Petre Ionita

University of Bucharest, București, Bucureşti, Romania

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Publications (64)109.23 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study reports the synthesis of silver nanoparticles (Ag NPs) by the sodium borohydride reduction method and their embedding in a silica shell functionalized with several antibiotics (ampicillin, penicillin G and isoniazide). The characterization of the novel materials was made by UV-visible absorption spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy, dynamic light scattering and thermal analysis. TEM micrographs revealed the formation of spherical nanoparticles with size ranging between 20 and 50 nm. The Ag NPs embedded in the silica network exhibited a good antimicrobial efficiency, comparable or even superior to that of antibiotic-containing formulations. This is the first report regarding the synergic antimicrobial effect of Ag NPs embedded in silica and ampicillin, both against planktonic cells and biofilms formed by P. aeruginosa and S. aureus, two of the most fearful resistant bugs. These results are demonstrating the great potential of these nanocomposites to be used in developing novel antimicrobial agents or improving the existent ones, by increasing their efficiency, extending their spectrum of activity and decreasing the probability to select resistance, by simultaneously targeting multiple targets in the microbial cells.
    Journal of Inorganic and Organometallic Polymers and Materials 07/2015; 25(4). DOI:10.1007/s10904-015-0176-7 · 1.16 Impact Factor
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    ABSTRACT: The rosemary extract was encapsulated in polyethylene or in covalently-based network gels. The covalent gels were obtained by the reaction of isocyanate end-capped polyethylene glycol (PEG) with β-cyclodextrin or glycerol. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was used to evaluate the antioxidant activity (AA) of rosemary extract entrapped in polymeric structures and in ethanol or water solutions. The AA of the rosemary extract was determined using a DPPH radical for samples prepared in ethanol, and a water-soluble derivative, the sulphonated DPPH radical (DPPH-SO3Na), for the rosemary extract in water. Formulation of the rosemary extract in polymeric gels ensures a rapid release which determines the AA values similar to those in solution.
    Chemical Papers 06/2015; 69(6):872-880. DOI:10.1515/chempap-2015-0024 · 0.88 Impact Factor
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    ABSTRACT: Low-molecular-weight organic gelators generate physical gels by the formation of three-dimensional fibrous network structures as a response to various physicochemical stimuli such as heat, light, ultrasound and chemical environments. Dibenzylidene sorbitol (DBS) represents a typical compound able to generate gels because of some prerequisite structural features: the presence of functional groups to form intermolecular hydrogen bonds and of aromatic groups to be involved in π-π interactions, or chirality. Herein, we present the synthesis of three derivatives of DBS-bearing carboxy groups attached to phenyl rings and the corresponding spin-labelled compounds. We studied the formation of physical gels resulting from self-assembly of DBS derivatives with the aim of highlighting the influence of the position of the carboxy group on the gel properties. These types of compounds can form gels in polar solvents (such as water, DMSO) by either temperature treatment or variation of the pH. In this study, the systems were investigated by rheological measurements, SEM analysis and EPR measurements. The results showed that the introduction of carboxy groups into the structure of DBS generates weaker gels compared with the parent gelator, DBS. The spin probes used in this study (spin-labelled DBS derivatives and 5-doxyl stearic acid) demonstrated that assembly of gelator molecules is a highly selective process. The two-component feature of EPR spectra of spin probes in gels is proof that EPR spectroscopy is sensitive to the non-homogeneity of these systems.
    Applied Magnetic Resonance 05/2015; DOI:10.1007/s00723-015-0690-3 · 1.17 Impact Factor
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    ABSTRACT: The paper describes a rapid and simple method for preparing silver nanoparticles coated with tunable silica shell thickness and their further functionalization with vitamins. Monodispersed silver nanoparticles (Ag NPs) with a mean particle size of 10 nm were prepared by chemical reduction. Silica coating was carried out using the Stober method, by mixing the as prepared silver nanoparticles with tetramethoxysilane and 3-aminopropyltrimethoxysilane. These core-shell nanoparticles were further functionalized with B vitamins in order to facilitate their rapid functionalization to a wide range of end applications. Characterization of the newly synthesized materials was made by UV-visible absorption spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS) and thermal analysis (TG). Their antibacterial activity against Gram-positive and Gram-negative bacterial strains was investigated and the results of our study showed that the linked vitamins on silver nanoparticles coated with silica lead to an increased antimicrobial activity at lower concentrations against planktonic bacterial cells and microbial biofilms. The present study can be useful for future development of different types of biological active materials.
