Pelin Zorlu

Dr. Sami Ulus Children's Hospital, Engüri, Ankara, Turkey

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Publications (29)19.83 Total impact

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    ABSTRACT: To determine different clinical presentations of vitamin B12 deficiency in infants. Infants at the age of 1-20 mo admitted to infancy clinic of authors' hospital between January 2011-2013 with various clinical presentations due to vitamin B12 deficiency were included in the study. Hospital records of all the patients were evaluated by means of history, physical, laboratory, imaging examinations and treatment. The diagnosis was based on a nutritional history of mothers and infants, clinical findings, hematological evaluation, and low level of serum vitamin B12. A total of 20 patients with a mean age of 6.65 ± 4.5 mo were included in the study. The weight and height were below the third percentile in four patients. The most common symptoms of the patients were; infections in 30 %, pallor in 25 %, hypotonia and neuro-developmental delay in 25 %, refusal to solid food or to suck in 20 %, failure to thrive in 15 %, fatigue in 10 %. Twenty-five percent of patients had neurologic signs and symptoms. Anemia was found in 16/20 (80 %) patients. Three (15 %) patients had leukopenia, 7 (35 %) had neutropenia, 2 (10 %) patients had thrombocytopenia. All of the mothers had vitamin B12 deficiency. All of the patients were fed with breast milk. Cyanocobalamin was administered to all the patients and mothers. After the treatment, clinical and laboratory findings of all the patients improved. Vitamin B12 deficiency should be considered in the differential diagnosis of some hematological, neurological, and gastrointestinal disturbances of infants.
    The Indian Journal of Pediatrics 04/2015; 82(7). DOI:10.1007/s12098-015-1725-3 · 0.87 Impact Factor
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    ABSTRACT: Hamartoma of the larynx is a very rare lesion, and the number of reported cases is limited. Signs and symptoms include stridor, changes in voice, eating and respiratory complaints. Stridor is a sign of upper airway obstruction. Patients presenting with stridor and severe respiratory distress necessitate urgent otolaryngologic evaluation. Herein, we report a case of laryngeal hamartoma presenting with recurrent pneumonia and persistent stridor in a 7-month-old patient. He was admitted to hospital with the initial diagnosis of recurrent pneumonia and persistent stridor. Stridor was not responsive to cool mist, nebulised epinephrine or dexamethasone. Cervical computed tomography (CT) revealed a solid, nodular mass on the posterolateral wall of larynx. The mass was excised surgically. After surgical removal of the hamartoma, the child was relieved of the obstruction. We want to emphasise that patients presenting with persistent stridor and severe distress necessitate urgent otolaryngologic evaluation.
    Balkan Journal of Medical Genetics 12/2014; 31(4):349-51. DOI:10.5152/balkanmedj.2014.13184 · 0.50 Impact Factor
  • P Zorlu · A S Eksioglu · M Ozkan · T Tos · S Senel
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    ABSTRACT: Wolf-Hirschhorn syndrome is caused by a deletion of the distal portion of the short arm of chromosome 4, and is characterized by psychomotor retardation, seizures, congenital malformations, and typical facial appearance including 'Greek warrior helmet' appearance of the nose. The form and the severity of clinical manifestations vary according to the size and location of the deletion. Major complications are severe growth retardation, developmental delay, seizures, feeding difficulties due to hypotonia, and predisposition to respiratory infections. Patients will benefit from supportive therapy and special education. It is important in terms of prognosis to provide counseling to families in this respect. We present here a case with Wolf-Hirschhorn Syndrome in order to remind its rarity and the ability of the patients' progress in the areas of motor skills, speech, social interaction.
