Laurence Vaivre-Douret

Université Paris-Sorbonne - Paris IV, Lutetia Parisorum, Île-de-France, France

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Publications (44)47.04 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Le diabète « néonatal » est une maladie génétique rare (1 naissance vivante sur 90 000 à 260 000). Il se définit par l’existence d’hyperglycémies liées à l’insuffisance ou à l’absence d’insuline circulante et survenant avant l’âge de un an. Ces hyperglycémies nécessitent un traitement soit de façon transitoire dans environ la moitié des cas, soit de façon permanente. Deux grands groupes de mécanisme expliquent la maladie : anomalie de développement du pancréas ou anomalie de fonction de la cellule β pancréatique. Les causes génétiques les plus fréquentes de diabète néonatal avec anomalie de fonction de la cellule β sont les anomalies du locus 6q24 et les mutations des gènes ABCC8, KCNJ11, codant pour les sous-unités du canal potassique de la cellule bêta impliqués dans le lien entre métabolisme de celle-ci et sécrétion d’insuline. D’autres gènes sont associés à une malformation du pancréas ou à une destruction des cellules β. Comparés aux patients avec une mutation dans ABCC8 ou KCNJ11, les patients avec anomalie de 6q24 ont un poids et une taille de naissance plus faibles, un âge au diagnostic et de rémission plus précoces et une fréquence plus importante de malformations. Les patients avec une mutation dans ABCC8 ou KCNJ11 ont des troubles neurologiques et neuropsychologiques chez tous ceux testés finement. Jusqu’à 86 % des patients ayant une rémission récidivent leur diabète à l’âge pubertaire, sans qu’il existe une différence selon la cause génétique. Ces résultats plaident pour l’importance d’un suivi au long cours par une équipe multidisciplinaire pédiatrique puis de médecins d’adultes.
    Annales d'Endocrinologie. 10/2014; 75(s 5–6):252.
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    ABSTRACT: Parents with past and current eating disorders (ED) have been shown to report troubles nourishing their infants. This could increase the risk of infant feeding problems linked to maternal anxiety and depression. It is not clear how mothers' eating difficulties before pregnancy and at the time of birth can affect infant's feeding. We aimed to specify the impact of eating disorders on mothers' adaptation and sensitivity to their offspring during feeding, by comparing a population of mothers with eating disorders and controls.
    BMC Pregnancy and Childbirth 08/2014; 14(1):274. · 2.52 Impact Factor
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    ABSTRACT: Our aim was to study horizontal and vertical smooth pursuit eye movements in children with developmental coordination disorder (DCD). Horizontal and vertical smooth pursuit eye movements of 91 children were studied using electro-oculography: 27 children with DCD (23 males, four females), according to the DSM-IV-TR criteria, and 64 comparison children (26 males, 38 females). All children were 7 to 12 years old (mean 9y, SD 1.5y). Among the group of children with DCD, eight had received intervention. Intervention exercised static and dynamic fixation, saccades, visual strategies, visuospatial abilities, and eye-hand coordination. A smooth pursuit gain index was calculated and statistical comparisons were made between the two groups of children. Horizontal pursuit gain was similar in both populations, but vertical pursuit gain was significantly impaired (p<0.001, after adjusting for age as covariate), i.e. more saccadic in children with DCD (18-99%; n=27, mean 51.6%, median 48.5%, SD 23.2%) than in comparison participants (35-97%; n=63, mean 66.4%, median 65.0%, SD 15.4%). Among the DCD group, the vertical pursuit index was also significantly higher (p=0.009) in the intervention subgroup (29-99%; n=8, mean 69.4%, median 75.5%, SD 28.7%) than in the non-intervention subgroup (18-74%; n=19, mean 44.1%, median 42.5%, SD 15.9%). These results suggest a delay in the maturation of the pursuit system in children with DCD.
