M Meurisse

Publications (194)220.19 Total impact

• Article: Evolution of native kidney function after pancreas transplantation alone.

  H Le Dinh, A Deroover, C Coimbra, L Weekers, J Léonet, M Meurisse, J P Squifflet
  [show abstract] [hide abstract]
  ABSTRACT: This study investigated changes in kidney function over time among a cohort of patients undergoing pancreas transplantation alone (PTA) from January 2002 to December 2011. Ten of eighteen PTA patients bearing functioning grafts for at least 1 year were recruited for the analysis. Primary endpoints were changes in mean serum creatinine (SCr, mg/L) and mean estimated glomerular filtration rate (eGFR) using the 4-variable Levey-MDRD equation (mL/min/1.73 m(2)) comparing baseline (pretransplantation) to 6-month, 1-year, 3-year, and 5-year posttransplantation values. Mean follow-up time was 75.7 ± 20.5 months (range, 46-106.5). Baseline eGFR was 89.3 ± 27.9 (range, 58-145). eGFR decreased to 75.7 ± 26.2, 71 ± 20.6, 66.5 ± 14.8, and 62.1 ± 11.2 at 6 months, 1, 3, and 5 years representing -15.2%, -20.5%, -15.8%, and -22.6% percentage decreases respectively (P < .05 for all pairwise comparisons). The Baseline SCr was 8.6 ± 2.3 mg/L (range, 5-13). SCr progressively increased to 10.1 ± 3, 10.5 ± 3.1, 10.9 ± 3.1, and 11.3 ± 1.7 at 6 months, 1, 3, and 5 years a 17.1%, 22%, 16.6%, and 19.9% increase respectively (P < .05 for all pairwise comparisons). One of ten, 2/8, and 3/7 patients displayed an eGFR <60 at transplantation versus 3 and 5 years thereafter, respectively. No patient developed a SCr > 25 mg/L or eGFR <30 or needed dialysis or kidney transplantation. Five of ten patients had micro-albuminuria or proteinuria before transplantation. Tacrolimus levels were within recommended therapeutic ranges over time. Kidney function deteriorated significantly after PTA. Understanding of risk factors for the development of renal impairment is important to preserve kidney function and to select appropriate candidates for PTA.
  Transplantation Proceedings 11/2012; 44(9):2829-33. · 1.00 Impact Factor
• Article: Delayed graft function does not harm the future of donation-after-cardiac death in kidney transplantation.

  H Le Dinh, L Weekers, C Bonvoisin, J M Krzesinski, J Monard, A de Roover, J P Squifflet, M Meurisse, O Detry
  [show abstract] [hide abstract]
  ABSTRACT: Delayed graft function (DGF) occurs more frequently in kidney transplants from donation after cardiac death (DCD) than from donation after brain death (DBD). We investigated the effect of DGF on posttransplantation outcomes among grafts from controlled DCD kidneys. This single-center retrospective study recruited 80 controlled DCD kidneys transplanted from January 2005 to December 2011. Mean patient follow-up was 28.5 months. There were no primary nonfunction grafts; the DGF rate was 35.5%. Overall graft survival rates between groups with versus without DGF were 92.4% and 95.2% at 1 year, 92.4% and 87.1% at 3 years, and 84.7% and 87.1% at 5 years, respectively (P = not significant (NS)). Patients with versus without DGF showed the same survival rates at the corresponding time 92.4% vs 97.2%, 92.4% vs 93.9%, and 84.7% vs 93.9% (P = NS). Estimated glomerular filtration rate was significantly lower in the DGF compared with the non-DGF group at hospital discharge (29 vs 42 mL/min; P = .00) and at 6 months posttransplantation (46 vs 52 mL/min; P = .04), but the difference disappeared thereafter: 47 vs 52 mL/min at 1 year, 50 vs 48 mL/min at 3 years, and 54 vs 53 mL/min at 5 years (P = NS). DGF did not increase the risk of an acute rejection episode (29.6% vs 30.6%; P = NS) or rate of surgical complications (33.3% vs 26.5%; P = NS). However, DGF prolonged significantly the length of hospitalization in the DGF versus the non- DGF group (18.9 vs 13 days; P = .00). Donor body mass index (BMI) ≥ 30 kg/m(2), recipient BMI ≥30 kg/m(2), and pretransplantation dialysis duration increased the risk of DGF upon multivariate logistic regression analysis. Apart from the longer hospital stay, DGF had no deleterious impact on the future of kidney allografts from controlled DCD, which showed comparable graft and patient survivals, renal function, rejection rates, and surgical complications as a group without DGF. Therefore, DGF should no longer be considered to be a medical barrier to the use of kidney grafts from controlled DCD.
  Transplantation Proceedings 11/2012; 44(9):2795-802. · 1.00 Impact Factor
• Article: Categories of donation after cardiocirculatory death.

