Laurence Vaivre-Douret

Université René Descartes - Paris 5, Lutetia Parisorum, Île-de-France, France

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Publications (62)87.75 Total impact

  • A. Paquet · B. Olliac · B. Golse · L. Vaivre-Douret ·

    Neurophysiologie Clinique/Clinical Neurophysiology 11/2015; 45(4-5):416. DOI:10.1016/j.neucli.2015.10.073 · 1.24 Impact Factor
  • A. Paquet · B. Olliac · M. Girard · B. Golse · L. Vaivre-Douret ·

    Neurophysiologie Clinique/Clinical Neurophysiology 11/2015; 45(4-5):411. DOI:10.1016/j.neucli.2015.10.060 · 1.24 Impact Factor
  • L. Vaivre-Douret · C. Lalanne · B. Golse ·

    Neurophysiologie Clinique/Clinical Neurophysiology 11/2015; 45(4-5):411-412. DOI:10.1016/j.neucli.2015.10.061 · 1.24 Impact Factor
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    ABSTRACT: Objective: Neonatal diabetes secondary to mutations in potassium-channel subunits is a rare disease but constitutes a paradigm for personalized genetics-based medicine, as replacing the historical treatment with insulin injections with oral sulfonylurea (SU) therapy has been proven beneficial. SU receptors are widely expressed in the brain, and we therefore evaluated potential effects of SU on neurodevelopmental parameters, which are known to be unresponsive to insulin. Research design and methods: We conducted a prospective single-center study. Nineteen patients (15 boys age 0.1-18.5 years) were switched from insulin to SU therapy. MRI was performed at baseline. Before and 6 or 12 months after the switch, patients underwent quantitative neurological and developmental assessments and electrophysiological nerve and muscle testing. Results: At baseline, hypotonia, deficiencies in gesture conception or realization, and attention disorders were common. SU improved HbA1c levels (median change -1.55% [range -3.8 to 0.1]; P < 0.0001), intelligence scores, hypotonia (in 12 of 15 patients), visual attention deficits (in 10 of 13 patients), gross and fine motor skills (in all patients younger than 4 years old), and gesture conception and realization (in 5 of 8 older patients). Electrophysiological muscle and nerve tests were normal. Cerebral MRI at baseline showed lesions in 12 patients, suggesting that the impairments were central in origin. Conclusions: SU therapy in neonatal diabetes secondary to mutations in potassium-channel subunits produces measurable improvements in neuropsychomotor impairments, which are greater in younger patients. An early genetic diagnosis should always be made, allowing for a rapid switch to SU.
    Diabetes care 10/2015; DOI:10.2337/dc15-0837 · 8.42 Impact Factor
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    A Paquet · B Olliac · B Golse · L Vaivre-Douret ·
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    ABSTRACT: Motor symptomatology in autism is currently poorly understood, and still not included in the autism spectrum disorder (ASD) diagnostic criteria, although some studies suggest the presence of motor disturbances in this syndrome. We provide here a literature review on early motor symptoms in autism, focusing on studies on psychomotor issues (tone, postural control, manual dexterity, handedness, praxis). The approach adopted in research to study altered motor behaviors is generally global and there is no detailed semiology of the motor or neuromotor disorders observed in people with ASD. This global approach does not enable understanding of the neuro-developmental mechanisms involved in ASD. Identification of clinical neuro-psychomotor profiles in reference to a standard would help to better understand the origin and the nature of the disorders encountered in ASD, and would thus give new directions for treatment.
    Child Neuropsychology 09/2015; DOI:10.1080/09297049.2015.1085501 · 2.42 Impact Factor
  • A. Boschi · P. Planche · A. Philippe · L. Vaivre-Douret ·

