Publications (83)249.84 Total impact
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Article: Poly(ethylene glycol)-poly(ε-caprolactone) Iodinated Nanocapsules as Contrast Agents for X-ray Imaging.
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ABSTRACT: PURPOSE: Synthesis and formulation of iodinated PCL-mPEG nanocapsules as new original blood pool contrast agents for computed tomography. METHODS: PCL-mPEG was synthesized and formulated following the emulsion-solvent diffusion process, in the form of iodinated nanocapsules. Physico-chemical characterization of such nano-materials was performed by DLS and transmission electron microscopy. A stability study of the nanocapsules suspension was followed-up to 3 month. Blood biocompatibility was performed. Finally, the nanocapsules suspension radiopacity was evaluated in vitro then in vivo in mice as micro-CT contrast agent. RESULTS: In this study, the iodine concentration in nanocapsules suspension was about 70 mgI/mL. Besides, these nanocarriers appeared non-toxic, and stable in suspension. In vivo, i.v. administration of 10 μL/g of mouse body weight of theses nano-particles induced a vascular contrast enhancement of 168 HU and a half-life in blood of 4.2 +/- 0.5 h. Elimination route of these particles appears mainly performed by the liver, without sequestration in spleen and lymph nodes confirming their stealth properties. CONCLUSIONS: This study proposes the first example of iodinated biodegradable polymeric blood pool contrast agent, able to induce an exploitable contrast enhancement. The main advantage of polymeric system compared to lipid ones, lies in their stability and handling, e.g. towards drying for storage.Pharmaceutical Research 04/2013; · 4.09 Impact Factor -
Article: Usefulness of Controlled Release of Growth Factors in Investigating the Early Events of Dentin-pulp Regeneration.
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ABSTRACT: Little information is yet available on the signals involved in progenitor cell migration that precede reparative dentin synthesis. Our aim was to investigate the effect of the controlled release of fibroblast growth factor (FGF)-2 and transforming growth factor β1 (TGF-β1) on permanent teeth pulp cell proliferation and progenitor cell migration. FGF-2 and TGF-β1 were encapsulated into a biodegradable polymer matrix of lactide and glycolide. Human pulp cells were prepared from third molars, and progenitor cells were sorted by STRO-1. The synthesized microsphere toxicity was checked with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test. The growth factor release kinetics were checked by an enzyme-linked immunosorbent assay while maintaining their biological activity and were evaluated by investigating their effects on pulp cell proliferation. Their chemotactic potential was investigated on STRO-1-sorted cells in a migration chamber on Matrigel (Cambrex Bio Science, Walkersville, MD). The cell viability was unaffected by the presence of microspheres. The released amount of FGF-2 and TGF-β1 from the microspheres was maintained after 21 days. Increasing the FGF-2-loaded microsphere concentration or the release period significantly increased dental pulp cell proliferation. TGF-β1 acted as a potent chemotactic factor of STRO-1-sorted cells. Encapsulating TGF-β1 and FGF-2 in a biodegradable polymer of lactide and glycolide microsphere allowed a sustained release of growth factors and provided a protection to their biological activities. Our results clearly show the usefulness of growth factor controlled release in investigating the early events of pulp/dentin regeneration. It provides additional data on the signals required for vital pulp therapy and future tissue engineering.Journal of endodontics 02/2013; 39(2):228-35. · 2.95 Impact Factor -
Article: Preparation of Liposomes: A Novel Application of Microengineered Membranes - Investigation of the Process Parameters and Application to the Encapsulation of Vitamin E
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ABSTRACT: Liposomes with a mean size of 59-308 nm suitable for pulmonary drug delivery were prepared by the ethanol injection method using nickel microengineered flat disc membranes with a uniform pore size of 5-40 [small mu ]m and a pore spacing of 80 or 200 [small mu ]m. An ethanolic phase containing 20-50 mg/ml phospholipid (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) or Lipoid[registered sign] E80), 5-12.5 mg/ml stabilizer (cholesterol, stearic acid or cocoa butter), and 0 or 5 mg/ml vitamin E was injected through the membrane into an agitated aqueous phase at a controlled flux of 142-355 l/m2/h and a shear stress on the membrane surface of 0.80-16 Pa. The mean particle size obtained under optimal conditions was 84 and 59 nm for Lipoid E80 and POPC liposomes, respectively. The particle size of prepared liposomes increased with increasing the pore size of the membrane and decreased with increasing the pore spacing. Lipoid E80 liposomes stabilized by cholesterol or stearic acid maintained their initial size within 3 months. A high entrapment efficiency of 99.87% was achieved when Lipoid E80 liposomes were loaded with vitamin E. Transmission electron microscopy images revealed spherical multi-lamellar structure of vesicles. A reproducibility of the developed fabrication method was high.RSC Adv. 01/2013; -
