Letterio Morgante

Publications (48)251.77 Total impact

• Source

  Available from: Angelo Antonini

  Dataset: 10072 2012 1112 Author

  Angelo Antonini, Giovanni Abbruzzese, Luigi Ferini-Strambi, Barbara Tilley, Jing Huang, Glenn T Stebbins, Christopher G Goetz, Paolo Barone, Monica Bandettini di Poggio, Giovanni Fabbrini, [......], Leonardo Lopiano, Maurizio Zibetti, Mario Zappia, Alessandra Nicoletti, Aldo Quattrone, Maria Salsone, Gianni Cossu, Daniela Murgia, Alberto Albanese, Francesca Del Sorbo
• Source

  Available from: Simone Rossi

  Article: [¹²³I]FP-CIT single photon emission computed tomography findings in drug-induced Parkinsonism.

  Michele Tinazzi, Andrea Cipriani, Angela Matinella, Antonino Cannas, Paolo Solla, Alessandra Nicoletti, Mario Zappia, Letterio Morgante, Francesca Morgante, Claudio Pacchetti, Massimo Sciarretta, Carlo Dallocchio, Simone Rossi, Maria Malentacchi, Roberto Ceravolo, Daniela Frosini, Stelvio Sestini, Tommaso Bovi, Corrado Barbui
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  ABSTRACT: Drug-induced parkinsonism (DIP) in patients treated with antipsychotic drugs is considered a form of post-synaptic parkinsonism, caused by D2-receptor blockade. Recent studies, however, carried out on small and heterogeneous patient samples, have shown that DIP may be associated with [(123)I]FP-CIT single photon emission computed tomography (SPECT) abnormalities, which are markers of dopamine nigrostriatal terminal defect. In the present study, outpatients fulfilling the DSM-IV criteria for schizophrenia and treated with antipsychotics for at least 6 months, were enrolled in order to estimate the prevalence of DIP and, among patients with DIP, the prevalence of [(123)I]FP-CIT SPECT abnormalities. Socio-demographic and clinical variables associated with the presence of DIP and SPECT abnormalities were also assessed. DIP was diagnosed in 149 out of 448 patients with schizophrenia (33%). Age, use of long-acting antipsychotics and a positive family history of parkinsonism were the only demographic variables significantly associated with the development of DIP. Neuroimaging abnormalities were found in 41 of 97 patients who agreed to undergo [(123)I]FP-CIT SPECT (42%). Only age differentiated this group of patients from those with normal imaging. These preliminary findings suggest that D2-receptor blockade may coexist with a dopamine nigrostriatal terminal defect, as assessed by [(123)I]FP-CIT SPECT abnormalities, in a relevant proportion of DIP patients. Longitudinal studies should be designed with the aim of improving our understanding of the mechanisms of pre-synaptic abnormalities in DIP patients and identifying specific treatment strategies.
  Biological Psychiatry 06/2012; 139(1-3):40-5. · 8.28 Impact Factor
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  Available from: Angelo Antonini

  Article: The progression of non-motor symptoms in Parkinson's disease and their contribution to motor disability and quality of life.

  Angelo Antonini, Paolo Barone, Roberto Marconi, Letterio Morgante, Salvatore Zappulla, Francesco Ernesto Pontieri, Silvia Ramat, Maria Gabriella Ceravolo, Giuseppe Meco, Giulio Cicarelli, [......], Francesco Iemolo, Laura Ferigo, Pasqualino Simone, Paola Soliveri, Biagio Troianiello, Domenico Consoli, Alessandro Mauro, Leonardo Lopiano, Giuseppe Nastasi, Carlo Colosimo
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  ABSTRACT: Non-motor symptoms are gaining relevance in Parkinson's disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1-10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I-II mild; III moderate; IV-V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features.
  Journal of Neurology 06/2012; · 3.47 Impact Factor
• Article: Validation of the Italian version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale.

