Ulku Ozan

Publications (3)8.86 Total impact

• Article: Bortezomib and extramedullary disease in multiple myeloma: the shine and dark side of the moon.

  Ridvan Ali, Fahir Ozkalemkas, Atilla Ozkan, Vildan Ozkocaman, Tulay Ozcelik, Ulku Ozan, Meral Kurt, Ahmet Tunali
  Leukemia Research 09/2007; 31(8):1153-5. · 2.92 Impact Factor
• Article: Tumour lysis syndrome with acute renal failure during imatinib therapy.

  Ridvan Ali, Fahir Ozkalemkas, Atilla Ozkan, Tulay Ozcelik, Vildan Ozkocaman, Ibrahim Akdag, Ulku Ozan, Ahmet Tunali
  Leukemia Research 05/2007; 31(4):573-4. · 2.92 Impact Factor
• Source

  Available from: PubMed Central

  Article: The bone marrow aspirate and biopsy in the diagnosis of unsuspected nonhematologic malignancy: a clinical study of 19 cases.

  Fahir Ozkalemkas, Ridvan Ali, Vildan Ozkocaman, Tulay Ozcelik, Ulku Ozan, Hulya Ozturk, Ender Kurt, Turkkan Evrensel, Omer Yerci, Ahmet Tunali
  [show abstract] [hide abstract]
  ABSTRACT: Although bone marrow metastases can be found commonly in some malignant tumors, diagnosing a nonhematologic malignancy from marrow is not a usual event. To underscore the value of bone marrow aspiration and biopsy as a short cut in establishing a diagnosis for disseminated tumors, we reviewed 19 patients with nonhematologic malignancies who initially had diagnosis from bone marrow. The main indications for bone marrow examination were microangiopathic hemolytic anemia (MAHA), leukoerythroblastosis (LEB) and unexplained cytopenias. Bone marrow aspiration was not diagnostic due to dry tap or inadequate material in 6 cases. Biopsy results were parallel to the cytological ones in all cases except one; however a meticulous second examination of the biopsy confirmed the cytologic diagnosis in this patient too. The most common histologic subtype was adenocarcinoma, and after all the clinical and laboratory evaluations, the primary focus was disclosed definitively in ten patients (5 stomach, 3 prostate, 1 lung, 1 muscle) and probably in four patients (3 gastrointestinal tract, 1 lung). All work up failed in five patients and these cases were classified as tumor of unknown origin (TUO). Our series showed that anemia, thrombocytopenia, elevated red cell distribution width (RDW) and hypoproteinemia formed a uniform tetrad in patients with disseminated tumors that were diagnosed via bone marrow examination. The prognosis of patients was very poor and survivals were only a few days or weeks (except for 4 patients whose survivals were longer). We concluded that MAHA, LEB and unexplained cytopenias are strong indicators of the necessity of bone marrow examination. Because of the very short survival of many patients, all investigational procedures should be judged in view of their rationality, and should be focused on treatable primary tumors.
  BMC Cancer 02/2005; 5:144. · 3.01 Impact Factor