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Nuklearmedizin 01/2011; 50(6):N64-5. · 1.28 Impact Factor
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ABSTRACT: In this work we aimed to use examples from various fields (physics, medicine and structural biology) and several mathematical libraries for Java (COLT and JLAPACK) to demonstrate the advantages of scientific computing using Java. We also compared the runtimes of different Java compilers (Sun, IBM and Blackdown) and found that IBM's Java compiler results in the smallest CPU time. © 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 18: 495–501, 2010; View this article online at wileyonlinelibrary.com; DOI 10.1002/cae.20217
Computer Applications in Engineering Education 03/2010; 18(3):495 - 501. · 0.33 Impact Factor
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E Dimou,
J Booij,
M Rodrigues,
H Prosch,
J Attems, P Knoll,
B Zajicek,
R Dudczak,
G Mostbeck,
C Kuntner,
O Langer,
T Bruecke,
S Mirzaei
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ABSTRACT: The neurodegenerative disorder Alzheimer's disease (AD) is the most common form of dementia. It is characterized by progressive impairment of cognitive functions and behavior. To distinguish clinically AD from other forms of dementia is an ongoing challenge. In addition, although mild cognitive impairment (MCI) is recognized as a risk factor for dementia, it remains a challenge to predict on an individual level who will convert to become demented. Amyloid beta (Abeta) is one of the crucial pathological findings in AD. Recently, amyloid tracers for PET imaging have been developed successfully which may offer the unique possibility for measuring fibrillar Abeta load in the living brain. Therefore, in the near future positron emission tomography (PET) may become an important tool for in vivo amyloid imaging contributing to early (differential) diagnosis as well as evaluation of treatment response in AD. Moreover, Abeta may play a role in prediction the conversion of MCI to AD. In this paper we review the recent development of the molecular imaging technique PET and its different radiopharmaceuticals on the trail for imaging amyloid in AD and the conversion of MCI to AD.
Current Alzheimer research 07/2009; 6(3):312-9. · 4.97 Impact Factor
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E. Dimou,
J. Booij,
M. Rodrigues,
H. Prosch,
J. Attems, P. Knoll,
B. Zajicek,
R. Dudczak,
G. Mostbeck,
C. Kuntner,
O. Langer,
T. Bruecke,
S. Mirzaei
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ABSTRACT: The neurodegenerative disorder Alzheimer's disease (AD) is the most common form of dementia. It is characterized by progressive impairment of cognitive functions and behavior. To distinguish clinically AD from other forms of dementia is an ongoing challenge. In addition, although mild cognitive impairment (MCI) is recognized as a risk factor for dementia, it remains a challenge to predict on an individual level who will convert to become demented. Amyloid β (Aβ) is one of the crucial pathological findings in AD. Recently, amyloid tracers for PET imaging have been developed successfully which may offer the unique possibility for measuring fibrillar Aβ load in the living brain. Therefore, in the near future positron emission tomography (PET) may become an important tool for in vivo amyloid imaging contributing to early (differential) diagnosis as well as evaluation of treatment response in AD. Moreover, Aβ may play a role in prediction the conversion of MCI to AD. In this paper we review the recent development of the molecular imaging technique PET and its different radiopharmaceuticals on the trail for imaging amyloid in AD and the conversion of MCI to AD.
Current Alzheimer Research 05/2009; 6(3):312-319. · 3.95 Impact Factor
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Acta Medica Austriaca 06/2008; 30(2):33 - 36.
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Nuklearmedizin 02/2008; 47(4):N38. · 1.28 Impact Factor
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ABSTRACT: Dementia, Alzheimer's disease (AD) being the most common cause of it, is a major and growing medical and social problem, particularly in the advanced age, with the highest rate in the population over 75 y. Recent sophisticated therapeutic measures require more sensitive diagnostic tests to recognize early stages of the disease. In this paper, the current neuronuclear imaging literature is reviewed with regard to early and differential diagnosis of dementia. Functional imaging with single photon emission computed tomography (SPECT) and positron emission tomography (PET) could provide the clinician with additional information complementary to morphological assessments, thus contributing to achieve a more adequate diagnosis, and also with information regarding prodromal stages of AD.
Current Alzheimer Research 09/2004; 1(3):219-29. · 3.95 Impact Factor
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ABSTRACT: A reliable assessment of dementia is essential for a differentiated treatment. Recent studies have demonstrated a poor accuracy of clinical criteria for diagnosis of Lewy body dementia. Diffuse Lewy body disease (LBD) is the second most common cause of senile degenerative dementia and is characterized histologically by the occurrence of Lewy bodies in allocortical, neocortical and subcortical structures. Seven male patients (mean age 81 years) with clinically suspected diffuse LBD were investigated with 18F-fluorodeoxyglucose (FDG)-PET using a Siemens ECAT-ART PET-scanner. The 18F-FDG-PET showed a diffuse glucose hypometabolism in the entire cerebral cortex with relative sparing of the primary sensory-motor cortex in all patients. This diffuse metabolic impairment in the entire cortex with relative sparing of central region seems to be a typical pattern for LBD, distinct from Alzheimer's disease.
