Pelin Zorlu

Dr. Sami Ulus Children's Hospital, Engüri, Ankara, Turkey

Are you Pelin Zorlu?

Claim your profile

Publications (22)16.47 Total impact

  • The Indian Journal of Pediatrics 05/2014; · 0.72 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Niemann-Pick hastalığı, belirli dokularda, özellikle retiküloendotelyel hücrelerde, sfingolipidlerin biriktiği, konjenital lipidoz grubundan otozomal resesif kalıtılan bir hastalıktır. Klinik fenotip olarak akut neonatal formdan geç başlangıçlı erişkin forma kadar aralığı oldukça değişkendir. Karaciğer ve dalak büyüklüğü şikayetiyle kliniğimize başvuran Niemann-Pick hastalığı tip A ve tip B tanıları alan iki hasta sunuldu.
    Marmara Medical Journal 01/2014; 27.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abusive head trauma (AHT) is perpetrated when an infant or young child is shaken violently by an abuser, resulting in injuries to various intracranial structures, historically called "shaken baby syndrome" (SBS). Three cases of AHT with different constellations of clinical symptoms are presented here. Case 1- Three-month-old female infant was admitted with recurrent seizures, drowsiness, and low grade fever. Ophthalmologic examination revealed retinal hemorrhages (RH) in the left eye. Computed tomography of cranium showed left frontal intra-parenchymal subdural hematoma (SDH). Case 2- Twelve-month-old male infant was admitted with a history of favoring left leg. Ophthalmologic examination revealed RH in the right eye. Cranial magnetic resonance imaging (MRI) revealed subacute SDH in the right frontoparietal region. Case 3- Three-month-old male infant was admitted with irritability and seizures. Ophthalmologic examination revealed bilateral disseminated RH. Cranial MRI scan showed bilateral frontoparietal subacute SDH. All cases were reported to Child Protective Services, who decided not to remove children from homes, but evaluated psychosocial risks and developed a safety plan, including home visits and family education. Physicians must be aware of possibility of AHT in infants presenting both subtle and overt neurologic symptoms. It is important to provide training on AHT to staff involved in the management of these cases.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES 05/2013; 19(3):261-266. · 0.34 Impact Factor
  • Mehtap Acar, Saliha Senel, Pelin Zorlu
    International journal of pediatric otorhinolaryngology 06/2011; 75(6):884; author reply 884-5. · 0.85 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Vascular rings are a group of aortic arch anomalies and usually presents with dispnea, stridor and feeding difficulties after birth. Pulmonary artery sling is created by anomalous origin of the left pulmonary artery from the posterior aspect of the right pulmonary artery. The anomalous left pulmonary artery compresses the lower trachea and right mainstem bronchus, producing upper airway symptoms. We presented a seven-month-old male patient who admitted to our clinic because of recurrent wheezing, stridor, and frequent lower respiratory tract infections.
    Tuberkuloz ve toraks 07/2010; 58(3):311-5.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Congenital syphilis is a rare, serious disease that continues to be a major health-care problem. The infected neonate may be asymptomatic or multiple-organ system involvement may occur. Anemia and thrombocytopenia are common hematological findings. Hemophagocytic lymphohistiocytosis (HLH) is a clinicopathological condition characterized by activation and uncontrolled nonmalignant proliferation of T lymphocytes and macrophages. The authors report an infant with congenital syphilis as a very rare cause of hemophagocytic syndrome. The reason for anemia and thrombocytopenia in congenital syphilis is not clear. The authors suggest that hemophagocytosis may play role in pathogenesis of cytopenia, particularly thrombocytopenia in patients with congenital syphilis.
    Pediatric Hematology and Oncology 10/2009; 26(6):461-6. · 0.90 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Jeune syndrome or asphyxiating thoracic dystrophy is a rare autosomal recessive skeletal dysplasia characterized by a small thorax, short-limbed dwarfism, renal and hepatic anomalies. It is estimated to occur in 1 per 100.000-130.000 live births. Radiological confirmation of diagnosis is essential. Prognosis of the disease is due to the severity of chest deformities and most of the patients are lost in their first year because of respiratory problems. We presented a 19-month-old female patient who admitted to our clinic because of recurrent lower respiratory tract infections and diagnosed as Jeune syndrome and reported due to its rarity.