  O Detry, H Le Dinh, T Noterdaeme, A De Roover, P Honoré, J-P Squifflet, M Meurisse
  [show abstract] [hide abstract]
  ABSTRACT: The interest in donation after cardiocirculatory death (DCD) was renewed in the early 1990s, as a means to partially overcome the shortage of donations after brain death. In some European countries and in the United States, DCD has become an increasingly frequent procedure over the last decade. To improve the results of DCD transplantation, it is important to compare practices, experiences, and results of various teams involved in this field. It is therefore crucial to accurately define the different types of DCD. However, in the literature, various DCD terminologies and classifications have been used, rendering it difficult to compare reported experiences. The authors have presented herein an overview of the various DCD descriptions in the literature, and have proposed an adapted DCD classification to better define the DCD processes, seeking to provide a better tool to compare the results of published reports and to improve current practices. This modified classification may be modified in the future according to ongoing experiences in this field.
  Transplantation Proceedings 06/2012; 44(5):1189-95. · 1.00 Impact Factor
• Article: Pancreas preservation for pancreas and islet transplantation: a minireview.

  J-P Squifflet, H LeDinh, A de Roover, M Meurisse
  [show abstract] [hide abstract]
  ABSTRACT: Pancreas preservation by cold storage using University of Wisconsin solution was the mainstay method used for pancreas transplantation during the past 2 decades. Other solutions, such as HTK, Celsior, and SCOT 15, could not demonstrate any advantage for short preservation periods. But the advent of clinical islet transplantation and the larger use of controlled non-heart-beating donors have prompted the transplantation community to develop methods for increasing pancreas graft quality while preventing ischemic reperfusion damages. Oxygenation by 1- or 2-layer methods during pancreas preservation, as well as the use of perfluorocarbons, might increase the islet yield. Based on the former methods, there is a renewed interest in machine perfusion and oxygenation in pancreas preservation for pancreas transplantation and islet preparation.
  Transplantation Proceedings 11/2011; 43(9):3398-401. · 1.00 Impact Factor
• Article: End of life care in the operating room for non-heart-beating donors: organization at the University Hospital of Liège.

  J Joris, A Kaba, S Lauwick, M Lamy, J-F Brichant, P Damas, D Ledoux, F Damas, B Lambermont, P Morimont, P Devos, M-H Delbouille, J Monard, M-F Hans, A DeRoover, P Honoré, J-P Squifflet, M Meurisse, O Detry
  [show abstract] [hide abstract]
  ABSTRACT: Non-heart-beating (NHB) organ donation has become an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many institutions the end of life care of the NHB donor (NHBD) is terminated in the operating room (OR) to reduce warm ischemia time. Herein we have described the organization of end of life care for these patients in our institution, including the problems addressed, the solution proposed, and the remaining issues. Emphasis is given to our protocol elaborated with the different contributors of the chain of the NHB donation program. This protocol specifies the information mandatory in the medical records, the end of life care procedure, the determination of death, and the issue of organ preservation measures before NHBD death. The persisting malaise associated with NHB donation reported by OR nurses is finally documented using an anonymous questionnaire.
  Transplantation Proceedings 11/2011; 43(9):3441-4. · 1.00 Impact Factor
• Article: Renal transplantation from living related donors: a single center experience in Viet Nam.

