[show abstract][hide abstract] ABSTRACT: The purpose of this study was to evaluate the effect and investigate the putative mechanism of botulinum toxin type A (BTA) applied to the treatment of benign prostatic hyperplasia (BPH). A total of 52 patients with symptomatic BPH were evaluated. Transperineal intraprostatic injection under transrectal ultrasonography was carried out. BTA dissolved in 4 to 9 mL of saline was used from 100 U to 300 U, according to prostate volume. Twenty-six patients received only BTA (BT group), and 26 received both BTA and one month of an alpha-adrenergic antagonist (BTalpha group). The therapeutic outcomes were evaluated by comparing parameters such as international prostate symptom score (IPSS), quality of life, prostate specific antigen, prostate volume, post-void residual urine, and peak urinary flow rate. At the one month follow- up, 18 patients in the BT group and 21 in the BTalpha group had subjective symptomatic relief (p = 0.337). Only IPSS5 (weak stream) was significantly different between the BT group and BTalpha groups (p = 0.034). At the three month follow-up, 39 patients had subjective symptomatic relief. The storage symptoms were improved more than the voiding symptoms. Additionally, about 50 percent of the patients whose voiding symptom improved expressed improved erectile function. BTA injection seems to be an alternative treatment for BPH. The differences after the one month evaluation between the BT and the BTalpha groups might suggest that the adrenergic influence could be relatively reinforced by the anticholinergic effect of BTA. Nitric oxide would thus be involved in a BTA action mechanism in BPH.
Yonsei Medical Journal 11/2006; 47(5):706-14. · 1.31 Impact Factor
[show abstract][hide abstract] ABSTRACT: The repair of extensive posterior urethral stricture often poses a therapeutic dilemma, especially when the urethral defect is too extensive to be repaired with traditional methods and the stricture portion has a poor blood supply. This report details the successful substitution of an extensive posterior urethral stricture using a reconfigured sigmoid colon neourethra.
[show abstract][hide abstract] ABSTRACT: Glomus tumors of the penis are extremely rare. We report a patient with a solitary glomus tumor involving the penis. A 19-year-old man presented with a complaint of a recurrent painful penile mass. Resection of the lesion was performed. The pathologic diagnosis was glomus tumor of the glans penis. This case emphasizes the need for complete extirpation of the glomus tumor to avoid additional surgery.
[show abstract][hide abstract] ABSTRACT: Although urethral caruncle is not a major disease, the technique to remove it has been rather difficult and complicated. We describe a simple method of removal that is comparable to its importance.
In 10 patients we applied a ligation technique using 1-zero silk at the base of the urethral caruncle during a 4-year period.
This technique was well tolerated by patients without analgesics or anesthesia. It also allowed obtaining tissue pathological evaluation if wanted. Seven to 14 days after ligation the caruncles broke off without any problem. The caruncles base healed satisfactorily. However, this technique requires at least 1 assistant.
We describe a simple treatment for urethral caruncle.
The Journal of Urology 11/2004; 172(5 Pt 1):1884-5. · 3.70 Impact Factor