T Akpolat

Publications (78)532.29 Total impact

• Article: Is localized prostate cancer an obstacle for an immediate consideration for renal transplantation? A case report.

  B Kocak, C Y Bilen, M Dilek, Z Adibelli, T Akpolat, S Sarikaya
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  ABSTRACT: Currently, renal failure patients with a history of prostate cancer are recommended to have a 2 to 5-year disease-free interval prior to being allowed to receive a kidney transplant. This disease is now amenable to curative therapy if diagnosed at an early stage when the tumor is organ-confined. We report a patient undergoing immediate renal transplantation following a laparoscopic radical prostatectomy for the treatment of prostate cancer. Candidates for renal transplantation who are diagnosed with early stage, organ-confined prostate cancer may be immediately considered for transplantation following radical prostatectomy in view of the high likelihood of cure of their prostate cancer.
  Transplantation Proceedings 07/2009; 41(5):1961-2. · 1.00 Impact Factor
• Article: Phosphorus control in peritoneal dialysis patients.

  A Yavuz, F F Ersoy, P S Passadakis, P Tam, D M Evaggelos, K P Katopodis, C Ozener, F Akçiçek, T Camsari, K Ateş, [......], I Karayaylali, T Arinsoy, C P Stathakis, M Yavuz, D J Tsakiris, A C Dimitriades, M E Yilmaz, M Gültekin, G Süleymanlar, D G Oreopoulos
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  ABSTRACT: Hyperphosphatemia is independently associated with an increased risk of death among dialysis patients. In this study, we have assessed the status of phosphate control and its clinical and laboratory associations in a large international group of patients on chronic peritoneal dialysis (PD) treatment. This cross-sectional multicenter study was carried out in 24 centers in three different countries (Canada, Greece, and Turkey) among 530 PD patients (235 women, 295 men) with a mean+/-s.d. age of 55+/-16 years and mean duration of PD of 33+/-25 months. Serum calcium (Ca(2+)), ionized Ca(2+), phosphate, intact parathyroid hormone (iPTH), 25-hydroxy vitamin D(3), 1,25-dihydroxy vitamin D(3), total alkaline phosphatase, and bone alkaline phosphatase concentrations were investigated, along with adequacy parameters such as Kt/V, weekly creatinine clearance, and daily urine output. Mean Kt/V was 2.3+/-0.65, weekly creatinine clearance 78.5+/-76.6 l, and daily urine output 550+/-603 ml day(-1). Fifty-five percent of patients had a urine volume of <400 ml day(-1). Mean serum phosphorus level was 4.9+/-1.3 mg per 100 ml, serum Ca(2+) 9.4+/-1.07 mg per 100 ml, iPTH 267+/-356 pg ml(-1), ionized Ca(2+) 1.08+/-0.32 mg per 100 ml, calcium phosphorus (Ca x P) product 39+/-19 mg(2)dl(-2), 25(OH)D(3) 8.3+/-9.3 ng ml(-1), 1,25(OH)(2)D(3) 9.7+/-6.7 pg ml(-1), total alkaline phosphatase 170+/-178 U l(-1), and bone alkaline phosphatase 71+/-108 U l(-1). While 14% of patients were hypophosphatemic, with a serum phosphorus level lower than 3.5 mg per 100 ml, most patients (307 patients, 58%) had a serum phosphate level between 3.5 and 5.5 mg per 100 ml. Serum phosphorus level was 5.5 mg per 100 ml or greater in 28% (149) of patients. Serum Ca(2+) level was > or =9.5 mg per 100 ml in 250 patients (49%), between 8.5 and 9.5 mg per 100 ml in 214 patients (40%), and lower than 8.5 mg per 100 ml in 66 patients (12%). Ca x P product was >55 mg(2)dl(-2) in 136 patients (26%) and lower than 55 mg(2)dl(-2) in 394 patients (74%). Serum phosphorus levels were positively correlated with serum albumin (P<0.027) and iPTH (P=0.001), and negatively correlated with age (P<0.033). Serum phosphorus was also statistically different (P = 0.013) in the older age group (>65 years) compared to younger patients; mean levels were 5.1+/-1.4 and 4.5+/-1.1 mg per 100 ml, respectively, in the two groups. In our study, among 530 PD patients, accepted uremic-normal limits of serum phosphorus control was achieved in 58%, Ca x P in 73%, serum Ca(2+) in 53%, and iPTH levels in 24% of subjects. Our results show that chronic PD, when combined with dietary measures and use of phosphate binders, is associated with satisfactory serum phosphorus control in the majority of patients.
  Kidney international. Supplement 04/2008;
• Article: An unusual presentation of sirolimus associated cough in a renal transplant recipient.

