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ABSTRACT: There is a wide interpersonal difference to dobutamine response during dobutamine stress echocardiography (DSE). The aim of this study was to determine an association between GNB3 825C>T gene polymorphism, encoding the β3-subunit of G protein, and heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP) response to dobutamine during DSE. The study involved 119 patients with clinical indications for DSE. Genotyping of GNB3 825C>T (rs5443) polymorphism was based on PCR-RFLP method with BseDI restriction enzyme. Significantly higher levels of both resting SBP and DBP in 825T allele carriers vs. 825CC patients were revealed. HR of 825CC vs. CT + TT subjects was slower along the test period reaching marked difference at dobutamine level 30 μg/kg/min (109 ± 20 vs. 116 ± 18 bpm, respectively, p = 0.047). SBP and DBP were markedly lower in 825CC homozygotes compared to 825T allele carriers throughout DSE. It can be concluded that GNB3 825C>T polymorphism is associated with resting SBP and DBP in Polish Caucasian patients subjected for diagnostic DSE. The polymorphism also modulate HR, SBP and DBP response during DSE.
Pharmacological reports: PR 01/2012; 64(1):123-8. · 2.44 Impact Factor
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ABSTRACT: The aim of this study was to determine an association between the ADRB1 1165C>G and 145A>G polymorphisms and hemodynamic response [heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure] to dobutamine during dobutamine stress echocardiography (DSE).
The study involved 144 patients with clinical indications for DSE. The PCR-restriction fragment length polymorphism method was used to identify the ADRB1 1165C>G and 145A>G polymorphisms.
Heart rate during DSE increased in all analyzed study groups. Patients with the ADRB1 1165CC and 1165CG+GG polymorphisms demonstrated similar HR, including magnitude of response [change in heart rate (ΔHR 0-30): 42.1 ± 17.5 vs. 46.1 ± 15.5 bpm, respectively]. HR and ΔHR 0-30 were comparable in ADRB1145AA and 145AG subjects in the course of DSE. SBP and DBP at all stages of DSE were similar in subjects with either polymorphism and did not differentiate patients with the ADRB1 145AA polymorphism from those with the ADRB1 145AG polymorphism, nor those with the ADRB1 1165CC polymorphism from those with the ADRB1 1165CG+GG polymorphism. No differences were noted in the magnitude of response, with the increase in SBP and DBP comparable in all genotypes. Similar observations were made in patients (25/144 studied) with atropine requirements during DSE.
The ADRB1 1165C>G and 145A>G polymorphisms are not associated with the HR, SBP and DBP responses in Polish Caucasian patients requiring diagnostic dobutamine stress echocardiography.
European Journal of Clinical Pharmacology 02/2011; 67(5):477-82. · 2.85 Impact Factor
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ABSTRACT: Assessment of the cerebral blood perfusion among patients with eating (ED), anxiety (AD) and depressive disorders (DD), diagnosed according to ICD-10.
57 females and 22 males, aged 17-50 were examined using the Single Photon Emission Computer Tomography (SPECT) and the neuropsychological tests, Benton and Bender. We also used the Beck Depression Inventory, the Hospital Anxiety and Depression Scale, and the Spielberger Self-Evaluation Questionnaire. Electroencephalography was also performed.
In ED, hypoperfusion occurred in 84.21%, and impairment of the central nervous system (CNS), was found in 27.77%, abnormalities in the electroencephalography--in 33.33% of the patients. In AD, hypoperfusion occurred in 72.72%, impairment of CNS--in 40%, abnormalities in EEG--in 48% of patients. In DD, hypoperfusion occurred in 81.48%, impairment of CNS--in 34.61%, abnormalities in EEG--in 38.46% of patients.
Hypoperfusion was observed mostly among patients with ED, mainly in the frontal, temporal areas, and in the thalamus, on the left hand side, similar to DD group. Among patients with AD, hypoperfusion at the left hand side occurred almost three times more frequently than among patients with DD (Chi2 = 6.54, p < .025) and was significant. Anxiety as a trait was the highest in ED, but not significant. Among patients with AD, anxiety as a trait and as a state were almost at the same level.
