Weiwei Dong

Shanghai Jiao Tong University, Shanghai, Shanghai Shi, China

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Publications (6)11.24 Total impact

  • Weiwei Dong · Xin Liu · Xiaobo Li · Dajian Yang · Lisheng Ding
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    ABSTRACT: A new triterpene saponin, androsacin (1), along with two known compounds, ardisiacrispin A (2) and saxifragifolin A (3), were isolated from the whole plants of Androsace integra. The chemical structure of the new compound was elucidated as 3β-O-{β-D-glucopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-[O-β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-16α-hydroxy-13β,28-epoxy-olean-30-al on the basis of spectral evidence. Ardisiacrispin A (2) was cytotoxic toward HepG2 cancer cell with the GI(50) value of 1.56μM.
    Fitoterapia 07/2011; 82(5):782-5. DOI:10.1016/j.fitote.2011.04.001 · 2.22 Impact Factor
  • Chunbin YANG · Meicai DENG · Weiwei DONG · Wei JIAO · Runhua LU
    Chinese Journal of Applied and Environmental Biology 06/2010; 2009(3):323-325. DOI:10.3724/SP.J.1145.2009.00323
  • Weiwei Dong · Minjie Li · Dajian Yang · Runhua Lu
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    ABSTRACT: A novel cadinane sesquiterpene with a propan-2-ylidene, named (1R,4R,6S,10R)-1-hydroxy-7(11)-cadinen-5,8-dione (1), and a new sesquiterpene, named (2R,6R,7S,9S)-1(10),4-cadinadiene-2,9-diol (2), were isolated from the ethanol extract of the rhizome of Acorus calamus L. Their structures were elucidated on the basis of spectroscopic data including NMR spectroscopy and X-ray crystallography. The absolute configurations of compounds 1 and 2 were confirmed by comparison of their experimental optical rotations with those obtained from theoretical calculations at the B3LYP/6-311+G (d) level of theory.
    Planta Medica 04/2010; 76(15):1742-5. DOI:10.1055/s-0030-1249833 · 2.34 Impact Factor
  • Source
    Weiwei Dong · Dajian Yang · Runhua Lu
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    ABSTRACT: Three new sesquiterpenes, 1 beta,7 alpha(H)-cadinane-4 alpha,6 alpha,10 alpha-triol (1), 1 alpha,5 beta-guaiane-10 alpha-O-ethyl-4 beta,6 beta-diol (2), and 6 beta,7 beta(H)-cadinane-1 alpha,4 alpha, 10 alpha-triol ( 3), together with 25 known ones, were isolated from the rhizome of Acorus calamus L. Their chemical structures were established on the basis of interpretation of spectroscopic data and comparison with those of the related known compounds.
    Planta Medica 10/2009; 76(5):454-7. DOI:10.1055/s-0029-1186217 · 2.34 Impact Factor
  • Source
    Wei Jiao · Weiwei Dong · Zhefeng Li · Meicai Deng · Runhua Lu
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    ABSTRACT: Two lathyrane diterpenes (1-2) together with previous ones (3-6) were isolated from Euphorbia lathyris. The structures of 1 and 2 were established on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques. Stereo configuration and conformation of 1 and 2 were analyzed by X-ray diffraction for the first time. The configuration of the unique isolathyrol diterpene 2 from the seeds of E. Lathyris, was rectified from S * to R * at C-5. All compounds were examined as modulators of multidrug resistance on MCF-7/ADM cell lines in vitro. Their structure-activity relationship was discussed from aspect of different skeletons. A class of potential P-gp inhibitors with five different types (jokinol, isolathyrol, epoxylathyrol, 7-hydroxylathyrol, lathyrol) was discovered.
    Bioorganic & medicinal chemistry 05/2009; 17(13):4786-92. DOI:10.1016/j.bmc.2009.04.041 · 2.95 Impact Factor
  • Source
    Meicai Deng · Weiwei Dong · Wei Jiao · Runhua Lu
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    ABSTRACT: New eremophilane sesquiterpenes, (3β,6β,8α,10β)-3-acetyl-6,8,10-trihydroxyeremophil-7(11)-eno-12,8-lactone (1), (3β,6β,8β,10β)-3-acetyl-8,10-dihydroxy-6-(2-methyl-1-oxobutoxy) eremophil-7(11)-eno-12,8-lactone (2), (3β,6β,10β)- and (3β,6β,10α)-3-acetyl-6,10-dihydroxyeremophila-7(11),8-dieno-12,8-lactone (3 and 4, resp.), and a dinoreremophilane derivative, (3aR,4R,5S,7aS)-2-acetyl-3a,4,5,6,7,7a-hexahydro-7a-hydroxy-1H-inden-5-yl acetate (5), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR spectra, and the structure of 1 was further confirmed by a single-crystal X-ray diffraction experiment. Among the isolated compounds, lactone 1 exhibited inhibitory activity towards PTP1B with an IC50 value of 1.34 μMin vivo. The other compounds were inactive.
    Helvetica Chimica Acta 03/2009; 92(3):495 - 501. DOI:10.1002/hlca.200800286 · 1.39 Impact Factor

Publication Stats

39 Citations
11.24 Total Impact Points

Institutions

  • 2011
    • Shanghai Jiao Tong University
      Shanghai, Shanghai Shi, China
  • 2009–2010
    • Chinese Academy of Sciences
      Peping, Beijing, China