  Z Adibelli, M Dilek, B Kocak, N Tülek, O Uzun, T Akpolat
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  ABSTRACT: Sirolimus-associated pulmonary problems are rare but life threatening. Pulmonary problems due to sirolimus treatment are interstitial pneumonitis, bronchiolitis obliterans organizing pneumonia (BOOP), and alveolar hemorrhage. We present a case of sirolimus-related cough in the absence of any pulmonary radiological findings. A 55-year-old man with a history of 4 years of hemodialysis therapy because of end-stage renal disease of unknown etiology underwent cadaveric renal transplantation in June 2006. Three days following the initiation of sirolimus therapy he complained of dry cough and fever. There were no clinical or laboratory findings compatible with specific pulmonary disease. After switching sirolimus to tacrolimus, the cough improved within 1-2 days and resolved in 5 days. Sirolimus should be considered in the differential diagnosis of pulmonary problems in the early posttransplantation period even in the absence of radiological findings.
  Transplantation Proceedings 01/2008; 39(10):3463-4. · 1.00 Impact Factor
• Article: Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis.

  H Taskapan, F F Ersoy, P S Passadakis, P Tam, D E Memmos, K P Katopodis, C Ozener, F Akcicek, T Camsari, K Ates, [......], G Wu, I Karayaylali, T Arinsoy, C P Stathakis, M Yavuz, D J Tsakiris, A D Dimitriades, M E Yilmaz, M Gültekin, D G Oreopoulos
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  ABSTRACT: The aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers. This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 and 1.25(OH)2D3 levels and some other clinical and laboratory indices of bone mineral metabolism. Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e., serum 25(OH)D3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e., serum 25(OH)D3 levels, 5-15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e., serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)2D3. We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation.
  Clinical nephrology 11/2006; 66(4):247-55. · 1.17 Impact Factor
• Article: Amyloidosis in Behçet's disease and familial Mediterranean fever.

  T Akpolat, E Yilmaz, I Akpolat, M Dilek, F Karagoz, B Balci, S Ozen
  Rheumatology 06/2002; 41(5):592-3. · 4.06 Impact Factor
• Article: Improvement of thyroid hormone profile and thyrotrophin (TSH) surge alterations in hemodialysis patients on erythropoietin treatment.