    Developmental Medicine & Child Neurology 01/2014; · 2.68 Impact Factor
  • S. Bydlowski, C. Lalanne, G. Apter, B. Golse, L. Vaivre-Douret
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    ABSTRACT: Background The overall objective of the study is to assess the relationship between early neonatal neuropsychomotor organization and maternal postpartum blues (PPB), studied longitudinally from immediate postpartum (IPP). The first part of the research identified three types of maternal emotional experience in the IPP (ordinary and emotionally mixed PPB; sad, intense and lasting PPB; without blues) and showed a strong correlation between ordinary blues and a set of specific skills in neuropsychomotrice organization, coordination, and maturity in their infants. Postpartum blues may promote a certain openness to emotional exchange between mother and her infant. Maternal psychological experience of this particular type of PPB could therefore facilitate the adjustment of the mother to her baby and allow him a better development of his self-regulatory capacity. The objective of the second part of the study, which is the subject of this publication, was to evaluate the evolution of the mother-infant dyads through mother-infant interactions at 2 months. Methods Twenty-one mother-infant dyads were included at maternity wards. Two semi-structured clinical interviews (at the maternity and D10) have identified the symptoms and the degree of transient or lasting PPB. The data collected allowed the construction of a clinical classification into three groups. Newborns were examined using the NBAS. At 2 months, 13 dyads were reviewed, assessment of mother-infant interactions allowed us to complete the Global Ratings for Mothers-Infant Interactions at 2 months. Findings Women with sad, intense and lasting PPB present a particularly straightforward relational mismatch in the interaction with their baby. The neuropsychomotrices skills and tonic postural babies facilitate the overall quality of their interactions with their mothers, regardless of the adjustment of the latter, even if the “cost” for the child to maintain a good relationship adjustment is probably higher when the mother has difficulty dealing with the child and the interaction. Our results suggest that these infant's regulatory capacities observed at 2 months-aged are to be connected to the characteristics during the IPP. Among the 8-week-old babies whose interactions were the most distorted with their mothers, as showed at the Global Ratings for Mothers-Infant Interactions at 2 months, a majority had less positive self-organization at birth at the Brazelton's examination. From birth to 2 months, our results show a form of coherent continuity: the presence of an ordinary and emotionally mixed PPB and high scores on the NBAS items at birth promote quality of mother-infant interactions a few weeks later. Conversely, when a number of maternal’ and infantile’ characteristics are negatively oriented at birth, interactions may be affected. Mother-infant’ interactions at 2 months show lack of mutuality and harmony when the mother was afflicted with a sad, intense and lasting PPB and her infant had low scores on the NBAS. Conclusion Taking into account the characteristics and methodological limitations of the study (longitudinal study, few subjects reviewed at 2 months), the blues appears as a prognostic manifestation for the mother-child bond. Ordinary and emotionally mixed BPP would contribute to a better regulation of the baby and to a better adjustment of the mother-child relation. Conversely, sad, intense and lasting PPB is the index of a maternal psychopathology, which is reflected in interactive difficulties mother-baby 2 months later.
    Neuropsychiatrie de l'Enfance et de l'Adolescence. 01/2014;
  • K Busiah, L Vaivre-Douret, C Yachi, H Cavé, M Polak
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    ABSTRACT: Neonatal diabetes mellitus is a rare condition (1/90,000 to 1/260,000 live births) defi ned as mild-to-severe hyperglycemia within the fi rst year of life. Permanent neonatal diabetes mellitus requires lifelong therapy, whereas transient form resolves early in life but may relapse later on. Two main physiopathological mechanisms may explain this disease: β cell functional impairment or absence (pancreas agenesis or β cells destruction). The main genetic causes of β cells impairment are 6q24 abnormalities and mutations in ABCC8 or KCNJ11 potassium channel (KATP channel) genes. Compared to the KATP subtype, the 6q24 subtype had specifi c features: developmental defects involving the heart, kidneys, or urinary tract, intrauterine growth restriction, and early diagnosis. Remission of neonatal diabetes mellitus occurred in 51 % of probands at a median age of 17 weeks. Recurrence was common at pubertal age, with no difference between the 6q24 and KATPchannel groups (82 % vs 86 %, p=0,36, respectively). Patients with mutations in ABCC8 or KCNJ11 genes had developmental delay with or without epilepsy but also developmental coordination disorder (particularly visual-spatial dyspraxia) or attention defi cits in all of those who underwent in-depth neuropsychomotor investigations..
