Linda Clare

Bangor University, Bangon, Wales, United Kingdom

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Publications (162)420.86 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Although it is often assumed that awareness decreases as dementia severity increases, there is limited evidence regarding changes in awareness over time. We examined awareness in 101 individuals with early-stage dementia (PwD) and their carers; 66 were reassessed after 12 months and 51 were seen again at 20 months. Awareness was assessed in relation to memory, everyday activities, and socio-emotional functioning using discrepancies between PwD and carer ratings on parallel questionnaires. PwD completed neuropsychological tests and measures of mood and quality of life. Carers completed measures of mood and stress. At initial assessment, discrepancies were greatest for activities of daily living, moderate for memory, and least pronounced for socio-emotional functioning. Discrepancy scores did not change over time. PwD self-ratings indicated perceived poorer functioning in everyday activities over time, but no change for memory and socio-emotional functioning. Carer ratings indicated perceived decline in everyday activities and socio-emotional functioning, but no change for memory. PwD declined in neuropsychological functioning, but self-ratings of depression, anxiety, and quality of life remained stable over time. Carer mood and stress levels also remained stable. At least in the earlier stages of dementia, it should not be assumed that awareness will inevitably decrease as dementia progresses.
    Alzheimer disease and associated disorders 09/2011; 26(2):140-7. · 2.88 Impact Factor
  • Lisa S. Caddell, Linda Clare
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    ABSTRACT: Research suggests that the onset and progression of dementia may pose a threat to a person’s sense of identity. This qualitative study used Interpretative Phenomenological Analysis to explore participants’ perceptions of the impact of dementia on their identity. Participants were ten people with dementia. The four themes emerging from the data represented participants’ views on aspects of their current identities, whether they believed that dementia would alter their identities in the future, perceptions of how dementia had affected their lifestyle, and relationships with friends and family. The analysis suggested that for the most part, participants felt that little had changed with respect to their identities as a whole, but most identified features of themselves that were different than they had been prior to the onset of dementia. Thus it appeared that participants were in a state of flux, experiencing both continuity and change in their sense of identity simultaneously.
    Dementia 07/2011; 10(3):379-398.
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    ABSTRACT: This study explores the extent to which awareness of social and emotional function is reduced in early-stage dementia and whether this relates to the quality of life of the person with dementia (PwD), the quality of the relationship between the PwD and carer and carer stress. Ninety-seven participants with a diagnosis of Alzheimer's, vascular or mixed dementia rated their social functioning using the Socio-Emotional Questionnaire (SEQ). Carers provided parallel ratings, allowing calculation of discrepancy scores used to index awareness. Neuropsychiatric symptoms, PwD quality of life, the perceived quality of the relationship for both partners and carer stress were also measured. Factor analysis of the SEQ indicated three domains of social functioning: emotional recognition and empathy (ERE), social relationships (SR) and prosocial behaviour (PB). For PwD unawareness was related to cognitive dysfunction and psychiatric disturbance, but not to quality of life or quality of relationship. Lower awareness was associated with greater carer stress and poorer perceived quality of relationship. Lack of awareness of social functioning had important implications for relationship quality and levels of carer stress.
    Aging and Mental Health 07/2011; 15(8):961-9. · 1.78 Impact Factor
  • Alzheimer's and Dementia 07/2011; 7(4). · 17.47 Impact Factor
  • Lisa S Caddell, Linda Clare
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    ABSTRACT: Recently, researchers have started to focus on ways to support self and identity in people with dementia. The purpose of this review is to discuss the main features of existing interventions aiming to support self and identity in people with dementia, to draw conclusions regarding the effectiveness of these interventions and to highlight the implications for future research. Systematic review of intervention studies aiming to support self and identity in people with dementia. Ten studies met the inclusion criteria. All reported some benefits to participants. There were significant methodological limitations and study quality was generally low. The interventions varied in terms of participant characteristics, content and outcome measures, making it difficult to draw overall conclusions about effectiveness. Interventions aiming to support self and identity in people with dementia are currently in the early stages of development. Firm recommendations cannot be made at this time. Further well-designed studies are required to provide more robust evidence.
