Takahiro Kiuchi

University of Tsukuba, Tsukuba, Ibaraki-ken, Japan

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Publications (31)83.55 Total impact

  • [show abstract] [hide abstract]
    ABSTRACT: PURPOSE: To investigate the influence of decorative lenses on ocular wavefront aberrations. METHODS: A wavefront analyzer was used to measure higher-order aberrations (HOAs) in 20 right eyes of 20 participants while they were wearing Vistacon contact lenses of different designs, namely, clear 1-day Acuvue, ring-design circle 1-day Acuvue Define (Accent style), or spoke-design circle 1-day Acuvue Define (Vivid style). All of these lenses are made of the same materials and have the same lens parameters, except for the tinted design. HOAs induced by each contact lens were measured for 4- and 6-mm pupils. The coma-like, spherical-like, and total HOAs of each lens type were compared. HOAs of well- and poorly fitting lenses were also compared. RESULTS: For a 4-mm pupil, the HOAs of the three lens types did not differ significantly. For the 6-mm pupil, coma-like and total HOAs were significantly larger with decorative lenses than with clear lenses (P < 0.05, Bonferroni test). No significant differences were observed between the two types of decorative lenses. Poorly fitting decorative lenses showed significantly larger HOAs than did well-fitting decorative lenses. CONCLUSIONS: Poorly fitting decorative lenses may reduce the quality of vision. Consequently, care should be taken that these lenses are properly centered.
    Japanese Journal of Ophthalmology 03/2013; · 1.27 Impact Factor
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    ABSTRACT: We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measured in 1 control eye and 3 eyes of trabeculectomy model rabbits. Polarization insensitive scattering OCT and the depth-resolved birefringence were measured simultaneously by PS-OCT. Abnormal birefringence was observed in keratoconus cases with advanced thinning and with a rupture of Descemet's membrane. The graft-host interface of the keratoplasty case showed abnormal birefringence. The appearance of abnormal birefringence in the cornea was likely to be an indication of cross-linking of collagen fibrils. The measurement of rabbit showed abnormal birefringence in the scarring eyes. Wide regions of strong birefringence were observed in the eyes of trabeculectomy patients who had high intraocular pressure. Visualization of scarring in bleb by PS-OCT may be useful for the planning of secondary surgery. PS-OCT showed promising for the study and diagnosis diseases related to abnormal fibrous tissues of the cornea and anterior eye segment.
    Biomedical Optics Express 08/2011; 2(8):2392-402. · 3.18 Impact Factor
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    ABSTRACT: To investigate the influence of 2% carteolol long-acting solution (long-acting carteolol) and 0.5% timolol gel-forming solution (timolol gel) on ocular wavefront aberrations. Ocular aberrations were assessed in the right eye of 24 healthy volunteers at baseline and at 2, 5, 10, and 15 min after instillation of long-acting carteolol, timolol gel or physiological saline using the Hartmann-Shack aberrometer. Ten serial measurements were taken over 10 s at each time point, and the root mean square (RMS) of second-, third-, fourth-, and total higher-order aberrations were calculated. The stability index and fluctuation index were also determined. Second-order aberrations did not change significantly after instillation of study eye-drops. Higher-order aberrations increased significantly after instillation of long-acting carteolol and timolol gel. Timolol gel induced significantly larger changes than long-acting carteolol in third-order RMS at 2 min (P = 0.001), fourth-order RMS at 2 (P < 0.001) and 5 (P = 0.013) min, and total higher-order RMS at 2 (P < 0.001) and 5 (P = 0.016) min after instillation, but not at 10 and 15 min after administration. Fluctuation index increased significantly after instillation of each eye-drop (P < 0.001), with significantly larger increases after timolol gel than long-acting carteolol at 2 min (P = 0.005) and 5 min (P = 0.011). No significant changes were observed in stability index. Both topical β blockers with a once-daily dosing regimen temporarily deteriorate optical quality of the eye by increasing higher-order aberrations, and the increases are much larger after instillation of timolol gel than long-acting carteolol.
