Omer Poyraz

Cumhuriyet University, Megalopolis, Sivas, Turkey

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Publications (15)23.77 Total impact

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    ABSTRACT: The purpose of this study is to determine erythrocyte sedimentation rate (ESR), C - reactive protein (CRP), serum amyloid-A (SAA) and cholesterol levels in patients with Crimean-Congo Hemorrhagic Fever (CCHF) and determine the relationship of these parameters with the severity of disease. By polymerase chain reaction and enzyme-linked immunosorbent assay (ELISA) method 40 patients were diagnosed as CCHF and 39 volunteer without any systemic disease whose blood were taken and their serum separated. SAA, CRP and ESR were measured with ELISA, nephelometry and Mix-Rate x100 vital diagnostic device, respectively, in serum samples. High density lipoprotein (HDL), low density lipoprotein (LDL) and total cholesterol levels were determined by using autoanalyzer HDL, LDL and total cholesterol kit (Syncron LX20). Statistically significant difference was determined between patients and controls in terms of the levels of SAA, CRP, HDL, LDL and total cholesterol (p<0.05). However, there was no significant difference between the groups in terms of the levels of ESR. In addition, neither SAA, CRP, ESR nor HDL, LDL and total cholesterol levels varied with the severity of disease in the cases assessed (p>0.05). Using of CRP and SAA together might increase the sensitivity of diagnosis of CCHF infection. However, none of the parameters investigated in this study were found to be a proper marker of the prognosis in CCHF. Cholesterol levels were significantly decreased in patients with CCHF, which was suggested to be associated with the increased serum levels of SAA in the patient group.
    Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences 02/2013; 13(1):21-6. · 0.44 Impact Factor
  • Hulya Toker · Aysun Akpınar · Huseyin Aydın · Omer Poyraz ·
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    ABSTRACT: The aim of this study was to evaluate the impact of smoking on the relationship between interleukin-1 (IL-1β) and oxidation in patients with periodontitis and response to nonsurgical periodontal therapy. Data were obtained from 30 patients with generalized chronic periodontitis (15 smokers and 15 nonsmokers) and from 10 periodontally healthy controls. IL-1β level, total oxidant status (TOS) and total antioxidant status (TAS) were recorded in gingival crevicular fluid. Probing depth, clinical attachment level, gingival and plaque indices and bleeding on probing were also measured. The gingival crevicular fluid and clinical parameters were recorded at baseline and 6 wk after periodontal treatment. The study showed statistically significant improvement of clinical parameters in both smokers and nonsmokers after periodontal treatment. Moreover, the baseline IL-1β levels were significantly higher in smokers compared with nonsmokers (p < 0.05). After periodontal treatment, the IL-1β levels were significantly reduced in both smokers and nonsmokers (p < 0.05). There were no significant differences in TOS and TAS between periodontitis patients and healthy controls at baseline and 6 wk after periodontal treatment. The level of IL-1β in gingival crevicular fluid was positively correlated with TOS in both smokers and nonsmokers. Periodontal treatment improved the clinical parameters in both smokers and nonsmokers. The results confirm that periodontal therapy has an effect on IL-1β levels in gingival crevicular fluid, but not on TOS and TAS.
    Journal of Periodontal Research 02/2012; 47(5):572-7. DOI:10.1111/j.1600-0765.2012.01468.x · 2.47 Impact Factor
  • T. Güneş · O. Poyraz · M. Ataş · N.H. Turgut ·
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    ABSTRACT: Aim: Tokat Province is an epicenter for Crimean-Congo hemorrhagic fever virus (CCHFV) in Turkey. The aim of this study was to investigate the seroprevalence of Rickettsia conorii and to clarify the epidemiological similarities between CCHFV and R. conorii in Tokat Province. Materials and methods: The prevalence of antibodies reactive with R. conorii was examined by ELISA in 364 sera, 151 of which were seropositive for CCHFV. Results: The overall prevalence of antibodies reactive with R. conorii was 36.81%. The prevalence of antibodies to R. conorii infection was higher in humans who showed CCHFV seropositivity than seronegativity, 52.32% and 25.82%, respectively (P = 0.001). A significant difference in seroprevalence was found between groups who had a history of tick bite and who did not, 41.52% and 29.29%, respectively (P = 0.019). Conclusion: Our data show that people who are a risk group for CCHFV are likely to be a risk group for R. conorii.