    Genetic counseling (Geneva, Switzerland) 11/2014; 25(3):299-303. · 0.44 Impact Factor
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    ABSTRACT: OBJECTIVES: Stridor is a sign of upper airway obstruction. In children, laryngomalacia is the most common cause of chronic stridor, while croup is the most common cause of acute stridor. Stridor may be inspiratory, expiratory, or biphasic. In this study, we aimed to present clinical features and treatments of patients admitted with chronic stridor and recurrent pulmonary infections. MATERIAL AND METHODS: Twelve patients hospitalized because of chronic stridor and recurrent pneumonia were analyzed clinically, radiologically and with regard to treatment methods. Early onset, frequent recurrence, and persistence of the symptoms, poor improvement in coexistent respiratory distress inspite of appropriate treatment, and also the presence of stridor pushed us to further evaluation. Patients presenting with acute stridor and mild laryngomalacia were excluded from the study. RESULTS: Five patients were diagnosed with vascular ring, where as other seven patients presented with tracheomalacia, severe laryngomalacia, laryngeal hamartoma, cervical bronchogenic cyst, foreign body aspiration, H-type tracheoesophagial fistula, and congenital subglottic stenosis. CONCLUSION: Noisy breathing that begins in the newborn and infancy periods, recurrent lower respiratory tract infections and associated symptoms of airway obstruction should suggest structural and functional abnormalities of the lungs and airways. In patients with recurrent respiratory problems accompanied by stridor, diagnosis can be made with comprehensive physical examination and radiological methods.
    07/2014; 15(3):122-127. DOI:10.5152/ttd.2014.4117
  • Journal of Clinical Research in Pediatric Endocrinology 06/2014; 1(2):104-107. DOI:10.4274/jpr.91300
  • Saliha Senel · Pelin Zorlu · Burcin Dogan · Mehtap Acar
    The Indian Journal of Pediatrics 05/2014; 81(12). DOI:10.1007/s12098-014-1454-z · 0.87 Impact Factor
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    ABSTRACT: Niemann-Pick hastalığı, belirli dokularda, özellikle retiküloendotelyel hücrelerde, sfingolipidlerin biriktiği, konjenital lipidoz grubundan otozomal resesif kalıtılan bir hastalıktır. Klinik fenotip olarak akut neonatal formdan geç başlangıçlı erişkin forma kadar aralığı oldukça değişkendir. Karaciğer ve dalak büyüklüğü şikayetiyle kliniğimize başvuran Niemann-Pick hastalığı tip A ve tip B tanıları alan iki hasta sunuldu.
    Marmara Medical Journal 01/2014; 27. DOI:10.5472/MMJ.2013.02845.2
  • 12/2013; DOI:10.12956/tjpd.2013.34
  • Meltem Erdem · Pelin Zorlu · Mehtap Acar · Saliha Senel
    09/2013; 7(03):134-137. DOI:10.12956/tjpd.2013.3.06
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    ABSTRACT: Abusive head trauma (AHT) is perpetrated when an infant or young child is shaken violently by an abuser, resulting in injuries to various intracranial structures, historically called "shaken baby syndrome" (SBS). Three cases of AHT with different constellations of clinical symptoms are presented here. Case 1- Three-month-old female infant was admitted with recurrent seizures, drowsiness, and low grade fever. Ophthalmologic examination revealed retinal hemorrhages (RH) in the left eye. Computed tomography of cranium showed left frontal intra-parenchymal subdural hematoma (SDH). Case 2- Twelve-month-old male infant was admitted with a history of favoring left leg. Ophthalmologic examination revealed RH in the right eye. Cranial magnetic resonance imaging (MRI) revealed subacute SDH in the right frontoparietal region. Case 3- Three-month-old male infant was admitted with irritability and seizures. Ophthalmologic examination revealed bilateral disseminated RH. Cranial MRI scan showed bilateral frontoparietal subacute SDH. All cases were reported to Child Protective Services, who decided not to remove children from homes, but evaluated psychosocial risks and developed a safety plan, including home visits and family education. Physicians must be aware of possibility of AHT in infants presenting both subtle and overt neurologic symptoms. It is important to provide training on AHT to staff involved in the management of these cases.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES 05/2013; 19(3):261-266. DOI:10.5505/tjtes.2013.01460 · 0.38 Impact Factor
  • Mehtap Acar · Saliha Senel · Pelin Zorlu
    International journal of pediatric otorhinolaryngology 06/2011; 75(6):884; author reply 884-5. DOI:10.1016/j.ijporl.2011.02.007 · 1.19 Impact Factor
  • Sit Uçar · Pelin Zorlu · Ozge Metin · Utku Arman Orün
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    ABSTRACT: Vascular rings are a group of aortic arch anomalies and usually presents with dispnea, stridor and feeding difficulties after birth. Pulmonary artery sling is created by anomalous origin of the left pulmonary artery from the posterior aspect of the right pulmonary artery. The anomalous left pulmonary artery compresses the lower trachea and right mainstem bronchus, producing upper airway symptoms. We presented a seven-month-old male patient who admitted to our clinic because of recurrent wheezing, stridor, and frequent lower respiratory tract infections.