    Archives de Pédiatrie 12/2013; 20 Suppl 4:S117-26. · 0.36 Impact Factor
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    ABSTRACT: Neonatal diabetes mellitus is a rare genetic form of pancreatic β-cell dysfunction. We compared phenotypic features and clinical outcomes according to genetic subtypes in a cohort of patients diagnosed with neonatal diabetes mellitus before age 1 year, without β-cell autoimmunity and with normal pancreas morphology. We prospectively investigated patients from 20 countries referred to the French Neonatal Diabetes Mellitus Study Group from 1995 to 2010. Patients with hyperglycaemia requiring treatment with insulin before age 1 year were eligible, provided that they had normal pancreatic morphology as assessed by ultrasonography and negative tests for β-cell autoimmunity. We assessed changes in the 6q24 locus, KATP-channel subunit genes (ABCC8 and KCNJ11), and preproinsulin gene (INS) and investigated associations between genotype and phenotype, with special attention to extra-pancreatic abnormalities. We tested 174 index patients, of whom 47 (27%) had no detectable genetic defect. Of the remaining 127 index patients, 40 (31%) had 6q24 abnormalities, 43 (34%) had mutations in KCNJ11, 31 (24%) had mutations in ABCC8, and 13 (10%) had mutations in INS. We reported developmental delay with or without epilepsy in 13 index patients (18% of participants with mutations in genes encoding KATP channel subunits). In-depth neuropsychomotor investigations were done at median age 7 years (IQR 1-15) in 27 index patients with mutations in KATP channel subunit genes who did not have developmental delay or epilepsy. Developmental coordination disorder (particularly visual-spatial dyspraxia) or attention deficits were recorded in all index patients who had this testing. Compared with index patients who had mutations in KATP channel subunit genes, those with 6q24 abnormalities had specific features: developmental defects involving the heart, kidneys, or urinary tract (8/36 [22%] vs 2/71 [3%]; p=0·002), intrauterine growth restriction (34/37 [92%] vs 34/70 [48%]; p<0·0001), and early diagnosis (median age 5·0 days, IQR 1·0-14·5 vs 45·5 days, IQR 27·2-95·0; p<0·0001). Remission of neonatal diabetes mellitus occurred in 89 (51%) index patients at a median age of 17 weeks (IQR 9·5-39·0; median follow-up 4·7 years, IQR 1·5-12·8). Recurrence was common, with no difference between the groups who had 6q24 abnormalities versus mutations in KATP channel subunit genes (82% vs 86%; p=0·36). Neonatal diabetes mellitus is often associated with neuropsychological dysfunction and developmental defects that are specific to the underlying genetic abnormality. A multidisciplinary assessment is therefore essential when patients are diagnosed. Features of neuropsychological dysfunction and developmental defects should be tested for in adults with a history of neonatal diabetes mellitus. Agence Nationale de la Recherche-Maladies Rares Research Program Grant, the Transnational European Research Grant on Rare Diseases, the Société Francophone du Diabète-Association Française du Diabète, the Association Française du Diabète, Aide aux Jeunes Diabétiques, a CIFRE grant from the French Government, HRA-Pharma, the French Ministry of Education and Research, and the Société Française de Pédiatrie.
    The lancet. Diabetes & endocrinology. 11/2013; 1(3):199-207.
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    ABSTRACT: Postpartum blues may promote a certain openness to emotional exchange between mother and her infant. Groups of mothers were assembled according to various types of emotional expression demonstrated during early postpartum. Links between mothers’ groups and newborns’ neuropsychomotor characteristics were assessed. Twenty‐one mother–infant dyads were included at maternity wards. A semistructured interview was established to identify symptoms of the blues and classify mothers into clinical groups: ordinary and emotionally mixed postpartum blues (OB); sad, intense, and lasting blues; or without blues. Newborns were examined using the Neonatal Behavioral Assessment Scale (T.B. Brazelton & J.K. Nugent, ). Cluster analysis revealed a two‐class structure, where 78% of women with OB were found to belong to the same class, with a higher median score on newborn “hand‐to‐mouth activity” which correlated to self‐quieting activity, heightened regulation of awake states, decreased need for adult support, better defensive movements, greater attentiveness, and diminished irritability. The acquired faculties demonstrated by newborns whose mothers experience OB reflect a distinct skillset of neuropsychomotor maturity.
