C Cordonnier

Université de Picardie Jules Verne, Amiens, Picardie, France

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Publications (58)44.65 Total impact

  • Archives de Pédiatrie. 05/2013; 20(5):537.
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    ABSTRACT: Prospective evaluation of bladder tumor targeting by Hexvix fluorescence. From September 2008 to April 2012, 107 patients have been evaluated using Hexvix technique (blue light) for typically papillary bladder tumor or suspected bladder tumor. Clinical and pathological data have been collected prospectively and patients have been classified using EORTC score. From the 107 patients, 67 have been identified with bladder cancer and 328 samples have shown positive fluorescence in blue light. Compared to white light, 13 additional tumors have been diagnosed by Hexvix for 11 patients: Cis (n=6), LMP (n=3), pTa low grade (n=3), pT1 low grade (n=1) (P=0.003). The false positive rate for Hexvix was 53.4% versus 52% for white light. Previous TCC history, multifocality and EORTC score for recurrence and progression have been associated with better bladder cancer targeting by Hexvix (P=0.007; P=0.01; P=0.03; P=0.04). In our experience, Hexvix targeting was associated with better diagnosis for bladder cancer with 9% (13/144) of new positive samples (P=0.003). In our study, false positive rate is a critical point (53.4%). Multifocality, previous TCC, and EORTC score for recurrence and progression might allow selecting patients to be targeted by Hexvix.
    Progrès en Urologie 03/2013; 23(3):195-202. · 0.80 Impact Factor
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    ABSTRACT: The long-term impact of subclinical acute rejection (SCAR) on renal graft function remains poorly understood. Furthermore, the interpretation of borderline lesions is difficult and their incidence is variable. The aim of this study was to analyze the characteristics of subclinical inflammation (SCI) in protocol biopsies performed 1-year after renal transplantation. SCI was defined as the presence of borderline lesions or SCAR according to the Banff 2005 classification. The patients included were a subpopulation of the CONCEPT study in which patients were randomized 3 months after transplantation to receive either sirolimus (SRL) or cyclosporine A (CsA) in combination with mycophenolate mofetil. At 1 year, we observed SCI in 37 of the 121 patients observed with an evaluable biopsy. The incidence was more frequent in the SRL group (SRL 45.2% vs. CsA 15.3%). At 30 months , SCI was associated with a significantly lower level of estimated glomerular filtration rate (mean MDRD 50.8 [±13.3] vs. 57.7 [±16.3] mL/min/1.73 m(2) , p = 0.035). In conclusion, SCI at 1-year posttransplantation is associated with worsening renal function and is more frequent in SRL-treated patients. Therefore, evaluation of SCI may be a valuable tool to allow the optimization of immunosuppressive regimens.
    American Journal of Transplantation 08/2011; 11(10):2153-61. · 6.19 Impact Factor
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    ABSTRACT: Sirolimus (SRL) is a potent immunosuppressant used in organ transplantation. It is known to decrease vascular endothelial growth factor (VEGF) synthesis, making it an interesting treatment option for transplant patients who develop Kaposi sarcoma or other malignant diseases. Because VEGF plays a key role in glomerular function and vascular remodelling, we determined the effect of SRL on renal VEGF expression. Using immunohistochemistry and quantitative image analysis, we examined renal VEGF expression in routine kidney biopsies performed at 1 year post-transplant in the CONCEPT study, a prospective randomized study comparing a cyclosporine (CsA)-based regimen to a SRL-based regimen in association with mycophenolate mofetil (MMF). A total of 74 patients were included in this substudy; 35 were randomized to the CsA group and 39 to the SRL group. Using continuous variables, the mean percentage of glomerular VEGF expression at Week 52 was significantly lower in the SRL group (14.7 ± 13%) compared to CsA group (21.2 ± 14%: P = 0.02). The percentage of glomerular VEGF expression at Week 52 was not influenced by recipient or donor age, gender, renal function, CsA dose, CsA blood level, SRL dose or SRL blood level. It was significantly lower in patients with a proteinuria over versus below 0.5 g/day (11.58 ± 7.9 versus 19.45 ± 15.53; P = 0.036). There is emerging evidence that the VEGF system can play either a beneficial or a detrimental role depending on the specific pathologic situations. Therefore, modulating the renal VEGF axis by using an SRL-based regimen may influence the evolution of kidney injury associated with renal transplantation.
    Nephrology Dialysis Transplantation 05/2011; 27(1):411-6. · 3.37 Impact Factor
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    ABSTRACT: Primary localized amyloidosis of the genitourinary tract is a rare entity characterized by small pseudotumors localized in the renal pelvis, ureters, or bladder. Amyloid fibrils are derived from immunoglobulin light chains, but no systemic plasma cell proliferation is detected. The clinical and radiologic features mimic urinary tract cancer, and local treatment is indicated. The prognosis is excellent in most cases, although disease recurrence is possible. We report 5 new cases of localized amyloidosis of the urinary tract, with lambda (4/5), or kappa (1/5) chain amyloid protein, involving the bladder (5/5), and the ureter and renal pelvis (1/5), with multiple, bilateral lesions in 1 case. The presenting complaint was painless hematuria in 4 cases. All cases were of primary (AL)-type amyloidosis. All patients underwent extensive investigation, and none presented any signs of generalized amyloidosis. A favorable outcome was observed in every case. We performed a comprehensive review of the literature, and summarize the data.
