Hyoung Jun Koh

Yonsei University Hospital, Sŏul, Seoul, South Korea

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Publications (118)271.79 Total impact

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    ABSTRACT: To investigate the acute effect of ethanol consumption on subfoveal choroidal thickness. This prospective interventional study included the right eyes of 30 healthy subjects (30 eyes). Ethanol (1.0 g/kg) was administered orally on the first visit. A matching volume of water was administered orally on the second visit. Oral administration of ethanol and water was performed at 14:00, and choroidal thickness was measured every 30 min until 16:00. Change of choroidal thickness after oral administration of ethanol and water was the main outcome measure. At baseline, choroidal mean subfoveal thickness was 299.0±73.4 µm (range, 186.5-472.5 µm) before ethanol consumption and 297.1±71.1 µm (range, 187.0-470.5 µm) before water consumption. After consumption of ethanol, mean subfoveal choroidal thickness increased during the first 60 min and then decreased during the next 60 min, which was a significant change over time (p<0.001). After consumption of water, there was no significant change in mean subfoveal choroidal thickness over time (p=0.310). Comparison of changes in the mean subfoveal choroidal thickness during 120 min showed significant difference between ethanol and water consumption (p<0.001). The results of current study show that consumption of ethanol significantly affected the choroidal thickness. Mean subfoveal choroidal thickness increased during the first 60 min and then decreased during the next 120 min after ethanol consumption. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
    The British journal of ophthalmology 07/2015; DOI:10.1136/bjophthalmol-2015-306969 · 2.81 Impact Factor
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    ABSTRACT: To identify significant fluorescein angiographic (FA) characteristics associated with visual acuity (VA) in Behçet retinal vasculitis. Retrospective review of 86 eyes of 48 patients (age: 35.6±10.2 years) with Behçet retinal vasculitis were performed. VA and FA findings as well as correlation between them were assessed. The mean initial VA of eyes with posterior pole-involved vasculitis (63 eyes; 73.3%) was significantly worse than that of those with peripheral vasculitis (23 eye; 26.7%) (logarithm of the minimum angle of resolution VA: 0.554±0.572 vs. 0.078±0.148; p<0.0001). Subgroup analysis revealed a more severe and diffuse pattern of vascular leakage in posterior pole-involved vasculitis compared to peripheral vasculitis (p<0.0001). Retinal vascular leakage (β=0.345; p<0.0001), optic disc hyperfluorescence (β=0.147; p=0.032), and macular leakage (β=0.107; p=0.047) were significantly associated with worse initial VA. During the follow up (mean: 33.3±17.9 months), the change of leakage showed no significant correlation with change of VA in posterior pole-involved vasculitis (τ=0.199, p=0.092). Posterior pole involvement, the degree of retinal vascular leakage, optic disc hyperfluorescence, and macular leakage are significantly associated with VA in Behçet retinal vasculitis.
    Yonsei medical journal 07/2015; 56(4):1087-1096. DOI:10.3349/ymj.2015.56.4.1087 · 1.26 Impact Factor
  • Ophthalmology 06/2015; DOI:10.1016/j.ophtha.2015.05.015 · 6.17 Impact Factor
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    ABSTRACT: To report the use of neodymium:yttrium-aluminum-garnet (Nd:YAG) laser internal limiting membranotomy to successfully treat the first reported case of subinternal limiting membrane (sub-ILM) hemorrhage that developed after coil embolization of a cerebral aneurysm. A 59-year-old Korean woman visited our clinic complaining of central scotoma in her left eye, which developed shortly after stent-assisted coil embolization of an unruptured internal carotid artery aneurysm. Fundus examination revealed a sub-ILM hemorrhage in her left eye, and after 2 days, a Nd:YAG laser membranotomy was performed with a single 4.5-mJ burst. There was a marked reduction in the sub-ILM hemorrhage 1 day after Nd:YAG laser membranotomy, and after 1 month, her best-corrected visual acuity improved to 20/20, with complete resolution of the sub-ILM hemorrhage. Sub-ILM hemorrhage can develop after coil embolization of a cerebral aneurysm, and Nd:YAG laser internal limiting membranotomy can be a useful noninvasive treatment alternative to surgical intervention.