  H Ledinh, O Detry, M S Pham, H M Truong, T P Tran, P K Nguyen, P D Ta, T Q M Nguyen, T N N Huynh, T V Bach, J Joris, C Bonvoisin, A De Roover, P Honoré, J P Squifflet, M Meurisse
  [show abstract] [hide abstract]
  ABSTRACT: End-stage renal disease is a major public health problem in Viet Nam. A cooperative project between the University of Liège, Belgium, and the University of Medicine Pham Ngoc Thach, Ho Chi Minh City, Viet Nam, has permitted the establishment of an autonomous program of renal transplantation from living-related donors at the Peoples' Hospital No 115. The aim of this paper was to report the primary results of the project and to draw conclusions for the future. From January 2004 to July 2008, we performed 33 living-related renal transplantations. Mean ages of donors and recipients were 31.8 ± 9.5 and 41.6 ± 13.5 years, respectively. Laparoscopic nephrectomy was performed in 6 donors. The immunosuppressive regimen consisted of three drugs associated with induction therapy using anti-interleukin-2 receptor monoclonal antibody. The 33 donors are in good health at follow-up. Four developed major intra- or postoperative hemorrhage necessitating transfusion, with a surgical re-exploration in 1 donor. Wound infection occurred in 2 donors. Posttransplant recipient and graft survivals at 1 versus 3 years were 82% and 73% versus 82% and 65%, respectively. Eight recipients presented 13 biopsy-proven acute rejection episodes that were reversible in 7, but 1 patient lost his graft due to an irreversible rejection. Two recipients developed cancer. These initial results have encouraged us to continue the program of renal transplantation from living-related donors. However, they also pointed out the need to develop other donor sources.
  Transplantation Proceedings 12/2010; 42(10):4389-91. · 1.00 Impact Factor
• Article: Contribution of donors after cardiac death to the deceased donor pool: 2002 to 2009 University of Liege experience.

  H Ledinh, N Meurisse, M-H Delbouille, J Monard, M-F Hans, C Bonvoisin, L Weekers, J Joris, A Kaba, S Lauwick, P Damas, F Damas, B Lambermont, L Kohnen, A Deroover, P Honoré, J-P Squifflet, M Meurisse, O Detry
  [show abstract] [hide abstract]
  ABSTRACT: In this study, we have evaluated the organ procurement and transplantation activity from donors after cardiac death (DCD) at our institution over an 8-year period. Our aim was to determine whether this program influenced transplantation programs, or donation after brain death (DBD) activity. We prospectively collected our procurement and transplantation statistics in a database for retrospective review. We observed an increasing trend in potential and actual DCD number. The mean conversion rate turning potential into effective donors was 58.1%. DCD accounted for 16.6% of the deceased donor (DD) pool over 8 years. The mean age for effective DCD donors was 53.9 years (range, 3-79). Among the effective donors, 63.3% (n = 31) came from the transplant center and 36.7% (n = 18) were referred from collaborative hospitals. All donors were Maastricht III category. The number of kidney and liver transplants using DCD sources tended to increase. DCD kidney transplants represented 10.8% of the DD kidney pool and DCD liver transplants made up 13.9% of the DD liver pool over 8 years. The DBD program activity increased in the same time period. In 2009, 17 DCD and 33 DBD procurements were performed in a region with a little >1 million inhabitants. The establishment of a DCD program in our institution enlarged the donor pool and did not compromise the development of the DBD program. In our experience, DCD are a valuable source for abdominal organ transplantation.
  Transplantation Proceedings 12/2010; 42(10):4369-72. · 1.00 Impact Factor
• Article: [Clinical case of the month. Cystic lymphangioma of the mesentery].

