Laurence Vaivre-Douret

Université Paris-Sorbonne - Paris IV, Lutetia Parisorum, Île-de-France, France

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Publications (39)46.6 Total impact

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    ABSTRACT: Parents with past and current eating disorders (ED) have been shown to report troubles nourishing their infants. This could increase the risk of infant feeding problems linked to maternal anxiety and depression. It is not clear how mothers' eating difficulties before pregnancy and at the time of birth can affect infant's feeding. We aimed to specify the impact of eating disorders on mothers' adaptation and sensitivity to their offspring during feeding, by comparing a population of mothers with eating disorders and controls.
    BMC Pregnancy and Childbirth 08/2014; 14(1):274. · 2.52 Impact Factor
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    ABSTRACT: Our aim was to study horizontal and vertical smooth pursuit eye movements in children with developmental coordination disorder (DCD). Horizontal and vertical smooth pursuit eye movements of 91 children were studied using electro-oculography: 27 children with DCD (23 males, four females), according to the DSM-IV-TR criteria, and 64 comparison children (26 males, 38 females). All children were 7 to 12 years old (mean 9y, SD 1.5y). Among the group of children with DCD, eight had received intervention. Intervention exercised static and dynamic fixation, saccades, visual strategies, visuospatial abilities, and eye-hand coordination. A smooth pursuit gain index was calculated and statistical comparisons were made between the two groups of children. Horizontal pursuit gain was similar in both populations, but vertical pursuit gain was significantly impaired (p<0.001, after adjusting for age as covariate), i.e. more saccadic in children with DCD (18-99%; n=27, mean 51.6%, median 48.5%, SD 23.2%) than in comparison participants (35-97%; n=63, mean 66.4%, median 65.0%, SD 15.4%). Among the DCD group, the vertical pursuit index was also significantly higher (p=0.009) in the intervention subgroup (29-99%; n=8, mean 69.4%, median 75.5%, SD 28.7%) than in the non-intervention subgroup (18-74%; n=19, mean 44.1%, median 42.5%, SD 15.9%). These results suggest a delay in the maturation of the pursuit system in children with DCD.
    Developmental Medicine & Child Neurology 01/2014; · 2.68 Impact Factor
  • K Busiah, L Vaivre-Douret, C Yachi, H Cavé, M Polak
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    ABSTRACT: Neonatal diabetes mellitus is a rare condition (1/90,000 to 1/260,000 live births) defi ned as mild-to-severe hyperglycemia within the fi rst year of life. Permanent neonatal diabetes mellitus requires lifelong therapy, whereas transient form resolves early in life but may relapse later on. Two main physiopathological mechanisms may explain this disease: β cell functional impairment or absence (pancreas agenesis or β cells destruction). The main genetic causes of β cells impairment are 6q24 abnormalities and mutations in ABCC8 or KCNJ11 potassium channel (KATP channel) genes. Compared to the KATP subtype, the 6q24 subtype had specifi c features: developmental defects involving the heart, kidneys, or urinary tract, intrauterine growth restriction, and early diagnosis. Remission of neonatal diabetes mellitus occurred in 51 % of probands at a median age of 17 weeks. Recurrence was common at pubertal age, with no difference between the 6q24 and KATPchannel groups (82 % vs 86 %, p=0,36, respectively). Patients with mutations in ABCC8 or KCNJ11 genes had developmental delay with or without epilepsy but also developmental coordination disorder (particularly visual-spatial dyspraxia) or attention defi cits in all of those who underwent in-depth neuropsychomotor investigations..
    Archives de Pédiatrie 12/2013; 20 Suppl 4:S117-26. · 0.36 Impact Factor
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    ABSTRACT: Postpartum blues may promote a certain openness to emotional exchange between mother and her infant. Groups of mothers were assembled according to various types of emotional expression demonstrated during early postpartum. Links between mothers’ groups and newborns’ neuropsychomotor characteristics were assessed. Twenty‐one mother–infant dyads were included at maternity wards. A semistructured interview was established to identify symptoms of the blues and classify mothers into clinical groups: ordinary and emotionally mixed postpartum blues (OB); sad, intense, and lasting blues; or without blues. Newborns were examined using the Neonatal Behavioral Assessment Scale (T.B. Brazelton & J.K. Nugent, ). Cluster analysis revealed a two‐class structure, where 78% of women with OB were found to belong to the same class, with a higher median score on newborn “hand‐to‐mouth activity” which correlated to self‐quieting activity, heightened regulation of awake states, decreased need for adult support, better defensive movements, greater attentiveness, and diminished irritability. The acquired faculties demonstrated by newborns whose mothers experience OB reflect a distinct skillset of neuropsychomotor maturity.