    Turkish Journal of Medical Sciences 01/2012; 42(3):441-448. DOI:10.3906/sag-1102-1383 · 0.84 Impact Factor
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    ABSTRACT: The role of various microorganisms including Chlamydophila (formerly Chlamydia) pneumoniae, have been frequently investigated in the pathogenesis of atherosclerosis. In our study, the relationship between C.pneumoniae seropositivity and risk factors for atherosclerosis have been evaluated. A total of 90 atherosclerotic patients (71 of them were male; age range: 45-87 years; mean age: 65.3 ± 8.7 years) and 90 control subjects without coronary diseases (41 of them were male; age range: 42-84 years; mean age: 61.6 ± 9.6 years) were included in the study. Both groups were also evaluated for the presence of risk factors such as age, gender, smoking, hypertension, diabetes, obesity, dyslipidemia, familial history and the high levels of ferritin, cholesterol (total, HDL and LDL) and HS (high sensitive)-CRP. The presence of C.pneumoniae IgG, IgM and IgA antibodies were investigated by micro-immunofluorescence (MIF) and ELISA methods using commercial kits (Euroimmun, Germany). The total antibody seropositivity rate was found 100% (90/90) in patient group by both MIF and ELISA methods, while this rate in control group was 94% (85/90) by MIF and 92% (83/90) by ELISA. When MIF test results were taken into consideration (since it is accepted as the reference method for C.pneumoniae serology), IgG, IgM and IgA positivity rates in patient and control groups were found as 100% (90/90) and 89% (80/90); 70% (63/90) and 59% (53/90); 3% (3/90) and 2% (2/90), respectively. Statistically significant difference between patient and control groups was detected only for IgG positivity (p< 0.05) and for total antibody positivities (100% and 94%, respectively) (p< 0.05). The evaluation of the risk factors revealed that age, hypertension, dyslipidemia and HS-CRP levels exhibited statistically significant differences between patient and control groups (p< 0.05 for each parameter tested). Statistically significant relation was detected only between high HS-CRP levels and C.pneumoniae seropositivity (p< 0.05). It was concluded that in areas with high C.pneumoniae infection prevalence, early diagnosis and specific treatment of C.pneumoniae infections, may prevent establishment of chronic infection and eliminate a risk factor for the development of atherosclerosis.
    Mikrobiyoloji bülteni 01/2012; 46(1):156-8. · 0.65 Impact Factor
  • Turabi Gunes · Omer Poyraz · Mehmet Atas · Nergiz Hacer Turgut ·
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    ABSTRACT: Aim: To investigate the seroprevalence of Anaplasma phagocytophilum in people living in 2 different climatic regions and to evaluate the co-seroprevalence rate of A. phagocytophilum with Borrelia burgdorferi. Sinop and Tokat provinces, both in the middle Black Sea region of Turkey, have distinct climatic features. Materials and methods: In 2006-2007, serum samples were collected from people living in rural areas of Tokat and Sivas, and anti-A. phagocytophilum IgG antibodies were explored by the IFA method. Positive samples were further investigated for the possible presence of B. burgdorferi IgG antibodies. Results: A. phagocytophilum seropositivity was found in 29 (10.62%) out of 273 serum samples in Sinop and 21 (5.77%) out of 364 serum samples in Tokat (P = 0.035). Co-seroprevalence for A. phagocytophilum and B. burgdorferi was found to be 3.30% in Sinop and 0.55% in Tokat (P = 0.012). Conclusion: The current study suggests that A. phagocytophilum infections can be seen in humans from different climatic regions of Turkey. Both the seroprevalence of A. phagocytophilum and the possibility of mixed infections of A. phagocytophilum and B. burgdorferi are higher in places with more suitable habitats for Ixodes ricinus ticks.
    Turkish Journal of Medical Sciences 10/2011; 41(5):903-908. DOI:10.3906/sag-1009-1148 · 0.50 Impact Factor
  • Turabi Gunes · Omer Poyraz · Zati Vatansever ·
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    ABSTRACT: During June and July 2007, about 3125 adult ticks were collected from humans, animals, and vegetation in a hyperendemic region (Sivas and Tokat) of Turkey. A total of 2193 ticks were pooled in 225 pools and screened for the Crimean Congo hemorrhagic fever virus (CCHFV) presence by antigen-capture enzyme-linked immunosorbent assay. Infection rates were calculated as the maximum likelihood estimation with 95% confidence intervals (CI). The dominant tick species was found to be Hyalomma marginatum with the following infestation rates in human, cattle and sheep, respectively: 47.43%, 66.07%, and 30.12%. Maximum likelihood estimation values of CCHFV in H. marginatum ticks collected from human, cattle, and sheep were 0.91% (CI 0.05-4.42), 2.10% (CI 1.12-3.64), and 3.11% (CI 1.18-6.87), respectively. CCHFV antigens were also demonstrated in Hyalomma excavatum, Haemaphysalis parva, and Boophilus annulatus ticks collected from cattle and Rhipicephalus bursa ticks from sheep. Our results suggest that the studied area might maintain its endemic properties in the near future unless effective tick control measures are implemented.