  Angelo Antonini, Giovanni Abbruzzese, Luigi Ferini-Strambi, Barbara Tilley, Jing Huang, Glenn T Stebbins, Christopher G Goetz, Paolo Barone, Monica Bandettini di Poggio, Giovanni Fabbrini, [......], Leonardo Lopiano, Maurizio Zibetti, Mario Zappia, Alessandra Nicoletti, Aldo Quattrone, Maria Salsone, Gianni Cossu, Daniela Murgia, Alberto Albanese, Francesca Del Sorbo
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  ABSTRACT: The Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) has been available in English since 2008. As part of this process, the MDS-UPDRS organizing team developed guidelines for development of official non-English translations. We present here the formal process for completing officially approved non-English versions of the MDS-UPDRS and specifically focus on the first of these versions in Italian. The MDS-UPDRS was translated into Italian and tested in 377 native-Italian speaking PD patients. Confirmatory and exploratory factor analyses determined whether the factor structure for the English-language MDS-UPDRS could be confirmed in data collected using the Italian translation. To be designated an 'Official MDS translation,' the Comparative Fit Index (CFI) had to be ≥0.90 relative to the English-language version. For all four parts of the Italian MDS-UPDRS, the CFI, in comparison with the English-language data, was ≥0.94. Exploratory factor analyses revealed some differences between the two datasets, however these differences were considered to be within an acceptable range. The Italian version of the MDS-UPDRS reaches the criterion to be designated as an Official Translation and is now available for use. This protocol will serve as outline for further validation of this in multiple languages.
  Neurological Sciences 06/2012; · 1.32 Impact Factor
• Article: The FRAGAMP study: environmental and genetic factors in Parkinson’s disease, methods and clinical features

  Alessandra Nicoletti, Pierfrancesco Pugliese, Giuseppe Nicoletti, Gennarina Arabia, Grazia Annesi, Michele De Mari, Paolo Lamberti, Simone Gallerini, Roberto Marconi, Antonio Epifanio, Letterio Morgante, Autilia Cozzolino, Paolo Barone, Giuseppina Torchia, Aldo Quattrone, Mario Zappia
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  ABSTRACT: The Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson (FRAGAMP) study is a multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in Parkinson’s disease (PD). Cases and controls were enrolled from five Movement Disorder centers in Central-Southern Italy. PD was diagnosed according to Gelb’s criteria while the control groups consisted of the spouses of the enrolled patients or of healthy controls matched by age and area of residence. Cases and controls underwent a standardised questionnaire and a blood sample was taken for molecular analyses. At the end of the study 585 cases and 481 control subjects (287 spouse-controls and 194 generic-controls) were enrolled. Patients had a Hoehn–Yahr score of 2.3±0.8; 85% of them took levodopa and 47% had motor complications. The FRAGAMP study represents one of the largest case–control studies carried out in Europe to investigate the possible role of environmental and genetic factors in PD.
  Neurological Sciences 04/2012; 31(1):47-52. · 1.32 Impact Factor
• Article: Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders.

  Roberto Marconi, Angelo Antonini, Paolo Barone, Carlo Colosimo, Tania P Avarello, Edo Bottacchi, Antonino Cannas, Maria G Ceravolo, Roberto Ceravolo, Giulio Cicarelli, [......], Anna Rita Bentivoglio, Fabrizio Stocchi, Giorgio Trianni, Paolo Del Dotto, Danilo De Gaspari, Lucia Grasso, Francesca Morgante, Gabriella Santangelo, Giovanni Fabbrini, Letterio Morgante
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  ABSTRACT: Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.
  Neurological Sciences 11/2011; 33(3):585-93. · 1.32 Impact Factor
• Article: Reproductive factors and Parkinson's disease: a multicenter case-control study.

  Alessandra Nicoletti, Giuseppe Nicoletti, Gennarina Arabia, Grazia Annesi, Michele De Mari, Paolo Lamberti, Lucia Grasso, Roberto Marconi, Antonio Epifanio, Letterio Morgante, Autilia Cozzolino, Paolo Barone, Aldo Quattrone, Mario Zappia
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  ABSTRACT: The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression). Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24-8.59; P = .01). Our data suggest that oral contraceptives could increase the risk of PD.
  Movement Disorders 09/2011; 26(14):2563-6. · 4.51 Impact Factor
• Article: Psychosis associated to Parkinson's disease in the early stages: relevance of cognitive decline and depression.