    Optometry and vision science: official publication of the American Academy of Optometry 05/2015; DOI:10.1097/OPX.0000000000000621 · 2.04 Impact Factor
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    ABSTRACT: To compare the visual outcomes and occurrences of postoperative complications after 23-gauge (G) and 25-G microincision vitrectomy surgery (MIVS) for idiopathic epiretinal membrane in pseudophakic eyes. A total of 239 pseudophakic eyes of 239 patients who underwent 23-G (n = 159) or 25-G MIVS (n = 80) for removal of idiopathic epiretinal membrane between March 2010 and March 2013 were included in this retrospective study. Patients were followed up on postoperative 1 day, 1 week, 1, 3, and 6 months. Postoperative visual acuity, intraocular pressure, and intraoperative or postoperative complications were compared between the 23-G and 25-G MIVS groups. Both groups showed a statistically significant improvement in best-corrected visual acuity at postoperative 1, 3, and 6 months (All P < 0.05). Furthermore, the mean change of best-corrected visual acuity was not significantly different between the 2 groups at postoperative 1, 3, and 6 months (P = 0.208, P = 0.547, and P = 0.519, respectively), but 25-G MIVS group showed faster visual recovery than 23-G MIVS group at postoperative 1 day and at 1 week (P = 0.015, and P < 0.001, respectively). Severe hypotony of intraocular pressure less than 6 mmHg (3 eyes, 1.9%) or intraocular pressure elevation over 30 mmHg at postoperative 1 day (3 eyes, 1.9%) was found in the 23-G group, but not in the 25-G group, and was not statistically different between the groups (P = 0.553). More eyes required intraoperative suturing of sclerotomy sites in the 23-G group (18 eyes, 11.3%), whereas none of the eyes in the 25-G group needed suturing of sclerotomy (P < 0.002). Both 23-G and 25-G MIVS yielded comparable visual outcomes for surgical treatment of idiopathic epiretinal membrane in pseudophakic eyes. The 25-G MIVS was associated with faster visual recovery and less postoperative hypotony than 23-G surgery.
    Retina (Philadelphia, Pa.) 05/2015; DOI:10.1097/IAE.0000000000000598 · 3.18 Impact Factor
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    ABSTRACT: PurposeTo investigate factors associated with good response to intravitreal bevacizumab (IVB) in central serous chorioretinopathy (CSC) patients.Methods We retrospectively reviewed 42 eyes of CSC patients of symptom duration more than 3 months who received a single or multiple successive IVBs on an as-needed basis (0.05 ml, 1.25 mg). High responders (HRs) were defined as complete resolution of subretinal fluid (SRF) on spectral domain optical coherence tomography (SD-OCT). Moderate responders (MRs) were defined as SRF resolution of 50-99% of pretreatment volume and poor responders (PRs) as SRF resolution <50%. Clinical, SD-OCT, fluorescein, and indocyanine green angiography findings were analyzed to find factors associated with HR. Descriptive statistics for all demographic and clinical variables were calculated, and comparisons were made using Wilcoxon's matched-pairs signed-rank test, the Mann-Whitney U-test for means with continuous data, Pearson's χ(2) test, and Fisher's exact test for categorical data.ResultsThe mean number of IVB was 1.9. At postoperative 1 month, there were 10 (24%) HRs, 18 (43%) MRs, and 14 (33%) PRs. At the last follow-up (the mean 8.6 months), there were 25 HRs (60%), 9 MRs (21%), and 8 PRs (19%). Thicker subfoveal choroid (P=0.036), smaller lesion diameter (P=0.019), and better baseline best-corrected visual acuity (P=0.002) predicted HRs at postoperative 1 month. HR at the last follow-up was associated with classic pattern fluorescein angiography finding.Conclusions Suboptimal effects of IVB on persistent CSC suggest primary IVB on selective cases with better vision, smaller lesion, and thicker choroid at baseline.Eye advance online publication, 8 May 2015; doi:10.1038/eye.2015.58.
