Bernard Dan

Université Libre de Bruxelles, Bruxelles, Brussels Capital, Belgium

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Publications (240)609.46 Total impact

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    ABSTRACT: Gait is an essential human activity which organizes many functional and cognitive behaviors. The biomechanical constraints of bipedalism implicating a permanent control of balance during gait are taken into account by a complex dialogue between the cortical, subcortical and spinal networks. This networking is largely based on oscillatory coding, including changes in spectral power and phase-locking of ongoing neural activity in theta, alpha, beta and gamma frequency bands. This coding is specifically modulated in actual gait execution and representation, as well as in contexts of gait observation or imagination. A main challenge in integrative neuroscience oscillatory activity analysis is to disentangle the brain oscillations devoted to gait control. In addition to neuroimaging approaches, which have highlighted the structural components of an extended network, dynamic high-density EEG gives non-invasive access to functioning of this network. Here we revisit the neurophysiological foundations of behavior-related EEG in the light of current neuropsychological theoretic frameworks. We review different EEG rhythms emerging in the most informative paradigms relating to human gait and implications for rehabilitation strategies. Copyright © 2015. Published by Elsevier Ltd.
    Neuropsychologia 07/2015; DOI:10.1016/j.neuropsychologia.2015.06.039 · 3.45 Impact Factor
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    ABSTRACT: Background: Children born preterm are at risk for developmental cerebral visual impairment. Several modalities of visual evoked potentials recording have been used to approach prognosis. The recent development of high-density EEG protocols allows evaluation of the oscillatory content of cortical activities evoked by specific stimulation. We aimed to document maturational EEG changes in response to visual stimulation in infants born preterm. Aim: to document maturational EEG changes in response to visual stimulation in infants born preterm. Material and methods: 12 newborn infants (8 boys/4 girls) born preterm (28-31 weeks of gestation) were recorded at term age and 3 months later using the ActiveTwo system (Biosemi) high-density EEG. Exclusion criteria were craniofacial congenital malformations, known genetic syndrome. No infants had retinopathy, intraventricular hemorrhage or cystic periventricular leukomalacia. We used size-adapted head caps with 64 sintered active Ag/AgCl electrodes positioned according to the 10/20 system. Sampling rate was 2048 Hz. We performed EEGLab analysis of theta, alpha, beta and gamma frequency spatiotemporal contents (incl. event-related spectral perturbation and intertrial coherence) of event related potentials evoked by slow (1Hz) and fast (9Hz) visual flash stimulation. Summed ear lobe potentials were used as reference. We used 1 Hz high-pass filter, 60 Hz low-pass filter and 48-52 Hz notch filter. Results: We recorded consistent changes posteriorly at the expected latency of visual evoked potentials for age (around 200ms following 1Hz stimulation) including increased alpha-beta power as well as local synchrony maximal in the same range of oscillations bands. At higher rates, resonance resulted in further power increase within the stimulation frequency with superimposed oscillatory processes in the beta and gamma range. The changes were significantly different at 3 months corrected age compared to term age. Conclusion: Oscillatory study of high-density EEG in infants allows precise maturational documentation of visual responses in young infants, paving the way for increased understanding of central processes involved during early neurological development. It may contribute to documenting physiological and deviant neurophysiological organization in the wider context of early neurodevelopmental diagnosis.