    Aging and Mental Health 06/2011; 15(7):797-810. · 1.78 Impact Factor
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    ABSTRACT: Awareness can be defined as a reasonable or realistic perception or appraisal of a given aspect of one's situation, functioning or performance, or of the resulting implications, expressed explicitly or implicitly. Disturbances of awareness have significant implications for people with dementia and their caregivers. The construction of awareness has been extensively studied in dementia, but a lack of conceptual and methodological clarity in this area means that few clear findings have emerged. This article presents a framework for conceptualizing awareness in people with Alzheimer's disease and associated dementias that can guide research and influence practice. This article begins by considering the general concept of awareness and the ways in which neurological damage can place constraints on awareness. Within an integrative biopsychosocial model that acknowledges the influence of neurocognitive, psychological, and social variables on awareness, challenges for empirical research on awareness in dementia are addressed, and a 'levels of awareness' framework is presented within which awareness operates at four levels of increasing complexity, providing a means of differentiating among awareness phenomena. Approaches to mapping awareness phenomena are discussed, and directions for future research and clinical practice are outlined. The levels of awareness framework should act as a stimulus to further research in this area, resulting in a more coherent understanding of the nature of awareness deficits, the implications of these for people with dementia and their caregivers, and the possibilities for targeted and effective interventions.
    Aging and Mental Health 06/2011; 15(8):936-44. · 1.78 Impact Factor
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    ABSTRACT: Spouse caregivers of people with dementia (PwD) report relatively poor marital relationship quality (RQ), but few studies have obtained the perspective of the PwD, examined discrepancies between spouses, or considered changes in RQ over time. This study explored caregiver and PwD perceptions of RQ, identified associated factors, and examined changes over an 18-month period. Participants were 54 couples where one spouse had early-stage dementia and 54 were control couples. RQ was assessed with the Positive Affect Index. Measures of mood, stress, and quality of life (QoL) were also administered. The clinical couples were followed up after 9 and 18 months. Caregivers gave significantly lower RQ ratings than controls. PwD ratings did not differ significantly from those of caregivers or controls. Dyadic discrepancies were significantly greater in the clinical than in the control group. Caregiver ratings were associated with stress, whereas PwD ratings were associated with depression and QoL. Discrepancies were associated with caregiver stress and with PwD mood, QoL, and age. Caregiver ratings declined significantly over time; PwD ratings did not decline significantly, but showed different trends for men and women. It is important to consider RQ when considering how to support couples where one partner has early-stage dementia.
    Alzheimer disease and associated disorders 06/2011; 26(2):148-58. · 2.88 Impact Factor
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    ABSTRACT: This article draws upon findings from a recent randomized controlled trial of cognitive rehabilitation to consider the extent to which people with early-stage Alzheimer's Disease (n = 69) were able to identify individual rehabilitation goals, and what kinds of goals were important to them. For those assigned to receive cognitive rehabilitation (n = 22), we further examine the nature of the goals selected as the basis for therapy, and analyze within-group results with regard to efficacy. All participants were able to identify goals and to rate their performance and satisfaction with performance. Participants assigned to cognitive rehabilitation worked on selected goals, and clinically significant improvements in performance and satisfaction ratings for these goals were corroborated by therapist ratings and goal attainment indicators.
    Clinical Gerontologist 05/2011; 34(3):220-236. · 0.66 Impact Factor
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    ABSTRACT: Research on awareness in dementia has yielded variable and inconsistent associations between awareness and other factors. This study examined awareness using a multidimensional approach and applied cluster analytic techniques to identify associations between the level of awareness and other variables. Participants were 101 individuals with early-stage dementia (PwD) and their carers. Explicit awareness was assessed at 3 levels: performance monitoring in relation to memory, evaluative judgement in relation to memory, everyday activities and socio-emotional functioning, and metacognitive reflection in relation to the experience and impact of the condition. Implicit awareness was assessed with an emotional Stroop task. Different measures of explicit awareness scores were related only to a limited extent. Cluster analysis yielded 3 groups with differing degrees of explicit awareness. These groups showed no differences in implicit awareness. Lower explicit awareness was associated with greater age, lower MMSE scores, poorer recall and naming scores, lower anxiety and greater carer stress. Multidimensional assessment offers a more robust approach to classifying PwD according to level of awareness and hence to examining correlates and predictors of awareness.
    Dementia and Geriatric Cognitive Disorders 04/2011; 31(5):317-27. · 2.79 Impact Factor
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    ABSTRACT: Insufficient attention has been paid to the influence of psychological and social factors on discrepancy-based measures of awareness. The present study tested a biopsychosocial model of awareness in early-stage dementia by gathering evidence regarding the relative contributions of neuropsychological, individual psychological and social factors to the level of scoring on measures used to index awareness. Awareness was assessed in relation to memory, activities of daily living and social functioning in 101 individuals with early-stage dementia participating in the Memory Impairment and Dementia Awareness (MIDAS) Study. People with dementia (PwD) and carers also completed measures of individual psychological and social variables, and PwD completed measures of neuropsychological functioning. Scores on discrepancy-based indices of awareness and on the self-ratings and informant ratings contributing to these indices were associated with a range of factors including neuropsychological functioning of PwD, individual traits and dispositions and current affective functioning of PwD, socio-demographic characteristics of PwD and carers, carer well-being and carer perceptions of PwD and of quality of relationship with PwD. Patterns of association varied across domains of functioning. The findings support the relevance of a biopsychosocial approach to understanding the factors that influence unawareness of impairment in dementia.