Psychiatria polska 43(3):329-40. · 0.19 Impact Factor
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Anna Banaś
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ABSTRACT: The long and difficult diagnostic and therapeutic process in a 21 year old patient with hypochondriac disorder was presented. In the past he had the streptococcal throat infection and during 5 years he was diagnosed and treated because of headache, heart, muscles and joints pains. His blood pressure was occasionally high. He had tonsillectomy and his ASO index was high (from 405 IU/ml to 2500 IU/ml). His cranial CT, EEG, ECG were normal. Finally he was diagnosed as having hypochondriac disorder and began psychiatric treatment. Because of lacking improvement in the out-patient therapy he was admitted to the Neurotic Ward of Medical Academy in Gdańsk. The results of cerebral SPECT showed hypoperfusion in different regions (prefrontal, frontal, temporal, parietal, about medial from 5-22%). The antibodies ABA type II/20/, ACA/ CA/ type III /10/, MSA /ASMA/++/ were found. The level of thrombomodulin was 36.64 ng/ ml. Psychological tests (Benton, Bender, MMPI) were normal. In result of the above findings and observation the diagnosis was changed from hypochondriac disorder to secondary immunologic vasculitis. The patient received probably the possibility to be properly treated.
Psychiatria polska 39(4):701-8. · 0.19 Impact Factor
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ABSTRACT: A group of 56 female patients with eating disorders (36 anorexic and 20 bulimic) aged 16-48 (average 23.9) was studied. According to DSM-IV and ICD-10 among anorectic 8 (14.3%) represented restricting type and 28 (50%)-bulimic type, among bulimic-12 (21.4%)-purging type and 8 (14.3%)-nonpurging type. They were treated average 21.5 months in the I Department of Psychiatry Medical University of Gdansk (some of them were outpatients) between 1995-2000. Duration of disorders was 4 months-10 years (X +/- SD33.8 +/- 28.6 months). Follow-up period lasted from 4 months to 2 years. All patients were examined twice time (before and after treatment) with the following methods: Structured Questionnaire, Hospital Depression and Anxiety Scale Beck Depression Inventory (BDI), PIL by Crumbaugh and Maholick, Spielberger Self-Evaluation Questionnaire. The aim of our examination was to define changes in the state of patients after complex treatment (pharmacotherapy and psychotherapy) and important parameters of quality of life in our groups. After complex treatment (pharmacotherapy, individual and group psychotherapy) which lasted average 21.5 months we observed significant improvement of depressive and anxiety symptoms. Pharmacotherapy included tricyclic antidepressants (55.4%), tetracyclic antidepressants (10.7%), SSRI (44.6%), neuroleptics (10.7%), carbamazepine (32.1%). Some patients were treated more than one medicine. We received high correlation between ideal weight and weight after treatment. Therefore we supposed that our complex therapy was effective and improved approval of self-image and weight. Significance of life after treatment depended on intensity of depression in BDI and intensity of anxiety as state. The long lasting complex therapy significantly lowered depressive and anxiety symptoms (in subjective and objective aspects) in our group of patients with eating disorders.
Psychiatria polska 36(6 Suppl):323-9. · 0.19 Impact Factor
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ABSTRACT: The aim of the study was to estimate usefulness of the single photon emission computed tomography (SPECT) for the diagnostics of the depressive disorders, neurotic and eating disorders, and detect the organic factors and correlation between cerebral hypoperfusion and results of Benton's and Bender's tests.
Study of 43 patients (33 women and 10 men) aged 16--59 years (SD+38, 65 +/- 11, 62) which were examined with single photon emission computed tomography (SPECT) and Benton's and Bender's tests during their treatment in the 1st Department of Psychiatry, Medical University in Gdańsk in the years 2000 to 2003. 30 patients were diagnosed with depression (first depressive episodes--8, recurrent depressive disorders--9, organic depression--13), 8--neurotic disorders and 5--eating disorders.
SPECT in 38 (88,37%) cases showed hypoperfusion mostly on the left side and in the frontal region. Hypoperfusion in the recurrent depressive disorders was considerably greater (nearly significant) in comparison with the first depressive episodes. The correlation between hypoperfusion and CNS impairment examined with Benton's and Bender's tests was observed. The correlation coefficient of was 0.6845.
Psychiatria polska 39(3):497-507. · 0.19 Impact Factor
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Anna Banaś
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ABSTRACT: A case of severe organic affective disorder after head trauma with loss of consciousness is presented. While CT in this case was normal, SPECT brain perfusion imaging showed hipoperfusion in the right frontal lobe and the left temporal-parietal region. The psychologic tests: Benton, Bender, MMPI confirmed changes in CNS as well. These findings help to explain the severity and chronicity of disorders and medical certification.
Psychiatria polska 37(5):851-6. · 0.19 Impact Factor
