; Group 4 included 49 (8.2%) patients with hyperechoic endometrial content only. The time needed until the uterine cavity was considered normal was significantly longer in Group 4 (median, 12 days) compared with Groups 3 and 2 (8 and 9 days, respectively, P < 0.0001). The duration of vaginal bleeding after the surgical procedure was longer in Group 4 (median, 10 days) compared with Groups 3, 2 and 1 (9, 7 and 5 days, respectively, P < 0.0001). Clinically, the patients were divided into two groups: asymptomatic (575 patients) and symptomatic (24 patients). The thickness of the abnormal endometrial content in the asymptomatic patients gradually decreased until normalization, around the time of menstruation. There was no such change in the symptomatic patients, who eventually needed surgical intervention. An abnormal intrauterine sonographic pattern 5-8 days following first-trimester uterine evacuation is common and usually resolves spontaneously around menses. Therefore, in asymptomatic patients, we recommend a conservative approach.
    Ultrasound in Obstetrics and Gynecology 05/2008; 31(5):555-9. DOI:10.1002/uog.5274 · 3.85 Impact Factor

  • American Journal of Obstetrics and Gynecology 12/2007; 197(6). DOI:10.1016/j.ajog.2007.10.388 · 4.70 Impact Factor
  • A Debby · O Sadan · M Glezerman · A Golan ·
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    ABSTRACT: To evaluate the outcome of midtrimester emergency cerclage with or without bulging of membranes. A retrospective cohort study of 99 women who underwent emergency second trimester cerclage (16-27 gestational weeks). In 75 women the cervix was dilated and effaced but without bulging of membranes (group 1), and in 24 women the dilation and effacement of the cervix were accompanied by bulging of membranes into the vagina in an hourglass formation (group 2). McDonald technique was applied in all patients. Prolongation of pregnancy was significantly longer in group 1 compared to group 2 (14.3+/-6.5 vs 9.3+/-4.8 weeks, p=0.007). The mean gestational age at delivery was significantly higher in group 1 compared to group 2 (34.6+/-4.6 vs 29.5+/-3.2 weeks, p=0.001). The incidence of chorioamnionitis was higher in group 2 compared to group 1 but statistically insignificant (25% vs 15%, p=0.2). The overall neonatal survival was 83% (82 out of 99 neonates), without statistical difference between the two groups (86% in group 1 and 71% in group 2, p=0.2). Favorable neonatal outcome may be accomplished in patients with cervical incompetence in the second trimester of pregnancy following cervical emergency suturing even performed when the membranes are bulging through the cervix into the vagina.
    International Journal of Gynecology & Obstetrics 02/2007; 96(1):16-9. DOI:10.1016/j.ijgo.2006.09.002 · 1.54 Impact Factor
  • A Debby · G Malinger · M Glezerman · A Golan ·
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    ABSTRACT: The aim of the study was to assess the clinical significance of intra-uterine fluid collection in postmenopausal women with cervical stenosis with and without vaginal bleeding. A group of 82 consecutive postmenopausal women with cervical stenosis and sonographically confirmed intra-uterine fluid collection underwent D&C with or without hysteroscopy. Diagnostic hysteroscopy was performed in all patients with an endometrial thickness (ET) was greater than 8mm, or with irregular endometrium at any degree of ET. The patients were divided and evaluated prospectively into two groups according to the presence or absence of postmenopausal bleeding (PMB). Twenty-six women were with PMB and 56 women were asymptomatic. The groups were similar as far as endometrial thickness and histopathological results were concerned. Atrophic endometrium was found in 69 patients (84%), 23 in the PMB group (89%) and 46 in the other group (82%), proliferative endometrium in 7 (9%) and endometrial polyps were found in 35 patients (43%), 12 in the PMB group (46%) and 23 in the other group (41%). When ET was > or =8 mm, in 93% of the cases an endometrial polyp was found (25 out of 27). No case of endometrial cancer was found. A premalignant condition was diagnosed in one patient with an endometrial polyp in the PMB group. All patients with endometrial thickness of less than 3 mm in ultrasound had atrophic endometrium. The incidence of intrauterine pathology increased with the increasing thickness of endometrium as observed by ultrasound. The presence of intra-uterine fluid collection in postmenopausal patients with cervical stenosis seems to be a benign condition. Normal endometrium of less than 3mm observed by ultrasound in postmenopausal women without vaginal bleeding does not necessarily need further surgical investigation.