    Vector borne and zoonotic diseases (Larchmont, N.Y.) 07/2011; 11(10):1411-6. DOI:10.1089/vbz.2011.0651 · 2.30 Impact Factor
  • Turabi Güneş · Omer Poyraz · Mehmet Ataş · Ahmet Alim ·
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    ABSTRACT: Tick-borne encephalitis (TBE), caused by tick-borne encephalitis virus (TBEV) is one of the serious neurological infections seen especially in the Asian and North European countries. The principal vectors of TBEV are hard ticks belonging to Ixodes genus. The major vector of European TBEV subtype is I.ricinus and the major vector of Far-Eastern and Siberian subtypes is I.persulcatus. I.ricinus exists in many climatic regions of Turkey, especially in the coastal areas. The aim of this study was to investigate the TBEV seroprevalence among the residents of rural areas in Sinop (a province located at the coast of Central Black-Sea region of Turkey). A total of 273 blood samples have been collected from the subjects (age range: 11-83 years) inhabiting in 12 villages of the central district of Sinop, during the months of May and June in 2006 and 2007. The presence of TBEV IgG antibodies in serum samples were searched by a commercial indirect fluorescent antibody kit (Euroimmun, Deutschland). TBEV IgG positivity was detected in 2.9% (8/273) of the subjects at a screening titer (1/10) and 7 (2.6%) of them also yielded positive results at further dilutions (1/100). The rates of TBEV seropositivity were not found statistically significant (p > 0.05), with respect to gender (141 of the subjects were male), age (142 of the subjects were between 21-50 years old), occupation (17 foresters, 57 were shepherds, 199 were farmers/stockbreeders) and history of tick bite (169 of the subjects had been bitten by ticks). Presence of IgG antibodies against Borrelia burgdorferi, another agent which is transmitted by the same vector, were also investigated in TBEV seropositive 8 subjects by a commercial ELISA kit (Zeus Scientific, The Netherlands). Four of these subjects yielded B.burgdorferi IgG positivity, so the TBEV - B.burgdorferi coinfection rate was estimated as 1.5% (4/273). However, since the results obtained by the tests used in this study (TBEV IgG IFA and B.burgdorferi IgG ELISA) have not been confirmed by additional confirmational tests, these subjects were referred as "probable cases". In recent years the detection rates of vector-borne viral infections is in an increment trend in Turkey due to the developments in diagnostic tests and awareness for emerging infections. In conclusion since Sinop, which is placed in the northernmost point of Turkey, is located close to TBEV endemic areas, the presence of TBEV in Sinop and the Black Sea region should always be considered.
    Mikrobiyoloji bülteni 10/2010; 44(4):585-91. · 0.65 Impact Factor
  • Omer Poyraz · Turabi Güneş ·
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    ABSTRACT: Babesia species are blood parasites which transmitted by ticks and located in erythrocytes. Babesia divergens in Europe and Babesia microti in America are the most significant etiologic agents of human babesiosis cases. The aim of this study was to determine serologically whether people living in Sinop where Ixodes ricinus ticks are commonly seen have been exposed to B. microti or not. For this purpose, during May and June of 2006-2007, blood specimens were obtained from 273 individuals who lived in villages of the Sinop region. B. microti IgG antibodies were investigated by the indirect fluorescent antibody test in sera obtained from blood specimens. B. microti seropositivity was found in 6.23% of these sera. There was no statistical difference in antibody seropositivity rates according to sex groups, age groups, occupational groups and recall of tick bites (p > 0.05). This study is the first seroepidemiologic report of B. microti antibodies in people living in Turkey.
    Turkiye parazitolojii dergisi / Turkiye Parazitoloji Dernegi = Acta parasitologica Turcica / Turkish Society for Parasitology 01/2010; 34(2):81-5.
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    ABSTRACT: In the Tokat and Sivas provinces of Turkey, the overall Crimean-Congo hemorrhagic fever virus (CCHFV) seroprevalence was 12.8% among 782 members of a high-risk population. CCHFV seroprevalence was associated with history of tick bite or tick removal from animals, employment in animal husbandry or farming, and being >40 years of age.