    Ceramics International 04/2015; 41(3):4460-4467. DOI:10.1016/j.ceramint.2014.11.138 · 2.61 Impact Factor
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    ABSTRACT: A series of several new isoniazid derivatives, isonicotinic acid 2-(2-hydroxy-8-substituted-tricyclo[]tridec-13-ylidene)-hydrazides, were synthesized and fully characterized. These new isoniazid derivatives were studied regarding their antibacterial activity and cytotoxicity, as well as their influences on some metabolizing enzymes. The best anti-mycobacterial activity was observed in the case of compounds containing alkyl side chains in the 8 position of tricyclo[]tridec-13-ylidene group. On contrary, the antimicrobial activity of these new compounds against various non-tuberculosis strains showed the best activity to be with the phenyl side chain of compound 6. It proved also to be the most toxic, inducing apoptosis and blocking the cell cycle in G0/G1 phase. The cell cycle was blocked in G0/G1 phase also by compound 3, but this compound did not show any toxicity. All compounds induced the expression of NAT1 and NAT2 genes in HT-29 cell line, and the expression of CYP1A1 in HT-29 and HCT-8 cell lines. The expression level of CYP3A4 was increased by compounds 1, 6 and 7 in HCT-8 cells. These results indicated that the activation of other metabolizing pathways, apart from those of isoniazid, take place. It might also point out the possibility of an increased isoniazid acetylation ratio by co-administration with new compounds in slow acetylators.
    Bioorganic & Medicinal Chemistry 12/2014; 23(3). DOI:10.1016/j.bmc.2014.12.038 · 2.79 Impact Factor
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    ABSTRACT: The efficiency of low and medium hydrophobic alcohols as mobile phase additives for lipophilicity determination of parabens was investigated using reversed-phase liquid chromatography and C18 chromatographic column as stationary phase. The eluting strength was evaluated by methylene selectivity determination for different mobile phases, containing water (0.1% H3PO4)-hydrophobic alcohols mixtures, starting with methanol and continued with methanol with 1% upper alcohols (differing through one methylene group, from ethanol to octanol) as organic additive. A good linear dependence (R 2 > 0.99) was observed between the retention factors (log k) and the organic content of the mobile phase in all cases. Several methodologies such as arithmetic mean computation of experimental retention values, extrapolation to zero methanol concentration procedure, and principal component analysis were applied to retention data values in order to determine relevant parameters [mlog k - mean of experimental retention values log k, log kw – extrapolated capacity factor to 100% water, and respectively PC1/log k (scores corresponding to the first principal component)]. The evaluation of the experimental lipophilicity parameters revealed a significant correlation with the reference octanol–water partition coefficients (log Kow) and also with various computed lipophilicity parameters (log P).
    Journal of Liquid Chromatography &amp Related Technologies 04/2014; 37(16). DOI:10.1080/10826076.2013.830270 · 0.61 Impact Factor
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    ABSTRACT: The aim of the study was to synthesize some new compounds with potential anti-tuberculosis activity, containing isoniazid and α,β-unsaturated thiocinnamamide-like thioamides as precursors. The obtained derivatives were evaluated regarding their biological activity (antioxidant and antibacterial), as well as their influence on the eukaryotic cell cycle. The results suggested that the newly obtained derivatives of isoniazid exhibited different biological activities, depending on their structure; thus, the most active compound in terms of anti-oxidant and anti-Mycobacterium tuberculosis effects proved to be the isonicotinic acid N'-(1-amino-1-mercapto-3-phenyl-propen-1-yl)-hydrazide. This compound also increased the expression of NAT1 and NAT2 genes, which are implicated in the metabolism of the isoniazid, demonstrating that it could be rapidly metabolized, and thus well tolerated. The largest spectrum of antibacterial activity (excluding M. tuberculosis) was noticed for the isonicotinic acid N'-[1-amino-1-mercapto-3-(p-chloro-phenyl)-propen-1-yl]-hydrazide, which was also the most cytotoxic, especially at high concentrations, although not significantly affecting the cellular cycle phases. The obtained results showed that the new derivatives could represent potential candidates for the treatment of M. tuberculosis infections, but further research is needed in order to improve their pharmacological properties, by increasing their antimicrobial activity and reducing the risk of side-effects.