    European Psychiatry 03/2015; 30:1214. DOI:10.1016/S0924-9338(15)30954-8 · 3.44 Impact Factor
  • J. Beltrand · K. Busiah · L. Vaivre-Douret · A.L. Fauret · R. Scharfmann · H. Cavé · M. Polak ·
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    ABSTRACT: Le diabète « néonatal » est une maladie génétique rare (1 naissance vivante sur 90 000 à 260 000). Il se définit par l’existence d’hyperglycémies liées à l’insuffisance ou à l’absence d’insuline circulante et survenant avant l’âge de un an. Ces hyperglycémies nécessitent un traitement soit de façon transitoire dans environ la moitié des cas, soit de façon permanente. Deux grands groupes de mécanisme expliquent la maladie : anomalie de développement du pancréas ou anomalie de fonction de la cellule β pancréatique. Les causes génétiques les plus fréquentes de diabète néonatal avec anomalie de fonction de la cellule β sont les anomalies du locus 6q24 et les mutations des gènes ABCC8, KCNJ11, codant pour les sous-unités du canal potassique de la cellule bêta impliqués dans le lien entre métabolisme de celle-ci et sécrétion d’insuline. D’autres gènes sont associés à une malformation du pancréas ou à une destruction des cellules β. Comparés aux patients avec une mutation dans ABCC8 ou KCNJ11, les patients avec anomalie de 6q24 ont un poids et une taille de naissance plus faibles, un âge au diagnostic et de rémission plus précoces et une fréquence plus importante de malformations. Les patients avec une mutation dans ABCC8 ou KCNJ11 ont des troubles neurologiques et neuropsychologiques chez tous ceux testés finement. Jusqu’à 86 % des patients ayant une rémission récidivent leur diabète à l’âge pubertaire, sans qu’il existe une différence selon la cause génétique. Ces résultats plaident pour l’importance d’un suivi au long cours par une équipe multidisciplinaire pédiatrique puis de médecins d’adultes.
    Annales d Endocrinologie 10/2014; 75(s 5–6):252. DOI:10.1016/j.ando.2014.07.020 · 0.87 Impact Factor
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    Claire Squires · Christophe Lalanne · Nasha Murday · Vassiliki Simoglou · Laurence Vaivre-Douret ·
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    ABSTRACT: Background Parents with past and current eating disorders (ED) have been shown to report troubles nourishing their infants. This could increase the risk of infant feeding problems linked to maternal anxiety and depression. It is not clear how mothers’ eating difficulties before pregnancy and at the time of birth can affect infant’s feeding. We aimed to specify the impact of eating disorders on mothers’ adaptation and sensitivity to their offspring during feeding, by comparing a population of mothers with eating disorders and controls. Methods Twenty-eight women agreed to participate in interviews and filmed mother-baby interactions. Pregnant women consulting at an obstetric unit for care follow-up were screened and tested for symptoms of eating disorders with the EDE-Q Questionnaire (Eating Disorders Examination Questionnaire) and the EDE Interview (Eating Disorders Examination Interview). Infant functional troubles and mothers’ sensitivity were investigated through the Symptom Check List. Reciprocal adaptation during feeding with their new-borns was filmed and analysed with the Chatoor Infant Feeding Scale. Before pregnancy, two women suffered from anorexia, three suffered from bulimia, three had binge eating symptoms and two were diagnosed with EDNOS (Eating Disorders Not Otherwise Specified). Results Mothers suffering from ED tended to show more difficult interactive patterns in terms of dyadic reciprocity when feeding their babies compared with mothers with no symptoms of eating disorders. In the interviews, other than the behavioural data gathered, ED mothers expressed feeling more dissatisfaction and uneasiness during feeding. Conclusions Pregnancy seems to be an useful period for interviewing women on eating disorders, allowing for the design and implementation of prevention programmes based on mothers’ narratives and infant/mother observations and treatment.
    BMC Pregnancy and Childbirth 08/2014; 14(1):274. DOI:10.1186/1471-2393-14-274 · 2.19 Impact Factor
  • L. Vaivre-Douret · D. Oriot · B. Golse ·