    Emerging Infectious Diseases 04/2009; 15(3):461-4. DOI:10.3201/eid1503.080687 · 6.75 Impact Factor
  • Hulya Toker · Omer Poyraz · Kaya Eren ·
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    ABSTRACT: The aim of this study was to examine the effect of phase I periodontal treatment on the levels of interleukin (IL)-1beta, IL-1ra, and IL-10 in gingival crevicular fluid (GCF) in patients with generalized aggressive periodontitis (G-AgP). Data were obtained from 15 patients with aggressive periodontitis and 15 healthy controls. GCF was collected from at least four pre-selected sites (one shallow, at least two moderate, or at least one deep pockets) in patients with G-AgP. In the healthy group, GCF samples were collected from one site. The cytokine levels were determined by an enzyme-linked immunosorbent assay. Probing depth, clinical attachment level (CAL), gingival and plaque indices, and bleeding on probing were measured. The GCF sampling and clinical measurements were recorded at baseline and 6 weeks later after periodontal treatment. IL-1beta levels were significantly higher at the moderate and deep pocket sites compared with the shallow sites (p<0.05). After periodontal therapy, IL-1beta levels were significantly reduced in the moderate and deep pocket sites (p<0.05). IL-1ra levels at baseline of the moderate and deep pocket sites were significantly lower than the control sites (p<0.05). IL-10 levels were similar in all pockets and did not change after periodontal therapy. The periodontal treatment improves the clinical parameters in G-AgP, and this improvement is evident in deep pocket sites for pocket depth and CAL values. These results confirm that IL-1beta is effective for evaluating the periodontal inflammation and can thus be used as a laboratory tool for assessing the activity of periodontal disease.
    Journal Of Clinical Periodontology 06/2008; 35(6):507-13. DOI:10.1111/j.1600-051X.2008.01213.x · 4.01 Impact Factor
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    ABSTRACT: Study was started in November 2005 and education practices and other activities have been realized between the dates of December 2005 and 5 January 2006. A wide group has been chosen from the students who are at the level of primary and secondary education to adults as a target mass to create awareness. Correspondences related to the subject have been done with Cumhuriyet University rector ship, Sivas governs ship, Sivas manager of education, Sivas mufti and essential otorizations got. Pictorial leaflets which introduce disease and explain infection and ways of protection are prepared and sent all province and county school by means of Manager of Education. Besides, lots of leaflet is distributed to tradesmen and public. Large sized posters are published about disease to make people aware of it. It is provided that these posters are distributed to all schools and mosques. Lectures are organized to introduce the disease and emphasize the ways of protection in five fixed center by two sessions. It is provided that 89 primary and secondary school students' attendance regularly with their teachers. Besides the working of society awareness, preparing executing and treating of control programs about cystic echinococcosis are other important and necessary stages.
    Turkiye parazitolojii dergisi / Turkiye Parazitoloji Dernegi = Acta parasitologica Turcica / Turkish Society for Parasitology 02/2007; 31(4):313-7.
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    Hulya Toker · Ismail Marakoglu · Omer Poyraz ·
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    ABSTRACT: The aim of the present study was to determine the effects of meloxicam after initial periodontal treatment on interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1ra) in gingival crevicular fluid (GCF) and clinical parameters in the chronic periodontitis patients. Data were obtained from 30 patients with chronic periodontitis. Fifteen chronic periodontitis patients received 7.5 mg meloxicam, and 15 patients received placebo tablets in a 1x1 regimen for 1 month. All subjects were nonsmokers and had not received any periodontal therapy. The plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL) were recorded. The GCF was collected using a paper strip: eluted and enzyme-linked immunoabsorbent assays (ELISAs) were performed to determine the cytokine levels. The clinical data and GCF samples were obtained after periodontal therapy and 1 month after periodontal therapy. The PI, GI, PD, and GCF IL-1ra decreased significantly (p<0.05) in meloxicam group at first month when comparing the initial levels. While decrease of the PI was statistically significant in control group (p<0.05), statistically significant changes were not determined in the other clinical parameters and GCF cytokine levels (p>0.05). There were no significant differences between two groups in any of the investigated parameters. Our observations did not reveal any influence of meloxicam on levels of IL-1beta and IL-1ra in chronic periodontitis. Additional clinical studies are advisable to determine whether COX-2 selective drugs alter periodontal disease outcome with greater safety.