    International Journal of Geriatric Psychiatry 03/2011; 27(2):167-77. · 3.09 Impact Factor
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    ABSTRACT: To determine whether people with dementia (PwD), and carers of PwD, show a processing bias to dementia-related words in an emotional Stroop task, and if so, whether the presence of such a bias is related to level of explicit awareness of the condition. Seventy-nine people with early stage Alzheimer's disease (AD), vascular or mixed dementia, and their carers, completed an emotional Stroop task. Time taken to colour-name dementia-related and neutral words was compared within and between groups. Additionally, as a comparison, ratings of the awareness of the condition shown by PwD were made on the basis of a detailed interview with each PwD and his/her carer. PwD and carers showed the same level of increase in response times to salient compared to neutral words. In the PwD this effect was unrelated to the degree of awareness that they demonstrated regarding the condition. The emotional Stroop effect in response to dementia-related words in PwD indicates that preserved implicit awareness of the condition can be elicited even where there is reduced explicit awareness.
    International Journal of Geriatric Psychiatry 01/2011; 26(1):92-9. · 3.09 Impact Factor
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    ABSTRACT: Evidence from some, but not all non-randomised studies suggest the possibility that cognitive training may influence cognitive functioning in older people. Due to the differences among cognitive training interventions reported in the literature, giving a general overview of the current literature remains difficult. To systematically review the literature and summarize the effect of cognitive training interventions on various domains of cognitive function (ie memory, executive function, attention and speed) in healthy older people and in people with mild cognitive impairment. The CDCIG Specialized Register was searched on 30 September 2007 for all years up to December 2005. The Cochrane Library, MEDLINE, EMBASE, PsycINFO and CINAHL were searched separately on 30 September 2007 to find trials with healthy people. These results were supplemented by searches from January 1970 to September 2007 in PsychInfo/Psyndex, ISI Web of Knowledge and PubMed. RCTs of interventions evaluating the effectiveness of cognitive training for healthy older people and people with mild cognitive impairment from 1970 to 2007 that met inclusion criteria were selected. Authors independently extracted data and assessed trial quality. Meta-analysis was performed when appropriate. Only data on memory training could be pooled for analysis. Within this domain, training interventions were grouped according to several outcome variables. Results showed that for healthy older adults, immediate and delayed verbal recall improved significantly through training compared to a no-treatment control condition. We did not find any specific memory training effects though as the improvements observed did not exceed the improvement in the active control condition. For individuals with mild cognitive impairment, our analyses demonstrate the same pattern. Thus, there is currently little evidence on the effectiveness and specificity of memory interventions for healthy older adults and individuals with mild cognitive impairment. There is evidence that cognitive interventions do lead to performance gains but none of the effects observed could be attributable specifically to cognitive training, as the improvements observed did not exceed the improvement in active control conditions. This does not mean that longer, more intense or different interventions might not be effective, but that those which have been reported thus far have only limited effect. We therefore suggest more standardized study protocols in order to maximize comparability of studies and to maximize the possibility of data pooling - also in other cognitive domains than memory.