    Tuberkuloz ve toraks 01/2009; 57(4):413-6.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Transfusion-related acute lung injury (TRALI) is a life-threatening adverse effect of transfusion that should be considered in the differential diagnosis of all patients who develop respiratory distress during or within 6 h of transfusion. Two children with TRALI are presented and the diagnosis, pathophysiology, treatment, and need for understanding and recognition to reduce morbidity and mortality are discussed.
    Pediatric Hematology and Oncology 07/2008; 25(4):319-24. · 0.90 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the present study was to evaluate cases of Shigella and determine the pattern of antimicrobial resistance of shigella species in central Turkey. One hundred and ninety-eight patients with shigella gastroenteritis presenting to Sami Ulus Children's Hospital from June 2002 to December 2002 were included in the study. The clinical and laboratory data of the patients with shigellosis were collected by chart review. Male/female ratio was 1.35 and mean age was 4.83 +/- 3.2 years (range: 1-16 years). Shigella sonnei (83.3%) was the most common serogroup. This was followed by S. flexneri (10.1%), then S. dysenteria (5.1%), and S. boydii (1.5%). The antibiotic susceptibility of the shigella strains was determined. Most strains of Shigella species were resistant to trimethoprim-sulfamethoxazole (90.4%). All strains were found to be sensitive to ciprofloxacin (100%). Ampicillin susceptibility was 86.4% and cefotaxim (and/or ceftriaxon) susceptibility was 98%. Ampicillin is the drug of choice in the treatment of shigella infection in this region of Turkey. Cefotaxim or ceftriaxon was the second choice of antibiotics. Thus, Shigella is an important etiologic agent of diarrhea in Turkey. To determine the antibiotic susceptibility of the Shigella strains and appropriate empiric antibiotic treatment in Turkey, further studies will be needed.
    Pediatrics International 11/2007; 49(5):589-92. · 0.88 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This report presents a case with partial trisomy 18q resulting from de novo unbalanced translocation of chromosomes 15 and 18 displaying the features of pure trisomy. This is the first reported case with partial trisomy 18q due to unbalanced translocation between chromosomes 15 and 18. Clinical findings of our case have been compared with the reported cases' had partial trisomy 18q and the importance to recognize the cases with chromosome abnormalities to give genetic counseling and prenatal diagnosis for subsequent pregnancies has emphasized.
    Annales de Génétique 01/2004; 47(4):393-8.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The effect of single dose povidone-iodine on serum thyrotropin and thyroxine levels and urinary iodine excretion in 30 preterm, 40 full-term newborns and 50 infants at Dr. Sami Ulus Children's Hospital was studied. There was no significant change of thyroid function in any of the groups (p>0.05). Urinary iodine excretion in preterm and full-term groups elevated significantly (p<0.05). The authors conclude that patients who receive single dose povidone-iodine for skin disinfection are not at risk for thyroid disorders.
    The Indian Journal of Pediatrics 08/2003; 70(8):675-7. · 0.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We present a male infant 2.5-months old with asymmetric skull, anophthalmia, apparent hypertelorism, abnormal nares, unilateral cleft lip and palate, and structural abnormalities of the central nervous system. These findings are similar to cerebro-oculo-nasal syndrome except for the appearance of nose. This case is either a clinical variability in cerebro-oculo-nasal syndrome or a new entity.
    American Journal of Medical Genetics Part A 08/2003; 120A(2):253-5. · 2.30 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We report on two siblings with tyrosinaemia type 2, a 6-year-old girl and her 3.5-year-old brother with a main complaint of painful palmo-plantar hyperkeratosis. The boy presented also conjunctival injection, photophobia, lacrimation and conjunctivitis. Blood tyrosine levels were increased in both patients, 150.6 and 202.3 micro mol/dl, respectively (reference value: 5.8+/-2.2 micro mol/dl). After 1 month of dietary treatment with low protein, low phenylalanine and tyrosine, tyrosine levels decreased to 37.7 and 65.6 micro mol/dl, respectively; the cutaneous lesions improved in both of them, and conjunctivitis disappeared. CONCLUSION: the association of bilateral ulcero-conjunctivitis with photophobia and palmo-plantar hyperkeratosis since early infancy is the clue to the diagnosis of tyrosinaemia type 2.