    Infant Mental Health Journal 11/2013; 34(6). · 0.61 Impact Factor
  • Elisabeth Lasserre, Laurence Vaivre-Douret, Véronique Abadie
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    ABSTRACT: Objective: We aimed to understand the mechanisms and sources of learning difficulties in children with CHARGE syndrome who attend school and to determine any specific developmental characteristics. Method: We analyzed the psychomotor and cognitive functions of eight children from 7 to 13 years old with classical CHARGE syndrome by using the Wechsler Intelligence Scale for Children (WISC), the Neuropsychomotor test (NP-MOT), and several subtests of the Developmental neuropsychological assessment (NEPSY) and Kaufman Assessment Battery for Children (K-ABC) instruments. Results: The IQ range was from 54 to 92. The main weaknesses related to three domains: static and dynamic postural control, visuospatio-constructive abilities, and both sequential processing and selective attention. The main strengths were in holistic perception, semantic competencies, logical reasoning and planning skills, with axial and peripheral hypotonia. The extent of psychomotor and cognitive deficits was not associated with severity of sensorial deficiencies. We discuss the multiple causal mechanisms of psychomotor and cognitive difficulties. Conclusion: We found a persistent and homogeneous psychomotor profile and specific cognitive difficulties in 8 children with CHARGE syndrome despite their large range of IQs. Highlighting these specific impairments is important to understand the nature and mechanisms of CHARGE for adapting educational and rehabilitation methods. These problems may be explained by sensory deficits, as well as dysfunction in integrating and/or regulatory regions of the brain.
    Child Neuropsychology 09/2013; 19(5):449-65. · 2.24 Impact Factor
  • L. Vaivre-Douret
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    ABSTRACT: À partir d’une revue de la littérature, les descriptions des enfants ayant des difficultés de coordination motrice et des mouvements maladroits ont été discutées depuis le début du 19e siècle. Selon le manuel diagnostique et statistique des troubles mentaux (DSM-IV), il s’agit d’un trouble avéré au niveau du développement de la coordination motrice fine et globale, touchant 6 % des enfants scolarisés. Tous ces enfants sont caractérisés par un trouble de l’acquisition de la coordination motrice (TAC) au niveau de l’apprentissage moteur et des nouvelles acquisitions d’habileté motrice, contrairement à l’apraxie chez l’adulte pour lequel il s’agit d’un trouble de l’exécution des mouvements déjà appris. Aucun consensus n’a été établi à propos de l’étiologie du TAC. L’approche intragroupe par une analyse factorielle et de classification souligne qu’un trouble moteur chez des enfants porteurs d’un TAC varie à la fois au niveau de la sévérité et de la nature du trouble. En effet, la plupart des études ont utilisé des mesures de screening de la performance sur quelques items développementaux basés sur des tests moteurs globaux. Peu d’études ont investigué un ensemble de différentes fonctions avec des évaluations standardisées, telles que le tonus musculaire et les signes neurologiques doux, sur des mesures quantitatives et qualitatives de la coordination motrice globale et fine, et sur des difficultés spécifiques – académique, langage, gnosique, visuo-motrice/visuo-perceptive et attentionnelle/exécutive – afin de permettre une meilleure identification des sous-groupes de TAC avec des critères diagnostiques et de fournir une compréhension des mécanismes et des zones cérébrales en jeu.