    Infant Mental Health Journal 11/2013; 34(6). · 0.61 Impact Factor
  • Elisabeth Lasserre, Laurence Vaivre-Douret, Véronique Abadie
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    ABSTRACT: Objective: We aimed to understand the mechanisms and sources of learning difficulties in children with CHARGE syndrome who attend school and to determine any specific developmental characteristics. Method: We analyzed the psychomotor and cognitive functions of eight children from 7 to 13 years old with classical CHARGE syndrome by using the Wechsler Intelligence Scale for Children (WISC), the Neuropsychomotor test (NP-MOT), and several subtests of the Developmental neuropsychological assessment (NEPSY) and Kaufman Assessment Battery for Children (K-ABC) instruments. Results: The IQ range was from 54 to 92. The main weaknesses related to three domains: static and dynamic postural control, visuospatio-constructive abilities, and both sequential processing and selective attention. The main strengths were in holistic perception, semantic competencies, logical reasoning and planning skills, with axial and peripheral hypotonia. The extent of psychomotor and cognitive deficits was not associated with severity of sensorial deficiencies. We discuss the multiple causal mechanisms of psychomotor and cognitive difficulties. Conclusion: We found a persistent and homogeneous psychomotor profile and specific cognitive difficulties in 8 children with CHARGE syndrome despite their large range of IQs. Highlighting these specific impairments is important to understand the nature and mechanisms of CHARGE for adapting educational and rehabilitation methods. These problems may be explained by sensory deficits, as well as dysfunction in integrating and/or regulatory regions of the brain.
    Child Neuropsychology 09/2013; 19(5):449-65. · 2.24 Impact Factor
  • L. Vaivre-Douret
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    ABSTRACT: À partir d’une revue de la littérature, les descriptions des enfants ayant des difficultés de coordination motrice et des mouvements maladroits ont été discutées depuis le début du 19e siècle. Selon le manuel diagnostique et statistique des troubles mentaux (DSM-IV), il s’agit d’un trouble avéré au niveau du développement de la coordination motrice fine et globale, touchant 6 % des enfants scolarisés. Tous ces enfants sont caractérisés par un trouble de l’acquisition de la coordination motrice (TAC) au niveau de l’apprentissage moteur et des nouvelles acquisitions d’habileté motrice, contrairement à l’apraxie chez l’adulte pour lequel il s’agit d’un trouble de l’exécution des mouvements déjà appris. Aucun consensus n’a été établi à propos de l’étiologie du TAC. L’approche intragroupe par une analyse factorielle et de classification souligne qu’un trouble moteur chez des enfants porteurs d’un TAC varie à la fois au niveau de la sévérité et de la nature du trouble. En effet, la plupart des études ont utilisé des mesures de screening de la performance sur quelques items développementaux basés sur des tests moteurs globaux. Peu d’études ont investigué un ensemble de différentes fonctions avec des évaluations standardisées, telles que le tonus musculaire et les signes neurologiques doux, sur des mesures quantitatives et qualitatives de la coordination motrice globale et fine, et sur des difficultés spécifiques – académique, langage, gnosique, visuo-motrice/visuo-perceptive et attentionnelle/exécutive – afin de permettre une meilleure identification des sous-groupes de TAC avec des critères diagnostiques et de fournir une compréhension des mécanismes et des zones cérébrales en jeu.