    Journal of ocular pharmacology and therapeutics: the official journal of the Association for Ocular Pharmacology and Therapeutics 02/2011; 27(2):179-85. · 1.46 Impact Factor
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    ABSTRACT: To investigate the influence of timolol maleate 0.5% gel-forming solution and brinzolamide 1% ophthalmic suspension on contrast sensitivity, ocular higher-order aberration (HOA), and corneal surface light scattering. Prospective, comparative study. Forty normal volunteers were enrolled in this study. We evaluated contrast sensitivity, ocular HOA, and corneal light scattering before and 2, 5, 10, and 15 minutes after instillation of antiglaucoma eyedrops. Contrast sensitivity function was assessed with the CSV-1000RN chart (Vector Vision Co., Greenville, OH). Higher-order aberration was measured for a 4-mm pupil using the Hartmann-Shack aberrometer (KR-9000PW; Topcon, Tokyo, Japan). Corneal surface light scattering was quantitatively evaluated by using the Scheimpflug camera (EAS-1000, Nidek, Aichi, Japan). Time course of changes in contrast sensitivity, ocular HOAs, and corneal light scattering. Both timolol gel-forming solution and brinzolamide significantly decreased contrast sensitivity for at least 5 minutes after instillation (P<0.01). There were no significant differences in contrast sensitivity between the drugs at any time points. Higher-order aberration, such as third- and fourth-order aberrations and total HOAs, significantly increased after instillation of each drug (P<0.001). Timolol gel-forming solution significantly increased HOA up to 5 minutes after instillation (P<0.05), whereas brinzolamide significantly increased HOA for at least 2 minutes after instillation (P<0.001). Corneal surface scattering significantly increased for 5 minutes after instillation of brinzolamide (P<0.01), but not after instillation of timolol gel-forming solution. Both drugs temporarily deteriorate contrast sensitivity function and optical quality of the eye. However, the mechanism underlying contrast sensitivity reduction seems to be different between the drugs. The reduction may be mainly attributed to increased HOA after instillation of timolol gel and increased light scattering after instillation of brinzolamide. The authors have no proprietary or commercial interest in any materials discussed in this article.
    Ophthalmology 11/2010; 117(11):2080-7. · 5.56 Impact Factor
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    Yuichi Kaji, Takahiro Kiuchi, Tetsuro Oshika
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    ABSTRACT: Anti-oxidant activities of adrenergic β-blockers are proposed in various organs. The aim of the present study was to investigate the effect of carteolol hydrochloride, an adrenergic β-blocker, on the production of reactive oxygen species (ROS) and the viable cell number after ultraviolet irradiation of cultured lens epithelial cells (LECs). Cultured LECs were exposed to 0, 10(-5), 10(-4), and 10(-3) M carteolol hydrochloride for 30 min followed by ultraviolet B (UVB) irradiation at intensity of 100, 200, or 400 mJ/cm(2). The amount of ROS in the LECs was measured using dichlorodihydrofluorescein at 30 min after exposure to UVB. In addition, the number of living LECs was counted at 15 h after exposure to UVB. Exposure to 10(-3) M carteolol hydrochloride significantly decreased the amount of ROS after exposure to UVB at intensities of 100, 200, and 400 mJ/cm(2). In addition, 10(-3) M carteolol hydrochloride significantly increased the viable cell number after exposure to UVB at 400 mJ/cm(2). However, 10(-4) and 10(-5)M carteolol hydrochloride had no significant effect on ROS or the viable cell number in LECs. Carteolol hydrochloride protects LECs against UVB irradiation by inhibiting the intracellular production of ROS.
    The Open Ophthalmology Journal 01/2010; 4:60-5.