    European Journal of Pediatrics 03/2003; 162(2):81-3. · 1.98 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In this study, the effects and side effects of rectal diazepam and intranasal midazolam were compared in the treatment of acute convulsions in children to develop a practical and safe treatment protocol. In the diazepam group, the seizures of 13 (60%) patients terminated in 10 minutes; however, 9 (40%) patients did not respond. In the midazolam group, 20 (87%) patients responded in 10 minutes, but 3 (13%) patients did not respond. Regarding the anticonvulsant effect, midazolam was found to be more effective than diazepam, and the difference was statistically significant (P < .05). The necessity of a second drug for the seizures that did not stop with the first drug was higher in the diazepam group than the midazolam group, and the difference was statistically significant (P < .05). We conclude that as an antiepileptic agent, intranasal midazolam is more effective than rectal diazepam. After administration, we did not observe any serious complications. Further investigations are necessary; however, intranasal administration is easy, so if the nasal drop and spray forms used in some European countries and the United States are available worldwide, it will be very useful for physicians in the emergency room.
    Journal of Child Neurology 02/2002; 17(2):123-6. · 1.39 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study was undertaken to assess the left ventricular mass (LV Mass) and systolic and diastolic functions of the left ventricle in children with protein energy malnutrition (PEM). Thirty children, aged between 2 months and 2 years with PEM (four kwashiorkor, seven marasmic- kwashiorkor, 19 marasmus), and 17 healthy, age-matched children, using Doppler echocardiography were studied. The mean LV Mass in the patients was lower than that in the controls (14.5 +/- 5.2 vs 19.8 +/- 4.7 g, P < 0.05). However, the LV Mass/body surface area was not different in the patients with PEM and in the control group (52 +/- 9.2 vs 53.9 +/- 8.2g/m(2), P > 0.05), indicating that LV Mass was reduced in proportion to decrease in body size in malnutrition. Left ventricular septal and posterior wall thickness in PEM were also lower than that in the controls, and the most significant reduction in the LV Mass, septal and posterior wall thickness were found in the kwashiorkor group. Cardiac output was reduced in proportion to decrease in body size in the patient group (1.6 +/- 0.5 vs 2.1 +/- 0.8 L/min, P < 0.05), therefore cardiac index was not significantly different between the patients and the control subjects (5.9 +/- 1.4 vs 5.7 +/- 1.6 L/min/m(2), P > 0.05). Systolic function indices including ejection fraction, fractional shortening, and diastolic function indices were not significantly different in the groups. We demonstrated that LV Mass and cardiac output were reduced in proportion to decrease in body size in patients with PEM, and LV systolic and diastolic functions were preserved in atrophic hearts.
    Journal of Paediatrics and Child Health 02/2001; 37(1):14-7. · 1.25 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Sixteen children, aged from 2 months to 14 years, with a diagnosis of acute seizures and seen at Dr. Sami Ulus Child Health and Disease Center, were included in this study. Midazolam (5 mg/mL) 0.2 mg/kg was administered intranasally in 30 seconds by an injector. The heart rate, respiratory rate, blood pressure, and oxygen saturation were recorded at 0, 5, and 10 minutes after administration. The seizures of three (18.7%) patients terminated within 1 minute, of seven (43.7%) patients in 1 to 2 minutes, and of three (18.7%) patients in 2 to 5 minutes. However, three (18.7%) patients did not respond to treatment. As a result, it was concluded that intranasal midazolam administration is easy and effective. The half-life of midazolam is shorter than diazepam, and midazolam has fewer complications when compared with diazepam. It is easier to use in nasal drop and spray forms.
    Journal of Child Neurology 01/2001; 15(12):833-5. · 1.39 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: It is generally accepted that celiac disease (CD) must always be considered when dealing with growth failure in children. Therefore, it is important to develop screening tests for detecting patients that need an intestinal biopsy. The aim of the present study was to investigate the value of plasma zinc levels for the diagnosis of monosymptomatic CD in short-statured children. Fourty-nine children with a short stature and 34 healthy controls were investigated. Plasma zinc levels were assayed by atomic absorption spectrophotometry in short-statured children and controls. All patients with short stature underwent endoscopic small intestinal biopsy. Duodenal mucosal histopathology was normal in 25 children. Low plasma zinc values were observed in 54.2% of patients with CD, 32.0% of patients with idiopathic short stature and 14.8% of controls. The mean values of plasma zinc levels were not significantly different among the three groups. Sensitivity, specificity and the positive and negative predictive values for plasma zinc were 45.8, 76.0, 64.7 and 59.4%, respectively. These results indicate that zinc deficiency is an important problem in CD children with short stature; however, plasma zinc levels are not useful as a screening test for selecting patients for jejunal biopsy.
