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ABSTRACT: The time-kill method was used to determine the bactericidal activity of cefditoren compared with oral cephalosporins, amoxicillin, amoxicillin/clavulanate and levofloxacin against a randomly selected group of strains isolated from community-acquired respiratory tract infections (CARTIs). Cefditoren was the only agent showing significant bactericidal activity (>or=3 log(10 )reduction of viable cells) within 4 h against all Streptococcus pneumoniae strains, both penicillin-susceptible (PEN S) or -resistant (PEN R), as well as against Streptococcus pyogenes, and Moraxella catarrhalis. Against beta-lactamase positive strains of Haemophilus influenzae, cefditoren was comparable to the quinolone and more active than other cephalosporins at 24 h. Cefditoren showed the best killing kinetic profiles and this observation may be important when choosing an oral third-generation cephalosporin as initial or sequential therapy.
Journal of chemotherapy (Florence, Italy) 09/2009; 21(4):378-82. · 1.08 Impact Factor
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ABSTRACT: The study was carried out to clarify the correlation between Chlamydia pneumoniae infection and peripheral arterial disease (PAD). The level of specific antibodies of the 133 consecutive patients suffering from PAD at 2nd stage of Leriche's classification were compared with 60 healthy controls by using a commercial Micro-IF Test. A higher incidence of serological evidence of C. pneumoniae infection was found in the patients (106/133) than in controls (6/60). These results are in agreement with other findings that measured the infection in atheromasic plaques. A strong cause-effect relationship between bacterial infection and peripheral arterial disease was not found, but the raised seropositivity level could be considered as a target for medical therapy of PAD.
Journal of chemotherapy (Florence, Italy) 03/2006; 18(1):103-6. · 1.08 Impact Factor
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ABSTRACT: Forty-six adult periodontal patients, selected on the basis of clinical examination, and 46 adult healthy subjects were examined. The subgingival plaque samples from one inflammatory and one non-inflammatory site of each periodontal patient were studied to determine Porphyromonas gingivalis prevalence related to other periodontal micro-organisms and to periodontal tissue destruction. The results showed Porphyromonas gingivalis as the main pathogenic micro-organism isolated in the inflammatory sites together with Bacteroides forsythus. Peptostreptococcus sp., Actinomyces sp. and Prevotella sp. were found as a normal oral flora in the healthy subjects. Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus and Eikenella corrodens were detected both in inflammatory and in non-inflammatory sites of periodontal patients as well as in the healthy subjects.
The new microbiologica: official journal of the Italian Society for Medical, Odontoiatric, and Clinical Microbiology (SIMMOC) 08/1999; 22(3):209-18. · 1.00 Impact Factor
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ABSTRACT: This study was carried out to determine the clinical efficacy and the clinical safety of azithromycin in a group of children with acute respiratory tract infections. The study involved 82 children treated with a single daily 10 mg/kg dose of azithromycin for three consecutive days. 7 days later, the overall clinical response was 100% (cure and improvement): bacteriological cure was achieved in 97.5% of the patients treated. Recurrences were never observed. Side effects not requiring interruption of therapy were observed in 3 patients (3.6%). The side effects were gastrointestinal disturbances. In conclusion azithromycin showed a remarkably clinical efficacy for treatment of acute respiratory infections in children. Tolerability and therapeutic compliance were excellent.
Minerva pediatrica 07/1995; 47(6):249-60.
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ABSTRACT: In previous investigations we considered the increasing resistance of Gram-negative organisms to aminoglycosides over time. We therefore performed further studies to evaluate eventual variations in the incidence of bacterial resistance to aminoglycosides over the last four years. We tested Gram-negative microorganisms recently isolated from pathological materials of various clinical origins with gentamicin, amikacin, tobramycin and netilmicin. Our data show evidence that there was no significant increasing resistance to aminoglycosides, and that netilmicin continues to be active as an anti-Gram-negative antibiotic.