    Neurophysiologie Clinique/Clinical Neurophysiology 01/2013; · 2.55 Impact Factor
  • Neurophysiologie Clinique/Clinical Neurophysiology 12/2012; 42(6):399–400. · 2.55 Impact Factor
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    ABSTRACT: Specific language impairment (SLI) is a primary developmental disorder in which language is significantly more impaired than other developmental domains. Abnormal electroencephalographic recordings without clinical seizures are often observed. The aim of this retrospective study was to characterize the frequency of these abnormalities, to describe them and to analyze their association with anamnestic, clinical, paraclinical and evolution characteristics. The cases of 35 children with a diagnosis of SLI, who also underwent electroencephalography and MRI, were systematically reviewed retrospectively. In this population, aged between 4 and 7 years, 49% (n=17) of patients exhibited a specific expressive language disorder and 51% (n=18) a specific receptive disorder. Forty-nine percent of the children featured abnormal electroencephalography results. Abnormalities were essentially localized on the left side of the brain and in two specific regions: the temporo-occipital (60%) and the frontorolandic (30%) regions. The groups with and without abnormalities were compared statistically with each other in terms of clinical, paraclinical and evolution characteristics. Evolution data were available for 24 patients through a telephone interview and for nine patients through a new complete language evaluation. The comparison of the two groups showed significant differences in terms of severity of the phonological disorder, a higher number of delayed acquisition of walking and cleanliness and a higher range of non specific psychomotor difficulties. A large proportion of children suffering from SLI present abnormal electroencephalography recordings with no clinical seizures. This rate is much higher than in the general population and the abnormalities are essentially localized on the left side of the brain in regions known for their specific role in language development. These abnormalities are more frequent in children with a severe phonological disorder, suggesting that they may share common pathophysiological features with SLI. The presence of EEG abnormalities in a large group of patients suffering from SLI associated with minor neurological abnormalities suggests a possible theoretical neurodevelopmental model. Minor neurodevelopmental abnormalities, genetically transmitted or acquired during the pre- or perinatal period, may create vulnerability towards SLI. This vulnerability, in conjunction with environmental influences such as family environment, linguistic stimuli, exposure to multiple languages, or transitory hearing loss, might take the form of SLI. This hypothesis underlines the importance of prevention and early detection of SLI when identifying vulnerable subjects. Monitoring the family early through parental guidance and early school support would facilitate the acquisition of language.
    L Encéphale 09/2012; 38(4):318-28. · 0.49 Impact Factor
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    ABSTRACT: With a large number of potentially relevant clinical indicators penalization and ensemble learning methods are thought to provide better predictive performance than usual linear predictors. However, little is known about how they perform in clinical studies where few cases are available. We used Random Forests and Partial Least Squares Discriminant Analysis to select the most salient impairments in Developmental Coordination Disorder (DCD) and assess patients similarity. We considered a wide-range testing battery for various neuropsychological and visuo-motor impairments which aimed at characterizing subtypes of DCD in a sample of 63 children. Classifiers were optimized on a training sample, and they were used subsequently to rank the 49 items according to a permuted measure of variable importance. In addition, subtyping consistency was assessed with cluster analysis on the training sample. Clustering fitness and predictive accuracy were evaluated on the validation sample. Both classifiers yielded a relevant subset of items impairments that altogether accounted for a sharp discrimination between three DCD subtypes: ideomotor, visual-spatial and constructional, and mixt dyspraxia. The main impairments that were found to characterize the three subtypes were: digital perception, imitations of gestures, digital praxia, lego blocks, visual spatial structuration, visual motor integration, coordination between upper and lower limbs. Classification accuracy was above 90% for all classifiers, and clustering fitness was found to be satisfactory. Random Forests and Partial Least Squares Discriminant Analysis are useful tools to extract salient features from a large pool of correlated binary predictors, but also provide a way to assess individuals proximities in a reduced factor space. Less than 15 neuro-visual, neuro-psychomotor and neuro-psychological tests might be required to provide a sensitive and specific diagnostic of DCD on this particular sample, and isolated markers might be used to refine our understanding of DCD in future studies.
