S E Moon

Seoul National University Hospital, Sŏul, Seoul, South Korea

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Publications (8)17.79 Total impact

  • S E Moon, J I Youn, J A Kim
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    ABSTRACT: In a mouse model, we investigated whether different exposure protocol of ultraviolet-B with the same total doses could induce a different degree of photodamage in mouse skin. Two different exposure frequencies, three times or six times a week, were applied under the condition of weekly same cumulative irradiation dose equally for 10 weeks. Then the photodamage parameters such as skin wrinkling, histochemical dermal change and epidermal and dermal thickness were evaluated. Wrinkle grade, histological assessment by score, and dermal thickness did not reveal any difference between the two groups. However, at irradiation week 10 epidermal thickness of the three times a week irradiation group was significantly thicker than that of the six times a week irradiation group. The same cumulative dose resulted in different epidermal thickness. Our results suggested that exposure frequency or scheduling could influence the epidermal damage by ultraviolet radiation even though the cumulative dose is equal.
    Photodermatology Photoimmunology and Photomedicine 05/2000; 16(2):74-7. · 1.52 Impact Factor
  • S E Moon, S B Park, H T Ahn, J I Youn
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    ABSTRACT: Several clinical reports have suggested that alpha hydroxy acids (AHAs), including glycolic acid, may improve photoaging. However, the mechanism of action of glycolic acid is not well understood. In order to investigate the mechanism of action of glycolic acid in improving photoaged skin, we observed the effect of glycolic acid on collagen metabolism and wrinkle effacement in chronically ultraviolet B (UVB) irradiated mice. Skh:HR-1 mice were exposed to UVB for 10 weeks and then treated topically with 15% glycolic acid for 10 weeks. We assessed the improvement in wrinkling, the depth of the dermal repair zone, and the extent of the increase in collagen synthesis. At treatment week 10, the glycolic acid-treated mice showed a significant decrease in wrinkle score, an increased thickness of the dermal repair zone, and an increase in the amount of collagen synthesized compared to vehicle (hydrophilic ointment base) treated mice. Topically applied glycolic acid may improve photoaging through modulation of collagen production.
    Dermatologic Surgery 04/1999; 25(3):179-82. · 1.87 Impact Factor
  • S W Kim, S E Moon, J A Kim, H C Eun
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    ABSTRACT: Many clinicians perform glycolic acid peels for facial acne patients, but there has not been a well-controlled study to compare this new therapy with other conventional modalities. To compare the effectiveness of treatment and side effects in the treatment of facial acne by two agents, 70% glycolic acid and Jessner's solution. Twenty-six patients with facial acne were treated simultaneously with 70% glycolic acid and Jessner's solution biweekly on each side of the face. The treatment sides were randomized and the evaluation of treatment was done biweekly by a blinded evaluator who did not know the randomization code. Dr. Cunliffe's acne grading system was used for objective comparison. All patients were also asked about the improvement of facial acne and about the side effects experienced. Finally, the patients answered the preference test between the 2 peeling methods. Acne grading of both treatments improved after 3 treatment sessions. However, there were no significant differences in treatment effects between the 2 methods. As far as side effects were concerned, sites treated with Jessner's solution showed a significantly increased degree of exfoliation compared to glycolic acid (p < 0.01). Glycolic acid is less widely used than Jessner's solution due to its inconvenient application technique. But considering the equal treatment effect and lesser degree of exfoliation in glycolic acid, we would recommend the use of glycolic acid over Jessner's solution for acne patients.
    Dermatologic Surgery 04/1999; 25(4):270-3. · 1.87 Impact Factor
  • S W Kim, S E Moon, J A Kim
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    ABSTRACT: Subungual osteochondroma is a rare form of benign bone tumor characterized by distinctive histopathological and radiological findings. The major clinical manifestation is a firm mass with tenderness. It must be differentiated from other similar diseases such as subungual exostosis, glomus tumor, and enchondroma to determine the proper surgical procedure. A 13-year-old boy had a history of a growing tender mass on the right third toe which recurred after simple excision. He was treated by careful dissection and total excision under local anesthesia. Histologic findings included a trabecular bone formation covered with hyaline cartilage cap and were compatible with osteochondroma.
    The Journal of Dermatology 01/1998; 25(1):60-2. · 1.77 Impact Factor
  • S W Kim, S E Moon, J A Kim
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    ABSTRACT: We report a 25-year-old man who had two protruding firm masses on his suprasternal region. These lesions were present at birth without any family history. He had no other subjective symptoms. In a histological specimen, there were numerous unevenly distributed telogen follicles that contained vellus hairs. Beneath a relatively narrow zone of fibrovascular tissue, lobules of fat with a central core of cartilage were seen. The mass was totally excised; during the follow-up period, there was no evidence of recurrence. The tragus derives from the first branchial arch. The accessory tragus can be found along the entire course of embryonic migration. It is usually located unilaterally in the preauricular region. To our knowledge, bilateral development on the suprasternal region has not been previously reported.
    The Journal of Dermatology 09/1997; 24(8):543-5. · 1.77 Impact Factor
  • B S Park, S E Moon, J A Kim
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    ABSTRACT: A 55-year-old male suffering from liver cirrhosis presented with diffuse annular hyperkeratotic papules of abrupt onset on the trunk and extremities. Histopathologic examination revealed cornoid lamella and eosinophilic spongiosis. He did not receive any medications other than cephalosporin for spontaneous bacterial peritonitis. A review of the literature revealed that three cases developed porokeratosis when their liver function declined and that, in one case, the porokeratosis disappeared spontaneously with liver transplantation. Although the precise mechanism is unclear, there is evidence demonstrating immunoincompetence in cirrhosis. Even though we did not perform immunologic studies or exclude the possibility of drug-induced porokeratosis in our case, it is conceivable that porokeratosis can be triggered by immunosuppression due to liver cirrhosis per se.
    The Journal of Dermatology 08/1997; 24(7):485-7. · 1.77 Impact Factor
  • S E Moon, B S Park, J A Kim, G Y Choe
    Acta Dermato Venereologica 06/1997; 77(3):247-8. · 3.49 Impact Factor
  • O S Kwon, S E Moon, J A Kim, K H Cho
    British Journal of Dermatology 03/1997; 136(2):295-6. · 3.76 Impact Factor

Publication Stats

43 Citations
17.79 Total Impact Points

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Institutions

  • 2000
    • Seoul National University Hospital
      • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 1997
    • Seoul National University
      • Department of Dermatology
      Seoul, Seoul, South Korea