  C Utas, H Taskapan, O Oymak, T Akpolat, T Arinsoy, F Kelestimur
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  ABSTRACT: BACKGROUND, MATERIAL AND METHODS: This study was performed in 20 patients with end-stage chronic renal failure (CRF) and 10 healthy volunteers. All of the patients were on regular hemodialysis treatment (RHD), 10 of whom were on recombinant human erythropoietin (rHuEPO) therapy. Hematocrit levels of the patients with CRF on rHuEPO were between 0.30 to 0.33 and not on rHuEPO were below 0.24. Baseline serum T3, T4, fT3, fT4 and TSH levels were measured and TRH stimulation test was performed in patients and control subjects. Serum TSH levels were measured hourly during the afternoon (2 to 5 p.m.) and at night (10 p.m. to 2 a.m.) to determine the nocturnal rhythm of TSH. RESULTS: The mean T3 in rHuEPO, not rHuEPO and control groups were 98.01 +/- 5.54, 70.55 +/- 7.09, 98.29 +/- 4.2 ng/dl; T4 6.47 +/- 0.68, 6.39 +/- 0.59, 8.35 +/- 0.46 ng/dl; fT3 2.24 +/- 0.19, 1.52 +/- 0.24, 2.29 +/- 0.17 pg/ml and fT4 0.88 +/- 0. 14, 0.75 +/- 0.14, 0.97 +/- 0.10 ng/dl, respectively. These values were significantly lower in patients not on rHuEPO compared to controls (p < 0.05). In patients on rHuEPO only T4 values were lower than in the controls (p < 0.05). In patients not on rHuEPO the T3, and fT3 were significantly lower than the values of patients on rHuEPO treatment (p < 0.05). Normal in 8 (80%), blunted in 1 (10%), no TSH response in 1 (10%) to TRH stimulation were obtained in rHuEPO group. TSH response was normal in 1 (10%), and delayed in 9 (90%) patients not on rHuEPO. The circadian nocturnal rhythm of TSH was abnormal in 8 (80%) patients not on rHuEPO, in 2 (20%) patients on rHuEPO. As a result, CRF and RHD distorts the circadian TSH rhythm and substantially change the thyroid hormone profile probably by affecting hypothalamic-pituitary-thyroid axis. Distortion of the circadian rhythm of TSH and TSH response to TRH points to a defect at the level of hypothalamus and pituitary gland. CONCLUSION: rHuEPO treatment has some beneficial effects on hypothalamo-pituitary-thyroid axis in the patients on RHD.
  Clinical nephrology 06/2001; 55(6):471-6. · 1.17 Impact Factor
• Article: Polyarteritis nodosa in patients with Familial Mediterranean Fever (FMF): a concomitant disease or a feature of FMF?

  S Ozen, E Ben-Chetrit, A Bakkaloglu, H Gur, K Tinaztepe, M Calguneri, C Turgan, A Turkmen, I Akpolat, M Danaci, N Besbas, T Akpolat
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  ABSTRACT: Familial Mediterranean Fever (FMF) is caused by mutations in the gene encoding pyrin and is characterized by self-limited, recurrent attacks of fever and serositis. Vasculitis has been increasingly reported in FMF. A study evaluating the prognosis in FMF and polyarteritis nodosa (PAN) patients has not been reported previously. To determine the special characteristics and the prognosis of PAN in FMF patients. A questionnaire was used for the present survey. The setting was 7 referral centers from Turkey and Israel. Seventeen patients who were diagnosed with FMF and who developed PAN were included. PAN was diagnosed in those who met the Chapel Hill consensus criteria for microscopic polyarteritis or classic PAN. The clinical features of these 17 patients and the outcomes of their vasculitis were analyzed. The age at diagnosis of PAN in these FMF patients ranged from 3.5 to 37 years. All patients had constitutional symptoms, elevated acute phase reactants, and myalgia at the time PAN was diagnosed. The diagnosis of PAN was confirmed by renal angiography in 8 patients, by renal biopsy in 6 patients, and by muscle and/or nodule biopsies in 6 patients. A number of patients had definite features of both classic PAN and microscopic polyarteritis. When compared with other PAN patients, those with FMF tended to have a younger age at PAN onset, more frequent perirenal hematomas, and an overall better prognosis. The cases with overlapping features of microscopic and classic PAN pose a problem for the current classification of vasculitis. We suggest that the clinical representation of PAN in FMF patients has certain characteristics and may be a feature of FMF per se.
  Seminars in Arthritis and Rheumatism 03/2001; 30(4):281-7. · 4.97 Impact Factor
• Article: Behçet's disease and diverticulosis.

