Ichiyo Matsuzaki

University of Tsukuba, Tsukuba, Ibaraki, Japan

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Publications (37)128.06 Total impact

  • Alzheimers & Dementia - ALZHEIMERS DEMENT. 01/2011; 7(4).
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    ABSTRACT: This study was designed to investigate how the interaction between the ability of medical residents (doctors in postgraduate training) to cope with stress and their working conditions might affect their level of job-related stress. A self-administered questionnaire was distributed to 549 first-year medical residents at 38 postgraduate education hospitals in Japan, 1-2 months after the start of clinical training. The questionnaires contained the 29-item Sense of Coherence (SOC) Scale, the Brief Scales for Job Stress (BSJS), the 12-item General Health Questionnaire (GHQ-12) and questions on basic conditions such as working hours. Sense of coherence is an important concept from the viewpoint of salutogenesis theory and influences stress recognition style. People with a strong SOC have a high ability to cope with stress. The mean +/- standard deviation (SD) score on the SOC Scale was 134.5 +/- 20.5. All participants were classified into three groups according to their SOC Scale scores. Although the objective working conditions of the three groups were statistically similar, the group with the weakest SOC Scale score showed poorer mental health status (p < 0.05) and scored lower for 'reward from work' compared with the groups with stronger SOC scores (p < 0.05). The weaker SOC group also scored higher for 'mental workload' and 'problems in personal relationships' than the other two groups (p < 0.05). Moreover, the weak SOC group scored less for 'support from colleagues and superiors' than the strong SOC group (p < 0.05). A stepwise multiple regression analysis for GHQ-12 score was conducted (R(2) = 0.45). 'Sleep time', 'workload', 'mental workload' and 'problems in personal relationships' were positively correlated with GHQ-12 scores. 'Reward from work' was negatively correlated with GHQ-12 scores. Residents' mental health was associated not only with working conditions, but also with their attitudes towards those working conditions. Enhancing residents' sense of 'reward from work' might be important in reducing their reactions to stress.
    Medical Education 08/2010; 44(8):826-34. · 3.55 Impact Factor
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    ABSTRACT: Objectives: There is disagreement over the roles of biological and psycho-social factors in the prolongation of whiplash symptoms. The issue of whether differences in recovery time result from differences in the severity of physical injury or from non-physiological social variables, such as insurance compensation, remains unresolved. We examined, for one year, the circumstances of Japanese receiving treatment who had been in rear-end collisions during a specified time period, and were presumed to have whiplash injuries. Methods: Subjects were 6,167 adults over 20 years of age who had been examined at an emergency center or a general hospital for symptoms such as neck pain presumed to be the result of cervical hyperextension caused by rear-end collision. No abnormalities were detected by neurological examinations, nor by X-rays. Data collected included the following items: gender, age, area of residence, date of accident, date of initial examination, occupation, seat belt use, whether they were driver or passenger, awareness of impending collision, behavior after accident, method of transportation to initial examination, whether there was loss of consciousness, and duration of medical treatment. We calculated the odds-ratios [OR] of those who continued to receive treatment and those who did not at 1.5 months, 3 months, and 6 months post-trauma. Results: Factors such as: female gender, use of emergency vehicle transportation, and early complaint of symptoms were significantly correlated with persistence of symptoms at six months post-trauma, while employment status had no significant association with continued treatment. Conclusions: Our results suggest that although both biological and social factors increased the probability of short- and medium-term prolongation [1.5 months and 3 months], the biological variables were mainly found to influence long-term prolongation of whiplash symptoms [6 months].
    01/2010; 5(2):71-84.
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    ABSTRACT: Via a large scale cross-sectional study among Japanese white color workers, the authors aimed to elucidate: (1) the distributions of Sense of Coherence (SOC), which reflect stress coping abilities, (2) the distributions of the Brief Scale for Coping Profile (BSCP) which reflect coping profiles for stressors; (3) and the association between SOC and BSCP. Anonymous self-administered questionnaires were sent to 20,742 employees at educational and research institutions in Tsukuba Research Park City. A total of 12,009 (57.9%) workers completed and returned the questionnaire; 10,317 workers without missing data were analyzed. SOC scale scores and BSCP subscale scores differed by gender, age, and other demographic features. Among the BSCP subscales, workers whose SOC scale scores were higher tended to adopt a problem-focused coping profile, whereas workers whose SOC scale scores were lower adopted an emotion-focused coping profile. The coping profile that workers adopted depended on their background and demographic characteristics. Stronger SOC allowed one to adopt a problem-focused coping profile that allows for better coping with work-related stressors.