  V Verdin, B Seydel, O Detry, D Van Daele, P Meunier, P Honoré, M Meurisse, J Belaïche
  [show abstract] [hide abstract]
  ABSTRACT: Cystic lymphangioma of the mesentery is a benign condition, probably of malformative origin, and frequently appearing in infancy. Its symptomatology can be very polymorphic. Its diagnosis is suspected by ultrasonography and computed tomography, and definitely confirmed by pathology. About a recent case of cystic lymphangioma of the mesentery diagnosed and operated on at the university hospital of Liège in an adult patient, the authors review its classification and its therapeutic strategy. Surgical resection is indicated in symptomatic cystic lymphangioma.
  Revue médicale de Liège 11/2010; 65(11):615-8.
• Article: [Image of the month. Cholecystectomy without a visible scar: laparoscopic cholecystectomy via the umbilicus].

  L Kohnen, C Coimbra, A Deroover, B Nsadi, A Kaba, S Lauwick, J Joris, S Maweja, E Hamoir, M Meurisse, P Honoré, O Detry
  Revue médicale de Liège 10/2010; 65(10):543-4.
• Article: Results of kidney transplantation from donors after cardiac death.

  H Ledinh, C Bonvoisin, L Weekers, A de Roover, P Honoré, J P Squifflet, M Meurisse, O Detry
  [show abstract] [hide abstract]
  ABSTRACT: Confronting the organ donor shortage, many transplant centers around the world increasingly use donors after cardiac death (DCD). Over the past 20 years, follow-up studies in kidney recipients comparing DCD and donors after brain death (DBD) have shown comparable long-term graft function and survival. As a consequence, DCD programs should be continued and expanded, for these donors constitute a potential solution to the imbalance between the numbers of end-stage kidney disease patients on waiting lists versus available kidney grafts. DCD kidneys do not necessarily signify suboptimal grafts; they may merit to be allocated the same as DBD grafts.
  Transplantation Proceedings 09/2010; 42(7):2407-14. · 1.00 Impact Factor
• Source

  Available from: Jean-Paul Squifflet

  Article: A retrospective monocenter review of simultaneous pancreas-kidney transplantation.

  E Decker, C Coimbra, L Weekers, O Detry, P Honoré, J-P Squifflet, M Meurisse, A De Roover
  [show abstract] [hide abstract]
  ABSTRACT: Herein we have reviewed a consecutive series of simultaneous pancreas-kidney (SPK) transplantations performed at our institution over a 6-year period. The study population included 22 patients (15 males and 7 females) who underwent SPK transplantation between 2001 and 2007. The mean recipient age was 47 years (range, 26-63 years). Eighteen patients suffered type 1 and 4 type 2 diabetes mellitus. The mean donor age was 33 years (range, 14-56 years). The mean HLA match was 2.1 (range, 1-5). Immunosuppressive treatment consisted of basiliximab induction followed by tacrolimus, mycophenolate mofetil, and prednisone. The mean hospital stay was 20 days (range, 11-52 days). After a mean follow-up of 44 months (range, 17-88 months), patient, kidney, and pancreas graft survivals were 86%, 82%, and 73%, respectively. Two patients died in the immediate postoperative period due to, respectively, disseminated intravascular coagulation and pulmonary embolism. A kidney graft was lost due to early hyperacute rejection. Other early complications associated with the pancreas graft included 2 cases of immediate reperfusion defects that led to early vascular thrombosis in 1 patient and a duodenal graft fistula in the other patient; a third patient developed type 2 diabetes mellitus. Beyond the postoperative period, graft loss was limited to 1 case of noncompliance to the immunosuppressive medications and 1 death secondary to pulmonary infection with a functional allograft after 4 years. SPK transplantation is a valid therapeutic option for patients with insulin-dependent diabetes mellitus and renal failure due to diabetic nephropathy. The main complications of SPK transplantation occur in the immediate postoperative period consequent to vascular or rejection processes.
  Transplantation Proceedings 10/2009; 41(8):3389-92. · 1.00 Impact Factor
• Article: [Pseudoaneurysm of the left gastric artery].