  Letterio Morgante, Carlo Colosimo, Angelo Antonini, Roberto Marconi, Giuseppe Meco, Massimo Pederzoli, Francesco E Pontieri, Giulio Cicarelli, Giovanni Abbruzzese, Salvatore Zappulla, Silvia Ramat, Michela Manfredi, Edo Bottacchi, Michele Abrignani, Alfredo Berardelli, Autilia Cozzolino, Claudio Paradiso, Danilo De Gaspari, Francesca Morgante, Paolo Barone
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  ABSTRACT: To evaluate the prevalence of psychosis associated with Parkinson's disease (PSY-PD) in its early stages, its incidence over a 24 month follow-up period and the association with motor and non-motor clinical features. PRIAMO is a 2 year longitudinal observational study that has enrolled patients with parkinsonism in 55 Italian centres. A cohort of 495 patients with early disease stage PD (baseline Hoehn and Yahr score ≤ 2, disease's duration (median) 3.4 years) were followed for 2 years. PSY-PD was evaluated by means of a clinician rated questionnaire and defined as the presence of at least one of the following symptoms occurring for at least 1 month: illusions, hallucinations, jealousy ideas and persecutory ideas. Patients with and without PSY-PD were compared on several clinical variables, encompassing motor and non-motor features. The prevalence of PSY-PD at baseline was 3%; the incidences at 12 and 24 months were 5.2% and 7.7%, respectively. Longer disease duration and prescription of dopamine agonists at baseline were associated with the development of PSY-PD over the 24 month period. At this follow-up time, worse disease severity, decline in cognitive performances, presence of depressive symptoms and anxiety were more frequently observed in PSY-PD. Psychotic type symptoms may occur in the early stages of PD although less frequently than in later stages. Beyond dopaminergic treatment, there are disease related factors, such as disease severity and the occurrence of cognitive and depressive symptoms, which may underlie the onset of psychotic type symptoms from the earliest stages.
  Journal of neurology, neurosurgery, and psychiatry 08/2011; 83(1):76-82. · 4.87 Impact Factor
• Article: Wine drinking and essential tremor: a possible protective role.

  Alessandra Nicoletti, Giovanni Mostile, Roberto Cappellani, Donatella Contrafatto, Gennarina Arabia, Paolo Lamberti, Roberto Marconi, Letterio Morgante, Paolo Barone, Aldo Quattrone, Mario Zappia
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  ABSTRACT: The purpose of this study was to evaluate the possible association of cigarette smoking, coffee drinking, and wine consumption with essential tremor using a matched case-control design. Cases and controls were enrolled from 6 Movement Disorder centers in central-southern Italy. Essential tremor was diagnosed according to Bain's criteria. Three unrelated healthy controls (not affected by neurological disorders) per each enrolled case, matched by sex and age (± 5 years), were selected. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. All cases and controls underwent a standard neurological examination. Adjusted odds ratios and 95% confidence intervals were estimated using conditional logistic regression for the matched cases and controls. Eighty-three patients with essential tremor (38 men and 45 women; mean age, 68.2 ± 8.6 years) and 245 matched control subjects (113 men and 132 women; mean age, 68.4 ± 9.7 years) were enrolled in the study. Multivariate analysis showed a significant negative association between essential tremor and wine consumption preceding the onset of disease (adjusted odds ratio, 0.23; 95% confidence interval, 0.08-0.64; P = .0005) with a significant dose effect (1-2 glass of wine per day: odds ratio, 0.32; 95% confidence interval, 0.10-0.95; P = .04; more than 3 glass of wine per day: odds ratio, 0.14; 95% confidence interval, 0.03-0.62; P = .01). In our sample no association between essential tremor and cigarette smoking or coffee drinking was found. Our data suggest a negative association between wine drinking and essential tremor, which could be explained by the long-term neuroprotective effect of its antioxidant components.
  Movement Disorders 06/2011; 26(7):1310-5. · 4.51 Impact Factor
• Article: Voluptuary habits and clinical subtypes of Parkinson's disease: the FRAGAMP case-control study.