    Maturitas 11/2006; 55(4):334-7. DOI:10.1016/j.maturitas.2006.04.026 · 2.94 Impact Factor
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    A Debby · G Malinger · E Harow · A Golan · M Glezerman ·
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    ABSTRACT: To assess the incidence of retained products of conception (RPOC) in relation to transvaginal ultrasound performed after first-trimester uterine evacuation. This was a prospective randomized study involving 809 women undergoing first-trimester uterine evacuation. The study group included 404 women in whom transvaginal sonography was performed at the end of the surgical procedure and the control group contained 405 women who did not undergo ultrasound examination. Initially, in the study group, recurettage was immediately performed if the endometrium appeared irregular but latterly only if endometrial thickness was > or = 8 mm. The patients were followed up by gynecological and ultrasound examinations 5-8 days following the surgical procedure. The total complication rate was 4.3%. RPOC presented in three women in the study group (0.7%) and in 15 women in the control group (3.7%, P < 0.05). Vaginal bleeding requiring hospitalization occurred in two women in the study group (0.5%) vs. seven in the control group (1.7%, P = 0.2). Endometritis was diagnosed in one woman in the study group (0.2%) vs. six in the control group (1.5%) and uterine perforation occurred in one woman in the control group vs. none in the study group. There were no cases of RPOC in women who had an endometrial thickness of < 8 mm as demonstrated by ultrasound at the end of the surgical procedure. Transvaginal sonography immediately following first-trimester uterine evacuation may reduce the incidence of RPOC and the total complication rate. When the endometrial thickness is > or = 8 mm at the end of suction curettage, an attempt at re-evacuation of the uterine cavity is indicated.
    Ultrasound in Obstetrics and Gynecology 12/2005; 27(1):61-4. DOI:10.1002/uog.2654 · 3.85 Impact Factor
  • S Ginath · A Debby · G Malinger ·
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    ABSTRACT: The purpose of this study was to evaluate the feasibility of obtaining good quality three-dimensional ultrasound pictures of the cranial sutures and fontanelles and to compare between two-dimensional and three-dimensional ultrasound in identifying the normal appearance of cranial sutures and fontanelles by the transvaginal approach at 15 to 16 weeks of gestation. Fifty fetuses were prospectively evaluated by two-dimensional and three-dimensional transvaginal sonography between 15 and 16 weeks of gestation. The sagittal, coronal, lambdoidal, and metopic sutures, as well as anterior and posterior fontanelles, were inspected. Three-dimensional ultrasound enabled visualization of all sutures in 37 (74%) fetuses compared to 28 (56%) fetuses examined by two-dimensional ultrasonography (p = NS). The visualization of the sagittal suture was significantly superior by three-dimensional ultrasonography compared to two-dimensional ultrasonography (50 (100%) vs 35 (70%), p < 0.001). No significant difference between the two modalities was found in visualization of the fontanelles. Sutures and fontanelles are usually satisfactorily demonstrated by two-dimensional and three-dimensional ultrasound at 15 to 16 weeks of gestation. The sagittal suture is difficult to visualize using two-dimensional ultrasound, and three-dimensional ultrasound appears to be the best method for its demonstration.
