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Publications (43)14.57 Total impact

  • Annales de Dermatologie et de Vénéréologie 01/2013; 140, Supplement 1:S84 -. · 0.60 Impact Factor
  • Annales de Dermatologie et de Vénéréologie 01/2013; 140, Supplement 1:S58 -. · 0.60 Impact Factor
  • Annales de Dermatologie et de Vénéréologie 01/2013; 140, Supplement 1:S139 -. · 0.60 Impact Factor
  • Annales de Dermatologie et de Vénéréologie 01/2013; 140, Supplement 1:S139 -. · 0.60 Impact Factor
  • Annales de Dermatologie et de Vénéréologie 01/2012; 139(12, Supplement):B175 -. · 0.60 Impact Factor
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    ABSTRACT: Introduction Le fibrome cémento-ossifiant psammomateux (FCOP) est une tumeur fibro-osseuse bénigne et rare. Elle atteint les maxillaires, les cavités nasales, les sinus paranasaux et l’éthmoïde. Elle est d’évolution lente et progressive d’aspect bénin mais localement extensif, pouvant simuler une tumeur maligne. Observation Nous rapportons une observation inhabituelle de FCOP nasoéthmoïdal avec extension orbitaire et endocrânienne chez une patiente de 36 ans. La tumeur a été révélée par une exophtalmie et une obstruction nasale. Le diagnostic a été affirmé histologiquement sur les biopsies. Le traitement a été chirurgical par voie transfaciale. Il n’y a pas eu de récidive un an après. Discussion Les extensions intraorbitaires et endocrâniennes des FCOP sont rares. Histologiquement, le diagnostic différentiel est souvent difficile avec une dysplasie fibreuse ou un méningiome psammomateux. L’exérèse chirurgicale complète doit permettre d’éviter les récidives.
    Revue de Stomatologie et de Chirurgie Maxillo-faciale. 02/2010; 111(1):43–45.
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    ABSTRACT: Le chondrosarcome myxoïde extrasquelettique (CME) est une entité rare, distincte sur le plan clinique, histologique, immunohistochimique, cytogénétique et évolutive. C’est un sarcome classé par l’OMS comme un sarcome de bas grade et qui représente 2,5 % des sarcomes des tissus mous. Son individualisation est importante, car elle est caractérisée par une agressivité essentiellement locale et une survie prolongée. La clé diagnostique est morphologique, aidée par l’immunohistochimie et l’étude génétique qui permettent de la différencier des autres tumeurs à stroma myxoïde et des chordomes. Nous en rapporterons un cas localisé au niveau du genou. The extraskeletal myxoid chondrosarcoma (CME) is a rare malignant soft tissue tumour described as a distinct clinical, histological, immunohistochemical, genetical and evolutive entity. It represents only 2.5% of soft tissue sarcomas, and is considered by WHO as a low grade sarcoma. Its individualization is important because it has a long and indolent clinical course, and tumour-related death often occurs after a long survival period. The diagnostic key is morphological supported by immunohistochemistry and genetics t(9;22) that allow to differentiate it from other tumours with myxoid stroma and from chordoma. A new case of soft tissue myxoid chondrosarcoma (chordoid sarcoma) of the knee is reported. Mots clésChondrosarcome myxoïde extrasquelettique-Genou-Tumeur maligne KeywordsExtraskeletal myxoid chondrosarcoma-Knee-Malignant tumour
    Journal africain du cancer / African Journal of Cancer 01/2010; 2(4):285-288.
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    ABSTRACT: Le carcinome micropapillaire infiltrant (CMI) du sein est une variété rare de carcinomes canalaires invasifs caractérisée par un aspect histologique unique et une incidence extrêmement élevée de métastases ganglionnaires lymphatiques (95 %). Histologiquement, le carcinome micropapillaire du sein a été bien décrit et, actuellement, bien identifié en pratique. Les carcinomes avec un aspect histologique de CMI montrent une invasion massive en nids épithéliaux entourés d’un espace clair au sein d’un stroma fibreux. Reconnaître cette entité est crucial, même si elle constitue un petit contingent d’un carcinome mammaire ordinaire, car cela permet de prédire les métastases ganglionnaires lymphatiques, sans tenir compte de la taille tumorale globale. Nous rapportons ici le cas d’une patiente âgé e de 29 ans, qui a présenté un carcinome mammaire comportant un contingent micropapillaire avec métastases ganglionnaires lymphatiques. Invasive micropapillary carcinoma (IMC) of the breast is a rare variant of the invasive ductal carcinoma; it is characterized by a unique histology and an extremely high-incidence of lymph node metastases (95%). Histologically, IMC of the breast has been well described but it remains insufficiently recognized in clinical practice. Carcinomas with an IMC histology show abundant invasive epithelial nests surrounded by a clear area, within a fine reticular to collagenous stroma. Recognizing this entity is crucial in predicting lymph node metastases, even if it only constitutes a small component of more ordinary breast carcinoma, regardless of the overall tumour size. We report a case of breast carcinoma with a partial micropapillary component occurring in a 29-year-old woman with positive lymph nodes. Mots clésSein–Adénocarcinome–Micropapillaire KeywordsBreast–Carcinoma–Micropapillary
    Oncologie 01/2010; 12:54-57. · 0.10 Impact Factor
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    ABSTRACT: Psammomatoid cemento-ossifying fibroma (PCOF) is a rare benign fibro-osseous lesion. It affects the maxilla, the nasal cavity, paranasal sinuses, and the ethmoid. It is slow-growing, progressive, and benign but it can be locally extended and mimic a malignant tumor. We report the unusual case of a 36-year-old woman with a nasal and ethmoid PCOF with orbital and endocranial extension. The tumor was revealed by exophthalmia and nasal obstruction. The diagnosis was proven histologicaly on biopsies. The treatment was transfacial surgery. There was no recurrence 1 year later. Intraorbital and endocranial extension of PCOF are rare aggressive behaviours. Histologically, the differential diagnosis is difficult between fibrous dysplasia or psammomatoid meningioma. Complete surgical excision is necessary to prevent recurrence.