    Cochrane database of systematic reviews (Online) 01/2011; · 5.94 Impact Factor
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    ABSTRACT: Delirium is a state of confusion characterized by an acute and fluctuating decline in cognitive functioning. Delirium is common and deadly in older adults with dementia, and is often referred to as delirium superimposed on dementia, or DSD. Interventions that treat DSD are not well-developed because the mechanisms involved in its etiology are not completely understood. We have developed a theory-based intervention for DSD that is derived from the literature on cognitive reserve and based on our prior interdisciplinary work on delirium, recreational activities, and cognitive stimulation in people with dementia. Our preliminary work indicate that use of simple, cognitively stimulating activities may help resolve delirium by helping to focus inattention, the primary neuropsychological deficit in delirium. Our primary aim in this trial is to test the efficacy of Recreational Stimulation for Elders as a Vehicle to resolve DSD (RESERVE- DSD). This randomized repeated measures clinical trial will involve participants being recruited and enrolled at the time of admission to post acute care. We will randomize 256 subjects to intervention (RESERVE-DSD) or control (usual care). Intervention subjects will receive 30-minute sessions of tailored cognitively stimulating recreational activities for up to 30 days. We hypothesize that subjects who receive RESERVE-DSD will have: decreased severity and duration of delirium; greater gains in attention, orientation, memory, abstract thinking, and executive functioning; and greater gains in physical function compared to subjects with DSD who receive usual care. We will also evaluate potential moderators of intervention efficacy (lifetime of complex mental activities and APOE status). Our secondary aim is to describe the costs associated with RESERVE-DSD. Our theory-based intervention, which uses simple, inexpensive recreational activities for delivering cognitive stimulation, is innovative because, to our knowledge it has not been tested as a treatment for DSD. This novel intervention for DSD builds on our prior delirium, recreational activity and cognitive stimulation research, and draws support from cognitive reserve theory. ClinicalTrials.gov identifier: NCT01267682
    Trials 01/2011; 12:119. · 2.12 Impact Factor
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    Linda Clare
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    ABSTRACT: Neuropsychological assessment is a systematic approach to evaluating a patient's cognitive functioning and identifying the nature, extent and severity of any impairments. Standardized tests provide results that can be compared with normative data to provide a profile of the patient's strengths and difficulties. This chapter outlines the principles of neuropsychological testing, explains the use of normative data, and describes the way in which standardized tests are used to identify and characterise impairments. The aims and scope of neuropsychological assessment of the older person are discussed, and the process of assessment is described. The information provided by a neuropsychological assessment can make an important contribution to decisions about diagnosis, management and intervention.
    Principles and Practice of Geriatric Psychiatry, Third Edition, 12/2010: pages 135 - 140; , ISBN: 9780470669600
  • Lisa Caddell, Linda Clare
    Gerontological Society of America 2010; 11/2010
  • Jeanette M Thom, Linda Clare
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    ABSTRACT: Evidence suggests that exercise and some cognition-focused intervention approaches can be used to elicit functional improvements in older people and, to some degree, those diagnosed with dementia. Independently, the two intervention types have been found to improve functional performance in people with dementia. The mechanisms underpinning these improvements come from comparable and diverse pathways. This suggests that it may be beneficial for the two intervention types to be coupled as part of regular care in individuals with a range of cognitive impairments. The aims of this review are threefold. The first aim is to present evidence to support the use for combining exercise and cognition-focused interventions. This will be achieved by reviewing the mechanisms of both approaches in improving functional performance in older people and in people with dementia and summarising recent progress. The increased risk of depression, falls and cardiovascular disease risk in people with dementia will also be highlighted. The second aim is to discuss the parameters of the two approaches that should be considered when combining them in terms of possible efficient models, especially in relation to exercise protocols as this is where the current literature shows the most promising outcomes. Maximisation of the efficacy of preventative and treatment interventions which focus on both cognitive functioning and physical health should lead to improving and extending functional independence. Key aspects of any combined intervention would involve the inclusion of both cardiovascular and other types of exercises, including falls reduction, and exercises addressing memory and executive function via goal setting in the real-life context. The third aim is to explore some of the issues that may arise when attempting to incorporate interventions into the regular treatment of people with dementia. Consideration must also be given to caregivers and the education of health professionals as well as to the mode of intervention itself. Further research is necessary in order to discern the most effective types of both intervention models. Provision of combined interventions might enhance the improvements in functional independence in people with dementia over and above the interventions being used separately.
    Gerontology 10/2010; 57(3):265-75. · 2.68 Impact Factor
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    ABSTRACT: Delirium is a common neuropsychiatric syndrome that occurs most frequently in older adults with dementia and is referred to as delirium superimposed on dementia (DSD). Our aim in this pilot project was to demonstrate that implementation of cognitively stimulating activities is clinically feasible and has potential to reduce delirium severity and duration and functional loss in post-acute care settings. We randomized newly admitted participants with DSD to treatment (n = 11) and control (n = 5) conditions and conducted daily blinded assessments of delirium, delirium severity, and functional status for up to 30 days. The control group had a significantly greater decrease in physical function and mental status over time compared with the intervention group. Delirium, severity of delirium, and attention approached significance, and improvement over time favored the intervention group. Although not statistically significant, a difference in mean (7.0 versus 3.27) and median (7.0 versus 3.0) days with delirium was found, with the control group having more days of delirium.