    Medicine 05/2011; 90(3):212-22. · 4.35 Impact Factor
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    ABSTRACT: Membranoproliferative glomerulonephritis type II is a rare renal disease, associated with uncontrolled activation of the complement alternative pathway because of C3 nephritic factor. Abnormalities in factor H have been rarely described in patients with membranoproliferative glomerulonephritis type II. We report the clinical history, molecular defect, and histologic description of 3 patients with factor H deficiency and various types of membranoproliferative glomerulonephritis. The 3 patients presented with severely decreased C3. Circulating factor H was undetectable. Complete factor H deficiency (CFH) was due to homozygous complement factor H mutations in short consesus repeat (SCR) 7, 10, and 11. Age at onset was 1 (patient 1), 17 (patient 2), and 33 years (patient 3). Symptoms at diagnosis included proteinuria of 0.5, 2.4, and 11 g/d, respectively, microhematuria, and normal renal function in all cases. The estimated glomerular filtration rate at last follow-up was 25, 43, and 112 mL/min per 1.73 m(2), at ages of 29, 24, and 37 years, respectively. Renal biopsies disclosed a membranoproliferative glomerulonephritis type II with atypical discontinuous dense deposits in patient 1; a membranoproliferative glomerulonephritis type I with immunoglobin G (IgG), C1q, and abundant C3 deposits in patient 2; and a membranoproliferative glomerulonephritis with isolated C3 deposits without dense deposits in patient 3. This report of factor H-deficient patients emphasizes the diversity of the histologic lesions associated with factor H deficiencies and the role of the alternative pathway in several subtypes of membranoproliferative glomerulonephritis.
    Human pathology 03/2011; 42(9):1305-11. · 3.03 Impact Factor
  • Revue De Medecine Interne - REV MED INTERNE. 01/2011; 32.
  • Journal de Radiologie 12/2010; 91(12 Pt 1):1313-7. · 0.35 Impact Factor
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    ABSTRACT: Prospective evaluation of bladder tumor targeting by Hexvix(®) fluorescence. From September 2008 to September 2009, 28 patients have been evaluated using Hexvix(®) technique (blue light) for typically papillary bladder tumor or suspected bladder tumor. Clinical and pathological data have been collected and patients have been classified using EORTC score. From the 28 patients, 14 have been identified with bladder cancer (31 tumors) and 90 samples have shown positive fluorescence in blue light. Compared to white light, four additional tumors have been diagnosed by Hexvix(®) for three patients (p=NS): two cis, one LMP, one pTa low grade. The false positive rate for Hexvix(®) was 65.5 versus 58.5% for white light. EORTC score for bladder cancer was associated with better bladder cancer targeting by Hexvix(®) (p<0.05). In our experience, Hexvix(®) targeting was associated with better diagnosis for bladder cancer. Thirteen percent of new positive samples have been found for 10.7% of patients. In our study false positive rate is a critical point (65.5%). EORTC score for recurrence and progression might allow to select patients to be targeted by Hexvix(®).
    Progrès en Urologie 10/2010; 20(9):644-50. · 0.80 Impact Factor
  • Journal de Radiologie 04/2010; 91(4):518-20. · 0.35 Impact Factor
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    Journal de Radiologie. 04/2010; 91(4):518–520.
  • Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2010; 17(6):118-118.
  • Journal De Radiologie - J RADIOL. 01/2010; 91(4):518-520.
  • Journal De Radiologie - J RADIOL. 01/2010; 91(12):1313-1317.
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    ABSTRACT: The aim of our survey was to assess the perception of teaching pathology by the medical students in the sixth year of the medical course (DCEM4), in the faculty of medicine of Amiens. Just after an exam in December 2008, an anonymous questionnaire of 19 items, dealing with pathology, the teaching of pathology and tutorials, was given to the 127 medical students in DCEM4. Seventy-four percent of the students out of the 127 students filled and gave back the questionnaire (response rate: 58%). Eighty-nine percent of the students considered their knowledge in pathology inadequate. Fifty-three percent of the students considered the teaching of pathology mediocre. For 85% of the students, tutorials were useful. For 93% of the students pathology plays a main role in modern medicine. Thirty-eight percent of the students considered that pathology was an interesting specialty. Sixty-nine percent of them did not know how a department of pathology functioned. Four percent of the students would like to choose a training in pathology. Although the results are not available for all French faculties of medicine, this survey underlines the present limits of the teaching of pathology, which is not coming up to the students' expectations. The students appreciate tutorials but pathology is not attractive. More lectures about pathology after the third year of the medical course, a better communication and the reception of more medical students in the departments of pathology could improve the situation.