    Revue de stomatologie et de chirurgie maxillo-faciale 08/2009; 111(1):43-5. · 0.35 Impact Factor
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    ABSTRACT: Pseudo-Kaposi's sarcoma or Stewart-Bluefarb subtype acroangiodermatitis is uncommon and is caused by arteriovenous fistula and malformation. We report a new case. A 33-year-old man presented with painful red-violet plaque on the dorsum of the toes with angiomatous nodules on the sole. Histological and immunohistochemical studies for CD34 were consistent with Kaposi's sarcoma. Doppler ultrasonography and femoral angiography showed multiple distal arteriovenous shunts. Free-flow embolisation with fragments of Ethibloc gelatin sponge was performed and arteriography, performed immediately afterwards, showed delayed venous drainage. The outcome was good with complete drainage of the angiomatous lesions. Pseudo-Kaposi's sarcoma Stewart-Bluefarb subtype begins early in life in male subjects, with unilateral skin lesions. It bears clinical and histological resemblance to Kaposi's sarcoma. Doppler ultrasonography and angiography show arteriovenous fistulas that classically develop at shunts, explaining the role of traumatism and high vascular pressure in the genesis of this disease.
    Annales de Dermatologie et de Vénéréologie 02/2008; 135(1):44-7. · 0.60 Impact Factor
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    ABSTRACT: Desmoplastic ameloblastoma is a benign, locally aggressive neoplasm of proliferating odontogenic epithelial origin. It is seen among old patients from 17 to 72 years with an average age 42 years and without predilection of sex. We report the case of a 7 year old child, having presented since the 5 years age, a gingival tumefaction on the left higher incisivo-canin group which increased volume gradually. The stomatologic examination showed a gingival tumefaction covered with a healthy mucous membrane, ovoid form and measuring 3 cm on its horizontal axis. The tomodensitometry of the jawbone showed in front of the 21st and the 22nd tooth, the presence of an osseous lesion associating of the hearths of osteolysis and osteocondensation with rupture of cortical and invasion of the soft tissue. A curetting of the lesion was carried out and the anatomopathologic examination retained the diagnosis of desmoplastic ameloblastoma. The characteristic of our observation is the youth of the patient. In addition, the desmoplastic ameloblastoma is relatively rare, is characterized by an anatomical distribution, a radiological appearance and a morphological aspect differents from the traditional ameloblastoma. A radical surgical treatment is suggested for this tumour to avoid recurrency.
    Revue de laryngologie - otologie - rhinologie 02/2008; 129(4-5):341-3.
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    ABSTRACT: Blastomycosis is a systemic fungal infection caused by a thermally dimorphic fungus, Blastomyces dermatitidis. The incidence in immunocompromised patients has increased in the last two decades. A 55-year-old man consulted for inflammatory nodules on the forearm. Biopsy of one nodules showed a pseudoepitheliomatous hyperplastic epidermis overlaying a dense agranulomatous inflammatory infiltrate containing free-formed ovoid bodies enclosing giant macrophageous cells. These findings were consistent with blastomycosis. After a month of treatment cutaneous lesions regressed partially but the patient's general status continued to deteriorate with the appearance of an edematous-ascitic syndrome and icterus. Laboratory blood testing demonstrated cholestasia and abdominal ultrasound showed hepatosplenomegaly. Needle liver biopsy revealed giant B-cell lymphomatous infiltration of the hepatic ducts. The patient's condition worsened rapidly and he died five months after diagnosis despite four rounds of chemotherapy. Blastomycosis is rare in Morocco. Primary infection is usually a pneumonic process. Isolated cutaneous infection is possible but uncommon. To our knowledge the association of blastomycosis and intravascular lymphoma has not been previously reported. In immunocompromised patients, clinical findings can be alarming and the outcome can be rapidly fatal.
    Médecine tropicale: revue du Corps de santé colonial 07/2007; 67(3):278-80.