Article: Membrane emulsification: A promising alternative for vitamin E encapsulation within nano-emulsion
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ABSTRACT: The purpose of our study was to develop a vitamin E-loaded nano-emulsion which could be a convenient drug carrier to be used for targeting the lungs. The nano-emulsion components (MCT oil and surfactant mixture Tween 80/Brij 35) were selected after solubility studies, and the concentration range was chosen after construction of ternary phase diagrams. For emulsion manufacturing, an SPG membrane emulsification process was developed. Key parameters influence on nano-emulsion characteristics was investigated. It has been established that small droplets and narrow size distribution were favored at low transmembrane pressure, high continuous phase flow rate and high agitation speed. Under optimal conditions, nano-emulsion with a span factor of 0.2570.01, which meant high monodispersity, and an average size of 7873 nm, was prepared. The high zeta potential of �22.970.9 mV was sufficient to prevent droplet coalescence. Vitamin E was successfully encapsulated within the optimized nano-emulsion with high entrapment efficiency value (99.770.4%). Transmission electron microscopy images revealed spherical-shaped and well-distributed nano-droplets. Additionally, special attention was paid on process reproducibility and preparations stability. Results confirmed the robustness of the optimized membrane emulsification technique which seems to be fast, simple and reliable.Journal of Membrane Science 12/2012; 423-424:85-96. · 3.85 Impact Factor -
Article: Nano-encapsulation of Vitamin D(3) Active Metabolites for Application in Chemotherapy: Formulation Study and in Vitro Evaluation.
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ABSTRACT: PURPOSE: Calcitriol (1,25-dihydroxyvitamin D(3)), the active metabolite of vitamin D(3), is a potential anticancer agent but with high risk of hypercalcemia which limits the achievement of effective serum concentrations. Thus, calcitriol targeting delivery by nanoparticles may present a good solution. METHODS: Vitamin D(3) active metabolites were encapsulated into polymeric nanoparticles and different formulation parameters were tested. The growth inhibitory efficiency of these nanoparticles was carried out in vitro on human breast adenocarinoma cells (MCF-7). RESULTS: Using cholecalciferol (the inactive metabolite), different polymer and oil ratios were compared to select nanoparticles presenting high encapsulation efficiency and sustained release profile. Calcidiol/calcitriol loaded nanoparticles had good encapsulation efficiencies (around 90%) associated with sustained releases over 7 days and enhanced stability. Moreover, loaded nanoparticles showed similar growth inhibition to non-encapsulated metabolites of vitamin D(3) on day 4 and higher activities on days 7 and 10 after treatment initiation. CONCLUSION: The nano-encapsulation of vitamin D(3) active metabolites may offer a new and potentially effective strategy for vitamin D(3)-based chemotherapy overcoming its actual limitations. The targeting delivery of vitamin D(3) metabolites should be encouraged.Pharmaceutical Research 12/2012; · 4.09 Impact Factor -
Article: Preparation, Characterization and Applications of Liposomes: State of the Art
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ABSTRACT: Liposomes, spherical-shaped nanovesicles, were discovered in the 60ies by Bangham. Since that, they were extensively studied as potential drug carrier. Due to their composition variability and structural properties, liposomes are extremely versatile leading to a large number of applications including pharmaceutical, cosmetics and food industrial fields. This bibliographic paper offers a general review on the background and development of liposomes with a focus on preparation methods including classic (thin film hydration, reverse-phase evaporation, ethanol injection…) and novel scalable techniques. Furthermore, liposome characterization techniques including mean size, zetapotential, lamellarity, encapsulation efficiency, in vitro drug release, vesicles stability and lipid analysis synthesized from different published works are reported. The current deepening and widening of liposome interest in many scientific disciplines and their application in pharmaceutics, cosmetics and food industries as promising novel breakthroughs and products were also handled. Finally, an opinion on the usefulness of liposomes in various applications ranging from unsubstantiated optimism to undeserved pessimism is given. The obtained information allows establishing criteria for selecting liposomes as a drug carrier according to its advantages and limitations.Journal of Colloid Science and Biotechnology. 12/2012; -
Article: Reactive Magnetic Poly(Divinylbenzene-co-Glycidyl methacrylate) Colloidal Particles for Specific Antigen Detection Using Microcontact Printing Technique.