    EACD 2015; 05/2015
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    ABSTRACT: Background: Angelman syndrome is a genetic neurodevelopmental disorder recognised to show characteristic (non-epileptic) high-amplitude slow rhythmic electroencephalographic patterns. These hypersynchronous neuronal activities have been studied to approach the pathophysiology of the condition. Aim: to analyse these patterns with enhanced recording technique (high-density EEG) and analysis method, using a recently developed technique for identifying subtle short-term repeated patterns that may be masked by non-stationarities, noise, and artefacts. Material and methods: 4 children (aged 2 to 5) with Angelman syndrome due to 15q11-q13 deletion. High-density EEG were recorded at resting state using the ActiveTwo system (Biosemi) with size-adapted head caps with 128 sintered active Ag/AgCl electrodes positioned radially equidistant from CZ. Sampling rate was 2048 Hz. We performed a channel spectra for the 128 channel of a 5 minutes resting state recording in order to find regions of interest for slow frequency bands. We performed a wave trigger averaging over the peaks of activity of this region and averaged it on a period of 2 seconds (-1,1second) centered on the peak activity. To localise the generator of this activity, we performed an inverse solution analysis with Sloreta matrix. Results: we found high-amplitude (from 140 μV to 188 μV) slow frequency oscillation (4Hz in all patients) mostly in parieto-occipital regions. The generator of this activity was located in the parietal lobe, in Brodman areas 7. Discussion: The slow rhythmic activity is consistent with a model of cortical and thalamo-cortical dysfunction resulting from dysregulation of synaptic GABAergic neurotransmission due to lack of UBE3A expression, or other factors. Brodmann area 7 specifically identified here correspond to the somatosensory association cortex, which play key roles in visuo-motor coordination and in language processing, both of which show specific impairments in Angelman syndrome.
    EACD 2015; 05/2015
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    ABSTRACT: Careful study of the phenotype can have implications at several levels, namely clinical diagnosis, pathophysiological reasoning, management planning, and outcome measurement. Behavioural phenotypes involve cognition, communication, social skills, and motor control. They can be documented in a host of neurodevelopmental conditions and approached with the recently refined perception-action-cognition-environment (PACE) paradigm, which focuses on the neurodevelopmental processes that underlie learning and adaption to the environment through perception, action, and cognitive processing. Although this paradigm was originally developed in the context of cerebral palsy, it can be applied along developmental trajectories in several neurogenetic conditions, including Down syndrome, fragile X syndrome, Rett syndrome, Angelman syndrome, and Williams syndrome, to name but a few. It must be recognized, however, that relevant, valid tools for assessment and management strategies still need to be developed. © 2015 The Authors. Developmental Medicine & Child Neurology © 2015 Mac Keith Press.
    Developmental Medicine & Child Neurology 04/2015; 57 Suppl 2(s2):52-4. DOI:10.1111/dmcn.12694 · 3.29 Impact Factor
  • Bernard Dan · Karine Pelc · Ana M Cebolla · Guy Cheron
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    ABSTRACT: Efforts to document early changes in the developing brain have resulted in the construction of increasingly accurate structural images based on magnetic resonance imaging (MRI) in newborn infants. Tractography diagrams obtained through diffusion tensor imaging have focused on white matter microstructure, with particular emphasis on neuronal connectivity at the level of fibre tract systems. Electroencephalography (EEG) provides a complementary approach with more direct access to brain electrical activity. Its temporal resolution is excellent, and its spatial resolution can be enhanced to physiologically relevant levels, through the combination of high-density recordings (e.g. by using 64 channels in newborn infants) and mathematical models (e.g. inverse modelling computation), to identify generators of different oscillation bands and synchrony patterns. The integration of functional and structural topography of the neonatal brain provides insights into typical brain organization, and the deviations seen in particular contexts, for example the effect of hypoxic-ischaemic insult in terms of damage, eventual reorganization, and functional changes. Endophenotypes can then be used for pathophysiolgical reasoning, management planning, and outcome measurements, and allow a longitudinal approach to individual developmental trajectories. © The Authors. Journal compilation © 2015 Mac Keith Press.