    BMC Medical Research Methodology 07/2012; 12:107. · 2.21 Impact Factor
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    ABSTRACT: Background Specific language impairment (SLI) is a primary developmental disorder in which language is significantly more impaired than other developmental domains. Abnormal electroencephalographic recordings without clinical seizures are often observed. The aim of this retrospective study was to characterize the frequency of these abnormalities, to describe them and to analyze their association with anamnestic, clinical, paraclinical and evolution characteristics. Methods The cases of 35 children with a diagnosis of SLI, who also underwent electroencephalography and MRI, were systematically reviewed retrospectively. Results In this population, aged between 4 and 7 years, 49% (n = 17) of patients exhibited a specific expressive language disorder and 51% (n = 18) a specific receptive disorder. Forty-nine percent of the children featured abnormal electroencephalography results. Abnormalities were essentially localized on the left side of the brain and in two specific regions: the temporo-occipital (60%) and the frontorolandic (30%) regions. The groups with and without abnormalities were compared statistically with each other in terms of clinical, paraclinical and evolution characteristics. Evolution data were available for 24 patients through a telephone interview and for nine patients through a new complete language evaluation. The comparison of the two groups showed significant differences in terms of severity of the phonological disorder, a higher number of delayed acquisition of walking and cleanliness and a higher range of non specific psychomotor difficulties. Discussion A large proportion of children suffering from SLI present abnormal electroencephalography recordings with no clinical seizures. This rate is much higher than in the general population and the abnormalities are essentially localized on the left side of the brain in regions known for their specific role in language development. These abnormalities are more frequent in children with a severe phonological disorder, suggesting that they may share common pathophysiological features with SLI. Conclusion The presence of EEG abnormalities in a large group of patients suffering from SLI associated with minor neurological abnormalities suggests a possible theoretical neurodevelopmental model. Minor neurodevelopmental abnormalities, genetically transmitted or acquired during the pre- or perinatal period, may create vulnerability towards SLI. This vulnerability, in conjunction with environmental influences such as family environment, linguistic stimuli, exposure to multiple languages, or transitory hearing loss, might take the form of SLI. This hypothesis underlines the importance of prevention and early detection of SLI when identifying vulnerable subjects. Monitoring the family early through parental guidance and early school support would facilitate the acquisition of language.
    L Encéphale 01/2012; 38:318-328. · 0.49 Impact Factor
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    ABSTRACT: The aim of the study was to identify clear clinical signs and symptoms, which are specific of developmental coordination disorder (DCD) or developmental dyspraxia subtypes.
    Neuropsychiatrie De L'enfance Et De L'adolescence. 12/2011;
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    ABSTRACT: Children with Developmental Coordination Disorder (DCD) are a group embracing clumsiness and developmental dyspraxia. Our study provides a better understanding of the nature of DCD and its etiology, and identifies subtypes of dyspraxia. Forty-three children with DCD (5-15 years) were enrolled on the Diagnostic and Statistical Manual of Mental Disorders (4th ed. [DSM-IV-TR]; American Psychiatric Association, 2000) criteria. Extensive standardized evaluations were conducted. We distinguished from two patterns of "pure" developmental dyspraxia: ideomotor and visual-spatial/visual-constructional, and mix dyspraxia with more co-morbidities. Our study provides a better understanding of the nature of DCD, and sheds light on its etiology and brain dysfunction, so as to identify subtypes of developmental DCD/dyspraxia with specific clinical criteria.
    Developmental Neuropsychology 07/2011; 36(5):614-43. · 2.90 Impact Factor
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    Laurence Vaivre-Douret
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    ABSTRACT: This study covers the interesting field of the development in gifted children which is often neglected in pediatrics because psychomotor development data are still rare, since "gifted" children are generally noticed towards the end of their primary schooling by IQ measurement. Developmental studies have shown the evidence from several fields that children identified as "high-level potentialities" or "intellectually gifted" develop sensory, locomotor, neuropsychological, and language skills earlier than typically expected. The hypothesis is offered that the earlier development originates from biological processes affecting the physical development of the brain and in turn even intellectual abilities are developed earlier, potentially allowing for advanced development. Further it is discussed how these developmental advances interact with the social environment and in certain circumstances may entail increased risk for developing socioemotional difficulties and learning disabilities that often go unaddressed due to the masking by the advance intellectual abilities.