    Annales de Pathologie 07/2009; 29(3):173-9. · 0.24 Impact Factor
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    ABSTRACT: We conducted the current study to investigate the clinical, laboratory, and histologic features at presentation and the outcome of renal sarcoidosis (RS). Exhaustive retrospective data were collected by the French Sarcoidosis Group. Forty-seven adult patients were assessed (30 male/17 female, M/F ratio: 1.76). Median estimated glomerular filtration rate (eGFR) was 20.5 mL/min per 1.73 m(2) (range, 4-93 mL/min per 1.73 m(2)). Moderate proteinuria was found in 31 (66%) patients (median, 0.7 g/24 h; range, 0-2.7 g/24 h), microscopic hematuria in 11 (21.7%) patients, aseptic leukocyturia in 13 (28.7%) patients. Fifteen of 47 (32%) patients had hypercalcemia (>2.75 mmol/L). Eleven of the 22 (50%) patients diagnosed between June and September had hypercalcemia compared with only 4 of the 25 (16%) cases diagnosed during the other months (p < 0.001). Thirty-seven patients presented with noncaseating granulomatous interstitial nephritis (GIN), and 10 with interstitial nephritis without granulomas. Apart from hypercalcemia, the clinical phenotype was also remarkable for the high frequency of fever at presentation. All patients initially received prednisone (median duration, 18 mo), 10 received intravenous pulse methylprednisolone. eGFR increased from 20 +/- 19 to 44 +/- 24.7 mL/min per 1.73 m(2) at 1 month (p < 0.001, n = 38), to 47 +/- 19.9 mL/min per 1.73 m(2) at 1 year (p < 0.001, n = 46), to 49.13 +/- 25 mL/min per 1.73 m(2) at last follow-up (p < 0.001, n = 47). A complete response to therapy at 1 year and at last follow-up was strongly correlated with complete response at 1 month (p < 0.01). Renal function improvement was inversely related to initial histologic fibrosis score. A complete response to therapy at 1 year was strongly correlated with hypercalcemia at presentation (p = 0.003). Relapses were purely renal (n = 3) and purely extrarenal (n = 10) or both (n = 4), often a long time after presentation, with in some cases severe cardiac or central nervous system involvement. We conclude that hypercalcemia and fever at presentation are often associated with RS; RS is most often and permanently responsive to corticosteroid treatment, but some degree of persistent renal failure is highly frequent and its degree of severity in the long run is well predicted from both histologic fibrotic renal score and response obtained at 1 month.
    Medicine 03/2009; 88(2):98-106. · 4.35 Impact Factor
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    ABSTRACT: Renal involvement in sarcoidosis displays a wide range of manifestations, and kidney dysfunction may involve all three mechanisms of renal failure. We report a new case of systemic sarcoidosis presenting as a severe renal failure due to hypercalcemia, sarcoidosis-related bilateral nephrolithiasis and granulomatous interstitial nephritis. A prostate adenocarcinoma was also diagnosed, but has to be regarded as an unrelated disease.
    Clinical nephrology 03/2009; 71(2):192-5. · 1.29 Impact Factor
  • Journal de Radiologie 03/2009; 90(3P1):327-330. · 0.35 Impact Factor
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    ABSTRACT: Introduction The aim of our survey was to assess the perception of teaching pathology by the medical students in the sixth year of the medical course (DCEM4), in the faculty of medicine of Amiens. Material and methods Just after an exam in December 2008, an anonymous questionnaire of 19 items, dealing with pathology, the teaching of pathology and tutorials, was given to the 127 medical students in DCEM4. Results Seventy-four percent of the students out of the 127 students filled and gave back the questionnaire (response rate: 58%). Eighty-nine percent of the students considered their knowledge in pathology inadequate. Fifty-three percent of the students considered the teaching of pathology mediocre. For 85% of the students, tutorials were useful. For 93% of the students pathology plays a main role in modern medicine. Thirty-eight percent of the students considered that pathology was an interesting specialty. Sixty-nine percent of them did not know how a department of pathology functioned. Four percent of the students would like to choose a training in pathology. Discussion Although the results are not available for all French faculties of medicine, this survey underlines the present limits of the teaching of pathology, which is not coming up to the students’ expectations. The students appreciate tutorials but pathology is not attractive. More lectures about pathology after the third year of the medical course, a better communication and the reception of more medical students in the departments of pathology could improve the situation.
    Annales De Pathologie - ANN PATHOL. 01/2009; 29(3):173-179.
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    Journal De Radiologie - J RADIOL. 01/2009; 90(3):327-330.

Publication Stats

119 Citations
44.65 Total Impact Points

Institutions

  • 2010–2013
    • Université de Picardie Jules Verne
      Amiens, Picardie, France
  • 2005–2009
    • Centre Hospitalier Universitaire d'Amiens
      • Service d'Anatomie et Cytologie Pathologiques
      Amiens, Picardie, France
  • 2000–2001
    • Centre Hospitalier Universitaire de Rennes
      • Service d'anatomie et cytologie pathologiques
      Roazhon, Brittany, France
  • 1996
    • CHU de Québec
      Québec, Quebec, Canada