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ABSTRACT: Epoxy-functionalized magnetic poly(divinylbenzene-co-glycidyl methacrylate) colloidal particles (MPDGs) were prepared via copolymerization reaction of 1,4-divinylbenzene (DVB) and glycidyl methacrylate (GMA) monomers. The reactions were conducted in batch emulsion polymerization in presence of oil in water (o/w) magnetic emulsion as a seed. The chemical composition, morphology, iron oxide content, magnetic properties, particle size and colloial stability of the prepared magnetic polymer particles were characterized using FT-IR, transmission electron microscope (TEM), thermal gravimetric analysis (TGA), vibrating sample magnetometer (VSM), dynamic light scattering (DLS), and zeta potential (ζ) techniques, respectively. The prepared MPDGs were immobilized on self-assembled monolayer (SAM) of 3-aminopropyltriethoxysilane (APTES)-Octadecyltrichlorosilane (OTS), which were patterned on glass using microcontact printing technique (μCP), forming MPDGs@APTES-OTS reactive surface. This construction (MPDGs@APTES-OTS) was used as a solid support for immunoassay. The immobilized magnetic particles were bio-conjugated with monoclonal anti-human IL-10 antibody (Ab) to provide specific and selective recognition sites for the recombinant human IL-10 protein (antigen) (Ag). Fluorescence microscopic examination was carried out to follow this immunoassay using the fluorescent-labelled anti-human IL-10 antibody (Ab∗). The results obtained proved the successfull use of MPDGs@APTES-OTS microcontact printed surfaces in immunoassay, which can be exploited and integrated in Microsystems in order to elaborate medical devices (e.g. biosensors), which provide fast analysis with high sensitivity for low volume analyte.Acta biomaterialia 10/2012; · 3.98 Impact Factor -
Article: Iodinated α-tocopherol nano-emulsions as non-toxic contrast agents for preclinical X-ray imaging.
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ABSTRACT: Micro-computed tomography (micro-CT) is an emerging imaging modality, due to the low cost of the imagers as well as their efficiency in establishing high-resolution (1-100 μm) three-dimensional images of small laboratory animals and facilitating rapid, structural and functional in vivo visualization. However use of a contrast agent is absolutely necessary when imaging soft tissues. The main limitation of micro-CT is the low efficiency and toxicity of the commercially available blood pool contrast agents. This study proposes new, efficient and non-toxic contrast agents for micro-CT imaging. This formulation consists of iodinated vitamin E (α-tocopheryl 2,3,5-triiodobenzoate) as an oily phase, formulated as liquid nano-emulsion droplets (by low-energy nano-emulsification), surrounded by a hairy PEG layer to confer stealth properties. The originality and strength of these new contrast agents lie not only in their outstanding contrasting properties, biocompatibility and low toxicity, but also in the simplicity of their fabrication: one-step synthesis of highly iodinated oil (iodine constitutes 41.7% of the oil molecule weight) and its spontaneous emulsification. After i.v. administration in mice (8.5% of blood volume), the product shows stealth properties towards the immune system and thus acts as an efficient blood pool contrast agent (t(1/2) = 9.0 h), exhibiting blood clearance following mono-exponential decay. A gradual accumulation predominantly due to hepatocyte uptake is observed and measured in the liver, establishing a strong hepatic contrast, persistent for more than four months. To summarize, in the current range of available or developed contrast agents for preclinical X-ray imaging, this agent appears to be one of the most efficient.Biomaterials 10/2012; · 7.40 Impact Factor -
Article: Synthesis and characterization of thermally and glucose-sensitive poly N-vinylcaprolactam-Based microgels.