  C Honoré, P-J Bruyère, S Maweja, P Meunier, M Meurisse, J-O Defraigne
  [show abstract] [hide abstract]
  ABSTRACT: We report the case of a 65-year-old man admitted for an upper-GI hemorrhage. A CT scan performed with vascular reconstructions demonstrated a pseudoaneurysm of the left gastric artery. Proximal vascular control of the celiac axis was obtained by balloon occlusion with a Fogarty balloon inserted retrograde via the femoral artery: the pseudoaneurysm was then successfully controlled with direct suture.
  Journal de Chirurgie 08/2009; 146(4):413-5. · 0.50 Impact Factor
• Article: Liver transplant donation after cardiac death: experience at the University of Liege.

  O Detry, B Seydel, M-H Delbouille, J Monard, M-F Hans, A De Roover, C Coimbra, S Lauwick, J Joris, A Kaba, P Damas, F Damas, A Lamproye, J Delwaide, J-P Squifflet, M Meurisse, P Honoré
  [show abstract] [hide abstract]
  ABSTRACT: Donation after cardiac death (DCD) has been proposed to overcome in part the organ donor shortage. In liver transplantation, the additional warm ischemia time associated with DCD procurement may promote higher rates of primary nonfunction and ischemic biliary lesions. We reviewed the results of liver transplantation from DCD. From 2003 to 2007, we consecutively performed 13 controlled DCD liver transplantations. The medical records of all donors and recipients were retrospectively reviewed, evaluating in particular the outcome and occurrence of biliary complications. Mean follow-up was 25 months. Mean donor age was 51 years, and mean intensive care unit stay was 5.4 days. Mean time between ventilation arrest and cardiac arrest was 9.3 minutes. Mean time between cardiac arrest and arterial flushing was 7.7 minutes. No-touch period was 2 to 5 minutes. Mean graft cold ischemia time was 295 minutes, and mean suture warm ischemia time was 38 minutes. Postoperatively, there was no primary nonfunction. Mean peak transaminase level was 2546 UI/mL. Patient and graft survival was 100% at 1 year. Two of 13 patients (15%) developed main bile duct stenosis and underwent endoscopic management of the graft. No patient developed symptomatic intrahepatic bile duct strictures or needed a second transplantation. Our experience confirms that controlled DCD donors may be a valuable source of transplantable liver grafts in cases of short warm ischemia at procurement and minimal cold ischemia time.
  Transplantation Proceedings 04/2009; 41(2):582-4. · 1.00 Impact Factor
• Article: [Clinical case of the month. Liver transplantation for hepatic epithelioid hemangioendothelioma].

  M Tonglet, V Delfosse, O Detry, A De Roover, I Scagnol, B Delhougne, C Brixko, D Dresse, V Fridman, J L Lismonde, M Meurisse, P Honoré
  [show abstract] [hide abstract]
  ABSTRACT: The epithelioid hemangioendothelioma is a rare malignant vascular lesion that may occur within the liver. In the hepatic multifocal and bilobar forms, liver transplantation is indicated as the curative management. In this case report, the authors describe the diagnosis and the management of a 52-year-old woman who was diagnosed with hepatic epithelioid hemangioendothelioma and who underwent successful liver transplantation.
  Revue médicale de Liège 03/2009; 64(2):68-70.
• Article: [When should we resect colorectal liver metastases?].

  C Honoré, O Detry, A Deroover, P Piront, M Polus, P Honoré, M Meurisse
  [show abstract] [hide abstract]
  ABSTRACT: 6000 new cases of colorectal cancer are diagnosed each year in Belgium. 50% of these patients shall develop liver metastasis. Resection remains the only chance of long term survival and must be considered as an endpoint from the beginning of the treatment. It is the result of a multidisciplinary discussion and a global approach of the disease. It is rarely directly feasible, but there are many techniques which may make it achievable in the end. Today, resection criteria are exclusively technical and neither bad prognosis factors, nor the presence of extra-hepatic metastases should exclude liver resection. This resection must be assessed by a confirmed hepatobiliary surgeon and must be proposed to all patients whatever their age as long as their general state of health is good.
  Revue médicale de Liège 11/2008; 63(10):595-9.
• Article: [Ultrasonic scalpel in thyroid surgery].