    Industrial Health 12/2009; 47(6):664-72. · 0.87 Impact Factor
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    ABSTRACT: Overweight and poor psychological well-being are becoming serious health issues in the Japanese workplace. Concurrence of those physical and mental conditions has been pointed out, especially in middle-aged workers. Therefore, we tried to determine common risk factors for body weight gain and the deterioration of psychological well-being in male middle-aged office workers using a five-year follow-up study. We administered General Health Questionnaire-12 (GHQ-12) as an indicator of psychological well-being to 110 male workers with ages ranging from 40-59 years, and analyzed the influence of several psychological factors, namely sense of coherence (SOC), health locus of control (HLC), and lifestyle variables such as exercise frequency, alcohol intake, smoking status, and dietary intake on changes of body mass index and GHQ-12 score. McNemar's chi-squared test showed significant concurrence of weight gain and deterioration of psychological well-being after five-year follow-up. Low-SOC score, low frequency of exercise, and high-dietary intake at supper were significantly associated with both weight gain and poorer psychological well-being in workers, results which were supported by multiple regression analysis. These results suggest that exercise and calorie restriction seem to prevent weight gain and promote psychological well-being in workers. Low SOC, which implies difficulty in coping with stress, may be an important risk factor not only for deterioration of psychological well-being but also for becoming overweight. These assumptions must be confirmed by conducting future intervention studies on SOC and lifestyle including exercise and eating behavior.
    Environmental Health and Preventive Medicine 09/2009; 14(6):319-27.
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    ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder that is the most common cause of dementia in the elderly and is frequently accompanied by emotional disorder, including agitation. Although evidence of neuroendocrine immune and inflammatory functions during emotional changes has been accumulated, the pathogenic mechanisms in the development of agitation accompanied by AD remain to be elucidated. To clarify the involvement of neuroendocrine and immune and inflammatory systems in agitation in AD, we examined agitation levels, circadian rhythms of behavior, cortisol, interleukin-1beta (IL-1beta), and natural killer cell activity (NKCA) in controls without dementia and 16 AD patients who were recognized to be easily agitated in their nursing homes. These behavioral and blood indicators were assessed according to the progress of the stage of agitation in 16 AD patients (stable, pre-agitation, and agitation stages). Elevations in night behavior and blood cortisol, IL-1beta and an reduced blood NKCA level in the evening were observed not only in the agitation stage, but also when stable in AD patients as compared to the control. Increased IL-1beta and decreased NKCA occurred in both the morning and evening in pre-agitation and agitation stages in AD. The increased IL-1beta and decreased NKCA with the progress of agitation in AD suggest that inflammation produces agitation and aggravates AD.
    International Journal of Geriatric Psychiatry 09/2009; 25(6):604-11. · 2.98 Impact Factor
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    ABSTRACT: The number of elderly workers has also been increasing and poor psychological well-being in elderly workers has been reported. The aim of this study is to elucidate the factors that are related to poor psychological well-being in elderly workers. We administered General Health Questionnaire-12 (GHQ-12) as an indicator of psychological well-being to 330 male elderly workers in the age range of 50-69, and analyzed different psychological factors, namely sense of coherence (SOC), and physical and lifestyle variables such as blood pressure, serum total cholesterol, smoking frequency, alcohol intake, exercise frequency, and body mass index (BMI) that are related to GHQ-12. When the cut-off point of GHQ-12 was 2/3, 97 workers who showed high GHQ-12 score were classified as one group having poor psychological well-being. A statistically significantly lower SOC score, higher stress score, lower frequency of exercise, higher smoking score and higher BMI, but not longer working hours or higher shift work score in the workers with higher GHQ-12 scores were observed than in the workers with normal GHQ-12 scores. Multiple logistic regression analysis showed that the low SCO score, low frequency of exercise, high smoking frequency and high BMI significantly contributed to the high GHQ-12 score. A low SOC score in elderly workers is assumed to be directly related to poor psychological well-being, or via the development of lifestyle problems such as lack of exercise, obesity, and smoking in elderly workers. This assumption must be confirmed by conducting future intervention studies on lifestyle.
    Environmental Health and Preventive Medicine 03/2007; 12(2):71-7.