    Neurophysiologie Clinique/Clinical Neurophysiology 01/2013; · 2.55 Impact Factor
  • Neurophysiologie Clinique/Clinical Neurophysiology 12/2012; 42(6):399–400. · 2.55 Impact Factor
  • Joëlle Winisdorffer, Laurence Vaivre-Douret
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    ABSTRACT: The authors wish to propose a possible procedure to general practitioners and pediatricians, in order to detect and accompany "high potential" children who they are brought to follow. It is a retrospective longitudinal study which permitted to follow 19 "high potential" children (tested using an IQ test, because of relational or scholar difficulties) during eighteen years of practice, in a general practitioner office. The gathering of clinical data was carried out using the health record of the child and longitudinal notes about pregnancy and neonatal period, about psycho motor development, the schooling, the centers of interest and the activities of the child. The ages of psycho motor acquirement were compared to the ones of the literature. The average age of our sample at the moment of the IQ test was 9 years and 9 months with a majority of boys (16) compared to girls (3); 14 of the children were followed to middle school and 8 to the high school. We highlighted on the one hand significantly precocious development of postural and locomotive acquirement (p <0.001) and of cognitive and linguistic acquirement (p < 0.05) compared to standards of French scales of child development. On the other hand, we noticed cognitive and relational behavioral characteristics specific to the mental functioning of these children. We noticed an important percentage of very precocious relational difficulties (73%) from as soon as preschool and moreover confirmed neuro-psychomotor troubles (22%) and aggressive or anxious behavior troubles (21%) correlated to scholar disengagement beginning in middle school for 50% of them. The forward detection for the precocious attainment is a marker of high potentiality which should draw doctor attention in preparation for prevent eventual learning and behavioral troubles, to provide moral assistance to the parents in their relationships. In case of possible difficulties (psycho-emotional, social, scholar), it's desirable to confirm the precocious attainment by using an IQ test, and complete the evaluation by further investigations (neuropsychological examinations, projective test...) in order to propose the best suited care to child difficulties with the intention to prevent personality troubles and scholar disengagement.
    La Revue du praticien 11/2012; 62(9):1205-11.
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    ABSTRACT: Specific language impairment (SLI) is a primary developmental disorder in which language is significantly more impaired than other developmental domains. Abnormal electroencephalographic recordings without clinical seizures are often observed. The aim of this retrospective study was to characterize the frequency of these abnormalities, to describe them and to analyze their association with anamnestic, clinical, paraclinical and evolution characteristics. The cases of 35 children with a diagnosis of SLI, who also underwent electroencephalography and MRI, were systematically reviewed retrospectively. In this population, aged between 4 and 7 years, 49% (n=17) of patients exhibited a specific expressive language disorder and 51% (n=18) a specific receptive disorder. Forty-nine percent of the children featured abnormal electroencephalography results. Abnormalities were essentially localized on the left side of the brain and in two specific regions: the temporo-occipital (60%) and the frontorolandic (30%) regions. The groups with and without abnormalities were compared statistically with each other in terms of clinical, paraclinical and evolution characteristics. Evolution data were available for 24 patients through a telephone interview and for nine patients through a new complete language evaluation. The comparison of the two groups showed significant differences in terms of severity of the phonological disorder, a higher number of delayed acquisition of walking and cleanliness and a higher range of non specific psychomotor difficulties. A large proportion of children suffering from SLI present abnormal electroencephalography recordings with no clinical seizures. This rate is much higher than in the general population and the abnormalities are essentially localized on the left side of the brain in regions known for their specific role in language development. These abnormalities are more frequent in children with a severe phonological disorder, suggesting that they may share common pathophysiological features with SLI. The presence of EEG abnormalities in a large group of patients suffering from SLI associated with minor neurological abnormalities suggests a possible theoretical neurodevelopmental model. Minor neurodevelopmental abnormalities, genetically transmitted or acquired during the pre- or perinatal period, may create vulnerability towards SLI. This vulnerability, in conjunction with environmental influences such as family environment, linguistic stimuli, exposure to multiple languages, or transitory hearing loss, might take the form of SLI. This hypothesis underlines the importance of prevention and early detection of SLI when identifying vulnerable subjects. Monitoring the family early through parental guidance and early school support would facilitate the acquisition of language.
    L Encéphale 09/2012; 38(4):318-28. · 0.49 Impact Factor
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    ABSTRACT: With a large number of potentially relevant clinical indicators penalization and ensemble learning methods are thought to provide better predictive performance than usual linear predictors. However, little is known about how they perform in clinical studies where few cases are available. We used Random Forests and Partial Least Squares Discriminant Analysis to select the most salient impairments in Developmental Coordination Disorder (DCD) and assess patients similarity. We considered a wide-range testing battery for various neuropsychological and visuo-motor impairments which aimed at characterizing subtypes of DCD in a sample of 63 children. Classifiers were optimized on a training sample, and they were used subsequently to rank the 49 items according to a permuted measure of variable importance. In addition, subtyping consistency was assessed with cluster analysis on the training sample. Clustering fitness and predictive accuracy were evaluated on the validation sample. Both classifiers yielded a relevant subset of items impairments that altogether accounted for a sharp discrimination between three DCD subtypes: ideomotor, visual-spatial and constructional, and mixt dyspraxia. The main impairments that were found to characterize the three subtypes were: digital perception, imitations of gestures, digital praxia, lego blocks, visual spatial structuration, visual motor integration, coordination between upper and lower limbs. Classification accuracy was above 90% for all classifiers, and clustering fitness was found to be satisfactory. Random Forests and Partial Least Squares Discriminant Analysis are useful tools to extract salient features from a large pool of correlated binary predictors, but also provide a way to assess individuals proximities in a reduced factor space. Less than 15 neuro-visual, neuro-psychomotor and neuro-psychological tests might be required to provide a sensitive and specific diagnostic of DCD on this particular sample, and isolated markers might be used to refine our understanding of DCD in future studies.