    Developmental Medicine & Child Neurology 04/2015; 57 Suppl 3:44-7. DOI:10.1111/dmcn.12728 · 3.29 Impact Factor
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    ABSTRACT: The highly stereotyped, crystal-like architecture of the cerebellum has long served as a basis for hypotheses with regard to the function(s) that it subserves. Historically, most clinical observations and experimental work have focused on the involvement of the cerebellum in motor control, with particular emphasis on coordination and learning. Two main models have been suggested to account for cerebellar functioning. According to Llinás's theory, the cerebellum acts as a control machine that uses the rhythmic activity of the inferior olive to synchronize Purkinje cell populations for fine-tuning of coordination. In contrast, the Ito-Marr-Albus theory views the cerebellum as a motor learning machine that heuristically refines synaptic weights of the Purkinje cell based on error signals coming from the inferior olive. Here, we review the role of timing of neuronal events, oscillatory behavior, and synaptic and non-synaptic influences in functional plasticity that can be recorded in awake animals in various physiological and pathological models in a perspective that also includes non-motor aspects of cerebellar function. We discuss organizational levels from genes through intracellular signaling, synaptic network to system and behavior, as well as processes from signal production and processing to memory, delegation, and actual learning. We suggest an integrative concept for control and learning based on articulated oscillation templates.
    The Cerebellum 03/2015; DOI:10.1007/s12311-015-0665-9 · 2.86 Impact Factor
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    ABSTRACT: Angelman syndrome (AS) is a genetic neurodevelopmental disorder in which cerebellar functioning impairment has been documented despite the absence of gross structural abnormalities. Characteristically, a spontaneous 160 Hz oscillation emerges in the Purkinje cells network of the Ube3a (m-/p+) Angelman mouse model. This abnormal oscillation is induced by enhanced Purkinje cell rhythmicity and hypersynchrony along the parallel fiber beam. We present a pathophysiological hypothesis for the neurophysiology underlying major aspects of the clinical phenotype of AS, including cognitive, language and motor deficits, involving long-range connection between the cerebellar and the cortical networks. This hypothesis states that the alteration of the cerebellar rhythmic activity impinges cerebellar long-term depression (LTD) plasticity, which in turn alters the LTD plasticity in the cerebral cortex. This hypothesis was based on preliminary experiments using electrical stimulation of the whiskers pad performed in alert mice showing that after a 8 Hz LTD-inducing protocol, the cerebellar LTD accompanied by a delayed response in the wild type (WT) mice is missing in Ube3a (m-/p+) mice and that the LTD induced in the barrel cortex following the same peripheral stimulation in wild mice is reversed into a LTP in the Ube3a (m-/p+) mice. The control exerted by the cerebellum on the excitation vs. inhibition balance in the cerebral cortex and possible role played by the timing plasticity of the Purkinje cell LTD on the spike-timing dependent plasticity (STDP) of the pyramidal neurons are discussed in the context of the present hypothesis.
    Frontiers in Systems Neuroscience 11/2014; 8:221. DOI:10.3389/fnsys.2014.00221
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    ABSTRACT: Autosomal recessive forms of Charcot-Marie-Tooth disease (ARCMT) are rare but severe disorders of the peripheral nervous system. Their molecular basis is poorly understood due to the extensive genetic and clinical heterogeneity, posing considerable challenges for patients, physicians, and researchers. We report on the genetic findings from a systematic study of a large collection of 174 independent ARCMT families. Initial sequencing of the three most common ARCMT genes (ganglioside-induced differentiation protein 1-GDAP1, SH3 domain and tetratricopeptide repeats-containing protein 2-SH3TC2, histidine-triad nucleotide binding protein 1-HINT1) identified pathogenic mutations in 41 patients. Subsequently, 87 selected nuclear families underwent single nucleotide polymorphism (SNP) genotyping and homozygosity mapping, followed by targeted screening of known ARCMT genes. This strategy provided molecular diagnosis to 22 % of the families. Altogether, our unbiased genetic approach identified pathogenic mutations in ten ARCMT genes in a total of 41.3 % patients. Apart from a newly described founder mutation in GDAP1, the majority of variants constitute private molecular defects. Since the gene testing was independent of the clinical phenotype of the patients, we identified mutations in patients with unusual or additional clinical features, extending the phenotypic spectrum of the SH3TC2 gene. Our study provides an overview of the ARCMT genetic landscape and proposes guidelines for tackling the genetic heterogeneity of this group of hereditary neuropathies.