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    ABSTRACT: Some antiglaucomatous eyedrops can cause blurred vision after application. Contrast sensitivity after application, however, has not been examined. The purpose of this study was to investigate the influence of antiglaucomatous eyedrops on contrast sensitivity function. In 23 eyes of 23 normal volunteers (34.9 +/- 14.5 years [mean +/- SD]), contrast sensitivity was measured before and 2, 5, 10, and 15 minutes after application of antiglaucomatous eyedrops. Three drugs, timolol maleate ion-activated gel, timolol maleate thermosetting gel, and brinzolamide were tested in this study, and the time course of changes in contrast sensitivity after instillation was statistically analyzed and compared between the drugs. All drugs significantly reduced contrast sensitivity function (p<0.001). The reduction in contrast sensitivity persisted for approximately 5 minutes after instillation of timolol maleate ion-activated gel and brinzolamide. For timolol maleate thermosetting gel, the reduction in contrast sensitivity lasted for about 10 minutes, but the reduction immediately (two minutes) after instillation was significantly smaller than that of the other two drugs (p<0.05). Instillation of these three drugs temporarily degrades contrast sensitivity function, leading to blurred vision, which should be sufficiently explained to patients before treatment with these eyedrops.
    Nippon Ganka Gakkai zasshi 12/2009; 113(12):1139-44.
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    ABSTRACT: To investigate the influence of 0.5% timolol gel-forming solution on ocular wavefront aberrations. In 17 normal volunteers, ocular aberration was assessed before and 5 min, 30 min, 1 h, 2 h, 3 h, 6 h and 12 h after instillation of timolol gel-forming solution. Ocular aberration was sequentially measured over a period of 10 s, and the root-mean-square (RMS) of the second-, third-, fourth- and total higher-order aberrations (HOAs) were determined. From the time course of changes in total HOAs in 10 s, the stability index (SI) and fluctuation index (FI) were calculated. The authors also investigated sequential changes in specific Zernike components such as vertical coma, horizontal coma and spherical aberration. No significant changes in second-order RMS were observed (p=0.452, repeated-measures ANOVA). Topical instillation significantly increased HOAs such as third-, fourth- and total higher-order RMS (p=0.023, p=0.007 and p=0.003, respectively). Multiple comparison analysis revealed significant increases in HOAs 5 min after instillation (p=0.005 for third-, p=0.001 for fourth- and p<0.001 for total higher-order RMS, Dunnett post hoc test). FI increased significantly 5 min after instillation (p=0.013), but SI did not change significantly. With respect to sequential changes in specific components, significant changes were observed in vertical coma (p=0.004, repeated-measures ANOVA) and horizontal coma (p=0.005), but not in spherical aberration. Instillation of timolol gel-forming solution significantly degrades optical quality of the eye for approximately 5 min by increasing HOAs, which may cause blurred vision.
    The British journal of ophthalmology 10/2009; 94(4):433-9. · 2.92 Impact Factor
  • Takahiro Kiuchi, Yuta Motoyama, Tetsuro Oshika
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    ABSTRACT: To evaluate whether postural changes of intraocular pressure (IOP) are associated with visual field damage by comparing both eyes of patients with previously untreated normal-tension glaucoma (NTG). Forty eyes of 20 patients newly diagnosed as bilateral NTG were studied. IOP was measured in both sitting and supine positions, and the magnitude of IOP elevation with postural change (ΔIOP) was calculated. Visual field was examined using Humphrey Field Analyzer, and the mean deviation (MD) value was obtained. By comparing ΔIOP between the 2 eyes of a patient, eyes were classified into either small or large ΔIOP group. The MD was compared between these 2 groups. The ΔIOP was 3.2 ± 1.9 mm Hg [mean ± standard deviation (SD)] and 4.5 ± 2.3 mm Hg in the small and large ΔIOP eyes, respectively. The MD in the large ΔIOP eyes [-8.9 ± 6.2 dB (mean ± SD)] was significantly worse than that in the small ΔIOP eyes (-5.9 ± 4.7 dB) (P<0.001). More advanced visual field damage was observed in eyes with greater magnitude of IOP elevation with postural changes. IOP measurement in the supine position at the time of first diagnosis of NTG may facilitate the planning of treatment strategy.