  Alessandra Nicoletti, Pierfrancesco Pugliese, Giuseppe Nicoletti, Gennarina Arabia, Grazia Annesi, Michele De Mari, Paolo Lamberti, Lucia Grasso, Roberto Marconi, Antonio Epifanio, Letterio Morgante, Autilia Cozzolino, Paolo Barone, Giusi Torchia, Aldo Quattrone, Mario Zappia
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  ABSTRACT: We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.
  Movement Disorders 10/2010; 25(14):2387-94. · 4.51 Impact Factor
• Article: The FRAGAMP study: environmental and genetic factors in Parkinson's disease, methods and clinical features.

  Alessandra Nicoletti, Pierfrancesco Pugliese, Giuseppe Nicoletti, Gennarina Arabia, Grazia Annesi, Michele De Mari, Paolo Lamberti, Simone Gallerini, Roberto Marconi, Antonio Epifanio, Letterio Morgante, Autilia Cozzolino, Paolo Barone, Giuseppina Torchia, Aldo Quattrone, Mario Zappia
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  ABSTRACT: The Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson (FRAGAMP) study is a multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in Parkinson's disease (PD). Cases and controls were enrolled from five Movement Disorder centers in Central-Southern Italy. PD was diagnosed according to Gelb's criteria while the control groups consisted of the spouses of the enrolled patients or of healthy controls matched by age and area of residence. Cases and controls underwent a standardised questionnaire and a blood sample was taken for molecular analyses. At the end of the study 585 cases and 481 control subjects (287 spouse-controls and 194 generic-controls) were enrolled. Patients had a Hoehn-Yahr score of 2.3 +/- 0.8; 85% of them took levodopa and 47% had motor complications. The FRAGAMP study represents one of the largest case-control studies carried out in Europe to investigate the possible role of environmental and genetic factors in PD.
  Neurological Sciences 11/2009; 31(1):47-52. · 1.32 Impact Factor
• Article: Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study.

  Carlo Colosimo, Letterio Morgante, Angelo Antonini, Paolo Barone, Tania P Avarello, Edo Bottacchi, Antonino Cannas, Maria Gabriella Ceravolo, Roberto Ceravolo, Giulio Cicarelli, [......], Silvia Ramat, Rossana Scala, Giampiero Volpe, Salvatore Zappulla, Anna Rita Bentivoglio, Fabrizio Stocchi, Giorgio Trianni, Paolo Del Dotto, Lucia Simoni, Roberto Marconi
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  ABSTRACT: The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.
  Journal of Neurology 09/2009; 257(1):5-14. · 3.47 Impact Factor
• Article: The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease.

  Paolo Barone, Angelo Antonini, Carlo Colosimo, Roberto Marconi, Letterio Morgante, Tania P Avarello, Eugenio Bottacchi, Antonino Cannas, Gabriella Ceravolo, Roberto Ceravolo, [......], Francesco E Pontieri, Rocco Quatrale, Silvia Ramat, Rosanna Scala, Giuseppe Volpe, Salvatore Zappulla, Anna Rita Bentivoglio, Fabrizio Stocchi, Giorgio Trianni, Paolo Del Dotto
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  ABSTRACT: We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0-32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ-39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales.
  Movement Disorders 07/2009; 24(11):1641-9. · 4.51 Impact Factor
• Article: Myocardial (123)I-MIBG scintigraphy for differentiation of Lewy bodies disease from FTD.