    Research in Gerontological Nursing 10/2010; 4(3):161-7. · 0.61 Impact Factor
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    ABSTRACT: To provide evidence regarding the clinical efficacy of cognitive rehabilitation (CR) in early-stage Alzheimer disease (AD). Single-blind randomized controlled trial comparing CR with relaxation therapy and no treatment. Outpatient, community-based setting. Sixty-nine individuals (41 women, 28 men; mean age 77.78 years, standard deviation 6.32, range = 56-89) with a diagnosis of AD or mixed AD and vascular dementia and a Mini-Mental State Examination score of 18 or above, and receiving a stable dose of acetylcholinesterase-inhibiting medication. Forty-four family carers also contributed. Eight weekly individual sessions of CR consisting of personalized interventions to address individually relevant goals supported by components addressing practical aids and strategies, techniques for learning new information, practice in maintaining attention and concentration, and techniques for stress management. The primary outcomes were goal performance and satisfaction, assessed using the Canadian Occupational Performance Measure. Questionnaires assessing mood, quality of life and career strain, and a brief neuropsychological test battery were also administered. A subset of participants underwent functional magnetic resonance imaging (fMRI). CR produced significant improvement in ratings of goal performance and satisfaction, whereas scores in the other two groups did not change. Behavioral changes in the CR group were supported by fMRI data for a subset of participants. The findings support the clinical efficacy of CR in early-stage AD. CR offers a means of assisting people with early-stage AD and their families in managing the effects of the condition.
    The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry 10/2010; 18(10):928-39. · 3.35 Impact Factor
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    ABSTRACT: It has been suggested that “memory retraining” has no lasting effect beyond the end of the treatment session (Rabins, 1996). Although this is contradicted by cognitive rehabilitation studies showing that gains can be demonstrated and maintained, few researchers have presented long-term follow-up data. Recent studies (Clare, Wilson, Breen, & Hodges, 1999; Clare et al., 2000) have provided post-intervention follow-up data for one participant that was collected over a 9 month period, during which performance on trained face-name associations remained at ceiling levels. This paper reports a further, naturalistic follow-up of this participant over an additional period of two years, during which his recall of 10 trained face-name associations was evaluated and compared to performance on three untrained, previously-known items retained as part of the full set of stimulus materials throughout the whole study. Recall remained relatively stable over year 1 and showed a modest decline for both trained and previouslyknown items during year 2. Differences between year 1 and year 2 were significant only for untrained items. At the end of year 2, performance on trained items remained well above initial baseline levels. These results are discussed in the context of information derived from neuropsychological assessment, scans and self-report measures. It is argued, on the basis of the results presented here, that long-term maintenance of gains resulting from targeted cognitive rehabilitation interventions is possible, and that in view of this it will be important to evaluate the broader impact of cognitive rehabilitation interventions on quality of life and on the progression of dementia.
    Neuropsychological Rehabilitation 09/2010; 11(3):477-494. · 2.07 Impact Factor
  • Linda Clare, Bob Woods
    Neuropsychological Rehabilitation 09/2010; July(2001):193-196. · 2.07 Impact Factor

Publication Stats

3k Citations
420.86 Total Impact Points

Institutions

  • 2004–2015
    • Bangor University
      • School of Psychology
      Bangon, Wales, United Kingdom
  • 2014
    • University of Toronto
      • Department of Psychology
      Toronto, Ontario, Canada
  • 2013
    • Australian National University
      • Centre for Research on Ageing, Health & Wellbeing (CRAHW)
      Canberra, Australian Capital Territory, Australia
  • 2011–2013
    • La Trobe University
      • Faculty of Science, Technology and Engineering
      Melbourne, Victoria, Australia
    • MRC Cognition and Brain Sciences Unit
      Cambridge, England, United Kingdom
  • 2009–2013
    • University of Western Australia
      • • Western Australian Centre for Health and Ageing
      • • School of Psychiatry and Clinical Neurosciences
      Perth, Western Australia, Australia
    • Hinchingbrooke Health Care NHS Trust
      Huntingdon, England, United Kingdom
    • University of Zurich
      Zürich, Zurich, Switzerland
  • 2012
    • University of Oxford
      • Nuffield Department of Clinical Medicine
      Oxford, England, United Kingdom
    • Lancaster University
      • Spectrum Centre for Mental Health Research
      Lancaster, ENG, United Kingdom
  • 2004–2008
    • University of Wales
      Cardiff, Wales, United Kingdom
  • 2007
    • Humboldt-Universität zu Berlin
      • Department of Psychology
      Berlin, Land Berlin, Germany
  • 2006
    • University of Birmingham
      • School of Psychology
      Birmingham, ENG, United Kingdom
    • Griffith University
      • School of Applied Psychology
      Brisbane, Queensland, Australia
    • University of Queensland 
      • School of Health and Rehabilitation Sciences
      Brisbane, Queensland, Australia
  • 2005
    • Sapienza University of Rome
      Roma, Latium, Italy
  • 1999–2004
    • University College London
      • Department of Clinical, Educational and Health Psychology
      London, ENG, United Kingdom