José Victor Maniglia

Publications (23)21.85 Total impact

• Source

  Available from: Vania Belintani Piatto

  Article: A seven-year experience with patients with juvenile nasopharyngeal angiofibroma.

  Alfredo Lara Gaillard, Vanessa Menegatti Anastácio, Vânia Belintani Piatto, José Victor Maniglia, Fernando Drimel Molina
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  ABSTRACT: Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor in adolescent males. It originates in the nasopharynx. To present the experience of JNA management at an Otorhinolaryngology Service between 2001 and 2008. Demographical data, clinical presentation, investigations as well as the treatment of sixteen JNA patients were reviewed and collected from medical records from the ORL Service. Cross-sectional, retrospective and descriptive study. Results: All JNA patients were male. The average age at diagnosis was 16.8 years (range 9-23 years). More than 56% of the patients were classified as Fisch II. Preoperative embolization was carried out in ten (62.5%) patients. All 16 patients were submitted to primary surgical resection. Two patients (66.7%) who didn't receive preoperative embolization required intraoperative blood transfusion. The overall recurrence rate was 43.75% and the cure rate was 93.75%. Preoperative embolization minimizes intraoperative blood loss. The recurrence rate was related to advanced tumoral stage at diagnostic and the lack of preoperative embolization. Surgery combined with preoperative embolization is the major treatment for JNA. All the patients should undergo preoperative imaging studies, especially CT, to assist in surgical planning and follow-up.
  Brazilian journal of otorhinolaryngology 76(2):245-50.
• Article: Analysis of the TAX1BP1 gene in head and neck cancer patients.

  Mariangela Torreglosa Ruiz, Janayna Fernanda Balachi, Raquel Aldrighi Fernandes, Ana Lívia Silva Galbiatti, José Victor Maniglia, Erika Cristina Pavarino-Bertelli, Eny Maria Goloni-Bertollo
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  ABSTRACT: In Brazil, there were 14,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. To assess the T --> A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. SERIES AND METHODS: A retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. There is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p =0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism.
  Brazilian journal of otorhinolaryngology 76(2):193-8.
• Source

  Available from: Joice Matos Biselli

  Article: [GSTM1 and GSTT1 genes analysis in head and neck cancer patients].

  Cássia Veridiana Dourado Leme, Luis Sérgio Raposo, Mariangela Torreglosa Ruiz, Joice Matos Biselli, Ana Lívia Silva Galbiatti, José Victor Maniglia, Erika Cristina Pavarino-Bertelli, Eny Maria Goloni-Bertollo
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  ABSTRACT: To establish the clinical and demographic profile and identify risk factors among patients with head and neck cancer and relate them to the polymorphism of GSTT1 and GSTM1. One hundred patients with head and neck cancer and 100 control group individuals without history of neoplasm were analyzed. . The molecular analysis were made by multiplex polymerase chain reaction. For statistical analysis, data were tabulated and compared by the Fisher's exact test, the Chi-square test and multiple logistic regression were also used. There was prevalence of smokers (OR = 5.32, CI 95% CI = 2.04-13.86 p = 0.0006), alcohol drinkers (OR = 5.04, CI 95% = 2.19-11.59 p = 0.0001) in head and neck cancer patients . The GSTT1 null genotype was found in 47% of the patient and 41% of the control group (OR = 0.67; CI 95%= 0.34-1.35; p = 0.2648). Likewise , the GSTM1 null genotype was found in 66% of the patient and 75% of the control group (OR = 2.25; CI 95%= 1.05 - 4.84; p = 0.0368). The combined GSTT1 and GSTM1 gene null genotype shown association between GSTM1 0/GSTT1 and occurrence of head and neck carcinoma (OR = 7.64; CI 95%= 1.72-34.04; p = 0.0076). Analysis of clinical-pathological features showed association between GSTT1 null genotype and larynx, the inverse relation between this genotype and pharynx. In our study it was possible to establish association between GSTM1 null genotypes and head and neck cancer.
  Revista da Associação Médica Brasileira 56(3):299-303. · 0.77 Impact Factor