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    ABSTRACT: We report a case of a 36 year old woman who presented a chronic rhinitis and a hypertrophy of the inferior turbinates. Primary nasal tuberculosis was discovered by chance after the inferior turbinectomy. Primary nasal tuberculosis is very rare and is more frequent in women. Symptomatology is often unilateral with nasal obstruction, anterior rhinorrhea or epistaxis. The clinical examination may discover ulceration or a polyp located generally in the nasal septum or the inferior turbinate. Diagnosis relies on the anatomopathologic and bacteriological examinations. The treatment is mainly medical based on antituberculosis drugs. In the light of this case report, a review of the literature was made.
    Revue de laryngologie - otologie - rhinologie 02/2007; 128(3):193-5.
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    ABSTRACT: The laryngeal tuberculous is the most frequent granulomatous disease of the larynx. It is generally associated with a pulmonary cave, and represents a prognosis element extremely serious and can be complicated extreme dysphagia and pains. Among all the extrapulmonary localisations. The isolated laryngée localisation is rare. It is secondary the dissemination coming hematogen, air or lymphatic way. All the structures of the larynx can be reached. The beginning is progressive and insidious and appears by the dysphony, cough, the odynophagy and dyspnea. We report the case of laryngeal tuberculosis in a 21 year old young man. The authors point out the characteristics of this localization and insist on the biopsy in front of any chronic laryngitis no aetiology. The treatment is medical.
    Revue de laryngologie - otologie - rhinologie 02/2007; 128(1-2):93-6.
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    ABSTRACT: Ganglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms. We report the case of a 22 year-old man who presented a ganglioneuroma localized in the zygoma. Ganglioneuroma generally develop in the abdomen or thorax soft tissue. The occurrence of ganglioneuroma in the bone is exceptional. To date less than ten cases have been reported, six of which involved the mandible. We discuss the possible causes of tumor development at this site.
    Revue de Stomatologie et de Chirurgie Maxillo-faciale 12/2006; 107(5):370-2. · 0.39 Impact Factor
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    ABSTRACT: Adult multisystem Langerhans cell histiocytosis is an excepted disorder, which have several treatments. The purpose of this study was to test the disease-controlling effect of thalidomide in a case of adult multisystem Langerhans cell histiocytosis with cutaneomucous and hypothalamic localizations at dermatology department, of Mohammed-V military hospital, Rabat. A 43-year-old women, presented multifocal chronic Langerhans cell histiocytosis confined to cutaneous, oral cavity, perianal, mastoid and hypothalamic areas, with severe disabling ulcers in intertriginous areas, diabetes insipid and amenorrhoea. We treated with thalidomide 200 mg/day after neurological examination. A rapid initial response with total diminution of the involved skin area, and diminution of diabetes insipid. She remained in remission for 1 year. No adverse effects from treatment were observed at clinical and electrophysiological examinations. Thalidomide treatment is an adequate therapeutic measure in adult Langerhans cell histiocytosis, which is rare and difficult to treat. Our case showed the efficacy of thalidomide at cutaneomucosal and hypothalamic manifestations.
    La Revue de Médecine Interne 09/2006; 27(8):633-6. · 0.90 Impact Factor
  • Annales de Dermatologie et de Vénéréologie 04/2006; 133(3):278-80. · 0.60 Impact Factor
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    ABSTRACT: IntroductionLe ganglioneurome est une tumeur bénigne rare, se développant à partir des cellules ganglionnaires du système nerveux sympathique. Elle constituerait moins de 1 % de tous les néoplasmes des tissus mous.ObservationNous rapportons une localisation à l’os zygomatique chez un jeune homme de 22 ans, aux antécédents de traumatisme orbitaire dans l’enfance. La tumeur se manifestait par une simple tuméfaction asymptomatique. Le diagnostic a été posé sur l’analyse de la pièce opératoire après ostéotomie modelante.DiscussionLes sites préférentiels du ganglioneurome sont l’abdomen et le thorax, la localisation osseuse est exceptionnelle avec moins de dix cas rapportés dans la littérature, dont six cas mandibulaires. Nous discutons les causes possibles de cette localisation exceptionnelle.IntroductionGanglioneuroma is an uncommon benign tumor that arises from the sympathetic nervous system accounting for less than 1% of all soft-tissue neoplasms.Case reportWe report the case of a 22 year-old man who presented a ganglioneuroma localized in the zygoma.DiscussionGanglioneuroma generally develop in the abdomen or thorax soft tissue. The occurrence of ganglioneuroma in the bone is exceptional. To date less than ten cases have been reported, six of which involved the mandible. We discuss the possible causes of tumor development at this site.
    Revue de Stomatologie et de Chirurgie Maxillo-faciale. 01/2006; 107(5):370-372.
  • Annales De Dermatologie Et De Venereologie - ANN DERMATOL VENEREOL. 01/2006; 133(3):278-280.
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    ABSTRACT: Laryngeal leiomyosarcoma is rare. The authors report the case of a 48-year-old patient who presented with progressive hoarseness. This symptomatology was associated with a laryngeal tumour. Immunohistopathological study indicated a leiomyosarcoma. Acute dyspnoea resulted in an urgent tracheostomy, followed by total laryngectomy without neck dissection later. In the light of this observation and a literature review, histopathological characteristics, clinical aspects and therapeutic indications will be discussed for this localisation.
    B-ENT 02/2005; 1(3):145-9. · 0.08 Impact Factor