    Eye (London, England) 05/2015; 29(6). DOI:10.1038/eye.2015.58 · 1.90 Impact Factor
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    ABSTRACT: To evaluate the accuracy of postoperative refractive outcomes of combined phacovitrectomy for epiretinal membrane (ERM) in comparison to cataract surgery alone. Thirty-nine eyes that underwent combined phacovitrectomy with intraocular lens (IOL) implantation for cataract and ERM (combined surgery group) and 39 eyes that received phacoemulsification for cataract (control group) were analyzed, retrospectively. The predicted preoperative refractive aim was compared with the results of postoperative refraction. In the combined surgery group, refractive prediction error by A-scan and IOLMaster were -0.305±0.717 diopters (D) and -0.356±0.639 D, respectively, compared to 0.215±0.541 and 0.077±0.529 in the control group, showing significantly more myopic change compared to the control group (p=0.001 and p=0.002, respectively). Within each group, there was no statistically significant difference in refractive prediction error between A-scan and IOLMaster (all p>0.05). IOL power calculation using adjusted A-scan measurement of axial length based on the macular thickness of the normal contralateral eye still resulted in significant postoperative refractive error (all p<0.05). Postoperative refraction calculated with adjusted axial length based on actual postoperative central foveal thickness change showed the closest value to the actual postoperative achieved refraction (p=0.599). Combined phacovitrectomy for ERM resulted in significantly more myopic shift of postoperative refraction, compared to the cataract surgery alone, for both A-scan and IOLMaster. To improve the accuracy of IOL power estimation in eyes with cataract and ERM, sequential surgery for ERM and cataract may need to be considered.
    Yonsei medical journal 05/2015; 56(3):805-11. DOI:10.3349/ymj.2015.56.3.805 · 1.26 Impact Factor
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    ABSTRACT: To investigate the causes of acute spontaneous submacular hemorrhage with indocyanine green angiography (ICGA). Retrospective observation case series. A total of 51 eyes from 51 patients with newly developed spontaneous submacular hemorrhage were enrolled. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography, spectral domain optical coherence tomography (OCT), and ICGA at baseline were analyzed. The extent of hemorrhage using fundus photography, height of hemorrhage, and central foveal thickness measured by OCT was analyzed to compare the diagnostic and nondiagnostic groups. The mean logarithm of the minimum angle of resolution (logMAR) BCVA at presentation was 1.21 ± 0.74 (Snellen equivalent, 20/324); the mean follow-up period was 23.9 ± 23.9 months. The cause of submacular hemorrhage was diagnosed in 43 of 51 eyes (84.3%) based on ICGA at presentation. The initial diagnoses were correct in 93% of eyes. In 3 cases, the initial diagnosis of age-related macular degeneration (AMD) was changed to polypoidal choroidal vasculopathy (PCV) based on follow-up ICGA. The central foveal thickness was significantly greater in the nondiagnostic group (1,102.4 vs. 666.7 μm, respectively; p = 0.008). The most common cause of submacular hemorrhage was neovascular AMD (52.9%), followed by PCV (37.3%), macroaneurysm (5.9%), and lacquer crack (3.9%). The mean final visual acuity was generally worse in patients with submacular hemorrhage with typical AMD (visual acuity 20/618) or PCV (visual acuity 20/240) compared to that in patients with retinal macroaneurysm (visual acuity 20/100) or lacquer crack (visual acuity 20/72). ICGA at initial presentation helps identify causes of submacular hemorrhage, allowing differential treatment approaches that may improve outcomes and safety. © 2015 S. Karger AG, Basel.
    Ophthalmologica 03/2015; DOI:10.1159/000380830 · 1.87 Impact Factor
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    ABSTRACT: To compare the functional and anatomical outcomes of intravitreal bevacizumab (IVB) with those of dexamethasone implant injection (IVD) for macular oedema associated with branch retinal vein occlusion (BRVO). Seventy-two patients with centre-involving macular oedema secondary to BRVO were retrospectively enrolled in the study; these patients were treated with either 1.25 mg IVB (44 eyes; mean injections: 2.92±1.38) pro re nata (PRN) by follow-up monthly or 700 µg IVD (28 eyes; mean injections: 1.71±0.47) given at 6-month intervals PRN and were followed for at least 12 months. Main outcome measures were changes in best-corrected visual acuity (BCVA) and central foveal thickness (CFT). There was no statistically significant difference of mean change of the logarithm of the minimum angle of resolution BCVA between IVB and IVD groups at monthly visits, up to 12 months (all p>0.05); however, there was a trend towards greater