Publications (2)14.88 Total impact
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Article: Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease.
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ABSTRACT: A genetic susceptibility to depression in PD, acting via the serotonergic system, has been suggested. We examined the influence of allelic variation (L/S) in a functional polymorphism in the serotonin transporter (5-HTTLPR) gene upon mood in 108 PD patients and 82 controls. Using a logistic regression model we found no evidence for an association between 5-HTTLPR genotypes, or the presence of the S allele, and depression.Parkinsonism & Related Disorders 05/2006; 12(3):139-41. · 3.80 Impact Factor -
Article: Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD.
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ABSTRACT: There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population-attributable risk for Parkinson's disease. There was no association between individual haplogroups or the UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases.Annals of Neurology 05/2005; 57(4):564-7. · 11.09 Impact Factor