    BMC Medical Research Methodology 07/2012; 12:107. · 2.21 Impact Factor
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    ABSTRACT: Background Specific language impairment (SLI) is a primary developmental disorder in which language is significantly more impaired than other developmental domains. Abnormal electroencephalographic recordings without clinical seizures are often observed. The aim of this retrospective study was to characterize the frequency of these abnormalities, to describe them and to analyze their association with anamnestic, clinical, paraclinical and evolution characteristics. Methods The cases of 35 children with a diagnosis of SLI, who also underwent electroencephalography and MRI, were systematically reviewed retrospectively. Results In this population, aged between 4 and 7 years, 49% (n = 17) of patients exhibited a specific expressive language disorder and 51% (n = 18) a specific receptive disorder. Forty-nine percent of the children featured abnormal electroencephalography results. Abnormalities were essentially localized on the left side of the brain and in two specific regions: the temporo-occipital (60%) and the frontorolandic (30%) regions. The groups with and without abnormalities were compared statistically with each other in terms of clinical, paraclinical and evolution characteristics. Evolution data were available for 24 patients through a telephone interview and for nine patients through a new complete language evaluation. The comparison of the two groups showed significant differences in terms of severity of the phonological disorder, a higher number of delayed acquisition of walking and cleanliness and a higher range of non specific psychomotor difficulties. Discussion A large proportion of children suffering from SLI present abnormal electroencephalography recordings with no clinical seizures. This rate is much higher than in the general population and the abnormalities are essentially localized on the left side of the brain in regions known for their specific role in language development. These abnormalities are more frequent in children with a severe phonological disorder, suggesting that they may share common pathophysiological features with SLI. Conclusion The presence of EEG abnormalities in a large group of patients suffering from SLI associated with minor neurological abnormalities suggests a possible theoretical neurodevelopmental model. Minor neurodevelopmental abnormalities, genetically transmitted or acquired during the pre- or perinatal period, may create vulnerability towards SLI. This vulnerability, in conjunction with environmental influences such as family environment, linguistic stimuli, exposure to multiple languages, or transitory hearing loss, might take the form of SLI. This hypothesis underlines the importance of prevention and early detection of SLI when identifying vulnerable subjects. Monitoring the family early through parental guidance and early school support would facilitate the acquisition of language.
    L Encéphale 01/2012; 38:318-328. · 0.49 Impact Factor
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    ABSTRACT: The aim of the study was to identify clear clinical signs and symptoms, which are specific of developmental coordination disorder (DCD) or developmental dyspraxia subtypes.
    Neuropsychiatrie De L'enfance Et De L'adolescence. 12/2011;
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    ABSTRACT: Children with Developmental Coordination Disorder (DCD) are a group embracing clumsiness and developmental dyspraxia. Our study provides a better understanding of the nature of DCD and its etiology, and identifies subtypes of dyspraxia. Forty-three children with DCD (5-15 years) were enrolled on the Diagnostic and Statistical Manual of Mental Disorders (4th ed. [DSM-IV-TR]; American Psychiatric Association, 2000) criteria. Extensive standardized evaluations were conducted. We distinguished from two patterns of "pure" developmental dyspraxia: ideomotor and visual-spatial/visual-constructional, and mix dyspraxia with more co-morbidities. Our study provides a better understanding of the nature of DCD, and sheds light on its etiology and brain dysfunction, so as to identify subtypes of developmental DCD/dyspraxia with specific clinical criteria.