    Neurophysiologie Clinique/Clinical Neurophysiology 01/2014; 44(1):143. DOI:10.1016/j.neucli.2013.10.103 · 1.24 Impact Factor
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    ABSTRACT: Our aim was to study horizontal and vertical smooth pursuit eye movements in children with developmental coordination disorder (DCD). Horizontal and vertical smooth pursuit eye movements of 91 children were studied using electro-oculography: 27 children with DCD (23 males, four females), according to the DSM-IV-TR criteria, and 64 comparison children (26 males, 38 females). All children were 7 to 12 years old (mean 9y, SD 1.5y). Among the group of children with DCD, eight had received intervention. Intervention exercised static and dynamic fixation, saccades, visual strategies, visuospatial abilities, and eye-hand coordination. A smooth pursuit gain index was calculated and statistical comparisons were made between the two groups of children. Horizontal pursuit gain was similar in both populations, but vertical pursuit gain was significantly impaired (p<0.001, after adjusting for age as covariate), i.e. more saccadic in children with DCD (18-99%; n=27, mean 51.6%, median 48.5%, SD 23.2%) than in comparison participants (35-97%; n=63, mean 66.4%, median 65.0%, SD 15.4%). Among the DCD group, the vertical pursuit index was also significantly higher (p=0.009) in the intervention subgroup (29-99%; n=8, mean 69.4%, median 75.5%, SD 28.7%) than in the non-intervention subgroup (18-74%; n=19, mean 44.1%, median 42.5%, SD 15.9%). These results suggest a delay in the maturation of the pursuit system in children with DCD.
    Developmental Medicine & Child Neurology 01/2014; 56(6). DOI:10.1111/dmcn.12384 · 3.51 Impact Factor
  • S. Bydlowski · C. Lalanne · G. Apter · B. Golse · L. Vaivre-Douret ·
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    ABSTRACT: L’objectif général de l’étude est d’évaluer les liens entre l’organisation neuropsychomotrice néonatale précoce et le blues du post-partum (BPP) maternel, longitudinalement à partir du post-partum immédiat (PPI). La première partie de la recherche a identifié trois types d’expérience émotionnelle maternelle dans le PPI (BPP ordinaire ; BPP triste, intense et durable ; absence de blues) et mis en évidence une corrélation étroite entre blues ordinaire et compétences particulières néonatales. L’objectif de la deuxième partie de l’étude, qui fait l’objet du présent article, était d’évaluer l’évolution de ces dyades mères-bébés grâce aux interactions mère-bébé à deux mois.
    Neuropsychiatrie de l Enfance et de l Adolescence 01/2014; 63(1). DOI:10.1016/j.neurenf.2014.08.004
  • L. Vaivre-Douret · C. Lalanne · D. Cabrol · B. Golse · B. Falissard ·

    European Psychiatry 12/2013; 28:1. DOI:10.1016/S0924-9338(13)77317-6 · 3.44 Impact Factor
  • K Busiah · L Vaivre-Douret · C Yachi · H Cavé · M Polak ·
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    ABSTRACT: Neonatal diabetes mellitus is a rare condition (1/90,000 to 1/260,000 live births) defi ned as mild-to-severe hyperglycemia within the fi rst year of life. Permanent neonatal diabetes mellitus requires lifelong therapy, whereas transient form resolves early in life but may relapse later on. Two main physiopathological mechanisms may explain this disease: β cell functional impairment or absence (pancreas agenesis or β cells destruction). The main genetic causes of β cells impairment are 6q24 abnormalities and mutations in ABCC8 or KCNJ11 potassium channel (KATP channel) genes. Compared to the KATP subtype, the 6q24 subtype had specifi c features: developmental defects involving the heart, kidneys, or urinary tract, intrauterine growth restriction, and early diagnosis. Remission of neonatal diabetes mellitus occurred in 51 % of probands at a median age of 17 weeks. Recurrence was common at pubertal age, with no difference between the 6q24 and KATPchannel groups (82 % vs 86 %, p=0,36, respectively). Patients with mutations in ABCC8 or KCNJ11 genes had developmental delay with or without epilepsy but also developmental coordination disorder (particularly visual-spatial dyspraxia) or attention defi cits in all of those who underwent in-depth neuropsychomotor investigations..
    Archives de Pédiatrie 12/2013; 20 Suppl 4:S117-26. DOI:10.1016/S0929-693X(13)71425-8 · 0.41 Impact Factor
  • K. Busiah · S. Drunat · L. Vaivre-Douret ·

