J. Cabau Rubies

Santa Maria Goretti Hospital, Littoria, Latium, Italy

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Publications (10)0 Total impact

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    ABSTRACT: Obstructive sleep apnea/hypopnea (OSAH) syndrome is a condition characterized by recurrent episodes of restricted airflow through the upper airway that causes oxygen desaturation, microarousals and destructed sleep with negative repercussions for quality of life and cardiovascular risk. This condition has been attracting special interest as it has been shown to be a cause of arterial hypertension as well as its concurrence with other risk factors. OSAH also produces other modifications in the circadian rhythm of arterial pressure, resulting in a tendency for patients to exhibit a less favorable nondipper pattern. In the present review, we examine the pathophysiological mechanisms involved in the relationship between OSAH and systemic arterial hypertension. We also consider other parallel processes through which OSAH may produce vascular lesions, including an increase in oxidative stress, and its negative impact on both the lipid profile and plaque adhesion. All of this contributes to the appearance of atheromatosis lesions in patients with OSAH and their repercussions in terms of related events. Furthermore, the article examines evidence provided by clinical trials that associates OSAH with a higher risk of left ventricular hypertrophy, systolic and diastolic cardiac failure, ischemic heart disease, cardiac arrhythmias, cerebrovascular disease, and a greater incidence of cardiovascular morbidity-mortality.The usual treatment recommended for this syndrome is continuous positive airway pressure (CPAP). CPAP has been shown to be effective in reducing arterial pressure in hypertensive patients with OSAH. Although this effect is apparently moderate, its results are clearly as the cases become more severe or when the level of arterial hypertension is greater. CPAP has also been shown in observational studies to be effective in reducing cardiovascular morbidity-mortality associated with the syndrome.
    Hipertensión y Riesgo Vascular 04/2009; 26(2). DOI:10.1016/S1889-1837(09)71179-1
  • Anales de medicina interna (Madrid, Spain: 1984) 02/2008; 25(1):46-7.
  • Anales de medicina interna (Madrid, Spain: 1984) 01/2008; 25(1). DOI:10.4321/S0212-71992008000100014
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    Anales de medicina interna (Madrid, Spain: 1984) 12/2007; 24(11):562-3.
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    ABSTRACT: Pericarditis is an unusual manifestation of gigantic cell arteritis. The following essay describes the case of a female patient who had been diagnosed, three years earlier, with several types of rheumatic myalgia, and because of this, she had had periodical tests in which no complications at all had been observed. At the age of 69, this female patient consulted the doctor for mild fever, dry cough, anorexia and diffuse abdominal pain. The echocardiography showed pericardium discharge and complementary explorations ruled out infectious or neoplasia processes. A corticoid treatment was started and the symptomatology improved in a few days, the pericardium discharge being solved in 3 months.
    Anales de medicina interna (Madrid, Spain: 1984) 09/2006; 23(8):382-4.
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    ABSTRACT: We present a very unusual clinical case of giant cell arteritis with uterus involvement, in a women of 66 years old, that began clinical features of pain and functional limitation of shoulders and hip 3 mouth before been operated of uterus prolapse with hysterectomy. Biopsy of uterus found affected arterial vesels with wall sclerosis and granulomatous inflamation with giant cells, without necrosis, involving media and perivascular portions suggesting giant cell arteritis. In a previous reports review, we only found ten similar clinical cases. In that cases, clinical features were no suggestif of the disease. Although the well known tendency of arteritis to involve some specific vascular areas, the case we present is an example of the systemic course of the disease and his difficulty to diagnose.
    Anales de medicina interna (Madrid, Spain: 1984) 07/2006; 23(6):282-4.
  • Anales de medicina interna (Madrid, Spain: 1984) 01/2006; 23(8). DOI:10.4321/S0212-71992006000800007
  • [Show abstract] [Hide abstract]
    ABSTRACT: We present a very unusual clinical case of giant cell arteritis with uterus involvement, in a women of 66 years old, that began clinical features of pain and functional limitation of shoulders and hip 3 mouth before been operated of uterus prolapse with hysterectomy. Biopsy of uterus found affected arterial vesels with wall sclerosis and granulomatous inflamation with giant cells, without necrosis, involving media and perivascular portions suggesting giant cell arteritis. In a previous reports review, we only found ten similar clinical cases. In that cases, clinical features were no suggestif of the disease. Althougt the well known tendency of arteritis to involve some specific vascular areas, the case we present is an example of the systemic course of the disease and his dificulty to diagnose.
    Anales de medicina interna (Madrid, Spain: 1984) 01/2006; 23(6). DOI:10.4321/S0212-71992006000600009
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    ABSTRACT: La artritis reumatoide (AR) está asociada a una amplia variedad de manifestaciones pulmonares, entre las que se incluye la presencia de nódulos reumatoides. Aportamos el caso de una paciente diagnosticada de AR y que por cuadro de tos y disnea a esfuerzos se le realizó una tomografía computarizada (TC) torácica que informó de la presencia de pequeños nódulos pulmonares. Una vez biopsiados fueron diagnosticados como granulomas de colesterol
    Reumatología Clínica 01/2006; 2(1).
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    ABSTRACT: Presentamos el caso de una paciente de 48 años diabética que ingresó en nuestro centro con clínica de fallo biventricular e hipertensión acelerada. Un análisis superficial del cuadro orientaba a esta hipótesis, ya que la paciente presentaba retinopatía hipertensiva de grado III, derrame pleural bilateral, severa disfunción diastólica comprobada por ecocardiografía y proteinuria atribuible a nefropatía hipertensiva o diabética. La evidencia de la existencia de elementos inexplicados (derrame pleural exudativo, anemia inflamatoria, velocidad de sedimentación glomerular y PCR elevadas) nos llevan a sospechar un proceso de mayor complejidad inflamatorio-sistémico subyacente que finalmente se confirma con unos anticuerpos antinucleares positivos titulo 1/1.280 patrón homogéneo y la realización de biopsia renal que muestra nefropatía lúpica de grado IV. Todo ello nos lleva a cambiar todo el enfoque diagnóstico.
    Hipertensión y Riesgo Vascular 01/2004; 21(8):418-421. DOI:10.1016/S1889-1837(04)71841-3