  C Sahan, T Akpolat, T Uçer, E Güner, M Dilek, M Danaci
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  ABSTRACT: Behçet's disease (BD) is a multisystem disorder characterized by vasculitis. The aim of this report is to present a patient with BD and diverticular disease of the colon and discuss the possible association between BD and diverticulosis. To our knowledge, diverticular disease of the colon has not been previously reported in a patient with BD. We conclude that the significance of this association between BD and diverticulosis needs to be clarified.
  Digestive Surgery 02/2001; 18(5):421-2. · 1.22 Impact Factor
• Article: MR imaging and MR angiography in vascular Behçet's disease.

  T Akpolat, M Danaci, U Belet, M L Erkan, H Akar
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  ABSTRACT: The aims of this study are to demonstrate the ability of magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) in the diagnosis and evaluation of vascular involvement in Behçet's disease. Twelve patients with vascular involvement due to Behçet's disease were included in this study. We believe that MRI and MRA are safe and noninvasive methods that can be used to confirm and monitor vascular Behçet's disease.
  Magnetic Resonance Imaging 12/2000; 18(9):1089-96. · 1.99 Impact Factor
• Source

  Available from: Arif mansur coşar

  Article: Effect of vitamin E and pentoxifylline on glycerol-induced acute renal failure.

  T Akpolat, I Akpolat, H Oztürk, S Sarikaya, A M Coşar, A Bedir, B Kandemir
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  ABSTRACT: The pathogenesis of acute renal failure may involve, among other causes, ischemia, vascular congestion, arachidonic acid pathways, and reactive oxygen metabolites. The aim of this study is to evaluate the effects of pentoxifylline and vitamin E on the prevention of experimental acute renal failure induced by glycerol. Eighty-five Sprague-Dawley rats weighing 170-230 g were included in the study. The rats were randomly divided into four groups: group 1 was given 1 ml saline; group 2, glycerol; group 3, glycerol plus vitamin E, and group 4, glycerol plus pentoxifylline. Extent of histological renal tubular necrosis and regeneration in each animal were graded. Blood urea nitrogen, serum creatinine, and creatine kinase concentrations were measured. Mean blood urea nitrogen and serum creatinine concentrations and tubular injury scores were significantly lower in group 1 than in groups 2-4 (p < 0.001), but there were no significant differences among groups 2-4. We conclude that postinsult administration of vitamin E and pentoxifylline does not have a beneficial effect on prevention and severity of acute renal failure and that controlled, multicenter studies involving a large number of patients are needed to clarify this subject.
  Nephron 03/2000; 84(3):243-7. · 13.26 Impact Factor
• Article: Small-cell carcinoma as a cause of superior vena cava syndrome in a patient with Behçet's disease.

  T Akpolat, L Yildiz, I Akpolat, M Bekir Selcuk, N Ozbek, I Yücel
  Respiration 02/2000; 67(5):593. · 2.26 Impact Factor
• Article: Tc-99m DMSA renal scan in polyarteritis nodosa with bilateral intraparenchymal renal artery aneurysms.

  T Basoglu, T Akpolat, F Canbaz, I Bernay, S Albayrak, M Kilic, M Danaci
  Clinical Nuclear Medicine 04/1999; 24(3):201-2. · 3.67 Impact Factor
• Source

  Available from: Hüseyin Akan

  Article: The prevalence of seminal vesicle cysts in autosomal dominant polycystic kidney disease.

  M Danaci, T Akpolat, M Baştemir, S Sarikaya, H Akan, M B Selçuk, K Cengiz
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  ABSTRACT: Autosomal dominant polycystic kidney disease (ADPKD) is a systemic hereditary disorder characterized by bilateral diffuse renal cysts. Extrarenal involvement is a well known manifestation of ADPKD. Data relating to the association between seminal vesicle cysts and ADPKD are limited. The aims of this study are to evaluate the frequency of seminal vesicle cysts in ADPKD and to assess the relationship between seminal vesicle cysts, with cysts in the liver and prostate, and creatininaemia. Forty five male patients (mean age 40 years, range 13-67) were included in the study. Each subject underwent a formal interview, physical examination; and abdominal and transrectal ultrasonography. Three patients were infertile, but one of the patients also had varicocele. Seminal vesicle cysts were present in 27 (60%) patients. Liver and prostate cysts were present in 19 (42%) and five (11%) patients, respectively. There was a positive correlation between seminal vesicle cysts, cysts in the liver, and serum creatinine concentrations. Our conclusions are: (i) seminal vesicle cysts are not uncommon in ADPKD; (ii) ADPKD should be looked for in patients with seminal vesicle cysts, and (iii) the clinical significance of seminal vesicle cysts in ADPKD remains to be defined.
  Nephrology Dialysis Transplantation 12/1998; 13(11):2825-8. · 3.40 Impact Factor
• Source