    International Journal of Pediatrics 01/2011; 2011:420297.
  • Neurophysiologie Clinique-clinical Neurophysiology - NEUROPHYSIOL CLIN. 01/2011; 41(4):219-219.
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    ABSTRACT: Data on growth status at birth in a French sample of gifted children identified at school age were analysed in a retrospective survey. Birth weight, gestational age, head circumference, stature, gender, parental socio-economic status, information on the pregnancy, and motor development were recorded. On the basis of standard growth curves, the sample was characterised according to the 10th, 50th, 75th and 90th percentiles. Three groups of gestational age were determined: preterm births (18.6%), full term births (63.2%) and post-term births (18.1%) with a high frequency of hypertrophy in preterm births (≥ 90th). Intellectual quotient (IQ) did not differ among the groups, showing a notable advance in motor development. This research shows that, among children later identified as gifted, compared to those born full term, preterm infants showed a significant relationship between homogeneity in anthropometric variables and future motor and intellectual development when these children were exposed to a favourable perinatal environment (few pregnancy complications) and a favourable postnatal parental socio-economic status.RésuméLes relations entre la croissance staturo pondérale à la naissance et le développement moteur et cognitif d’un échantillon d’enfants français surdoués. Les données sur la croissance staturo pondérale à la naissance sur un échantillon français d’enfants surdoués identifiés à l’âge scolaire, ont été analysées. Dans une enquête rétrospective, nous avons enregistré le poids de naissance, l’âge gestationnel, le périmètre crânien, la taille, le sexe, le satut socioéconomique des parents, des informations sur la grossesse et sur le développement moteur. Sur la base des courbes officielles de croissance, l’échantillon a été classé en fonction des 10e, 50, 75 et 90e percentiles. Trois groupes d’âge gestationnel ont été déterminés à la naissance : prématurés (18,6 %), à terme (63,2 %) et post-terme (18,1 %) avec une haute fréquence d’hypertrophiques (> 90e). Le quotient intellectuel ne diffère pas entre les groupes, montrant une avance notable du développement moteur. Cette recherche met en évidence que parmi les enfants identifiés surdoués, les enfants prématurés comparés à ceux nés à terme montrent une relation significative entre des variables anthropométriques homogènes et leur futur développement moteur et intellectuel quand ces enfants sont exposés à un environnement périnatal (avec peu de complications pendant la grossesse) et socioéconomique parental postnatal favorable.
    Revue Européenne de Psychologie Appliquée/European Review of Applied Psychology. 01/2010; 60(1):1–9.
  • Laurence Vaivre-Douret, Bernard Golse, Nelly Thomas, Jean-Claude Janaud
    Soins. Pediatrie, puericulture 10/2009;
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    ABSTRACT: Preterm newborns admitted to the Neonatal Intensive Care Unit are deprived of sensory stimulation. Tactile/kinaesthetic stimulation results in weight gain. Studies involving the cutaneous application of vegetable oils have shown improvement in somatic growth and on skin barrier function. To assess the neurodevelopmental and biological benefits of the simultaneous use of multimodal stimulation (SMS) and the cutaneous application of vegetable oils. Setting Tertiary referral centre serving the Poitou-Charentes region of France. Randomized controlled trial of 49 low-risk preterm infants, born at 31- to 34-week gestation. Each infant was randomly assigned to one of three treatment groups, Sensori-Tonico-Motor (STM) touch for 10 days with either: sweet almond oil, ISIO4 blended oil, or placebo - normal saline, or to a control group who did not receive any intervention. The primary outcome was weight gain. Secondary outcomes were linear growth, neurological maturation, psychomotor development and number of days of admission. Analysis was by intention-to-treat. The group who received STM with ISIO4 oil demonstrated enhanced weight gain (+57%, 95% CI 37-76) compared with controls (P = 0.030). All STM groups showed shorter admission times (mean reduction 15 days, 95% CI 23-50 days hospitalised, P = 0.005), and an increase in body length (P = 0.030). Both groups of oil massaged babies (almond and ISIO4) showed an increased neurological score (P = 0.001) compared to controls. The infants receiving ISIO4 oil had an associated increase in psychomotor scores (P = 0.028), time spent in quiet wakefulness (P = 0.036), improved orientation (P = 0.036), and enhanced development of the oculomotor (P = 0.012) and sensorimotor (P = 0.003) systems. An additional benefit seen was improved moisturization (P = 0.001), and quicker recovery of dermatological conditions. No adverse dermatological events were observed. The combination of STM and cutaneous application of oils to healthy preterm babies resulted in enhanced weight gain and neurological development, and a shorter stay in hospital.
