Kalomoira Kefala-Agoropoulou

Publications (3)5.1 Total impact

• Article: Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review.

  Kalomoira Kefala-Agoropoulou, Efthimia Protonotariou, Danai Vitti, Sofia Sarafidou, Athanasia Anastasiou, Konstantinos Kollios, Emmanuel Roilides
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  ABSTRACT: We report an unusual case of serious, multifocal, invasive infection due to community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in a 10-year-old girl with favorable outcome. The child manifested femoral osteomyelitis, pyomyositis, deep femoral vein thrombosis, pneumonia, encephalopathy, and disturbances of almost all organs. She remained in a critical condition for a week. Fever persisted for 6 weeks and acute phase reactants remained increased for 6 months, necessitating a 7-month antistaphylococcal therapy with a glycopeptide and clindamycin. This led to resolution of infection-associated problems during the subsequent 36 months of follow-up. CA-MRSA strain isolated from the patient harbored both staphylococcal chromosomal cassette type IV (SCCmec type IV) and Panton-Valentine leukocidin genes. A literature review of serious CA-MRSA infections indicated that only a small minority of published cases had favorable outcome.
  European Journal of Pediatrics 05/2009; 169(1):47-53. · 1.88 Impact Factor
• Article: Cutaneous zygomycosis in an infant with Pearson syndrome.

  Kalomoira Kefala-Agoropoulou, Evangelia Farmaki, John Tsiouris, Emmanuel Roilides, Aristea Velegraki
  Pediatric Blood & Cancer 05/2008; 50(4):939-40. · 1.89 Impact Factor
• Article: Pearson syndrome in an infant heterozygous for C282Y allele of HFE gene.

  Kalomoira Kefala-Agoropoulou, Emmanuel Roilides, Anna Lazaridou, Eliza Karatza, Evangelia Farmaki, Haido Tsantali, Persephone Augoustides-Savvopoulou, John Tsiouris
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  ABSTRACT: Pearson syndrome is a rare mitochondrial disorder characterized by sideroblastic anemia, liver disease, renal tubulopathy and exocrine pancreas deficiency. We describe a female infant suffering from anemia since birth who gradually developed the complete picture of Pearson syndrome by 13 months. Iron overload was disproportionate to blood transfusions. The patient was heterozygous for HFE gene C282Y mutation (type I hemochromatosis). After an initial response to deferoxamine she presented with cutaneous zygomycosis and died after metabolic derangement and Pneumocystis jiroveci pneumonia. This is the second case of a Pearson syndrome individual who was also heterozygous for HFE gene mutation C282Y published. It is also the second case report of a Pearson patient suffering from severe iron overload and liver disease that responded to therapy with deferoxamine.
  Hematology (Amsterdam, Netherlands) 01/2008; 12(6):549-53. · 1.33 Impact Factor