    Bioorganic & medicinal chemistry 06/2013; 21(17). DOI:10.1016/j.bmc.2013.06.013 · 2.79 Impact Factor
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    ABSTRACT: Starting from benzocaine, a well-known anaesthetic, ten derivatives were synthesized and characterized by UV–vis, IR, NMR, and elemental analysis. Most of the compounds contain residues with recognized biological activity, like nicotinic acid (vitamin B3 or PP), biotin (vitamin B7 or H), lipoic acid (thioctic acid), adamantine, as well as other residues of crown-ether type, benzofurazane, naphtylurea, di- and tri-nitrobenzene, and a nitroxide radical. The biological evaluation of the obtained compounds included hydrophobicity (lipophobicity) assay, total antioxidant and microbiological activity tests.
    Comptes Rendus Chimie 05/2013; 16(7):665-671. DOI:10.1016/j.crci.2013.03.012 · 1.71 Impact Factor
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    ABSTRACT: A thermal analysis study has been performed for the stable free radical 2,2-diphenyl-1-picrylhydrazyl and other ten free radical congeners, together with their corresponding parent hydrazines. Qualitative studies on the decomposition products showed that nitrogen dioxide plays a key role. A mechanistic decomposition pathway is also proposed.
    Journal of Thermal Analysis and Calorimetry 04/2013; 116(1). DOI:10.1007/s10973-013-3448-x · 2.04 Impact Factor
  • Petre Ionita
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    ABSTRACT: Starting from the commercially available silica supported TEMPO and gaseous nitrogen dioxide, a heterogeneous catalyst was obtained and characterized; this is able to convert under mild and clean conditions alcohols into aldehydes and ketones, using molecular oxygen as the final oxidant. A mechanistic pathway is proposed, in which silica supported TEMPO acts as a scavenger and a generator for nitrogen dioxide.
    RSC Advances 01/2013; 3(44):21218. DOI:10.1039/c3ra44863k · 3.84 Impact Factor
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    ABSTRACT: Silver nanoparticles are prepared by a chemical reduction method, using silver nitrate as the metal precursor and sodium borohydride as the reducing agent. Polyvinylpyrrolidone and 1,2-dimethoxy-ethane are used as stabilizing ligands on the surface nanoparticles. The silver nanoparticles obtained with this method are shown to exhibit typical surface plasmon absorption behavior at about 400 nm, and transmission electron microscopy and dynamic light scattering show that the average size of silver nanoparticles is between 30–50 nm, depending on the chemical procedure and the stabilizer used. The effect of hydrogen peroxide as the oxidant and hydrazine as the reducing agent is studied in conjunction with methylene blue dye. It is demonstrated that the chemical surface modification has great influence on silver nanoparticle reactivity.
    Digest Journal of Nanomaterials and Biostructures 01/2013; 8(4-4):1761-1770. · 0.95 Impact Factor
  • Petre Ionita
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    ABSTRACT: A simple and rapid colorimetric chemosensor for the detection of several nitro-explosives is presented. The method is based on the oxidation of colorless ABTS to its intense blue–green colored radical cation ABTS+ by nitrogen dioxide, which can be generated from nitro-explosives by one of the following two methods: (i) digestion of very small amounts of explosives with alkali hydroxide, yielding nitrite anions, which in acidic medium generate nitrogen dioxide, or (ii) by thermal decomposition of nitro-explosives, which generates directly nitrogen dioxide. In these processes nitrogen dioxide acts as a catalytic intermediate, thus enhancing the detection.
    Tetrahedron Letters 12/2012; 53(52):7143–7146. DOI:10.1016/j.tetlet.2012.10.095 · 2.38 Impact Factor
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    ABSTRACT: Acid–base interactions between amino-silica and carboxyl-gold protected nanoparticles, functionalized or not with free stable radicals or fluorescent moieties, were studied by ESR, fluorescence, and TEM. While those nanoparticles are stable in solution, mixing them induces aggregation, due to acid–base interactions; addition of a base or an acid redissolves them. By ESR, strong spin–spin interactions were noticed; by fluorescence, only small differences may be observed, while by TEM, it was noticed that gold nanoparticles are distributed evenly on the surface of the silica nanoparticles.
    Chemical Physics Letters 09/2012; 546:133–135. DOI:10.1016/j.cplett.2012.08.009 · 1.90 Impact Factor
  • G. Ionita · I. Zarafu · A. Paun · P. Ionita
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    ABSTRACT: A hybrid hydrazine–nitroxide monoradical and the corresponding heterohydrazyl– nitroxide diradical were used as probes in 4-cyano-4′-pentylbiphenyl liquid crystal. EPR data (hyperfine constants, rotational time, and anisotropy parameter values) are reported in the range of 25°C–55°C. It was shown by EPR spectrometry that the nitroxide moiety gives an anisotropic triplet line, while the hydrazyl moiety cannot be detected under these conditions.