    Prenatal Diagnosis 10/2004; 24(10):812-5. DOI:10.1002/pd.988 · 3.27 Impact Factor
  • A Debby · T Levy · H Hayat · Y Brenner · M Glezerman · J Menczer ·
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    ABSTRACT: The value of consolidation therapy in advanced epithelial ovarian carcinoma patients is controversial. The aim of the present study was to assess the long-term survival of patients with a pathologically confirmed complete remission who had consolidation by single-dose, whole-abdominopelvic radiotherapy. Of 96 histologically confirmed stage II-IV epithelial ovarian carcinoma patients who underwent cytoreductive surgery followed by high-dose, platin-based chemotherapy, 57 were in complete clinical remission at the end of therapy and 50 underwent a second-look laparotomy. The study group comprises 32 consecutive patients who had no pathological evidence of disease and who received 800 cGy single-dose, whole-abdominal radiotherapy by an 8 MEV linear accelerator in a single fraction. The absolute 5-year survival and the actuarial 10-year survival were 78.7 and 63.3%, respectively. The survival was significantly better in patients who had < or =2 cm residual disease at the completion of the original operation. No severe postradiation complications were encountered. Mild complications were seen in three (9.4%) patients. Our data indicate a favorable long-term survival of patients with a negative second-look laparotomy who had consolidation with single-dose, whole-abdominal radiotherapy. These results seem to suggest that a collaborative, prospective, randomized multiarm study is indicated to solve the controversial issue of consolidation therapy.
    International Journal of Gynecological Cancer 09/2004; 14(5):794-8. DOI:10.1111/j.1048-891X.2004.014510.x · 1.96 Impact Factor
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    A. Debby · G. Malinger · R. Sagiv · M. Glezerman · A. Golan ·

    Ultrasound in Obstetrics and Gynecology 08/2004; 24(3):306-306. DOI:10.1002/uog.1443 · 3.85 Impact Factor
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    A. Debby · G. Malinger · O. Sadan · A. Golan · M. Glezerman ·

    Ultrasound in Obstetrics and Gynecology 08/2004; 24(3):288 - 288. DOI:10.1002/uog.1379 · 3.85 Impact Factor
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    A. Debby · G. Malinger · E. Harow · R. Sagiv · M. Glezerman · A. Golan ·

    Ultrasound in Obstetrics and Gynecology 08/2004; 24(3):222 - 222. DOI:10.1002/uog.1142 · 3.85 Impact Factor
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    ABSTRACT: To present our experience with clinical and sonographic diagnosis of retained products of conception and to evaluate its correlation with histopathologic findings. This was a retrospective study on 156 patients admitted for retained products of conception. Women were referred because of 1 or more of the following: abdominal pain, bleeding, and fever. The status of the cervix was evaluated by bimanual examination. The diagnosis of retained products of conception was made when a sonographic finding of hyperechoic or hypoechoic material was seen in any part of the uterine cavity or the presence of a thickened endometrial stripe greater than 8 mm and an irregular interface between the endometrium and myometrium was found. One hundred twenty-one women (77.6%) were admitted after dilation and curettage for abortion, and 35 (22.4%) were admitted after spontaneous labor. Histopathologic reports confirmed the diagnosis of retained products of conception in 86 (71%) of 121 women in the postabortion group and in 17 (48.5%) of 35 women in the postpartum group. The overall false-positive rate for sonographic diagnosis was 34%. For women after abortion and after delivery, the false-positive rates were 28.9% and 51.5%, respectively. Reliance on common signs and symptoms to diagnose retained products of conception as well as the use of sonography is associated with an unacceptably high false-positive rate, mainly after delivery. A more conservative approach to the treatment of retained products of conception is suggested.
    Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine 04/2004; 23(3):371-4. · 1.54 Impact Factor
  • A Debby · R Sagiv · O Girtler · O Sadan · M Glezerman · A Golan ·
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    ABSTRACT: This study compared the course of midtrimester termination of pregnancies with fetal demise and those with a viable fetuses by extra-amniotic prostaglandin (PG) E(2). A total of 275 women who underwent second trimester abortion with extra-amniotic PGE2(2) were divided into two groups: 95 patients (35%) with fetal demise and 180 women (65%) with a live fetuses. Extra-amniotic PGE2(2) was administered in doses of 200 micro g every 2 h up to 20 doses. Bumm curettage was performed in the majority of the patients. We compared the duration and complication rate between the groups. The median induction to abortion interval was significantly shorter in the fetal demise group (13 vs. 21 h) than in the live fetus group. Mean gestational ages and complication rates were similar. Midtrimester termination of pregnancy with extra-amniotic PGE2(2) is a safe method with a low complication rate. In cases of pregnancy with fetal demise extra-amniotic PGE2(2) is associated with a significantly shorter induction to abortion interval than with a live fetus.