    Neurogenetics 09/2014; 16(1). DOI:10.1007/s10048-014-0422-0 · 2.66 Impact Factor
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    ABSTRACT: Biological motion observation has been recognized to produce dynamic change in sensorimotor activation according to the observed kinematics. Physical plausibility of the spatial-kinematic relationship of human movement may play a major role in the top-down processing of human motion recognition. Here, we investigated the time course of scalp activation during observation of human gait in order to extract and use it on future integrated brain-computer interface using virtual reality (VR). We analyzed event related potentials (ERP), the event related spectral perturbation (ERSP) and the inter-trial coherence (ITC) from high-density EEG recording during video display onset (-200-600 ms) and the steady state visual evoked potentials (SSVEP) inside the video of human walking 3D-animation in three conditions: Normal; Upside-down (inverted images); and Uncoordinated (pseudo-randomly mixed images). We found that early visual evoked response P120 was decreased in Upside-down condition. The N170 and P300b amplitudes were decreased in Uncoordinated condition. In Upside-down and Uncoordinated conditions, we found decreased alpha power and theta phase-locking. As regards gamma oscillation, power was increased during the Upside-down animation and decreased during the Uncoordinated animation. An SSVEP-like response oscillating at about 10 Hz was also described showing that the oscillating pattern is enhanced 300 ms after the heel strike event only in the Normal but not in the Upside-down condition. Our results are consistent with most of previous point-light display studies, further supporting possible use of virtual reality for neurofeedback applications.
    Frontiers in Systems Neuroscience 09/2014; 8:169. DOI:10.3389/fnsys.2014.00169
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    ABSTRACT: In this study we employed a dynamic recurrent neural network (DRNN) in a novel fashion to reveal characteristics of control modules underlying the generation of muscle activations when drawing figures with the outstretched arm. We asked healthy human subjects to perform four different figure-eight movements in each of two workspaces (frontal plane and sagittal plane). We then trained a DRNN to predict the movement of the wrist from information in the EMG signals from seven different muscles. We trained different instances of the same network on a single movement direction, on all four movement directions in a single movement plane, or on all eight possible movement patterns and looked at the ability of the DRNN to generalize and predict movements for trials that were not included in the training set. Within a single movement plane, a DRNN trained on one movement direction was not able to predict movements of the hand for trials in the other three directions, but a DRNN trained simultaneously on all four movement directions could generalize across movement directions within the same plane. Similarly, the DRNN was able to reproduce the kinematics of the hand for both movement planes, but only if it was trained on examples performed in each one. As we will discuss, these results indicate that there are important dynamical constraints on the mapping of EMG to hand movement that depend on both the time sequence of the movement and on the anatomical constraints of the musculoskeletal system. In a second step, we injected EMG signals constructed from different synergies derived by the PCA in order to identify the mechanical significance of each of these components. From these results, one can surmise that discrete-rhythmic movements may be constructed from three different fundamental modules, one regulating the co-activation of all muscles over the time span of the movement and two others elliciting patterns of reciprocal activation operating in orthogonal directions.
    Frontiers in Computational Neuroscience 09/2014; 8:100. DOI:10.3389/fncom.2014.00100 · 2.23 Impact Factor
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    ABSTRACT: Owing to excellent time resolution and optimized spatial resolution related to increased number of recording electrodes, high-density electroencephalography allows localization of the sources of cortical activities evoked by specific stimulation. Here we evaluate the feasibility of a high-density EEG mismatch negativity of event-related potentials approach involving auditory cortical processing of phonemes in newborn infants born preterm (28 and 31 weeks’ gestation) in a routine clinical set-up. We recorded 64-channel EEG at term age. We identified the classical evoked components and found the amplitude of P1 and N2 to be significantly higher in the deviant (target) condition than in the standard condition. We analyzed the signals using standardized weighted low-resolution brain electromagnetic tomography (swLORETA) on theta, alpha, beta and gamma frequency bands. High theta and alpha power spectrum appeared in the superior and the middle temporal gyrus in following the standard and target stimulation. Additionally, delayed frontal area recruitment was seen after the target stimulation. Beta-gamma event-related synchronization was observed in BA10, BA46 and BA10, more markedly following target than standard stimulation. This suggests ability for auditory memory and change detection in neonates and shows early results in source localization. This approach paves the way for increased understanding of central processes involved during early neurological development. It may contribute to documenting physiological and deviant neurophysiological organization in the wider context of early diagnosis of features associated with preterm birth.