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    ABSTRACT: Whole genome scan analyses have revealed that the chromosomal region 3p21.3, which contains a gene cluster of the CC chemokine receptor, is possibly critical for the pathogenesis of allergic inflammation. Japanese cedar pollinosis is mediated by a type I allergy and induces seasonal rhinitis and conjunctivitis in humans as the most common form of hay fever in spring in Japan, although the candidate genes for cedar pollinosis remain to be elucidated. We sequenced CCR1, CCR2, CCR3, CCR5, and CCXCR1 using the PCR restriction fragment length polymorphism method in subjects with cedar pollinosis and controls. We found 8 polymorphisms of A111G, Arg127Cys and Arg252Gln in CCXCR1, T885C in CCR1, Val64Ile and T780C in CCR2, T51C in CCR3 and Arg223Gln in CCR5. The transmission disequilibrium test using 60 children with pollinosis and their parents and an association study using unrelated adult subjects (151 patients and 157 controls) showed a significant association of 64Ile in CCR2 and 51C in CCR3 with cedar pollinosis. The frequency of haplotype 64Ile/780C/51C in pollinosis was significantly higher than in controls. Our results suggest that CCR2 and CCR3 genes are candidate genes for Japanese cedar pollinosis.
    International Archives of Allergy and Immunology 02/2007; 142(4):329-34. · 2.25 Impact Factor
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    ABSTRACT: Japanese cedar pollinosis is the most common form of hay fever in spring in Japan. We have previously demonstrated that single nucleotide polymorphism Pro358Leu of exon 7 in the eosinophil peroxidase (EPO) gene is associated with cedar pollinosis, although the association has not been confirmed by analysis of the whole gene in a different population. We sequenced all exons of the EPO gene in 60 children with pollinosis and their parents using the PCR-restriction fragment length polymorphism method. We found 8 polymorphisms, Ile40Met, Gln122His, Arg202Arg (A660G), Asn303Asn (C909T), Arg326Pro, Arg326His, Pro358Leu, and Asn572Ty, in the EPO gene. As a result of the transmission disequilibrium test, we recognized significant transmissions of 202Arg (660G) in exon 6 in addition to 358Leu of exon 7 in the EPO gene of affected children. Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis.
    International Archives of Allergy and Immunology 10/2004; 135(1):40-3. · 2.25 Impact Factor
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    ABSTRACT: Several studies suggest that heat stress affects placental functions including uteroplacental circulation, subsequently leading to pregnancy failure and birth weight reduction. To clarify the involvement of endothelin and placental prostaglandin (PG) systems in the uteroplacental circulation during heat stress, we examined the effects of i.v. administration of the endothelin receptor antagonist bosentan and the cyclooxygenase inhibitor indomethacin on uteroplacental blood flow and on placental PGE2 and PGF2alpha levels and their 13,14-dyhydro-15-keto-metabolites (PGEM and PGFM, respectively) in heat-exposed or non-heat-exposed pregnant rats. The administration of bosentan or indomethacin did not change uteroplacental blood flow in non-heat-exposed pregnant rats. In contrast, heat reduced uteroplacental blood flow in pregnant rats, but the reduction was reversed by the administration of bosentan or indomethacin before heat exposure. Heat did not change placental PGE2 or PGEM levels, but in pregnant rats it increased placental PGF2alpha and PGFM levels, which were reversed by bosentan or indomethacin. Our results suggest that the activation of placental endothelin receptor and PGF2alpha systems are involved in the uteroplacental circulatory disturbances produced by heat. PGF2alpha systems activated by heat may be involved in the vasoconstricting effects of endothelin-A and -B receptors during heat exposure.
    Canadian Journal of Physiology and Pharmacology 05/2004; 82(4):225-30. · 1.56 Impact Factor
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    ABSTRACT: Japanese cedar pollinosis is the most common form of hayfever in Japan in spring and has remarkably increased since 1960. We sought to clarify the candidate genes for cedar pollinosis using a case-control study. After diagnosing 351 subjects on the basis of an intradermal test, nasal provocation test, and questionnaire regarding nasal and conjunctival symptoms, we determined the blood-specific IgE values and genotypes of eosinophil peroxidase (EPO) and interleukin-4 receptor alpha-chain (IL4RA) in 145 patients with pollinosis and 206 healthy subjects, including 75 healthy subjects with higher specific IgE values. We found significant differences in the frequencies of Pro358Leu in EPO and of Ile50Val and Glu375Ala in IL4RA between patients and healthy subjects. There was a significantly higher frequency of 358Leu in EPO in patients than in healthy subjects showing a higher specific IgE value. In contrast, we recognized significant changes in the prevalence of Ile50Val and Glu375Ala in IL4RA in healthy subjects with a normal IgE value compared with those in healthy subjects with a higher specific IgE value. The relationship between EPO polymorphisms and the onset of symptoms was exactly opposite that for IL4RA. These results suggest that Pro358Leu in EPO is strongly involved in the development of cedar pollinosis. Ile50Val and Glu375Ala in IL4RA seem to be related to cedar pollen sensitization. Subjects with Ile50 or Glu375 might develop cedar pollinosis with increased exposure to cedar pollen.