  Fabiana Novellino, Antonio Bagnato, Maria Salsone, Giuseppe Lucio Cascini, Giuseppe Nicoletti, Gennarina Arabia, Pierfrancesco Pugliese, Maurizio Morelli, Sandra Paglionico, Stefania Cipullo, Ida Manna, Elvira Valeria De Marco, Francesca Condino, Carmelina Chiriaco, Letterio Morgante, Mario Zappia, Aldo Quattrone
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  ABSTRACT: Clinical distinction between Lewy bodies disease (LBD) and frontotemporal dementia (FTD) is sometimes difficult. Nigrostriatal dopaminergic degeneration occurs in both LBD and FTD, limiting helpfulness of DAT imaging to differentiate these forms of dementia. Several studies have emphasized the usefulness of myocardial scintigraphy with (123)Metaiodobenzylguanidine ((123)I-MIGB) in assessing the sympathetic nerve terminals in LBD demonstrating that cardiac (123)I-MIGB uptake is decreased in patients with this disease. We investigated the role of cardiac (123)I-MIBG scintigraphy in differentiating patients with LBD from those with FTD. Clinical diagnosis of LBD and FTD was determined according to established consensus criteria. Nine patients with LBD (1 possible and 8 probable), 6 patients with FTD, and 16 control subjects were involved in the study. The heart to mediastinum ratio (H/M) of (123)I-MIBG uptake was markedly reduced in all patients with LBD (H/M early: 1.25±0.12; delayed: 1.14±0.13) whereas it was normal in patients with FTD (H/M early: 1.86±0.20; delayed: 1.80±0.23) and in controls (H/M early: 1.91±0.17; delayed: 1.99±0.19), suggesting that cardiac (123)I-MIBG scintigraphy can help distinguish patients with LBD from those with FTD.
  Neurobiology of aging 02/2009; 31(11):1903-11. · 5.94 Impact Factor
• Article: Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease

  Giuseppe Nicoletti MD, Caterina Tonon MD, Raffaele Lodi MD, Francesca Condino PhD, David Manners DPhil, Emil Malucelli PhD, Maurizio Morelli MD, Fabiana Novellino MD, Sandra Paglionico MD, Pierluigi Lanza MD, [......], Maurizio Morelli, Fabiana Novellino, Sandra Paglionico, Pierluigi Lanza, Demetrio Messina, Paolo Barone, Letterio Morgante, Mario Zappia, Bruno Barbiroli, Aldo Quattrone
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  ABSTRACT: The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA-P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA-P in order to evaluate its differential diagnostic value in vivo. Twenty-eight patients with PSP (14 with possible-PSP and 14 with probable-PSP), 15 PD, 15 MSA-P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA-P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA-P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society
  Movement Disorders 12/2008; 23(16):2370 - 2376. · 4.51 Impact Factor
• Article: Cardiac MIBG scintigraphy in Primary Progressive Freezing Gait.

  Maria Salsone, Antonio Bagnato, Fabiana Novellino, Giuseppe Lucio Cascini, Sandra Paglionico, Stefania Cipullo, Maurizio Morelli, Pierfrancesco Pugliese, Giuseppe Nicoletti, Demetrio Messina, Francesca Condino, Gennarina Arabia, Letterio Morgante, Aldo Quattrone
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  ABSTRACT: Freezing of gait (FOG) generally occurs as a late manifestation of Parkinson's Disease (PD). FOG, however, can present in isolation, constituting the so-called "Primary Progressive Freezing Gait"(PPFG). Myocardial (123)Metaiodiobenzylguanidine (MIBG) enables the assessment of postganglionic sympathetic cardiac nerve terminals. MIBG uptake reflects sympathetic system integrity, and reduced myocardial uptake of the tracer has been observed in nearly all patients with PD. We investigated MIBG uptake in 7 patients with PPFG, 14 patients with mild PD, and 6 patients with advanced PD and FOG (PD-FOG), and 18 control subjects. Our study shows that myocardial MIBG uptake was normal in all patients with PPFG (H/M ratio: mean+/-SD, 1.85+/-0.11 early; 1.71+/-0.15 delayed) and in the controls (H/M ratio: mean+/-SD, 1.94+/-0.18 early; 2.02+/-0.19 delayed) whereas it was markedly decreased in the patients with mild and advanced PD (H/M ratio: mean+/-SD, PD: 1.17+/-0.02 early; 1.16+/-0.02 delayed; PD-FOG: 1.22+/-0.10 early; 1.08+/-0.06 delayed). Our findings demonstrate that cardiac sympathetic denervation did not occur in patients with PPFG, confirming that PPFG and PD are distinct diseases.
  Parkinsonism & Related Disorders 12/2008; 15(5):365-9. · 3.80 Impact Factor
• Article: Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005.