  C Coimbra, T Defechereux, N Meurisse, J P Squifflet, M Meurisse
  [show abstract] [hide abstract]
  ABSTRACT: The thyroid gland is highly vascularized and, in all Thyroid surgery, a special attention must be paid to haemos. tasis and coagulation. Any carelessness in the control of thyroid vessels can indeed entail serious consequences. In this respect, the ultrasonic scalpel represents a significant progress. In this paper, the ultrasonic dissector will first be presented. Then a prospective, randomized trial comparing the results obtained with this apparatus to those obtained with the conventional method of hemostasis in a series of 34 patients submitted to total thyroidectomy for multinodular goiter will be summarized. Without increasing the costs, the ultrasonic dissector allows a saving of operative time as well as a reduction of peroperative bleeding and of postoperative use of antalgics. Finally, the results of 1696 total thyroidectomies performed with the use of the ultrasonic dissector will be briefly outlined.
  Revue médicale de Liège 02/2007; 62 Spec No:83-5.
• Article: [How do you investigate an elevated calcitonin level?].

  E Rikir, H Valdes-Socin, L Vroonen, A Daly, A Thiry, M Meurisse, A Beckers
  [show abstract] [hide abstract]
  ABSTRACT: This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a neuroendocrine neoplasm with ectopic calcitonin secretion. The article first reviews the physiology of calcitonin, then outlines the diagnostic tests that are required to investigate hypercalcitoninemia and finally discusses the interpretation of test results.
  Revue médicale de Liège 04/2006; 61(3):195-200.
• Article: [Hemostasis and ultrasonic shears for thyroid surgery].

  T Defechereux, M Meurisse
  [show abstract] [hide abstract]
  ABSTRACT: Hemostasis and coagulation are vital during thyroidectomy. The gland is highly vascularised and any lack in the control of thyroid vessels has immediate consequence in terms of morbidity. General principles of coagulation are reminded and the use of ultrasonic dissector is presented as an attractive alternative. A comparative study performed in 2000 and more recent data confirm the advantage of the new device in terms of operative time saving.
  Annales de Chirurgie 03/2006; 131(2):154-6. · 0.35 Impact Factor
• Article: [Alveolar echinococcosis].

  O Wauters, C Honoré, O Detry, J Delwaide, J Demonty, P Léonard, A Thiry, M P Hayette, A De Roover, P Honoré, J Boniver, J Belaïche, M Meurisse
  [show abstract] [hide abstract]
  ABSTRACT: Alveolar echinococcosis is a serious parasitic disease, leading to large hepatic lesions. It must be distinguished from cystic echinococcosis, or hydatic cyst, caused by Echinococcus granulosus. Early diagnosis may allow surgical removal of the lesions by segmental hepatectomy, the only curative treatment. Parasitostatic medical treatment with albendazole may promote stabilization of the disease. Until recently, Belgium was considered a country at very low risk for alveolar echinococcosis, as no human case was reported, despite up to 51% of fox infection in southern Belgium autopsy series. Recently four patients presented with alveolar echinococcosis at the University Hospital Center of Liege, leading to the fear of a possible alveolar echinococcosis endemy in southern Belgium. Two of these patients underwent curative hepatectomy, but the other two had already pulmonary metastases at diagnosis and received palliative albendazole therapy. This article presents these cases, and reviews the clinical features of this parasitic disease.
  Revue médicale de Liège 12/2005; 60(11):867-74.
• Article: [Laparoscopic liver resection of a hydatid cyst].

  O Detry, P Léonard, J Delwaide, L de Leval, V Radermacher, A De Roover, M Meurisse, P Honoré
  [show abstract] [hide abstract]
  ABSTRACT: Most of the echinococcosis cases treated in Belgium are contracted in African and Mediterranean countries. In this paper the authors describe the case of a Mediterranean patient suffering from a hepatic hydatid cyst treated by oral albendazole and laparoscopic liver resection.
  Revue médicale de Liège 10/2005; 60(9):700-2.