    Journal of Allergy and Clinical Immunology 01/2004; 112(6):1127-31. · 12.05 Impact Factor
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    ABSTRACT: Cold water-immersion induces vasoconstriction with an elevation of blood endothelin-1, which is a potent vasoconstrictor peptide, in patients with primary Raynaud's phenomenon (PRP). However, physiological involvement of endothelin-1 in cold-induced vasodilation (CIVD) remains to be elucidated. We monitored changes of finger blood flow during cold water (10 degrees C) immersion and assayed blood endothelin-1 in 7 PRP patients and 7 workers with vibration-induced white finger (VWF) and in the respective control subjects. While significant reductions in finger blood flow at 2 min after the immersion were observed in PRP patients and VWF workers, its elevation at 4 min, which was considered to reflect CIVD, was recognized only in PRP patients. In healthy controls, blood endothelin-1 increased at 4 min and returned to the basal level immediately after the immersion. The increase in blood endothelin-1 at 4 min in PRP patients was greater than that in controls, and continued even after the immersion. Conversely, the increase neither at 4 min nor after immersion was seen in VWF workers. Local vascular changes produced by repetitive vibration may be responsible for the attenuated CIVD and unchanged blood endothelin-1 during cold water-immersion in VWF workers. Our results showing elevated blood endothelin-1 during and after immersion in PRP contrast with that in VWF suggesting that endothelin-1 is related to sympathetic hyperactivity which is more involved in PRP rather than VWF. It seems unlikely that endothelin-1 is functionally or directly associated with CIVD.
    International angiology: a journal of the International Union of Angiology 10/2003; 22(3):243-9. · 1.46 Impact Factor
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    ABSTRACT: We have previously demonstrated that a sense of coherence (SOC), a candidate for a mediating stress factor, is involved in natural killer cell activity (NKCA) reduced in smokers, whereas the relationship among exercise, NKCA and SOC is unclear. To clarify the effects of exercise on SOC and NKCA, we examined the changes in SOC and NKCA before and after health education to encourage exercise. Of one-hundred and one male office workers who received the health education for one year, 27 improved, 65 were unchanged and 9 had deteriorated exercise habits. The repeated measures analysis of variance showed that SOC in workers with improvement in the exercise habit were increased more significantly by the health education than those in workers without improvement (p<0.05). Although the change in NKCA produced by health education was recognized to be significantly different in those who had never smoked from that in current smokers (p<0.05), multiple regression analysis demonstrated that improvement in health practice significantly contributed to increases in both SOC (p<0.01) and NKCA (p<0.05) in never smokers, independently of other psychological factors. These results suggest that subjects with improvement in exercise enhance NKCA through increased SOC in never smokers.
    Journal of Occupational Health 09/2003; 45(5):278-85. · 1.63 Impact Factor
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    ABSTRACT: Exposure to high-density microwaves can cause detrimental effects on the testis, eye, and other tissues, and induce significant biologic changes through thermal actions. To examine nonthermal effect of continuous wave (CW) 915MHz microwaves used in cellular phones, we compared the effects of microwaves with those of heat. Thirty-six pregnant rats were assigned to six groups: rats exposed to microwaves at 0.6 or 3mW/cm(2) incident power density at 915MHz for 90min, rats immersed in water at 38 or 40 degrees C, which induces about the same increase in colonic temperature of 1.0 or 3.5 degrees C as 0.6 or 3mW/cm(2) microwaves, respectively; rats immersed in water at 34 degrees C, which is considered to be thermoneutral; and control rats. We identified significant differences in the uteroplacental circulation, and in placental endocrine and immune functions between pregnant rats immersed in water at 34 and 38 degrees C, but not between rats immersed at 38 degrees C and those exposed to microwaves at 0.6mW/cm(2). By contrast, we observed significant decreases in uteroplacental blood flow and estradiol in rats exposed to microwaves at 3mW/cm(2) as compared with those immersed in water at 40 degrees C. These results suggest microwaves at 0.6mW/cm(2) at 915MHz, equal to a specific absorption rate (SAR) of 0.4W/kg, which is the maximum permissible exposure level recommended by the American National Standards Institute (ANSI), do not exert nonthermal effects on blood estradiol and progesterone, on splenic natural killer cell activity, on the uteroplacental circulation.