  • Bernard Dan
    Developmental Medicine & Child Neurology 09/2014; 57(1). DOI:10.1111/dmcn.12568 · 3.29 Impact Factor
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    ABSTRACT: BACKGROUND: Although there is increasing recognition of the role of somatic mutations in genetic disorders, the prevalence of somatic mutations in neurodevelopmental disease and the optimal techniques to detect somatic mosaicism have not been systematically evaluated. METHODS: Using a customized panel of known and candidate genes associated with brain malformations, we applied targeted high-coverage sequencing (depth, ≥200×) to leukocyte-derived DNA samples from 158 persons with brain malformations, including the double-cortex syndrome (subcortical band heterotopia, 30 persons), polymicrogyria with megalencephaly (20), periventricular nodular heterotopia (61), and pachygyria (47). We validated candidate mutations with the use of Sanger sequencing and, for variants present at unequal read depths, subcloning followed by colony sequencing. RESULTS: Validated, causal mutations were found in 27 persons (17%; range, 10 to 30% for each phenotype). Mutations were somatic in 8 of the 27 (30%), predominantly in persons with the double-cortex syndrome (in whom we found mutations in DCX and LIS1), persons with periventricular nodular heterotopia (FLNA), and persons with pachygyria (TUBB2B). Of the somatic mutations we detected, 5 (63%) were undetectable with the use of traditional Sanger sequencing but were validated through subcloning and subsequent sequencing of the subcloned DNA. We found potentially causal mutations in the candidate genes DYNC1H1, KIF5C, and other kinesin genes in persons with pachygyria. CONCLUSIONS: Targeted sequencing was found to be useful for detecting somatic mutations in patients with brain malformations. High-coverage sequencing panels provide an important complement to whole-exome and whole-genome sequencing in the evaluation of somatic mutations in neuropsychiatric disease. (Funded by the National Institute of Neurological Disorders and Stroke and others.).
    New England Journal of Medicine 08/2014; 371(8):733-43. DOI:10.1056/NEJMoa1314432 · 54.42 Impact Factor
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    ABSTRACT: Background: The continuation of binge drinking is associated with the development of neurocognitive brain abnormalities similar to those observed in patients with alcohol dependence. Alcohol cue reactivity constitutes a risk marker for alcohol dependence. Through event-related potentials (ERPs), we aimed to examine its potential presence as well as its evolution over time in binge drinkers in a one-year period. Methods: ERPs were recorded during a visual oddball task in which controls (n=15) and binge drinkers (n=15) had to detect infrequent deviant stimuli (related or unrelated to alcohol) among frequent standard stimuli. The test was performed twice with a one-year interval in order to explore the long-lasting influence of drinking habits. Results: Contrary to the controls, binge drinkers showed significantly reduced amplitudes of the P1 component for both alcohol and non-alcohol-related cues and of the P3 component only for neutral cues in the second assessment compared with the first. Conclusion: The continuation of binge drinking over one year is associated with the development of brain functional abnormalities (indexed by the P1 component) as well as a higher reactivity to alcohol-related stimuli and/or a decreased reactivity to non-alcohol-related stimuli (indexed by the P3 component).