    Journal of glaucoma 06/2009; 19(3):191-3. · 1.74 Impact Factor
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    ABSTRACT: To investigate the internal structures of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography (3-D CAS OCT). Observational case series. Thirty-eight filtering blebs in 31 patients who had undergone trabeculectomy examined retrospectively. Intrableb structures were examined using 3-D CAS OCT. The blebs were classified clinically as successful (intraocular pressure [IOP] <18 mmHg without glaucoma medication) or failed. Bleb structures were assessed in terms of the visibility of the drainage route, scleral flap, and microcysts. The length and height of the internal fluid-filled cavity, maximum and minimum bleb wall thickness, total bleb height, volumes of the internal fluid-filled cavity and hyporeflective area, and number of microcysts were analyzed. Intrableb drainage route, scleral flap, and microcysts were observed in 92.1%, 94.7%, and 86.8% eyes, respectively. The IOP showed a significant negative correlation with horizontal and vertical length of the fluid-filled cavity (Spearman correlation coefficient [r(s)] = -0.634; P<0.0001; and r(s) = -0.539; P = 0.0008, respectively), height of the fluid-filled cavity (r(s) = -0.334; P = 0.031), maximum bleb wall thickness (r(s) = -0.491; P = 0.0023), total bleb height (r(s) = -0.629; P<0.0001), volume of the internal fluid-filled cavity (r(s) = -0.480; P = 0.0029), volume of hyporeflective area (r(s) = -0.443; P = 0.0056), and number of microcysts (r(s) = -0.451; P = 0.0045). There were 26 successful (64.8%) and 12 failed (31.6%) blebs. Significant differences were observed between these groups in IOP (P<0.0001), horizontal and vertical length of the fluid-filled cavity (P<0.0001 and P = 0.0019, respectively), height of the fluid-filled cavity (P = 0.0046), maximum bleb wall thickness (P = 0.0029), total bleb height (P = 0.0003), volume of the internal fluid-filled cavity (P = 0.0006), volume of hyporeflective area (P = 0.0020), and number of microcysts (P = 0.0025). The internal aqueous humor outflow channel and scleral flap could be visualized, and the 3-D volume of the intrableb cavity was calculated using 3-D CAS OCT. The successful blebs exhibited a large internal fluid-filled cavity, an extensive hyporeflective area, and thicker bleb walls with more microcysts. The author(s) have no proprietary or commercial interest in any materials discussed in this article.
    Ophthalmology 03/2009; 116(5):848-55. · 5.56 Impact Factor
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    ABSTRACT: To evaluate trabeculectomy blebs by using 3-dimensional anterior segment optical coherence tomography (OCT). We prospectively examined 4 eyes of 4 patients who developed filtering blebs after trabeculectomy. A 1310-nm high-speed OCT prototype was used to image the 3-dimensional structure of the filtering blebs. The 3-dimensional structure of the filtering blebs was clearly observed in the OCT images. Three types of filtering blebs were observed: diffuse blebs in 2 eyes, an encapsulated bleb in 1 eye, and a nonfunctioning cystic bleb in 1 eye. The volume of each bleb was 9.97, 1.10, 0.76, and 0.88 mm3, respectively. En-face OCT images clearly showed the aqueous outflow channels at the margins of the scleral flaps. Three-dimensional OCT allows objective and noninvasive assessment of filtering blebs after trabeculectomy.
    Journal of Glaucoma 01/2008; 17(3):193-6. · 1.87 Impact Factor
  • Takahiro Kiuchi, Yuta Motoyama, Tetsuro Oshika
    Ophthalmology 12/2007; 114(12):2362. · 5.56 Impact Factor
  • Takahiro Kiuchi, Yuta Motoyama, Tetsuro Oshika
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    ABSTRACT: To investigate the effect of various ocular hypotensive eyedrops on the intraocular pressure (IOP) fluctuations caused by the postural change in patients with normal-tension glaucoma (NTG). Randomized crossover single-blind study. Twenty-four eyes of 24 newly diagnosed NTG patients were enrolled. One of the three eyedrops including timolol maleate, latanoprost, and brinzolamide was randomly administered for one month. Each patient received all three eyedrops with a one-month washout period between the drugs. The IOP at baseline and after each treatment trial was measured in both sitting and supine positions. Compared with the baseline level, the magnitude of IOP elevation associated with the postural change did not alter significantly by the application of any eyedrops (one-way repeated-measures analysis of variance, P = .288). The mechanism of action underlying the IOP change with the postural change is different from the pharmacologic action of these hypotensive agents.