BCVA gain in the IVB group than in the IVD group at 6 months (p=0.053). Additionally, 52.6% in the IVB group and 50% in the IVD group gained two or more lines of Snellen visual acuity at 12 months (p=0.85). The mean CFT decreased by 160 µm for the IVB group and by 140.7 µm for the IVD group at 12 months. Both the IVB group and the IVD group achieved statistically similar improvement of CFT at monthly visits, up to 5 months (all p>0.05); however, the CFT began to deteriorate after 5 months in the IVD group, and at 6 months, improvement in the IVB group was significantly greater than that in the IVD group (p=0.007). After a second IVD injection at 6 months, the IVD group showed significant improvement of CFT, and there was no significant difference of CFT change between the IVB and IVD groups until 12 months. For macular oedema secondary to BRVO, IVB administered PRN monthly and IVD administered PRN at 6-month intervals, yielded functionally and anatomically comparable outcomes at 12 months. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
    British Journal of Ophthalmology 03/2015; DOI:10.1136/bjophthalmol-2014-306236 · 2.81 Impact Factor
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    ABSTRACT: To report short-term surgical outcomes of single-stage simultaneous rescue and sutureless intrascleral fixation of dislocated intraocular lens (IOLs). Sixteen eyes of 16 patients who underwent simultaneous rescue and intrascleral fixation of dislocated 3-piece IOLs were retrospectively evaluated. Partial thickness limbal-based scleral flaps (2.0 × 2.0 mm) were created, and a 22-gauge round needle was used to create a sclerotomy at 1.5 mm from the limbus under the previously created scleral flap, and a 23-gauge trans pars plana vitrectomy was performed. Bimanual maneuvers using two 23-gauge end-grasping forceps under chandelier illumination and a wide-angle viewing system enabled 1 step rescue of IOLs from the posterior vitreous cavity with 1 hand and simultaneous haptic externalization through sclerotomy with the other hand. An externalized haptic was placed into the 3-mm intrascleral tunnel created using a bent 26-gauge needle. Fibrin glue was used to fixate haptics and close the scleral flaps. Intraocular lenses were successfully rescued and sclera-fixated through intrascleral tunnels in all 16 eyes (mean age, 56.56 ± 19.89 years). The mean preoperative logarithm of the minimum angle of resolution best-corrected visual acuity was 0.92 ± 0.68, and this significantly improved at 6 months to 0.289 ± 0.36 (P = 0.003). During the follow-up period (10.1 ± 3.21 months), no significant change of endothelial cell count or central foveal thickness was noted postoperatively (P = 0.203 and P = 0.979, respectively). There were no significant postoperative complications such as IOL dislocation, IOL decentration, retinal detachment, endophthalmitis, or postoperative hypotony. Simultaneous rescue and sutureless intrascleral haptic fixation of dislocated 3-piece IOLs using bimanual maneuvers is an effective, safe, and minimally invasive surgical method to rescue and fixate the dislocated IOL without further explant.
    Retina 02/2015; 35(7). DOI:10.1097/IAE.0000000000000484 · 3.18 Impact Factor
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    Korean Journal of Ophthalmology 10/2014; 28(5):424-426. DOI:10.3341/kjo.2014.28.5.424
  • Hae Min Kang, Hyoung Jun Koh, Sung Chul Lee
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    ABSTRACT: Purpose To assess the visual outcome and prognostic factors after surgery for a secondary epiretinal membrane (ERM) due to branch retinal vein occlusion (BRVO). Methods Medical records of 33 patients (33 eyes) were retrospectively reviewed. All patients underwent vitrectomy and completed at least one year of follow-up. Patients characteristics, including baseline best-corrected visual acuity (BCVA; logMAR, logarithm of the minimum angle resolution), fluorescein angiography and optical coherence tomography findings were analyzed. Results Twenty eyes (60.6%) were non-ischemic and nine eyes (27.3%) had ischemic maculopathy. The mean BCVA was 0.82 ±0.56 logMAR (20/132 Snellen equivalent) at baseline and 0.43 ±0.37 logMAR (20/53 Snellen equivalent) at 1 year (p = 0.001). At 1 year three eyes (9.1%) had visual loss with 0.3 logMAR or more deterioration than baseline whereas 16 eyes (48.5%) gained vision. The mean central macular thickness (CMT) was 407.3 ±138.8 μm at baseline and 274.71 ±40.5 μm at 1 year after surgery (p = 0.001). Photoreceptor integrity was intact in 20 eyes (60.6%). Photoreceptor integrity (B = 0.248, p = 0.001) at baseline was significantly correlated with visual outcome after surgery. Conclusion Surgery for a secondary ERM associated with BRVO led to a relatively favorable visual outcome. The integrity of photoreceptors at baseline seems to be useful in predicting visual outcome in these patients.