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ABSTRACT: Temperature and glucose sensitive microgels were prepared via radical precipitation polymerization, using N-vinylcaprolactam (NVCL) as the main monomer, N,N-methylenebisacrylamide (MBA) as a crosslinker, V50 as initiator and 4-vinylphenylboronic acid (VPBA) as a functional monomer. The LCST of homopoly (NVCL) was first determined and found to be around 33 degrees C. The preparation of microgels was examined as a function of crosslinker (MBA) and VPBA amount in the polymerization recipe. Each polymerization was examined by considering the polymerization conversion and water-soluble polymer formation. Transmission electron microscopy, dynamic light scattering (DLS) and FT-IR characterizations show that the prepared microgels are monodisperse submicron particles, thermally sensitive and containing boronic acid functions. The effect of glucose on the swelling ability of boronic acid containing microgel was particularly examined and revealed the presence of specific interaction.Journal of Biomedical Nanotechnology 10/2012; 8(5):709-19. · 4.22 Impact Factor -
Article: Iodinated nano-emulsions as contrast agents for preclinical X-ray imaging: Impact of the free surfactants on the pharmacokinetics.
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ABSTRACT: This study presents new important aspects in the design of contrast agents for X-ray preclinical imaging. The first one is a new simple formulation of long circulating contrast agents, formulated from a commercial iodinated oil, and resulting in CT contrast agents containing more than twice the iodine concentration commercial contrast agents. The second point is a methodological aspect, utilizing tangential filtration for reducing the residual surfactants in the bulk phase and serving as well for concentrating droplets (and iodine) in the suspension. The last point is a more general aspect regarding the influence of the free surfactant on the pharmacokinetics and biodistribution of the nano-emulsion droplets on mice. We showed that cross-flow filtration is efficient for concentrating the droplets and reducing the concentration of free surfactant from 10wt.% to 1wt.%, without any changes in the nano-emulsion droplet morphologies or surface properties. We also showed that the presence of free surfactant has a significant impact on the elimination way of the nano-emulsion droplets, shared between liver and kidneys. The purified nano-emulsions are preferentially eliminated by the kidneys in contrast to raw nano-emulsions, predominantly eliminated by the liver. In practice, for two similar suspensions, half-life decreases from 4.1±1.10h to 2.5±0.77h before and after purification. Since the design and development of long circulating systems are critical in numerous domains, and not for preclinical CT imaging, this study presents important results in that field, taken under a formulation and technical point of view.European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 09/2012; · 3.15 Impact Factor -
Chapter: Spironolactone-Loaded Liposomes Produced Using a Membrane Contactor Method: An Improvement of the Ethanol Injection Technique
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ABSTRACT: Spironolactone, a hydrophobic drug, has been encapsulated within liposomes using two different preparation methods: the ethanol injection technique and the membrane contactor. The effects of the technique on the prepared liposomes characteristics have been investigated. For this aim, the spironolactone-loaded liposomes were characterized in terms of size, zeta potential, microscopic morphology, encapsulation efficiency and in vitro release profile. Results indicated a significant influence of the applied preparation method. Indeed, when the membrane contactor method was used, the mean size was smaller (123 nm instead of 200 nm), the encapsulation efficiency was higher (93% instead of 80%), and the release profile showed a better dissolution behaviour which may enhance the preparation availability. In conclusion, these results confirmed that the membrane contactor presents an improvement of the ethanol injection technique allowing a continuous production of liposomes at large scale.07/2012: pages 23-28; , ISBN: 978-3-642-28973-6 -
Article: Engineered nanoparticulate drug delivery systems: the next frontier for oral administration?
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ABSTRACT: For the past few decades, there has been a considerable research interest in the area of oral drug delivery using nanoparticle (NP) delivery systems as carriers. Oral NPs have been used as a physical approach to improve the solubility and the stability of active pharmaceutical ingredients (APIs) in the gastrointestinal juices, to enhance the intestinal permeability of drugs, to sustain and to control the release of encapsulated APIs allowing the dosing frequency to be reduced, and finally, to achieve both local and systemic drug targeting. Numerous materials have been used in the formulation of oral NPs leading to different nanoparticulate platforms. In this paper, we review various aspects of the formulation and the characterization of polymeric, lipid, and inorganic NPs. Special attention will be dedicated to their performance in the oral delivery of drug molecules and therapeutic genes.The AAPS Journal 07/2012; 14(4):688-702. · 5.09 Impact Factor -
Article: Silica-based nanoparticles for biomedical applications.