    The Lancet Diabetes & Endocrinology 11/2013; 1(3):E14-E14. DOI:10.1016/S2213-8587(13)70115-3 · 9.19 Impact Factor
  • Sarah Bydlowski · Christophe Lalanne · Bernard Golse · Laurence Vaivre-Douret ·
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    ABSTRACT: Postpartum blues may promote a certain openness to emotional exchange between mother and her infant. Groups of mothers were assembled according to various types of emotional expression demonstrated during early postpartum. Links between mothers’ groups and newborns’ neuropsychomotor characteristics were assessed. Twenty‐one mother–infant dyads were included at maternity wards. A semistructured interview was established to identify symptoms of the blues and classify mothers into clinical groups: ordinary and emotionally mixed postpartum blues (OB); sad, intense, and lasting blues; or without blues. Newborns were examined using the Neonatal Behavioral Assessment Scale (T.B. Brazelton & J.K. Nugent, ). Cluster analysis revealed a two‐class structure, where 78% of women with OB were found to belong to the same class, with a higher median score on newborn “hand‐to‐mouth activity” which correlated to self‐quieting activity, heightened regulation of awake states, decreased need for adult support, better defensive movements, greater attentiveness, and diminished irritability. The acquired faculties demonstrated by newborns whose mothers experience OB reflect a distinct skillset of neuropsychomotor maturity.
    Infant Mental Health Journal 11/2013; 34(6). DOI:10.1002/imhj.21410 · 0.61 Impact Factor
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    ABSTRACT: Neonatal diabetes mellitus is a rare genetic form of pancreatic β-cell dysfunction. We compared phenotypic features and clinical outcomes according to genetic subtypes in a cohort of patients diagnosed with neonatal diabetes mellitus before age 1 year, without β-cell autoimmunity and with normal pancreas morphology. We prospectively investigated patients from 20 countries referred to the French Neonatal Diabetes Mellitus Study Group from 1995 to 2010. Patients with hyperglycaemia requiring treatment with insulin before age 1 year were eligible, provided that they had normal pancreatic morphology as assessed by ultrasonography and negative tests for β-cell autoimmunity. We assessed changes in the 6q24 locus, KATP-channel subunit genes (ABCC8 and KCNJ11), and preproinsulin gene (INS) and investigated associations between genotype and phenotype, with special attention to extra-pancreatic abnormalities. We tested 174 index patients, of whom 47 (27%) had no detectable genetic defect. Of the remaining 127 index patients, 40 (31%) had 6q24 abnormalities, 43 (34%) had mutations in KCNJ11, 31 (24%) had mutations in ABCC8, and 13 (10%) had mutations in INS. We reported developmental delay with or without epilepsy in 13 index patients (18% of participants with mutations in genes encoding KATP channel subunits). In-depth neuropsychomotor investigations were done at median age 7 years (IQR 1-15) in 27 index patients with mutations in KATP channel subunit genes who did not have developmental delay or epilepsy. Developmental coordination disorder (particularly visual-spatial dyspraxia) or attention deficits were recorded in all index patients who had this testing. Compared with index patients who had mutations in KATP channel subunit genes, those with 6q24 abnormalities had specific features: developmental defects involving the heart, kidneys, or urinary tract (8/36 [22%] vs 2/71 [3%]; p=0·002), intrauterine growth restriction (34/37 [92%] vs 34/70 [48%]; p<0·0001), and early diagnosis (median age 5·0 days, IQR 1·0-14·5 vs 45·5 days, IQR 27·2-95·0; p<0·0001). Remission of neonatal diabetes mellitus occurred in 89 (51%) index patients at a median age of 17 weeks (IQR 9·5-39·0; median follow-up 4·7 years, IQR 1·5-12·8). Recurrence was common, with no difference between the groups who had 6q24 abnormalities versus mutations in KATP channel subunit genes (82% vs 86%; p=0·36). Neonatal diabetes mellitus is often associated with neuropsychological dysfunction and developmental defects that are specific to the underlying genetic abnormality. A multidisciplinary assessment is therefore essential when patients are diagnosed. Features of neuropsychological dysfunction and developmental defects should be tested for in adults with a history of neonatal diabetes mellitus. Agence Nationale de la Recherche-Maladies Rares Research Program Grant, the Transnational European Research Grant on Rare Diseases, the Société Francophone du Diabète-Association Française du Diabète, the Association Française du Diabète, Aide aux Jeunes Diabétiques, a CIFRE grant from the French Government, HRA-Pharma, the French Ministry of Education and Research, and the Société Française de Pédiatrie.