    Albrecht von Graæes Archiv für Ophthalmologie 07/2014; 253(4). DOI:10.1007/s00417-014-2731-2 · 2.33 Impact Factor
  • Min Kim, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee
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    ABSTRACT: To investigate choroidal thickness (CT) in healthy Korean subjects measured by enhanced depth imaging optical coherence tomography and its association with age, axial length, and refractive error. Choroidal scans using enhanced depth imaging optical coherence tomography in each eye of 286 healthy eyes were obtained at the macula. Choroidal thickness was measured at the fovea. Two separate line scans were obtained (one horizontal and one vertical). The mean (±SD) age was 40.18 (±17.89) years (range, 13 to 75 years). The mean (±SD) subfoveal CT was 307.26 (±95.18) μm. Multivariable linear regression suggested that age and refractive error were the most significant factors associated with subfoveal CT (all p < 0.0001) with an adjusted R = 0.181. In subjects younger than 60 years, refractive error or axial length and age retained statistically significant correlation with subfoveal CT, whereas such a relationship was lost in subjects older than 60 years. The mean subfoveal CT measurement showed the most significant positive correlation with refractive error and the most significant negative correlation with age. For patients younger than 60 years, there was a significant correlation of subfoveal CT with age and refractive error or axial length, whereas such significant association was not observed in subjects older than 60 years.
    Optometry and vision science: official publication of the American Academy of Optometry 04/2014; 91. DOI:10.1097/OPX.0000000000000229 · 2.04 Impact Factor
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    ABSTRACT: This case describes the reversal of early central retinal vein occlusion (CRVO) with disc swelling after intravitreal dexamethasone implant (Ozurdex) injection. A 44-year-old female presented with sudden-onset intermittent blurred vision in her left eye. Fundus examination revealed multiple retinal hemorrhages without macular edema (ME). Two weeks later, an increased number of retinal hemorrhages with severe disc swelling were noted with still no sign of ME. An intravitreal dexamethasone implant was injected. Five days later, there were improvements in disc swelling and retinal hemorrhage. One month later, her subjective visual symptoms were completely improved, and fundus examination revealed marked improvement along with almost complete resolution of disc swelling. Intravitreal dexamethasone implant injection may potentially change the natural course of CRVO progression and its various subsequent complications.
    Korean Journal of Ophthalmology 04/2014; 28(2):192-3. DOI:10.3341/kjo.2014.28.2.192
  • Dong Hyun Lee, Sung Soo Kim, Min Kim, Hyoung Jun Koh
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    ABSTRACT: To investigate identifiable peripheral retinal lesions in patients with myopia or high myopia and to evaluate the usefulness of ultra-widefield scanning laser ophthalmoscope in retina clinic settings.
    Journal of the Korean Ophthalmological Society 01/2014; 55(12):1814. DOI:10.3341/jkos.2014.55.12.1814
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    ABSTRACT: To report the effectiveness of intravitreal bevacizumab treatment for serous retinal detachment associated with Leber's idiopathic stellate neuroretinitis.
    Journal of the Korean Ophthalmological Society 01/2014; 55(10):1562. DOI:10.3341/jkos.2014.55.10.1562
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    ABSTRACT: To evaluate the characteristics of rhegmatogenous retinal detachment (RD) in patients with previous laser in-situ keratomileusis (LASIK) and compared them to RD in patients with previous laser assisted sub-epithelial keratomileusis (LASEK) and myopic patients with no previous refractive surgery. Retrospective, comparative case series METHODS: Among 106 eyes of 106 patients, RD patients with previous refractive surgery included 21 eyes with LASIK and 13 eyes with LASEK. 72 myopic patients with refractive errors of -3.0 diopters or less were grouped as the R (-) group. Characteristics of RD included distribution of RD and associated retinal breaks, location and number of retinal breaks, presence of lattice degeneration, and axial lengths. The mean interval between refractive surgery and the onset of rhegmatogenous RD was 63.7±43.5 months, occurring across a broad spectrum of time interval. There were no significant differences among LASIK group, LASEK group, and R (-) group in axial length (26.8 mm vs. 26.4 mm vs. 26.9 mm, respectively), mean number of retinal holes/tears, (2.1/1.5, 0.9/1.4, 1.5/1.6, respectively) and the presence of lattice degeneration(52.4%vs. 46.2% vs. 43.1%, respectively). Distribution of RD and associated retinal breaks were also not significant different, as retinal holes and tears were more prevalent in the temporal quadrants, and inferotemporal quadrants was the most commonly detached area in both LASEK/LASIK group and R (-) group. Myopia is a well-known risk factor for rhegmatogenous RD and may contribute more to the development of RD in myopic patients after refractive surgery, rather than refractive surgery itself.