    American Journal of Ophthalmology 05/2007; 143(4):693-5. · 3.63 Impact Factor
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    ABSTRACT: To report a new technique to visualize bleb leakage using indocyanine green (ICG) staining during trabeculectomy. The ICG solution was widely applied over the filtering bleb including the conjunctival wound before completion of trabeculectomy. This procedure was performed in 48 eyes of 44 consecutive patients undergoing trabeculectomy between December 2004 and October 2005. Without staining, bleb leakage was not identified by the direct observation under the operating microscope. ICG staining clearly visualized aqueous leakage from the bleb in 5 eyes (10.4%). The bleb leakage in these eyes was easily repaired with 10-0 nylon sutures, and no eyes, including these 5 cases, showed bleb leakage after surgery. There were no intraoperative and postoperative complications related to ICG application. The application of ICG during trabeculectomy is a simple and useful technique to facilitate detection and repair of the bleb leakage.
    Journal of Glaucoma 04/2007; 16(2):257-9. · 1.87 Impact Factor
  • Takahiro Kiuchi, Yuta Motoyama, Tetsuro Oshika
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    ABSTRACT: To evaluate whether postural changes of intraocular pressure (IOP) are associated with progression of visual field damage in patients with normal-tension glaucoma (NTG). Prospective, noncomparative, nonrandomized study. Sixty eyes of 33 patients with NTG. Intraocular pressure, blood pressure (BP), and pulse rate (PR) were measured in both sitting and supine positions. Visual fields were examined using Humphrey Field Analyzer (HFA; Zeiss-Humphrey Instruments, Inc., San Leandro, CA). Changes in mean deviation (MD) per year (dB/year), that is, MD slope, were calculated by linear regression analysis of the HFA Statpac 2 program. The relationship between postural changes of IOP and MD slope was analyzed. The correlation between postural changes of IOP and cardiovascular parameters such as BP and PR also was analyzed. The IOP in the supine position was significantly higher than that in the sitting position (P<0.001, paired t test). There was no significant correlation between MD slope and sitting IOP (Pearson r = 0.172; P = 0.188), but a significant correlation was found between MD slope and supine IOP (r = -0.261; P = 0.043). The MD slope significantly correlated with IOP elevation caused by the postural change (r = -0.682; P<0.001). The systolic BP in the supine position correlated with postural changes of IOP (r = 0.364; P = 0.004), but other cardiovascular parameters did not correlate with IOP parameters. The progression of visual field damage in NTG is associated with IOP in the supine position and the magnitude of IOP elevation accompanying postural changes. These results suggest that deterioration in NTG may occur when patients are lying flat during sleep.
    Ophthalmology 01/2007; 113(12):2150-5. · 5.56 Impact Factor
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    ABSTRACT: To compare postoperative performance and stability of 6.0-mm optic single- and 3-piece acrylic foldable intraocular lenses (IOLs). Prospective, randomized, self-controlled trial. Eighty eyes of 40 patients with bilateral senile cataracts. Phacoemulsification and IOL implantation were performed. One eye of a patient was randomly assigned to the SA60AT single-piece IOL, and the contralateral eye was allocated to the MA60AC 3-piece IOL. Best-corrected visual acuity (BCVA), spherical equivalent, aqueous flare intensity, anterior chamber depth, amount of IOL decentration and tilt, area of anterior capsule opening, and degree of posterior capsule opacification (PCO) were measured 2 days, 1 week, and 1, 3, 6, and 12 months after surgery. Specular microscopy was performed at 12 months postoperatively. In the SA60AT group, the anterior chamber depth did not show significant changes after surgery (P>0.05; paired t test), and the refraction remained highly stable throughout the 1-year study period. The MA60AC group showed significant shallowing of the anterior chamber (P<0.05) and a myopic shift (P<0.05) up to 1 month after surgery. There were no significant differences between the 2 groups (P>0.05) in BCVA, aqueous flare intensity, the amount of IOL decentration, IOL tilt, area of anterior capsule opening, and degree of PCO throughout the 12-month follow-up period. Both the SA60AT single-piece and MA60AC 3-piece lenses showed a minimum amount of decentration, tilt, anterior capsule contraction, and PCO. Although the MA60AC showed significant forward shift and myopic refractive changes after surgery, the SA60AT displayed little axial movement associated with highly stable refraction after surgery. This feature of the SA60AT should facilitate earlier spectacle prescription and quicker visual/social rehabilitation of patients after cataract surgery.