    Reproductive Toxicology 01/2003; 17(3):321-6. · 3.14 Impact Factor
  • Kotaro Hatta, Hiroyuki Nakamura, Ichiyo Matsuzaki
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    ABSTRACT: A case-control study was conducted to investigate possible predictors of response to antipsychotic treatment in acute schizophrenic patients. During a 14-month period, 13 female first-episode schizophrenic patients were included. According to their antipsychotic treatment response 8 weeks after admission, they were placed in either a good-response group (n = 8) or poor-response group (n = 5). Scores of the two groups differed on several items of the Positive and Negative Syndrome Scale (PANSS) at baseline and during the following 8 weeks. At baseline, the maximum scores for Conceptual disorganization, Poor rapport, Passive/apathetic social withdrawal, and Stereotyped thinking in the good-response group were lower than the corresponding minimum scores in the poor-response group. Furthermore, minimum improvements after 1 week in scores for excitement in the good-response group were higher than the maximum improvements in the corresponding scores of the poor-response group. These PANSS items might serve as simple and rapid predictors of treatment resistance. In addition, Lack of judgment and insight significantly improved by 1 week, and further improved by 5 weeks in the good-response group. This suggests that treatment in the good-response group will be optimal if provided during a hospital stay of appropriate length.
    General Hospital Psychiatry 01/2003; 25(1):39-45. · 2.98 Impact Factor
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    ABSTRACT: We have demonstrated involvement of the serotonergic system in orexin-induced behavioral responses in rats. Orexin-A and -B (hypocretin-1 and -2) significantly increased total locomotor activity when administered centrally. They also induced behavioral alterations; increasing grooming, face washing and wet dog shaking in rats. Haloperidol inhibited orexin-induced hyperlocomotion and these behavioral alterations. Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations. These results suggest that the dopaminergic system might be involved in orexin-induced hyperlocomotion, while both the serotonergic system as well as the dopaminergic system might be involved in orexin-induced behavioral responses.
    Regulatory Peptides 04/2002; 104(1-3):119-23. · 2.06 Impact Factor
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    ABSTRACT: Although intravenous haloperidol (HAL) is an effective medication that is often prescribed to treat agitation, several instances of torsade de pointes or prolonged QT interval have been reported. To investigate the association between intravenous HAL and QT prolongation and between intravenous HAL and ventricular tachyarrhythmia, a cross-sectional cohort study was performed that included measuring corrected QT intervals (QTc) on an emergency basis before intravenous HAL and continuously monitoring electrocardiographic (ECG) findings after intravenous HAL. During a 2-month period, 47 patients received intravenous injections to control psychotic disruptive behavior. According to clinical practice, patients were divided as follows. The FZ-alone group was treated with intravenous flunitrazepam (FZ), and the FZ-plus-HAL group received intravenous FZ followed by intravenous HAL. Although the difference in the mean QTc immediately after intravenous FZ between the two groups was not significant, the mean QTc after 8 hours in the FZ-plus-HAL group was longer than that in the FZ-alone group (p < 0.001). Four patients in the FZ-plus-HAL group had a QTc of more than 500 msec after 8 hours. The change in QTc during 8 hours significantly differed between the two groups (t = 2.64, p > 0.05). Furthermore, the change in QTc was moderately correlated with the dose of intravenous HAL, as evidenced by a coefficient of correlation of 0.48 (p < 0.001). However, ventricular tachyarrhythmia was not detected among 307 patients within a 1-year period, although the ECG was continuously monitored for at least 8 hours after intravenous HAL. The modest nature of QTc prolongation and the apparent absence of ventricular tachyarrhythmia under continuous ECG monitoring indicate that QTc prolongation associated with intravenous HAL is not necessarily dangerous. However, in an emergency situation, clinicians cannot exclude patients predisposed to torsade de pointes, such as those with inherited ion channel disorders. Therefore, clinicians should be aware of the association between intravenous HAL and QT prolongation.