    Journal of Psychopharmacology 08/2014; 28(11). DOI:10.1177/0269881114545663 · 2.81 Impact Factor
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    ABSTRACT: Children with attention deficit/hyperactivity disorder (ADHD) have been found to show theta-beta correlation in rhythmic brain oscillations. We aimed to further analyse scalp activity in order to study global amplitude of activation and topographical stability during a visual-cued task in children with ADHD. Participants and methods: Fourteen ADHD and 14 aged-matched control children underwent EEG while performing a visual-cued GO-NOGO task. We performed theta-beta corroboration, topographical activation study, including global field potential (GFP) and transiently stable brain states (microstates). We performed a topographical ANOVA to establish differences between conditions and other statistical analysis (comprising unpaired t-tests) to fit maps within subject. Results: ADHD children had significantly smaller amplitude at first and third peak and larger second peak in the W-shaped GFP after CUE, GO and NOGO visual onsets than control children, who showed the reverse image to this. W-shaped GFP peak topography remained almost the same for the three peaks. Children with ADHD also had more intermediary topographies than controls. Conclusion: There were significant differences in microstates between children with ADHD and controls. Excess intermediary topographies in ADHD group may index and give insights into abnormal executive function in ADHD.
    European Academy of Child Disability 2014; 07/2014
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    ABSTRACT: Angelman syndrome(AS)is a neurogenetic disorder with well-described developmental and behavioural features. Its biophenotype includes rhythmic EEG abnormalities described according to their main frequency and topography. Pattern I is classically reported as runs of frontal high-amplitude (>200-300μV) 2-3/s (delta) activity, and Pattern II as prolonged runs of 4-6/s (theta) activity >80-100 μV predominating over centro-temporal regions. We aimed to better characterise these rhythmic activities. Participants and methods: 14 children with AS (8 girls, 6 boys; 12 del15q11-q13, 1 UBE3A mutation, 1 paternal uniparental disomy) who had undergone EEG were identified in a retrospective setting. We performed spectral analysis using ASA Advance source of analysis) in 22 recordings obtained between 14 months and 12 years. Results: Pattern I appeared mostly as delta activity, particularly intense in frontal regions but also extending to occipital and sometimes central regions. Pattern I was also associated with theta rhythms recorded in the same channels as delta rhythm but showing higher correlation with alpha activity. Beta rhythm was poorly represented in all analyses but showed more intensity when delta rhythm was more intense. In Pattern II, delta rhythm was often more intense than theta rhythm. Both delta and theta rhythms were represented widely but predominated in centro-temporal regions. Alpha and beta rhythms correlated with theta rhythm. Conclusion: Spectral analysis of the EEG patterns classically described in AS highlights involvement of other frequency bands and topographical distribution than those usually reported based on visual inspection. This may have implications in pathophysiology and diagnostic contribution.
    26th Annual Meeting of the European Academy of Childhood Disability; 07/2014
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    ABSTRACT: Non-convulsive status epilepticus is often challenging in paediatric practice. It is a treatable cause of cognitive deterioration and behavioural disturbances in many neurological conditions. It has a high association with Angelman syndrome, where differential electrodiagnosis with the typical non-epileptic rhythmic EEG patterns may be difficult. In this exploratory pilot study, we aimed to compare EEG patterns associated with non-convulsive status epilepticus in Angelman syndrome and other conditions. Participants and methods: EEG recordings obtained during nonconvulsive status epilepticus in three children with Angelman syndrome and four children with other conditions were retrospectively retrieved and analysed using ASA (Advance source of analysis).Results: In children with Angelman syndrome and nonconvulsive status epilepticus, the epileptic activity appeared mainly in the frontal regions as high-amplitude delta (6000-13000 ìV*2), theta (5000 ìV*2), alpha (1000 ìV*2) and beta (200-800 ìV*2) rhythms. In the other children, during non-convulsive status epilepticus, the epileptic mainly appeared in the centro-frontal regions as relatively lower amplitude delta (3000-6000 ìV*2), theta (1800 ìV*2), alpha (200 ìV*2) and beta (80 ìV*2). Cluster analysis showed segregation between the two groups. Conclusion: EEG associated with non-convulsive status epilepticus may have different electrogenetic properties in Angelman syndrome as compared with other conditions.