    Archives of Gynecology and Obstetrics 11/2003; 268(4):301-3. DOI:10.1007/s00404-002-0369-5 · 1.36 Impact Factor
  • Abraham Debby · Abraham Golan · Ron Sagiv · Oscar Sadan · Marek Glezerman ·
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    ABSTRACT: To investigate whether extraamniotic prostaglandin E2 (PGE2) for midtrimester pregnancy interruption in women with a scarred uterus has any adverse effects compared to those without an uterine scar. Two hundred and sixty-two women who underwent second trimester (16-27 gestational weeks) termination of pregnancy were enrolled in this study. Thirty-one women with a uterine scar were compared with 231 patients without a scarred uterus. Extraamniotic PGE2 was applied in serial doses of 200 mcg every 2 h up to 20 doses. Intravenous infusion of oxytocin was added in cases when the fetus was not expelled. Curettage was performed in the majority of the patients. The two groups were similar for indications for pregnancy termination, maternal age and gestational age. Gravidity and parity were significantly higher in the group with an uterine scar. The mean induction to abortion time and the complication rate were similar in both groups. No uterine rupture was observed. Extraamniotic PGE2 for midtrimester termination of pregnancy is a safe procedure with a low complication rate, even in patients with an uterine scar.
    European Journal of Obstetrics & Gynecology and Reproductive Biology 09/2003; 109(2):177-80. DOI:10.1016/S0301-2115(03)00121-0 · 1.70 Impact Factor
  • A Golan · R Sagiv · A Debby · M Glezerman ·
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    ABSTRACT: To access a method that attempts to reduce the risk of bowel and blood vessel trauma in entry-risk patients during laparoscopy. Three-year observational study (Canadian Task Force classification II-2). Tertiary university hospital. Thirty-one women defined as entry-risk due to previous multiple abdominal surgeries or repair of umbilical hernia. Laparoscopy performed with a 2 mm minilaparoscope inserted at Palmer's point, a midclavicular position under the lower left rib. In most cases the minilaparoscope was used to inspect the anterior abdominal wall for adhesions. When a location free from adhesions was seen or created by adhesiolysis, the 5- or 10-mm cannula was inserted, followed by the laparoscope. Periumbilical adhesions were more common after previous longitudinal incisions. There were no complications. Minilaparoscopy is safe and effective for identifying and preparing a proper cannula insertion point. This may be useful for avoiding bowel or other cannula-related trauma in women at high risk for such a complication.
    The Journal of the American Association of Gynecologic Laparoscopists 03/2003; 10(1):14-6. DOI:10.1016/S1074-3804(01)80074-8 · 1.61 Impact Factor
  • A Debby · M Glezerman · R Sagiv · O Sadan · G Malinger · A Golan ·
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    ABSTRACT: The aim of the study was to determine the impact of midtrimester abortion with extra-amniotic PGE(2) on future fertility and reproduction. Two hundred and fifteen women were enrolled. The mean induction-to-abortion interval was 21.3 h. The complication rate was 11.7%. Twenty women (9.3%) were lost to follow-up, 82 patients (38.1%) used contraception. Spontaneous pregnancy occurred in 110 out of 113 women who desired fertility (97%). Three patients were defined as infertile but conceived following treatment. The average time between the abortion and the next conception was 15.9 months (range 1-77 months). Seventy patients (63.7%) delivered at term. Premature delivery occurred in 18 patients (16.4%). Eighteen women aborted spontaneously in the first and 3 in the second trimester. One extrauterine pregnancy occurred. Second-trimester abortion with extra-amniotic PGE(2) is a safe procedure with a low rate of complication. Apparently it does not affect future fertility, but may be associated with an increased rate of premature deliveries in future gestations.
    Gynecologic and Obstetric Investigation 02/2003; 56(3):168-72. DOI:10.1159/000074064 · 1.70 Impact Factor