    11/2013; 1(3):199-207. DOI:10.1016/S2213-8587(13)70059-7
  • Elisabeth Lasserre · Laurence Vaivre-Douret · Véronique Abadie ·
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    ABSTRACT: Objective: We aimed to understand the mechanisms and sources of learning difficulties in children with CHARGE syndrome who attend school and to determine any specific developmental characteristics. Method: We analyzed the psychomotor and cognitive functions of eight children from 7 to 13 years old with classical CHARGE syndrome by using the Wechsler Intelligence Scale for Children (WISC), the Neuropsychomotor test (NP-MOT), and several subtests of the Developmental neuropsychological assessment (NEPSY) and Kaufman Assessment Battery for Children (K-ABC) instruments. Results: The IQ range was from 54 to 92. The main weaknesses related to three domains: static and dynamic postural control, visuospatio-constructive abilities, and both sequential processing and selective attention. The main strengths were in holistic perception, semantic competencies, logical reasoning and planning skills, with axial and peripheral hypotonia. The extent of psychomotor and cognitive deficits was not associated with severity of sensorial deficiencies. We discuss the multiple causal mechanisms of psychomotor and cognitive difficulties. Conclusion: We found a persistent and homogeneous psychomotor profile and specific cognitive difficulties in 8 children with CHARGE syndrome despite their large range of IQs. Highlighting these specific impairments is important to understand the nature and mechanisms of CHARGE for adapting educational and rehabilitation methods. These problems may be explained by sensory deficits, as well as dysfunction in integrating and/or regulatory regions of the brain.
    Child Neuropsychology 09/2013; 19(5):449-65. DOI:10.1080/09297049.2012.690372 · 2.42 Impact Factor
  • L. Vaivre-Douret ·
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    ABSTRACT: À partir d’une revue de la littérature, les descriptions des enfants ayant des difficultés de coordination motrice et des mouvements maladroits ont été discutées depuis le début du 19e siècle. Selon le manuel diagnostique et statistique des troubles mentaux (DSM-IV), il s’agit d’un trouble avéré au niveau du développement de la coordination motrice fine et globale, touchant 6 % des enfants scolarisés. Tous ces enfants sont caractérisés par un trouble de l’acquisition de la coordination motrice (TAC) au niveau de l’apprentissage moteur et des nouvelles acquisitions d’habileté motrice, contrairement à l’apraxie chez l’adulte pour lequel il s’agit d’un trouble de l’exécution des mouvements déjà appris. Aucun consensus n’a été établi à propos de l’étiologie du TAC. L’approche intragroupe par une analyse factorielle et de classification souligne qu’un trouble moteur chez des enfants porteurs d’un TAC varie à la fois au niveau de la sévérité et de la nature du trouble. En effet, la plupart des études ont utilisé des mesures de screening de la performance sur quelques items développementaux basés sur des tests moteurs globaux. Peu d’études ont investigué un ensemble de différentes fonctions avec des évaluations standardisées, telles que le tonus musculaire et les signes neurologiques doux, sur des mesures quantitatives et qualitatives de la coordination motrice globale et fine, et sur des difficultés spécifiques – académique, langage, gnosique, visuo-motrice/visuo-perceptive et attentionnelle/exécutive – afin de permettre une meilleure identification des sous-groupes de TAC avec des critères diagnostiques et de fournir une compréhension des mécanismes et des zones cérébrales en jeu.
    Neurophysiologie Clinique/Clinical Neurophysiology 01/2013; 44(1). DOI:10.1016/j.neucli.2013.10.133 · 1.24 Impact Factor
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    Isabelle Simoes Loureiro · Laurent Lefebvre · Laurence Vaivre-Douret ·