    Journal of Clinical Psychopharmacology 07/2001; 21(3):257-61. · 3.51 Impact Factor
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    ABSTRACT: In order to clarify the characteristics of job stress in scientific researchers, a self-administered questionnaire survey for 16,330 workers was carried out at Tsukuba Research Park City, Japan. The data of 7,063 (43%) workers aged 20-59 years old were analyzed, and the characteristics of job stress in 3,290 scientific researchers were compared with those of 1,799 technicians and 1,849 clerks. The researchers perceived higher quantitative and qualitative workload, greater job control (job decision latitude), and greater reward from work, than did the other two job groups. In addition, young male researchers received a large amount of support from their coworkers, while middle-aged male researchers perceived difficulty in personal relationships with their coworkers. From the viewpoints of the demand-control-support model and the effort-reward imbalance model, the researchers, particularly men, were typically occupied in active jobs, and the large amount of effort required for their work seemed to be balanced by greater reward from work. Compared with male researchers, however, female researchers perceived lesser job demand, lesser job control, and lesser reward from work. The working environment of female researchers may be related to the so-called career stress of working women. The mental health status of these scientific researchers should be examined directly in a future study.
    International Archives of Occupational and Environmental Health 05/2001; 74(3):199-205. · 2.10 Impact Factor
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    ABSTRACT: To clarify whether corticotropin releasing hormone (CRH) and beta-endorphin (betaEP) system mediate maternal immunosuppression in pregnant rats exposed to heat through central or placental pathway, we examined the effects of intravenous (iv) (100 or 500 microg) or intracerebroventricular (icv) (5 microg) administration of CRH receptor antagonist alpha-helical CRH (9-41) on splenic natural killer cell activity (NKCA) as well as betaEP in blood, pituitary lobes, and placenta in pregnant rats at 15 to 16 days gestation. Two-way ANOVA revealed that heat reduced NKCA and elevated blood and pituitary betaEP but did not change placental betaEP. Iv administered 500 microg and icv administered alpha-helical CRH reversed the reduced NKCA and the elevated pituitary betaEP, while iv administration of 100 microg alpha-helical CRH did not. The increased blood betaEP was reversed by iv 100 and 500 microg alpha-helical CRH and icv administration. Both iv and icv administrations reduced placental betaEP independent of heat exposure. Thus, the response of placental betaEP to iv administration of alpha-helical CRH seemed to be stronger than that of pituitary betaEP. These results indicate that alpha-helical CRH which acts on pituitary betaEP antagonizes heat-induced immunosuppression during pregnancy, suggesting that immunosuppression produced by heat stress during pregnancy is mediated by the central CRH system. The placental CRH-betaEP system seems unlikely to be involved in the immunosuppression. Physiologic roles of placental CRH and opioid system should be clarified by future in vitro experiments using placenta specimen including placental immunocyte.
    Brain Behavior and Immunity 04/2001; 15(1):43-53. · 5.61 Impact Factor
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    ABSTRACT: Beta-Endorphin has been reported to enhance natural killer (NK) activity in vitro. However, few studies have examined the precise regulation of the cytolytic stage of NK cells. We therefore investigated the regulation by beta-endorphin of cytotoxicity-associated molecules such as granzyme B, perforin, and Fas ligand (FasL) in human CD16(+) NK cells. On semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) assay, the granzyme B mRNA level apparently increased in CD16(+) NK cells from high responding subjects having ratios >1.5 for the LU(30) ratio. An increase in intracellular granzyme B molecules was also detected in CD16(+) NK cells by flow cytometry. On the other hand, perforin and FasL appeared not to be involved in regulation by beta-endorphin. These findings suggest that up-regulation of granzyme B expression may be involved in the enhancement of NK activity by beta-endorphin.
    Brain Behavior and Immunity 04/2000; 14(1):27-40. · 5.61 Impact Factor

Publication Stats

3k Citations
128.06 Total Impact Points

Institutions

  • 1997–2010
    • University of Tsukuba
      • Institute of Community Medicine
      Tsukuba, Ibaraki, Japan
  • 2004–2007
    • Kochi Medical School
      Kôti, Kōchi, Japan
  • 2003
    • Juntendo University
      • Department of Psychiatry
      Edo, Tōkyō, Japan
    • Kanazawa University
      • Department of Environmental and Preventive Medicine
      Kanazawa, Ishikawa, Japan
  • 1997–2001
    • Kanazawa Medical University
      Kanazawa, Ishikawa, Japan
  • 1996
    • National Institute for Environmental Studies
      Tsukuba, Ibaraki, Japan