    Ophthalmology 05/2006; 113(4):585-90. · 5.56 Impact Factor
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    ABSTRACT: To assess the retention and removal properties of a new viscous dispersive ophthalmic viscosurgical device (OVD), DisCoVisc, in comparison with those of cohesive (Provisc), dispersive (Viscoat), and viscoadaptive (Healon5) OVDs. In 20 porcine eyes, cataract surgery was simulated using one of the four OVDs which were stained with fluorescein for better visualisation. Three parameters were measured. Firstly, the presence/absence of OVDs in the chamber at the completion of phacoemulsification was recorded. Secondly, the time until the OVDs were completely removed from the anterior chamber using the phaco needle was measured. Thirdly, after intraocular lens (IOL) implantation, the time needed to completely remove the OVDs from the chamber with irrigation/aspiration tip was recorded. At the completion of phacoemulsification, the OVDs retained in 0% (0/5) for Provisc, 80% (4/5) for Healon5, 100% (5/5) for DisCoVisc, and 100% (5/5) for Viscoat. The retention of OVDs during phacoemulsification was greatest with Viscoat followed by, in descending order, DisCoVisc, Healon5, and Provisc. The removal of OVDs after IOL implantation took longest with Viscoat followed by Healon5, DisCoVisc, and Provisc. The viscous dispersive DisCoVisc showed excellent retention during phacoemulsification, while its removal after IOL implantation was very easy. When compared with the viscoadaptive Healon5, DisCoVisc was retained better in the chamber and was easier to remove. These features of DisCoVisc should be highly advantageous when considering covering the entire cataract surgery procedure with a single OVD.
    British Journal of Ophthalmology 05/2006; 90(4):485-7. · 2.73 Impact Factor
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    ABSTRACT: An 82-year-old woman with age-related cataract and high myopia had uneventful phacoemulsification and intraocular lens (IOL) implantation. Preoperative visual acuity was 20/60 with -16.00 -3.00 x 70 and axial length was 29.29 mm. An IOL (MA60MA, Alcon) of +5.0 diopters (D) was selected with target refraction of -1.5 D. The next day, visual acuity was 20/15 with +5.50 -2.00 x 60. It was found that an IOL of -5.0 D was inadvertently inserted instead of +5.0 D because of an identical package appearance of the opposite-diopter IOLs except for a small negative sign before the diopter label. The -5.0 D IOL was surgically replaced with +5.0 D IOL, and visual acuity became 20/15 with -0.50 -2.00 x 70. When selecting an IOL for highly myopic patients, attention should be paid to the extreme resemblance of the package of opposite-diopter IOLs.