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    ABSTRACT: In this paper, we synthesize results about intellectual, cognitive, social, psychological, developmental and physiological profiles of highly gifted children obtained in previously works. Moreover, socio-economical measures are equally considered. The criterion currently used to determine highly potentialities is the Intelligence Quotient (IQ), defined by the Wechsler Intelligence Scale for children (third version). The analyze of specific intellectual profiles allows to notice singularities in specific highly gifted children groups. We find that there is often a significant difference between Verbal Intelligence Quotient (VIQ) and Performance Intelligence Quotient (PIQ) in highly gifted children but also noticed that the size of the difference between these two quotients is positively correlated to the appearance of neuropsychological troubles. We also put in prominent, like other authors, that highly gifted children are more frequently concerned with psychological and social troubles whatever the IQ profile. Many children with highly potentialities suffer from anxiety, depression, sleep disorders and social integration disorders. In addition, some physiological characteristics like abnormal pregnancy of the mother, premature birth, myopia and allergies are frequently associated with highly gifted abilities. At least, we consider socio-economical measures and find that a favorable environment is correlated to high IQ. We will propose that the specific profiles observed in highly gifted children can be interpreted like the products of a specific cerebral structure that results from the combination of innate and environmental factors.
    Intelligence Quotient : Testing, Role of Genitics and the Environment and Social Outcomes, Edited by J. C. KUSH, 01/2013: chapter Contribution of Intellectual, Psychological, Developmental and Socio-Economic Data to Highlight Specific Profiles of Highly Gifted Children: pages 169-183; Nova Science Publishers., ISBN: 978-1-62618-728-3
  • L. Vaivre-Douret · C. Lalanne · D. Cabrol · B. Golse · B. Falissard ·
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    ABSTRACT: The DSM-IV-TR criteria for Developmental Coordination Disorder (DCD) involve a marked impairment in the development of motor coordination although visuo-spatial, digital and visuo-motor perception, neuromuscular tone, qualitative and quantitative measures of gross and fine motor coordination related impairments might be used to isolate three main subtypes of DCD/dyspraxia: ideo-motor, visuo-spatial and constructional, and a mix group sharing common impairments with additional comorbidities. This study focus on isolating specific markers of coordination disorder and their interactions in mix vs. pure form of dyspraxia.Methods Tree-based bagged classifiers were used to highlight relevant markers among 49 pass/fail tests that best discriminate two clinical subgroups based on a sample (N = 63) of 5–15 years old children having IQ in the expected range (40% mix dyspraxia). Model calibration was done on a training sample through nested repeated 5-fold cross-validation while predictive performance were assessed on a held-out validation sample, using a split ratio of 0.7/0.3.ResultsWe found that digital praxia, imitation of gestures, manual dexterity, digital perception, lego blocks, and visual motor integration were among the top most important impairments when predicting subtypes. Specific interactions among those predictors and other impairments (motor pathway, visual evoked potential, language) were shown to provide additional insights into DCD subtyping.Conclusions Taylored follow-up of patients presenting with DCD should consider the specificity of visuo-spatial, neuromotor and neuropsychological impairments whose co-occurrence allow to define different subtypes of DCD.
    European Psychiatry 12/2012; 27:1. DOI:10.1016/S0924-9338(12)74515-7 · 3.44 Impact Factor

Publication Stats

285 Citations
87.75 Total Impact Points


  • 2008-2015
    • Université René Descartes - Paris 5
      • Faculté de Médecine
      Lutetia Parisorum, Île-de-France, France
    • French Institute of Health and Medical Research
      Lutetia Parisorum, Île-de-France, France
  • 2014
    • Université Paris-Sorbonne - Paris IV
      Lutetia Parisorum, Île-de-France, France
    • Université Paris-Sud 11
      Orsay, Île-de-France, France
  • 2009
    • Université Paris Ouest Nanterre La Défense
      Nanterre, Île-de-France, France
  • 2000-2005
    • Pierre and Marie Curie University - Paris 6
      Lutetia Parisorum, Île-de-France, France
  • 1995-2002
    • Unité Inserm U1077
      Caen, Lower Normandy, France