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ABSTRACT: In this short review we highlight novel uses of silica-based nanoparticles (NPs) in the biomedical sector. Silica NPs are widely used in nanotechnology because they are easy to prepare and inexpensive to produce. Their specific surface characteristics, porosity and capacity for functionalization make them good tools for biomolecule detection and separation, providing solid media for drug delivery systems and acting as contrast agent protectors. In addition, they are used as safety and biocompatible pharmaceutical additives. Here, we focus on novel techniques based on silica NPs for the most important biomedical applications.Drug discovery today 07/2012; 17(19-20):1147-54. · 6.63 Impact Factor -
Article: Lipid-based carriers: manufacturing and applications for pulmonary route.
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ABSTRACT: INTRODUCTION: Recent advances in aerosol therapy have sparked considerable interest in the development of novel drug delivery systems for pulmonary route. Development of colloidal carriers as pharmaceutical drug delivery systems has spurred an exponential growth; the encapsulation of bioactive molecules into relatively inert and non-toxic carriers for in vivo delivery constitutes a promising approach for improving their therapeutic index while reducing the side effects. Extraordinary success has been made toward improving efficacy by developing lipid-based carriers (LBCs); among classical examples are liposomes and solid lipid nanoparticles (SLNs). AREAS COVERED: The authors review lipid-based colloidal carriers - liposomes and SLNs - as pulmonary drug delivery systems. Conventional methods of liposome preparation and recently developed systems are discussed. Special attention is given to SLNs and their main manufacturing techniques. Finally, a summary of recent scientific publications and important results in the field of pulmonary lipidic carriers are presented. Some practical considerations regarding the toxicological concerns of such systems are briefly cited. EXPERT OPINION: Despite several scientific investigations, numerous advantages and encouraging results, LBCs for pulmonary route have attained only few great achievements as many challenges still remain. Problems limiting the use of such system seem to be the complexity of the respiratory tract as well as the lack of toxicity assessment risks of colloidal carriers.Expert Opinion on Drug Delivery 06/2012; 9(9):1111-27. · 4.90 Impact Factor -
Article: Theranostic applications of nanoparticles in cancer.
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ABSTRACT: Nanoparticles are the moieties that have undergone the most investigation in recent years for biomedical applications. They are applied in the field of oncology in the same way as in other branches of biomedical nanotechnology. Regarding cancer, nanoparticles, and especially magnetic nanoparticles, are studied for diagnosis, drug delivery, gene delivery, bioseparation, hyperthermia, phototherapy, chemotherapy, imaging mechanisms, among other uses. Different techniques are used to prepare multifunctional nanoparticles and modify nanoparticle surfaces required for different applications. This review focuses on the basic theranostic approach, the different materials used in theranostics, theranostic applications and future directions based on recent developments in these areas.Drug discovery today 03/2012; 17(17-18):928-34. · 6.63 Impact Factor -
Article: Development of a nanoparticle-based system for the delivery of retinoic acid into macrophages.
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ABSTRACT: The aim of the present work is to prepare nanoparticulate systems that can target and modulate the functions of mononuclear phagocytes by local administration. All-trans retinoic acid (RA) was chosen as an immunomodulator to be encapsulated in biodegradable nanoparticles (NP). Different formulations were prepared by the nanoprecipitation method and poly(d,l)lactic acid based nanocapsules (NC) were selected to continue the study. RA-NC demonstrated a sustained release profile and an enhanced stability for 7 days. The uptake of fluorescent (NileRed) labeled NP was conducted on bone marrow derived macrophages (BMM) in vitro and xenograft glioma nude mice in vivo. Fluorescent microscopy observations and flow cytometry analysis demonstrated that NR-NC were engulfed by BMM in vitro and lasted inside over 7 days. The intratumoral injection of NR-NC confirmed that NC were efficiently uptaken by infiltrated macrophages. The effects of RA loaded NC on BMM were also evaluated by RT(2)-PCR array. Our results suggest that polymeric nanoparticles are suitable carriers to deliver RA into macrophages and can offer a new strategy in tumor macrophage-based treatment.International journal of pharmaceutics 03/2012; 430(1-2):207-15. · 2.96 Impact Factor -
Article: Liposome and niosome preparation using a membrane contactor for scale-up.