  Gianluca Trifirò, Rodolfo Savica, Letterio Morgante, Nicola Vanacore, Michele Tari, Salvatore Moretti, Mariella Galdo, Edoardo Spina, Achille P Caputi, Vincenzo Arcoraci
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  ABSTRACT: Aim of this study was to evaluate prevalence of use and prescribing pattern of Anti-Parkinson Drugs (APDs) in general practice of Southern Italy. Among 120,000 individuals registered in the lists of 93 general practitioners of Southern Italy, we estimated one-year prevalence and incidence of APD use in the years 2003-2005. Overall, prevalence of APD use remained stable over the years and it strongly increased in subjects over 70 years of age. L-Dopa with a dopa decarboxylase inhibitor was the most frequently prescribed APD, although the use of both ergot and non-ergot derivative DAs has increased, particularly, in the elderly. A high proportion of APD users (15-20%) received only one prescription during the study period.
  Parkinsonism & Related Disorders 08/2008; 14(5):420-5. · 3.80 Impact Factor
• Article: Long-term survival and outcome after first stroke in the Sicilian Aeolian Island Archipelago population.

  Paolino La Spina, Rodolfo Savica, Salvatore Serra, Rocco Salvatore Calabrò, Paolo Postorino, Letterio Morgante, Giovanni Savettieri, Rosa Musolino
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  ABSTRACT: Only a restricted number of population studies based on long-term prognosis after a stroke have been published. We analyzed long-term survival and outcome in insular first-ever stroke population from the Aeolian Archipelago. From 1 July, 1999 to 30 June 2002, 62 patients with first-ever stroke were recruited to evaluate short-term incidence and outcome. Information for every patient was collected by phone interviews after 3 months, 1 year, and 4 years. 30 days case fatality rate was 24.2% (95% C.I. 14.22 to 36.75). Fifty-one percent (95% C.I. 35.8 to 66.3) of patients died before last survey and 39.1% died during the first year of follow-up. Annual approximate death risk amounted to about 10%. The cerebrovascular causes were the most frequent causes of death (65.2%). A high level of invalidity at 4 years was present in many survivors (40%). None of the deceased had followed physio-kinesitherapy, or applied for equipment or services. More attentive medical care for stroke patients could help improve outcome, reducing mortality for patients from the Aeolian island, who already showed a low incidence.
  Neurological Sciences 07/2008; 29(3):153-6. · 1.32 Impact Factor
• Article: The PRIAMO study: background, methods and recruitment.

  Angelo Antonini, Carlo Colosimo, Roberto Marconi, Letterio Morgante, Paolo Barone
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  ABSTRACT: PRIAMO (PaRkinson And non Motor symptOms) is an epidemiology study aimed to assess the prevalence and incidence of non-motor symptoms (NMS) in patients with parkinsonism. PRIAMO consists of two phases: (1) a transversal assessment of the prevalence of NMS and (2) a longitudinal observation with two follow-up visits at 12 and 24 months to establish the incidence of NMS. A secondary aim of PRIAMO is to study the relationship between NMS and quality of life. Patients with parkinsonism have been evaluated in 59 Neurology Centres widely distributed throughout Italy. PRIAMO has analysed a total of 1307 patients (out of 1325 initially enrolled). We expect that PRIAMO will substantially help to quantify the burden of NMS in patients with parkinsonism.
  Neurological Sciences 05/2008; 29(2):61-5. · 1.32 Impact Factor
• Article: Burden of cardiovascular diseases in elderly with Parkinson's disease who start a dopamine agonist agent.

  Gianluca Trifirò, Letterio Morgante, Michele Tari, Vincenzo Arcoraci, Rodolfo Savica
  Journal of the American Geriatrics Society 03/2008; 56(2):371-3. · 3.74 Impact Factor