    Pediatrics International 01/2001; 42(6):682-4. · 0.88 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: It is generally accepted that celiac disease (CD) must always be considered when dealing with growth failure in children. Therefore, it is important to develop screening tests for detecting patients that need an intestinal biopsy. The aim of the present study was to investigate the value of plasma zinc levels for the diagnosis of monosymptomatic CD in short-statured children.Methods: Fourty-nine children with a short stature and 34 healthy controls were investigated. Plasma zinc levels were assayed by atomic absorption spectrophotometry in short-statured children and controls. All patients with short stature underwent endoscopic small intestinal biopsy.Results: Duodenal mucosal histopathology was normal in 25 children. Low plasma zinc values were observed in 54.2% of patients with CD, 32.0% of patients with idiopathic short stature and 14.8% of controls. The mean values of plasma zinc levels were not significantly different among the three groups. Sensitivity, specificity and the positive and negative predictive values for plasma zinc were 45.8, 76.0, 64.7 and 59.4%, respectively.Conclusions: These results indicate that zinc deficiency is an important problem in CD children with short stature; however, plasma zinc levels are not useful as a screening test for selecting patients for jejunal biopsy.
    Pediatrics International 12/2000; 42(6):682 - 684. · 0.88 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Pneumonia is an important cause of death in childhood, especially in the infancy period. Since the respiratory and cardiovascular systems cannot be thought of independently, it is important to detect cardiovascular changes during pneumonia. We prospectively studied 50 children aged 2-24 months admitted to the hospital because of pneumonia in order to evaluate their cardiovascular findings with noninvasive methods. Patients were classified according to the World Health Organization (WHO) criteria of pneumonia, and evaluated by obtaining complete blood counts, serum electrolytes, renal and liver function tests, blood gases, creatinine kinase MB fraction (CK-MB), chest X-ray, electrocardiography (ECG) and echocardiography at the admission and after clinical recovery. Right ventricular systolic pressure (RVSP) was found to be high in 70% of patients and there was a correlation between the severity of the pneumonia and RVSP All patients had normal left ventricular dimensions and functions, but in 68% of them CK-MB was elevated. In these infants, T voltages in D1 derivation showed a significant rise with clinical recovery. Seven cases developed congestive heart failure, and three died. CK-MB was found to be high in all patients who died and in six of seven patients with congestive heart failure. Our findings suggest that myocarditis incidence in children with pneumonia may be higher than previously known. Since myocarditis can be a fatal disease, its detection is important by noninvasive techniques like ECG, echocardiography and cardiac enzyme measurements.
    The Turkish journal of pediatrics 45(4):306-10. · 0.56 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: 1 Dr. Sami Ulus Çocuk Sal ve Hastalklar Eitim ve Aratrma Hastanesi, Pediatri Klinii, ANKARA ÖZET Cornelia de Lange sendromu, karakteristik dismorfik yüz bulgular, üst ekstremite malformasyonlar, hirsutizm, kalp defektleri, gelime gerilii, zeka gerilii, göz ve genitoüriner anomaliler, iitme kayb ve gastroözofagial disfonksiyon ile karakterize nadir görülen geliimsel bir bozukluktur. Prevalans, 1/10.000 ie 1/50.000 arasnda deimekte ve rk fark göstermemektedir. Tekrarlayan alt solunum yolu enfeksiyonu ve gelime gerilii nedeniyle kliniimize bavuran be aylk erkek hasta ve büyüme gerilii nedeniyle kliniimize bavuran üç aylk kz hastaya Cornelia de Lange sendromu tans konuldu ve nadir görülmesi nedeniyle sunuldu. ABSTRACT Cornelia de Lange Syndrome: A report of two cases Cornelia de Lange syndrome is a rarely seen developmental disorder characterized by characteristic dysmorphic facial features, upper-extremity malformations, hirsutism, cardiac defects, failure to thrive, mental retardation, ophthalmologic and genitourinary anomalies, hearing loss, and gastroesophageal dysfunction. Its prevalance has been reported to vary from 1:10.000 to 1:50.000, without any known racial predilection. We presented a 5-month-old male patient who admitted to our clinic because of recurrent lower respiratory tract infections and failure to thrive and a 3-month-old female patient who admitted to our clinic because of growth failure diagnosed as Cornelia de Lange syndrome and reported due to its rarity.