European Journal of Neurology 10/2003; 10(5):573-5. · 3.69 Impact Factor
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ABSTRACT: Detection of metastatic involvement of lymph nodes is essential for management and prognostic evaluation in breast cancer patients. The success of lymphatic mapping depends on identifying the sentinel lymph node(s) draining the primary tumour. However, when mapping is performed with a radiocolloidal agent, the number of hot lymph nodes varies with the agent and its size, among other factors. In this study, we evaluated prospectively the detection rate of sentinel lymph nodes in breast cancer when injecting large particles (100-600 nm) of human serum albumin colloids (Senti-Scint). In 128 consecutive breast cancer patients without palpable lymph nodes, pre-operative static lymphoscintigraphic mapping of the breast was performed after subcutaneous injection of 15 MBq of the radiocolloid. Lymphoscintigrahic results were compared with intra-operative surgical gamma detection probe and blue dye mapping data. Pre-operative lymphoscintigraphy and surgical gamma detection probe both correctly detected 203 sentinel lymph nodes in 122/128 patients (95%), while blue dye mapping showed only 183 sentinel lymph nodes in 82% of the patients. Only one or two sentinel lymph nodes were identified in each patient, which allowed the surgeon easily to find the sentinel lymph node(s) intra-operatively. In conclusion, lymphoscintigraphy with large particles of human serum albumin colloids is a helpful and reliable procedure for the surgical management of breast cancer.
European journal of nuclear medicine and molecular imaging 07/2003; 30(6):874-8. · 4.99 Impact Factor
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ABSTRACT: Up to now, there has been no software model available that adequately addresses the growing importance of flexibility in using different information tools. Based on Java, Jini technology provides distributed and therefore robust software architecture. In case of an application crash, Jini is able to minimize the damage by adding functions that reverse the effects of the crash. Owing to increasing user mobility, it is necessary to be able to receive location-independent information. The growing use of powerful telecommunications suggests the application of 'wireless application protocol' (WAP) mobile telephones also for medical purposes. This paper presents the application of these new software trends (Jini and wireless application protocol).
Acta Medica Austriaca 02/2003; 30(2):33-6.
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ABSTRACT: Algorithms used to reconstruct single photon emission computed tomography (SPECT) data are based on one of two principles: filtered back projection or iterative methods. In this paper, an evolution strategy (ES) was applied to reconstruct transaxial slices of SPECT data. Evolutionary algorithms are stochastic global search methods that have been used successfully for many kinds of optimization problems. The newly developed reconstruction algorithm consisting of μ parents and λ children uses a random principle to readjust the voxel values, whereas other iterative reconstruction methods use the difference between measured and simulated projection data. The (μ + λ)-ES was validated against a test image, a heart, and a Jaszczak phantom. The resulting transaxial slices show an improvement in image quality, in comparison to both the filtered back projection method and a standard iterative reconstruction algorithm.
IEEE Transactions on Evolutionary Computation 01/2003; · 3.34 Impact Factor
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ABSTRACT: The curative treatment of carcinoma of the rectum in the early stage of the disease is radical local surgery. If there is a solitary liver metastasis, resection is also a curative treatment. This report describes a female patient with rectal carcinoma, in whom a solitary liver metastasis in the left lobe was diagnosed only by FDG-PET and verified at surgery. This case report demonstrates the potential role of FDG-PET even for primary staging in detecting occult hepatic and extrahepatic metastases, thus significantly influencing the therapeutic management and prognosis of these patients.
Der Chirurg 10/2001; 72(9):1058-61. · 0.70 Impact Factor
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The Lancet 10/2001; 358(9287):1102. · 38.28 Impact Factor
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European Journal of Nuclear Medicine 10/2001; 28(9):1437-8.
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New England Journal of Medicine 07/2001; 344(26):2030-1. · 53.30 Impact Factor
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Journal of Nuclear Medicine 06/2001; 42(5):826. · 6.38 Impact Factor
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Journal of Digital Imaging 04/2001; 14(1):49. · 1.25 Impact Factor
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European Journal of Nuclear Medicine 03/2001; 28(2):254.
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Journal of Nuclear Medicine 03/2001; 42(2):390-1. · 6.38 Impact Factor
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ABSTRACT: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.
We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.
Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.
Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.
Neuropsychobiology 02/2001; 43(4):260-4. · 2.67 Impact Factor