    Tuberkuloz ve toraks 07/2010; 58(3):311-5.
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    Sinan SARI · Pelin ZORLU · Ülker ERTAN
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    ABSTRACT: Aim: The aim of the present study was to determine the relative frequency of recurrent pneumonia in children and to describe its underlying illnesses. Materials and methods: Children between 3 months and 16 years old who had a history of 2 or more episodes of pneumonia per year, or 3 or more episodes in a lifetime were investigated retrospectively at Doctor Sami Ulus Children's Training and Research Hospital between January 2002 and December 2004. Results: Out of 595 children admitted for pneumonia, 62 (10.42%) met the criteria for recurrent pneumonia. An underlying illness was demonstrated in 56 patients (90.32%). In this study, the underlying illness was diagnosed during recurrence in all patients. The patients with persistent pneumonia were excluded from the study. Underlying diseases were bronchial asthma (30.64%), immune deficiency disorders (17.75%), aspiration syndromes (17.75%), and congenital anomalies (16.12%). No predisposing illness could be demonstrated in 6 patients (9.68%). Conclusion: Approximately 1 in 10 children with pneumonia in our hospital had recurrent pneumonia. Most of these children had an underlying illness, which was demonstrated. Bronchial asthma was the most common underlying illnesses for undiagnosed recurrent pneumonia in children.
    Turkish Journal of Medical Sciences 01/2010; 40(1). DOI:10.3906/sag-0906-15 · 0.84 Impact Factor
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    ABSTRACT: Congenital syphilis is a rare, serious disease that continues to be a major health-care problem. The infected neonate may be asymptomatic or multiple-organ system involvement may occur. Anemia and thrombocytopenia are common hematological findings. Hemophagocytic lymphohistiocytosis (HLH) is a clinicopathological condition characterized by activation and uncontrolled nonmalignant proliferation of T lymphocytes and macrophages. The authors report an infant with congenital syphilis as a very rare cause of hemophagocytic syndrome. The reason for anemia and thrombocytopenia in congenital syphilis is not clear. The authors suggest that hemophagocytosis may play role in pathogenesis of cytopenia, particularly thrombocytopenia in patients with congenital syphilis.
    Pediatric Hematology and Oncology 10/2009; 26(6):461-6. DOI:10.3109/08880010903091897 · 1.10 Impact Factor
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    ABSTRACT: Jeune syndrome or asphyxiating thoracic dystrophy is a rare autosomal recessive skeletal dysplasia characterized by a small thorax, short-limbed dwarfism, renal and hepatic anomalies. It is estimated to occur in 1 per 100.000-130.000 live births. Radiological confirmation of diagnosis is essential. Prognosis of the disease is due to the severity of chest deformities and most of the patients are lost in their first year because of respiratory problems. We presented a 19-month-old female patient who admitted to our clinic because of recurrent lower respiratory tract infections and diagnosed as Jeune syndrome and reported due to its rarity.