    Clinical Oral Investigations 12/2006; 10(4):305-10. DOI:10.1007/s00784-006-0062-3 · 2.35 Impact Factor
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    ABSTRACT: The aims of this study were to investigate the presence of vector ticks for Borrelia burgdorferi and to determine the seropositivity of lyme disease in Sivas region of Middle Anatolia. A total of 10,303 ticks were collected and classified at genus level, however, none of them belonged to Ixodes genus, the vector of B. burgdorferi. For the seroepidemiological study, serum samples were collected from 270 subjects who inhabited in rural area and raised livestock, and from 135 subjects as the control group who inhabited in urban area and have no livestock story. The samples were screened for the presence of B. burgdorferi IgG antibodies with a commercial enzyme immunoassay kit (ImmunoWell Borrelia, Genbio, San Diego). As a result, one subject in the each group (0.4% and 0.7%, respectively) yielded positive result, however as these sera gave positive reaction in rapid plasma reagin (RPR) test, these were evaluated as cross-reactivity (false positivity). These results indicated that lyme disease is not endemic in our region since neither Ixodes genus ticks nor seropositive subjects were detected.
    Mikrobiyoloji bülteni 11/2005; 39(4):503-8. · 0.65 Impact Factor
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    ABSTRACT: Urease-producing bacteria have been shown to affect the formation of infection stones by splitting urea into ammonia, bicarbonate and carbonate. An increase in alkaline pH results in urinary supersaturation of the ions. The increase in ammonia also causes injury to the urothelial glycosaminoglycan layer. Non-urease-producing bacteria have been speculated to form urinary stones. Midstream voided bladder urine and fractured stone nidus samples from 72 patients undergoing surgery for urolithiasis were cultured on specific media for genital mycoplasmata and on conventional media. Urine samples were obtained from a control group of 40 healthy subjects. Genital mycoplasmata and other bacteria were evaluated with regard to the composition of urinary stones. Compared with other origins of stones, the relation between isolation of Ureaplasma urealyticum and infection stone disease was statistically proven. Isolation of genital mycoplasmata was significantly higher in women than in men in the study group. The urinary stones comprised 84.7% calcium stones, 8.3% uric acid stones and 6.9% infection (magnesium ammonium phosphate) stones. Coagulase-negative Staphylococci, Escherichia coli, Corynebacterium spp., Enterobacterium spp. and U. urealyticum were cultured from stone samples. The results suggests that non-urease-producing bacteria, as well as urease-producing bacteria, may influence the formation of urinary stones.
    Infectious Diseases 02/2003; 35(5):315-7. DOI:10.1080/00365540310004018 · 1.50 Impact Factor
  • Ahmet Alim · Yahya Hakgüdener · Omer Poyraz ·
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    ABSTRACT: Microbiological contamination of hot spring waters is a public health problem, and hot spring waters have been thought to be a potential source of Legionella infections. In this study, 209 water samples collected from 69 thermal pools of 36 hot springs in the Central Anatolia Region were examined for the presence of Legionella spp. between September and November 2001. The water samples were concentrated via filtration, and the filtrates were decontaminated by low-pH method. Then the samples were cultured on non-selective (Buffered Charcoal Yeast Extract Agar, BCYE) and selective (GVPC; BCYE supplemented with glycine, vancomycin, polymyxin B, cycloheximide, and MWY; BCYE supplemented with glycine, anisomycin, polymyxin B, vancomycin, bromthymol blue, bromcresole purple) media, and suspected colonies were confirmed by Legionella Latex Kit (Oxoid) and direct fluorescent antibody test. As a result, 24 out of 209 (11.5%) water samples were found positive for Legionella pneumophila, and a total 26 L. pneumophila strains were isolated from these 24 samples. Two of these isolates were found reactive with serogroup 1, 20 were reactive with serogroup 2-14 antisera in agglutination test, while 2 samples collected from the same thermal pool, have yielded 2 strains, of which one was serogroup 1 and the other was serogroup 2-14. L. pneumophila was detected in 22.2% of hot springs (8 of 36) and 14.5% of thermal pools (10 of 69). L. pneumophila concentrations which were detected in water samples ranged from 10 to 430 CFU/100 ml. This is the first data for the prevalence of Legionnaires' disease agent in hot spring spas in the Central Anatolia Region of Turkey. Colonization of bacterium in some spas indicates that the certain hot springs might be endemic focuses for Legionnaires' disease in our country.
    Mikrobiyoloji bülteni 01/2002; 36(3-4):237-46. · 0.65 Impact Factor