  Available from: oxfordjournals.org

  Article: M680I(Arm2)/M694V(Med) mutations in a patient with familial Mediterranean fever and polyarteritis nodosa.

  T Akpolat, E Yilmaz, S Ozen, I Akpolat, M Danaci, B Kandemir
  Nephrology Dialysis Transplantation 11/1998; 13(10):2633-5. · 3.40 Impact Factor
• Source

  Available from: oxfordjournals.org

  Article: Acute renal failure--an unusual consequence of uterine prolapse.

  F F Yanik, T Akpolat, I Koçak
  Nephrology Dialysis Transplantation 11/1998; 13(10):2648-50. · 3.40 Impact Factor
• Article: Seminal vesicle cysts in the patients with adult polycystic kidney disease.

  M Danaci, T Akpolat, M Baştemir, H Akan, M Selçuk
  Clinical nephrology 10/1998; 50(3):199-200. · 1.17 Impact Factor
• Article: Hepatitis G and erythropoietin therapy in patients undergoing hemodialysis.

  K Cengiz, M Günaydin, T Akpolat, A Pekbay
  Nephron 09/1998; 79(4):507. · 13.26 Impact Factor
• Article: Nonrelated living-donor kidney transplantation: medical and ethical aspects.

  M Colakoglu, M Yenicesu, T Akpolat, A Vural, C Utaş, T Arinsoy, S Sindel, E Akoglu, U Yasavul, C Turgan, S Caglar
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  ABSTRACT: Several patients with end-stage renal disease went to Bombay for renal transplantation from nonrelated living donors and then returned to Turkey for posttransplantation follow-up. The aims of this study are to evaluate the long-term results of renal transplantation from nonrelated living donors in Turkish patients with end-stage renal disease and to discuss the ethical and social aspects of nonrelated kidney donation. One hundred and twenty-seven patients (89 males, 38 females; mean age 38.1, range 17-63 years) were investigated retrospectively. None of the patients went to Bombay on our advice. All transplantations were performed between 1991 and 1995. The mean follow-up period after transplantation was 34.2 (range 1-68) months. Graft survival rates were 85, 83, and 57% after 3 months and 1 and 5 years, respectively. Patient survival rates were 94, 93, and 92% after 3 months and 1 and 5 years, respectively. Seven patients died within the first 3 months after the transplantation. Surgical problems, infections, acute rejection, ciclosporin nephrotoxicity, and hepatic problems were common complications. We conclude that medical and surgical complications occur frequently in paid kidney transplantation, but most of these complications can be prevented by adequate preoperative management, and precautionary measures should be taken to prevent commercialization of renal transplantation before the spread of emotionally related living kidney donation.
  Nephron 09/1998; 79(4):447-51. · 13.26 Impact Factor
• Article: Phrenic nerve palsy caused by subclavian vein catheterization.

  I Işlek, T Akpolat, M Danaci
  Nephrology Dialysis Transplantation 05/1998; 13(4):1023-5. · 3.40 Impact Factor
• Article: The value of bone marrow biopsy for the diagnosis of amyloidosis secondary to tuberculosis.

  I Akpolat, T Akpolat, L Yildiz, L Erkan, B Kandemir
  The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 04/1998; 2(3):262. · 2.73 Impact Factor