    Molecular Crystals and Liquid Crystals 08/2012; 562(1):141-146. DOI:10.1080/15421406.2012.676834 · 0.49 Impact Factor
  • C Remes · A Paun · I Zarafu · M Tudose · M T Caproiu · G Ionita · C Bleotu · L Matei · P Ionita
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    ABSTRACT: Starting from 4-amino-antipyrine, six new compounds were synthesized and characterized. The new compounds contain moieties with particular properties, such are ionophore (benzo-15-crown-5), fluorescent (nitrobenzofurazan), stable free radical (nitroxide), or other types of biological active residues, like nitroderivatives, antipyrine or isoniazid residues. They were fully characterized by appropriate means ((1)H and (13)C NMR, IR, UV-Vis, fluorescence, EPR, elemental analysis) and some of their biological properties were evaluated. Hydrophobicity (R(M0), log P), total antioxidant capacity (TAC), and antimicrobial properties are also presented and discussed.
    Bioorganic Chemistry 04/2012; 41-42:6-12. DOI:10.1016/j.bioorg.2011.12.003 · 2.15 Impact Factor
  • M. Tudose · D. Culita · G. Marinescu · C. Ghica · P. Ionita
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    ABSTRACT: Abstract Silica has been derivatized with aminopropyl groups which subsequently have been chemically modified with N-methoxy-2,6-dinitroaniline derivatives to yield a solid which changes its color in the presence of arginine or lysine, from yellow to blue. Other amino-acids (such as glycine, valine, cysteine, cystine, alanine, phenylalanine, histidine) do not showed this behavior. The same procedure may be applied to silica nanoparticles. The new materials were characterized by UV–Vis, IR, and TEM. Graphical Abstract Visible spectra of a water solution of derivatives silica nanoparticles in absence (dash line) and in the presence of arginine or lysine (solid line).
    Journal of Inorganic and Organometallic Polymers and Materials 09/2011; 21(3). DOI:10.1007/s10904-011-9470-1 · 1.16 Impact Factor
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    ABSTRACT: Starting from the Kryptofix 22 azacrown compound, mono-and di-branched derivatives have been synthesized, by coupling with one or two 4-chloro-3,5-dinitrobenzoyl chloride units and then substituting the chlorine(s) on the aromatic ring(s) with methoxyamine. The two new compounds were characterized by IR, NMR, and UV-Vis spectra; they are soluble in organic solvents, yielding a yellow color, which is changing to blue in the presence of a base (such as alkali metal hydroxides), thus acting as colorimetric chemosensors. The ratios of complexation and extraction constants with alkali metal cations were measured.
    03/2011; II(2):343-354.
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 12/2010; 29(49). DOI:10.1002/chin.199849023
  • ChemInform 12/2010; 33(48). DOI:10.1002/chin.200248074
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    ABSTRACT: Starting from 4-chloro-3,5-dinitrobenzoic acid 1, compounds 2–10 (N-alkoxy-3,5-dinitro-4-aminobenzoic acid esters where alkoxy stands for methoxy, carboxymethoxy, triphenylmethoxy, or corresponding amides) have been obtained, from which compounds 3–5 and 7–10 are new, and for the known compounds 2 and 6 the synthetic procedure has been improved. The new derivatives have been characterized by appropriate means (IR, UV–Vis, 1H- and 13C-NMR, fluorescence) and their properties were studied. Thus, depending on their structure, the compounds have acid properties, fluorescence and complexing properties with alkaline cations. Keywords N-Alkoxy-3,5-dinitro-4-aminobenzoic acid derivatives-Fluorescence-Ionophore properties
    Structural Chemistry 12/2010; 21(6):1227-1234. DOI:10.1007/s11224-010-9666-y · 1.84 Impact Factor

Publication Stats

648 Citations
109.23 Total Impact Points


  • 2009–2015
    • University of Bucharest
      • • Department of Organic Chemistry, Biochemistry and Catalysis
      • • Faculty of Chemistry
      • • Department of Inorganic Chemistry
      București, Bucureşti, Romania
  • 2007–2010
    • Texas A&M University - Galveston
      Galveston, Texas, United States
  • 2006–2008
    • Institute of Physical Chemistry
      Bucureşti, Bucureşti, Romania
  • 2000–2008
    • The University of York
      • Department of Chemistry
      York, England, United Kingdom
  • 2002–2005
    • Romanian Academy
      • Institute of Physical Chemistry "Ilie Murgulescu"
      Bucureşti, Hunedoara, Romania