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ABSTRACT: The scaling-up ability of liposome and niosome production, from laboratory scale using a syringe-pump device to a pilot scale using the membrane contactor module, was investigated. For this aim, an ethanol injection-based method was applied for liposome and niosome preparation. The syringe-pump device was used for laboratory scale batches production (30 ml for liposomes, 20 ml for niosomes) then a pilot scale (750 ml for liposomes, 1000 ml for niosomes) were obtained using the SPG membrane contactor. Resulted nanovesicles were characterized in terms of mean vesicles size, polydispersity index (PdI) and zeta potential. The drug encapsulation efficiency (E.E.%) was evaluated using two drug-models: caffeine and spironolactone, a hydrophilic and a lipophilic molecule, respectively. As results, nanovectors mean size using the syringe-pump device was comprised between 82 nm and 95 nm for liposomes and between 83 nm and 127 nm for niosomes. The optimal E.E. of caffeine within niosomes, was found around 9.7% whereas the spironolactone E.E. reached 95.6% which may be attributed to its lipophilic properties. For liposomes these values were about 9.7% and 86.4%, respectively. It can be clearly seen that the spironolactone E.E. was slightly higher within niosomes than liposomes. Optimized formulations, which offered smaller size and higher E.E., were selected for pilot scale production using the SPG membrane. It has been found that vesicles characteristics (size and E.E.%) were reproducible using the membrane contactor module. Thus, the current study demonstrated the usefulness of the membrane contactor as a device for scaling-up both liposome and niosome preparations with small mean sizes.Colloids and surfaces. B, Biointerfaces 01/2012; 94:15-21. · 2.60 Impact Factor -
Article: Modified double emulsion process as a new route to prepare submicron biodegradable magnetic/polycaprolactone particles for in vivo theranostics
Soft Matter 01/2012; · 4.39 Impact Factor -
Article: Nanocapsules prepared via nanoprecipitation and emulsification-diffusion methods: comparative study.
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ABSTRACT: The encapsulation of hydrophobic drugs has been widely investigated using mainly oil phase in order to enhance the encapsulation efficiency. However, the effect of the starting materials on the colloidal properties of the final nanocapsules irrespective of the elaboration process has been neglected, and the hydrophobic drug location in the disperse media has not been completely elucidated. Therefore, this paper describes the effect of the oil used in the recipe and the preparation method on the behavior of nanocapsules prepared via nanoprecipitation and via emulsification-diffusion. The colloidal stability of the final dispersions, drug location and the drug release are preparation method dependent. In turn, the type of oil governs drug encapsulation efficiency regardless of the method and the size when nanocapsules are prepared by nanoprecipitation.European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 01/2012; 80(1):235-9. · 3.15 Impact Factor -
Article: Encapsulation of a pressure-sensitive adhesive by spray-drying: microparticles preparation and evaluation of their crushing strength.
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ABSTRACT: An industrial pressure-sensitive adhesive was microencapsulated by spray-drying using an aqueous colloidal ethylcellulose dispersion (Aquacoat® ECD) plasticised by triacetin to form the wall material. Unloaded (0:100) and adhesive-loaded (25:75) particles were produced in a Büchi B-191 mini spray-dryer with product yields of 62% and 57%, respectively. Microparticles were spherical and narrow sized with mean D₃,₂ diameters of 3.165 ± 0.001 and 5.544 ± 0.105 µm, respectively. The microparticles were found to redisperse well in water and exhibit enough stability in neutral and alkaline aqueous media to be further used in a coating slip. Crush tests on single microparticles with diameters ranging from 2 to 12 µm were performed using a nanoindenter. They revealed that the crushing force of both kinds of microparticles increased linearly with their diameter and that the adhesive loading reduced the mechanical strength of the prepared microparticles.Journal of Microencapsulation 12/2011; 29(2):185-93. · 1.55 Impact Factor
Top co-authors
Top Journals
Institutions
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2008–2012
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French National Centre for Scientific Research
Lyon, Rhone-Alpes, France
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2007–2012
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Université de Lyon
Lyon, Rhone-Alpes, France
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1998–2012
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Université Claude Bernard Lyon 1
- Laboratoire d'automatique et de génie des procédés (LAGEP)
Villeurbanne, Rhone-Alpes, France
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2006
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Laboratoire Réactions et Génie des Procédés (LRGP)
Nancy, Lorraine, France
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