    American Journal of Ophthalmology 12/2013; 157(3). DOI:10.1016/j.ajo.2013.12.004 · 4.02 Impact Factor
  • Hae Min Kang, Hyoung Jun Koh
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    ABSTRACT: To investigate the prevalence of polypoidal choroidal vasculopathy (PCV) in patients with myopic choroidal neovascularization (CNV) using indocyanine green angiography (ICGA). Retrospective cross-sectional study. A total of 297 eyes (255 patients) who presented with treatment-naive myopic CNV between January 2005 and December 2011 at Yonsei University Medical Center in Seoul, South Korea, were reviewed. Fluorescein angiography (FA) images obtained from the patients were analyzed to detect CNV presence and classify disease type. ICGA images were reviewed to detect polypoidal lesions. The main outcome measure was the prevalence of polypoidal lesions in patients with myopic CNV. All 297 eyes with myopic CNV were type 2 CNV, and mean age at diagnosis was 47.32 ± 14.69 years. The mean refractive error was -11.95 ± 5.88 diopters, and the mean axial length was 29.39 ± 2.02 mm in the affected eyes. Among the myopic CNV eyes, 141 eyes (118 patients) were older than 50 years of age (mean 60.48 ± 7.34 years). No eyes with myopic CNV showed polypoidal lesions on ICGA at initial presentation. After treatments for myopic CNV, 243 eyes (206 patients) completed at least 12 months of follow-up, and 86 eyes (35.4%) showed at least one recurrence of CNV during follow-up. The follow-up imaging studies, FA, and ICGA, showed no polypoidal lesions associated with recurred myopic CNV. ICGA analysis demonstrated no polypoidal component in myopic eyes with CNV.
    American Journal of Ophthalmology 12/2013; 157(2). DOI:10.1016/j.ajo.2013.09.018 · 4.02 Impact Factor
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    ABSTRACT: To evaluate the long-term visual outcome after combination therapy of photodynamic therapy (PDT) with intravitreal bevacizumab injections for polypoidal choroidal vasculopathy (PCV). Retrospective, observational study. The medical records of 34 eyes (34 patients) with naive PCV who were treated with combination therapy were analyzed. All patients completed at least 3 years of follow-up. All clinical data, including age, best-corrected visual acuity (BCVA, logMAR; logarithm of the minimum angle resolution), imaging data of fluorescein angiography, indocyanine green angiography, and optical coherence tomography, were investigated. During a mean follow-up period of 46.82 ± 5.22 months, a mean of 1.44 ± 0.71 times of PDT and 9.18 ± 6.61 intravitreal bevacizumab injections were performed. During follow-up, 21 eyes (61.8%) showed at least one recurrence. Mean BCVA was 0.59 ± 0.35 logMAR (20/77 Snellen equivalent) at baseline, and 0.39 ± 0.34 logMAR (20/49 Snellen equivalent) at 3 years (P=.004). At 3 years, 14 patients (41.2%) gained 0.3 logMAR or more BCVA, and 4 patients (11.8%) lost 0.3 logMAR or more BCVA than baseline. Baseline polyp size (B=.551; P=.005) and location of polyps (B= -.400; P=.033) were significantly correlated with long-term visual outcome after combination therapy for PCV. Combination therapy of PDT with intravitreal bevacizumab injections showed favorable visual outcomes, and significant visual improvement was maintained in PCV patients. A total of 88.2% of patients avoided visual loss at 3 years after treatments. Largest polyp size at baseline and location of polypoidal lesions were prognostic factors for long-term visual outcomes in these patients.
    American Journal of Ophthalmology 11/2013; 157(3). DOI:10.1016/j.ajo.2013.11.015 · 4.02 Impact Factor
  • Acta ophthalmologica 10/2013; 92(1). DOI:10.1111/aos.12285 · 2.51 Impact Factor

Publication Stats

1k Citations
271.79 Total Impact Points


  • 2000–2015
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2001–2013
    • Yonsei University
      • The Institute of Vision Research
      Sŏul, Seoul, South Korea
  • 2006–2009
    • University of California, San Diego
      • Department of Ophthalmology
      San Diego, CA, United States
  • 2008
    • National Health Insurance Corporation Ilsan Hospital
      Sŏul, Seoul, South Korea
  • 2007
    • Inje University
      • College of Medicine
      Kimhae, South Gyeongsang, South Korea
  • 2004
    • National University (California)
      San Diego, California, United States