    26th Annual Meeting of the European Academy of Childhood Disability; 07/2014
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    ABSTRACT: Infant botulism is a rare neuroparalytic disease caused by the neurotoxin of Clostridium botulinum. Initial clinical features are constipation, poor feeding, descending hypotonia, drooling, irritability, weak crying and cranial nerve dysfunctions. We describe the clinical progression and the epidemiological investigation carried out in a 3-month-old infant. Better knowledge of the disease should allow faster diagnosis and adequate management. We emphasize the risks associated with honey exposure in children less than one year old and that honey should not be fed to infants under 12 months of age.
    Archives de Pédiatrie 06/2014; DOI:10.1016/j.arcped.2014.03.009 · 0.41 Impact Factor
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    ABSTRACT: Infant botulism is a rare neuroparalytic disease caused by the neurotoxin of Clostridium botulinum. Initial clinical features are constipation, poor feeding, descending hypotonia, drooling, irritability, weak crying and cranial nerve dysfunctions. We describe the clinical progression and the epidemiological investigation carried out in a 3-month-old infant. Better knowledge of the disease should allow faster diagnosis and adequate management. We emphasize the risks associated with honey exposure in children less than one year old and that honey should not be fed to infants under 12 months of age.
    Archives de Pédiatrie 04/2014; · 0.41 Impact Factor
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    ABSTRACT: The N30 component of the somatosensory evoked potential is known to be modulated by sensory interference, motor action, movement ideation and observation. We introduce a new paradigm in which the observation task of another person's hand movement triggers the somatosensory stimulus, inducing the N30 response in participants. In order to identify the possible contribution of the mirror neuron network (MNN) to this early sensorimotor processing, we analyzed the N30 topography, the event-related spectral perturbation and the inter-trial coherence on single electroencephalogram (EEG) trials, and we applied swLORETA to localize the N30 sources implicated in the time-frequency domain at rest and during observation, as well as the generators differentiating these two contextual brain states. We found that N30 amplitude increase correlated with increased contralateral precentral alpha, frontal beta, and contralateral frontal gamma power spectrum, and with central and precentral alpha and parietal beta phase-locking of ongoing EEG signals. We demonstrate specific activation of the contralateral postcentral and parietal cortex where the angular gyrus (BA39), an important MNN node, is implicated in this enhancement during observation. We conclude that this part of the MNN, involved in proprioceptive processing and more complex body-action representations, is already active prior to somatosensory input and may enhance N30.
    NeuroImage 03/2014; 95. DOI:10.1016/j.neuroimage.2014.03.039 · 6.36 Impact Factor

Publication Stats

4k Citations
609.46 Total Impact Points

Institutions

  • 1998–2015
    • Université Libre de Bruxelles
      • • Laboratory of Neurophysiology and Movement Biomechanics (LNMB)
      • • Faculty of Motricity Sciences (FMP)
      • • Department of Psychiatry
      • • Department of Nephrology and Urology
      Bruxelles, Brussels Capital, Belgium
  • 1999–2014
    • University Hospital Brussels
      Bruxelles, Brussels Capital, Belgium
  • 1997–2014
    • Hôpital Universitaire des Enfants Reine Fabiola
      • Department of Neurology
      Bruxelles, Brussels Capital Region, Belgium
  • 1999–2011
    • Vrije Universiteit Brussel
      • • Department of Neurology
      • • Department of Pediatrics
      Bruxelles, Brussels Capital Region, Belgium
  • 2004–2010
    • University-Hospital Brugmann UVC
      Bruxelles, Brussels Capital, Belgium
  • 2004–2009
    • Université de Mons
      Mons, Walloon, Belgium
  • 2002
    • Great Ormond Street Hospital for Children NHS Foundation Trust
      • Department of Neurophysiology
      Londinium, England, United Kingdom