    Tuberkuloz ve toraks 01/2009; 57(4):413-6.
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    ABSTRACT: Transfusion-related acute lung injury (TRALI) is a life-threatening adverse effect of transfusion that should be considered in the differential diagnosis of all patients who develop respiratory distress during or within 6 h of transfusion. Two children with TRALI are presented and the diagnosis, pathophysiology, treatment, and need for understanding and recognition to reduce morbidity and mortality are discussed.
    Pediatric Hematology and Oncology 07/2008; 25(4):319-24. DOI:10.1080/08880010802016870 · 1.10 Impact Factor
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    ABSTRACT: The aim of the present study was to evaluate cases of Shigella and determine the pattern of antimicrobial resistance of shigella species in central Turkey. One hundred and ninety-eight patients with shigella gastroenteritis presenting to Sami Ulus Children's Hospital from June 2002 to December 2002 were included in the study. The clinical and laboratory data of the patients with shigellosis were collected by chart review. Male/female ratio was 1.35 and mean age was 4.83 +/- 3.2 years (range: 1-16 years). Shigella sonnei (83.3%) was the most common serogroup. This was followed by S. flexneri (10.1%), then S. dysenteria (5.1%), and S. boydii (1.5%). The antibiotic susceptibility of the shigella strains was determined. Most strains of Shigella species were resistant to trimethoprim-sulfamethoxazole (90.4%). All strains were found to be sensitive to ciprofloxacin (100%). Ampicillin susceptibility was 86.4% and cefotaxim (and/or ceftriaxon) susceptibility was 98%. Ampicillin is the drug of choice in the treatment of shigella infection in this region of Turkey. Cefotaxim or ceftriaxon was the second choice of antibiotics. Thus, Shigella is an important etiologic agent of diarrhea in Turkey. To determine the antibiotic susceptibility of the Shigella strains and appropriate empiric antibiotic treatment in Turkey, further studies will be needed.
    Pediatrics International 11/2007; 49(5):589-92. DOI:10.1111/j.1442-200X.2007.02425.x · 0.73 Impact Factor
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    ABSTRACT: This report presents a case with partial trisomy 18q resulting from de novo unbalanced translocation of chromosomes 15 and 18 displaying the features of pure trisomy. This is the first reported case with partial trisomy 18q due to unbalanced translocation between chromosomes 15 and 18. Clinical findings of our case have been compared with the reported cases' had partial trisomy 18q and the importance to recognize the cases with chromosome abnormalities to give genetic counseling and prenatal diagnosis for subsequent pregnancies has emphasized.
    Annales de Génétique 10/2004; 47(4):393-8. DOI:10.1016/j.anngen.2004.03.009
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    ABSTRACT: The effect of single dose povidone-iodine on serum thyrotropin and thyroxine levels and urinary iodine excretion in 30 preterm, 40 full-term newborns and 50 infants at Dr. Sami Ulus Children's Hospital was studied. There was no significant change of thyroid function in any of the groups (p>0.05). Urinary iodine excretion in preterm and full-term groups elevated significantly (p<0.05). The authors conclude that patients who receive single dose povidone-iodine for skin disinfection are not at risk for thyroid disorders.
    The Indian Journal of Pediatrics 08/2003; 70(8):675-7. DOI:10.1007/BF02724261 · 0.87 Impact Factor
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    ABSTRACT: We present a male infant 2.5-months old with asymmetric skull, anophthalmia, apparent hypertelorism, abnormal nares, unilateral cleft lip and palate, and structural abnormalities of the central nervous system. These findings are similar to cerebro-oculo-nasal syndrome except for the appearance of nose. This case is either a clinical variability in cerebro-oculo-nasal syndrome or a new entity.
    American Journal of Medical Genetics Part A 07/2003; 120A(2):253-5. DOI:10.1002/ajmg.a.20232 · 2.16 Impact Factor