Journal of chemotherapy (Florence, Italy) 01/1992; 3(6):352-6. · 1.08 Impact Factor
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Journal of chemotherapy (Florence, Italy) 08/1989; 1(4 Suppl):965-6. · 1.08 Impact Factor
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Journal of chemotherapy (Florence, Italy) 08/1989; 1(4 Suppl):35-6. · 1.08 Impact Factor
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ABSTRACT: Dactimicin (ST 900) is the first aminoglycoside antibiotic of Dactylosporangium origin. This drug shows resistance to many enzymes that destroy aminoglycosides. In this first approach, the authors have pointed out the activity of dactimicin against Gram-negative rods, particularly Klebsiella, Enterobacter, Serratia and Gram-positive bacteria, especially methicillin susceptible and resistant staphylococci. Dactimicin showed remarkable antibacterial activity against all strains tested; however this activity was strongly influenced by the inoculum size. The bactericidal activity of dactimicin towards some Gram-positive and Gram-negative bacteria was also evaluated.
Drugs under experimental and clinical research 02/1987; 13(12):727-9.
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ABSTRACT: The authors carried out a study to evaluate the epidemiology and resistance of netilmicin, gentamicin, tobramycin and amikacin during the 1984-1985 period. Clinical specimens of different origin, drawn both from hospitalized and outpatients were used in the study. The strains were tested for their sensitivity to aminoglycosides. In particular the degree of resistance in both fermentative and non-fermentative gram-negative strains was determined. As previously pointed out in other works, netilmicin showed good antimicrobial activity in respect to other aminoglycosides.
Chemioterapia: international journal of the Mediterranean Society of Chemotherapy 07/1986; 5(3):191-5.
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ABSTRACT: In recent years there has been a gradual increase in the number of infections caused by Klebsiella, Enterobacter and Serratia and non-fermentative bacilli such as Pseudomonas, Alcaligenes and Acinetobacter. The object of this investigation was to evaluate the antibacterial properties of the cephalosporins cefoxitin, cefoperazone, cefotaxime and of gentamicin, in comparison with cefotetan, a new cephamycin with a high degree of stability to beta-lactamases. The cefotetan MIC was not affected either by size of the bacterial inoculum, or the culture medium and the serum protein binding of cefotetan was 85%. Cefotetan showed only moderate antibacterial activity, similar to that of the other cephalosporins tested, against the Gram-positive cocci, whereas it was very active against fermentative and non-fermentative Gram-negative bacilli, except for Pseudomonas aeruginosa. The remarkable activity of cefotetan against Klebsiella, Enterobacter and Serratia is of particular interest.
Journal of Antimicrobial Chemotherapy 02/1983; 11 Suppl:79-85. · 5.07 Impact Factor
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Giornale di clinica medica 01/1981; 61(12):906-18.
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ABSTRACT: Antibacterial activity of amikacin with regards to gentamicin resistant, Gram-negative bacteria was evaluated. Probable systems of enzymatic inactivation of antibiotic were postulated for amikacin and other aminoglycosides.
Bollettino dell'Istituto sieroterapico milanese 02/1979; 57(6):713-7.
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Giornale di batteriologia, virologia ed immunologia 73(7-12):215-21.
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Giornale di batteriologia, virologia ed immunologia 74(1-6):61-6.
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Annali Sclavo. Collana monografica 20(3):395-400.
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Giornale italiano di chemioterapia 24(1-2):7-10.
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Antibiotica 13(2-3):80-99.
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Giornale italiano di chemioterapia 32(1):211-5.
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ABSTRACT: Occurrence of non-fermenting Gram-negative bacteria was investigated by the Authors in various clinical specimens expecially of compromised hosts. 15 non-fermenting Gram-negative bacterial strains were isolated and identificated by two routine diagnostic systems. Isolates, were resistant to tetracycline, ampicillin, chloramphenicol and carbenicillin, while were shown to have different pattern of susceptibility to the aminoglycoside antibiotics examined.
Annali Sclavo. Collana monografica 20(5):763-9.
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Giornale italiano di chemioterapia 26(1-2):167-72.