    Child Care Health and Development 11/2008; 35(1):96-105. · 1.70 Impact Factor
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    ABSTRACT: An evaluation of eye movements is very useful in neurological disorders but is complicated by issues such as maturation and lack of normative data in children. In order to address these issues we studied smooth pursuit eye movements of 65 normal children aged 7-11 years old. The gain of horizontal smooth pursuit (HSP) was higher than the gain of the vertical smooth pursuit (SP) and this difference had a statistical tendency to disappear with aging from 7 to 11 years. These data suggest that, in the cerebral regions involved in the control of SP, i.e. posterior parietal and superior temporal lobe regions, the networks for VSP mature latter than those for HSP.
    European journal of paediatric neurology: EJPN: official journal of the European Paediatric Neurology Society 10/2008; 13(4):362-6. · 2.01 Impact Factor
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    ABSTRACT: The 22q13.3 deletion syndrome (Online Mendelian Inheritance in Man No. 606232) is a neurodevelopmental disorder that includes hypotonia, severely impaired development of speech and language, autistic-like behavior, and minor dysmorphic features. Although the number of reported cases is increasing, the 22q13.3 deletion remains underdiagnosed because of failure in recognizing the clinical phenotype and detecting the 22qter deletion by routine chromosome analyses. Our goal is to contribute to the description of the neurobehavioral phenotype and brain abnormalities of this microdeletional syndrome. We assessed neuromotor, sensory, language, communication, and social development and performed cerebral MRI and study of regional cerebral blood flow measured by positron emission tomography in 8 children carrying the 22q13.3 deletion. Despite variability in expression and severity, the children shared a common developmental profile characterized by hypotonia, sleep disorders, and poor response to their environment in early infancy; expressive language deficit contrasting with emergence of social reciprocity from ages approximately 3 to 5 years; sensory processing dysfunction; and neuromotor disorders. Brain MRI findings were normal or showed a thin or morphologically atypical corpus callosum. Positron emission tomography study detected a localized dysfunction of the left temporal polar lobe and amygdala hypoperfusion. The developmental course of the 22q13.3 deletion syndrome belongs to pervasive developmental disorders but is distinct from autism. An improved description of the natural history of this syndrome should help in recognizing this largely underdiagnosed condition.
    PEDIATRICS 08/2008; 122(2):e376-82. · 4.47 Impact Factor
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    ABSTRACT: We investigated the recognition of pairs of faces (same or different facial identities and expressions) in two groups of 14 children aged 6-10 years, with either an expressive language disorder (ELD), or a mixed language disorder (MLD), and two groups of 14 matched healthy controls. When looking at their global performances, children with either expressive (ELD) or MLD have few differences from controls in either face or emotional recognition. At contrary, we found that children with MLD, but not those with ELD, take identical faces to be different if their expressions change. Since children with mixed language disorders are socially more impaired than children with ELD, we think that these features may partly underpin the social difficulties of these children.
    European Child & Adolescent Psychiatry 05/2008; 17(8):507-15. · 3.70 Impact Factor

Publication Stats

141 Citations
46.60 Total Impact Points

Institutions

  • 2014
    • Université Paris-Sorbonne - Paris IV
      Lutetia Parisorum, Île-de-France, France
  • 2008–2013
    • Université René Descartes - Paris 5
      Lutetia Parisorum, Île-de-France, France
    • Paris Diderot University
      Lutetia Parisorum, Île-de-France, France
  • 2000–2005
    • Pierre and Marie Curie University - Paris 6
      Lutetia Parisorum, Île-de-France, France
  • 2002
    • Unité Inserm U1077
      Caen, Lower Normandy, France