    Developmental Neuropsychology 07/2011; 36(5):614-43. · 2.90 Impact Factor
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    Laurence Vaivre-Douret
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    ABSTRACT: This study covers the interesting field of the development in gifted children which is often neglected in pediatrics because psychomotor development data are still rare, since "gifted" children are generally noticed towards the end of their primary schooling by IQ measurement. Developmental studies have shown the evidence from several fields that children identified as "high-level potentialities" or "intellectually gifted" develop sensory, locomotor, neuropsychological, and language skills earlier than typically expected. The hypothesis is offered that the earlier development originates from biological processes affecting the physical development of the brain and in turn even intellectual abilities are developed earlier, potentially allowing for advanced development. Further it is discussed how these developmental advances interact with the social environment and in certain circumstances may entail increased risk for developing socioemotional difficulties and learning disabilities that often go unaddressed due to the masking by the advance intellectual abilities.
    International Journal of Pediatrics 01/2011; 2011:420297.
  • Neurophysiologie Clinique-clinical Neurophysiology - NEUROPHYSIOL CLIN. 01/2011; 41(4):219-219.
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    ABSTRACT: Data on growth status at birth in a French sample of gifted children identified at school age were analysed in a retrospective survey. Birth weight, gestational age, head circumference, stature, gender, parental socio-economic status, information on the pregnancy, and motor development were recorded. On the basis of standard growth curves, the sample was characterised according to the 10th, 50th, 75th and 90th percentiles. Three groups of gestational age were determined: preterm births (18.6%), full term births (63.2%) and post-term births (18.1%) with a high frequency of hypertrophy in preterm births (≥ 90th). Intellectual quotient (IQ) did not differ among the groups, showing a notable advance in motor development. This research shows that, among children later identified as gifted, compared to those born full term, preterm infants showed a significant relationship between homogeneity in anthropometric variables and future motor and intellectual development when these children were exposed to a favourable perinatal environment (few pregnancy complications) and a favourable postnatal parental socio-economic status.RésuméLes relations entre la croissance staturo pondérale à la naissance et le développement moteur et cognitif d’un échantillon d’enfants français surdoués. Les données sur la croissance staturo pondérale à la naissance sur un échantillon français d’enfants surdoués identifiés à l’âge scolaire, ont été analysées. Dans une enquête rétrospective, nous avons enregistré le poids de naissance, l’âge gestationnel, le périmètre crânien, la taille, le sexe, le satut socioéconomique des parents, des informations sur la grossesse et sur le développement moteur. Sur la base des courbes officielles de croissance, l’échantillon a été classé en fonction des 10e, 50, 75 et 90e percentiles. Trois groupes d’âge gestationnel ont été déterminés à la naissance : prématurés (18,6 %), à terme (63,2 %) et post-terme (18,1 %) avec une haute fréquence d’hypertrophiques (> 90e). Le quotient intellectuel ne diffère pas entre les groupes, montrant une avance notable du développement moteur. Cette recherche met en évidence que parmi les enfants identifiés surdoués, les enfants prématurés comparés à ceux nés à terme montrent une relation significative entre des variables anthropométriques homogènes et leur futur développement moteur et intellectuel quand ces enfants sont exposés à un environnement périnatal (avec peu de complications pendant la grossesse) et socioéconomique parental postnatal favorable.
    Revue Européenne de Psychologie Appliquée/European Review of Applied Psychology. 01/2010; 60(1):1–9.
  • Laurence Vaivre-Douret, Bernard Golse, Nelly Thomas, Jean-Claude Janaud
    Soins. Pediatrie, puericulture 10/2009;

Publication Stats

151 Citations
47.04 Total Impact Points

Institutions

  • 2014
    • Université Paris-Sorbonne - Paris IV
      Lutetia Parisorum, Île-de-France, France
  • 2008–2013
    • Université René Descartes - Paris 5
      Lutetia Parisorum, Île-de-France, France
    • Paris Diderot University
      Lutetia Parisorum, Île-de-France, France
  • 2007
    • Assistance Publique – Hôpitaux de Paris
      Lutetia Parisorum, Île-de-France, France
  • 2000–2005
    • Pierre and Marie Curie University - Paris 6
      Lutetia Parisorum, Île-de-France, France
  • 2002
    • Unité Inserm U1077
      Caen, Lower Normandy, France