    Journal of Cataract and Refractive Surgery 02/2006; 32(1):166-7. · 2.53 Impact Factor
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    ABSTRACT: To compare corneal thickness measurements using Orbscan II scanning slit topography, Topcon SP-2000P noncontact specular microscopy, and ultrasonic pachymetry in eyes with keratoconus. Central corneal thickness was measured in 22 eyes with keratoconus. Eyes with apparent corneal opacity were excluded. Scanning slit topography, noncontact specular microscopy, and ultrasonic pachymetry were used in this sequence. The acoustic equivalent correlation factor (0.92) was used for Orbscan readings. Three devices gave significantly different corneal thickness readings (P < 0.001, repeated-measure analysis of variance). Measurements with Orbscan scanning slit topography (449.5 +/- 43.2 [SD] mum) were significantly smaller than those of ultrasonic pachymetry (485.0 +/- 29.3 microm; P < 0.001, Tukey multiple comparison) and SP-2000P noncontact specular microscopy (476.7 +/- 28.3 microm; P = 0.002). There were significant linear correlations between ultrasonic pachymetry and scanning slit topography (Pearson correlation coefficient r = 0.741, P < 0.001), between scanning slit topography and noncontact specular microscopy (r = 0.880, P < 0.001), and between noncontact specular microscopy and ultrasonic pachymetry (r = 0.811, P < 0.001). In eyes with keratoconus, Orbscan II scanning slit topography system gave significantly smaller corneal thickness readings than the other 2 devices. Measurements taken by noncontact specular microscopy and ultrasonic pachymetry were comparable. Three devices showed significant linear correlations with one another.
    Cornea 12/2005; 24(8):967-71. · 1.75 Impact Factor
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    ABSTRACT: To report a patient with a significant amount of ocular coma-like aberration that was caused by the tilting of an intraocular lens (IOL) who was treated successfully by IOL repositioning surgical procedure. Interventional case report. At the Department of Ophthalmology, University of Tsukuba, a 52-year-old man complained of unclear and distorted vision in his left pseudophakic eye. The tilt and decentration of IOL were measured with the Scheimpflug videophotography system. Ocular and corneal wavefront aberrations were measured with the Hartmann-Schack aberrometer. The tilting angle was 28.87 degrees, and decentration was 1.78 mm. The ocular coma-like aberration was increased remarkably to 0.451 microm at 4.0 mm aperture diameter, and the simulated retinal image of a Landolt ring was blurred substantially. Ocular spheric-like, corneal coma-like, and corneal spheric-like aberrations were not increased. The IOL repositioning surgery significantly improved the IOL tilt, which resulted in the reduction of ocular coma-like aberration, recovery of simulated retinal image, and resolution of the patient's complaints. Major IOL tilting induces a large amount of ocular coma-like aberration, which deteriorates the patient's quality of vision.
    American Journal of Ophthalmology 11/2005; 140(4):744-6. · 3.63 Impact Factor
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    ABSTRACT: There have been no reports of the topical application of micafungin to the eye. The aim of this study was to evaluate the safety of topical instillation of 0.1% micafungin ophthalmic solution in rabbit eyes. In New Zealand white rabbits (n = 6), 50 microL of 0.1% micafungin solution was topically instilled to 1 eye, and 50 microL of sterile saline was applied to the other eye. Both eyedrops were administered hourly from 7 A.M. for 7 days. Measurements were conducted on corneal thickness, intraocular pressure, endothelial cell density, and lactate dehydrogenase (LDH) activity of tear samples. The eyes were examined slit-lamp biomicroscopically and histopathologically. Topical micafungin application for 1 week did not induce any changes in intraocular pressure, endothelial cell density, and tear LDH. Corneal thickness after instillation was slightly, but significantly, smaller in the micafungin group than in the control group (P = 0.0156, paired t test), but this difference disappeared within 24 hours after the final instillation. Biomicroscopy and histopathology revealed no significant toxic influence of micafungin application on the cornea. Topical instillation of micafungin solution had no apparent toxicity to the cornea. These results warrant future studies on the efficacy of micafungin ophthalmic solution against corneal fungal infection.
    Journal of Ocular Pharmacology and Therapeutics 05/2005; 21(2):149-56. · 1.29 Impact Factor

Publication Stats

373 Citations
83.55 Total Impact Points

Institutions

  • 1996–2011
    • University of Tsukuba
      • Department of Ophthalmology
      Tsukuba, Ibaraki-ken, Japan
  • 2004–2006
    • Miyata Eye Hospital
      Miyakonozyō, Miyazaki, Japan
    • University Hospital Medical Information Network
      Edo, Tōkyō, Japan