E Marinho

Publications (47)88.64 Total impact

• Article: [Stevens-Johnson syndrome concurrent with primary Epstein-Barr virus infection].

  F Brunet-Possenti, M Steff, E Marinho, B Crickx, V Descamps
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  ABSTRACT: Primary EBV infection mainly affects children and young adults. Most patients present the characteristic triad of fever, pharyngitis and lymphadenopathy. Symptoms may include a morbilliform eruption, occasionally induced by amoxicillin. We report a case of Stevens-Johnson syndrome concurrent with EBV infection. A 17-year-old boy consulted for an eruption suggestive of Stevens-Johnson syndrome, which was supported by the histopathology results. The patient had taken no medication during the previous weeks. Laboratory examinations showed atypical activated T lymphocytes. Serological tests and PCR results confirmed the diagnosis of primary EBV infection. The outcome was spontaneously favorable with only symptomatic treatment being required. Stevens-Johnson syndrome is characterized by "target" lesions and profuse mucous membrane involvement. Stevens-Johnson syndrome is frequently drug-induced, being due less frequently to infections. Stevens-Johnson syndrome is very rarely a manifestation of infectious mononucleosis, with only one case being reported in the literature. When confronted with Stevens-Johnson syndrome without any imputable medication, complete screening for infection should be performed, in particular for primary EBV infection.
  Annales de Dermatologie et de Vénéréologie 02/2013; 140(2):112-5. · 0.72 Impact Factor
• Article: Intravenous immunoglobulins as a treatment of interstitial granulomatous dermatitis with arthritis.

  R Alghamdi, C Bejar, M Steff, L Deschamps, E Marinho, B Crickx, V Descamps
  British Journal of Dermatology 01/2012; 167(1):218-20. · 3.67 Impact Factor
• Article: Granulomatous foreign-body reaction with facial dermal fillers after omalizumab treatment for severe persistent allergic asthma: a case report.

  A Dammak, C Taillé, E Marinho, B Crestani, B Crickx, V Descamps
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  ABSTRACT: Complications with the increased use of dermal fillers and new therapies with immunomodulatory effects may be increasing. We report on a 50-year-old woman who presented disfiguring facial edema 1 month after the initiation of omalizumab treatment for severe persistent allergic asthma. She had received multiple cosmetic filler injections, including hyaluronic acid and calcium hydroxylapatite, for 4 years without any previous side effects. A biopsy of a lip nodule revealed a foreign-body granulomatous reaction. Treatment was with high-dose prednisone and doxycycline, with clinical improvement. As was previously reported with interferon, foreign-body granulomatous reaction may occur with omaluzimab treatment after dermal filler injections.
  British Journal of Dermatology 01/2012; 166(6):1375-6. · 3.67 Impact Factor
• Article: [Melanoma in HIV patients: 14 cases].

  S Qasmi, C Sutra-Loubet, E Maubec, F Boitier, P Duvillard, A Carlotti, E Marinho, S Jacobelli, N Franck, I Gorin, M C Vacher-Lavenu, F Bouscarat, B Crickx, N Dupin, M F Avril
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  ABSTRACT: a clinical study of 14 patients presenting both malignant melanoma and HIV infection, and analysis of the literature to determine the frequency and specific features of this association. ten men and four women of median age 43 years were included. In 50% of cases, the primary melanoma consisted of spreading superficial melanoma with a mean Breslow thickness of 2.83 mm. In two cases, regional lymph node metastasis was discovered but with no primary melanoma being identified. HIV infection was already documented on diagnosis of melanoma in 11 cases, and it was discovered in three cases at the time of surgery for melanoma (treatment of the primary melanoma in two cases, and in one case, regional lymph node dissection two years after the initial diagnosis). Eight patients died within a mean period of 39 months, with melanoma being the cause of death in six cases. Following relapse of melanoma, the course of the disease was severe, with mean stage IV survival of 3.6 months. No response to chemotherapy was observed where such treatment was feasible. the presence of HIV appears to be an aggravating factor for the outcome of metastatic melanoma. our study suggests the importance of clinical examination of pigmented lesions in HIV patients in order to ensure early identification of melanoma.
  Annales de Dermatologie et de Vénéréologie 12/2010; 137(12):769-74. · 0.72 Impact Factor
• Article: [A case of acute and necrotizing cutaneous Mycobacterium marinum infection in a patient treated with infliximab for Crohn's disease].

  A Guyot, E Begon, L Abramowitz, J Landry, E Marinho, V Descamps, B Crickx
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  ABSTRACT: The increasing use of anti-TNFalpha exposes patients to emerging risks, particularly that of infection. We report a case of severe cutaneous Mycobacterium marinum infection in a patient treated with infliximab and we discuss therapeutic options. A man treated with infliximab for Crohn's disease developed a severe cutaneous infection with M. marinum. Despite withdrawal of infliximab and the introduction of triple antibiotic therapy, the patient's lesions worsened and surgical treatment was required. The worsening experienced by our patient 1 week after the beginning of the treatment is comparable with the immune reconstitution syndrome occasionally observed in tuberculosis in immunocompromised hosts, thus raising the question of the potential value of continuing infliximab treatment. Recommendations are needed concerning the prevention and treatment of M. marinum infections in patients on anti-TNFalpha biotherapies.
  Annales de Dermatologie et de Vénéréologie 11/2009; 136(11):806-10. · 0.72 Impact Factor
• Article: [Long-term efficacy of autologous stem cell transplantation for stage IV mycosis fungoides].

  J Di Lucca-Chrisment, E Maubec, M Grossin, E Marinho, B Varet, H Maillard, B Crickx
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  ABSTRACT: Mycosis fungoides during large cell transformation to lymphoma has a poor prognosis with mean survival of 36 months. Autologous stem cell transplantation is rarely proposed in this indication. We report the case of a young man still in complete remission for transformed mycosis fungoides 14 years after autologous stem cell transplantation. A 25-year-old man presenting eczema-like patches since childhood was treated by chemotherapy for multiple lymphadenopathies considered as Hodgkin's lymphoma. He was referred with diffuse skin tumours and infiltrated patches. Histology of tumour samples revealed atypical T-cell infiltrate with epidermotropism and presence of more than 25% of large CD30-positive cells. Non-infiltrated patches showed small T-cell lymphoma with epidermotropism. Histological verification of a previous lymphadenopathy confirmed the diagnosis of transformed mycosis fungoides. Despite multiple courses of chemotherapy, the disease progressed, with neurological involvement in particular. Because of tumour aggressiveness, autologous stem cell transplantation was performed and resulted in rapid regression of the tumours, lymphadenopathy and neurological symptoms. Non-transformed mycosis fungoides patches persisted but were controlled with topical mechlorethamine. This patient is still in complete remission for tumour and extracutaneous lesions 14 years after the autograft. This was probably a case of juvenile mycosis fungoides diagnosed and transformed in adult age. Neurological involvement by mycosis fungoides is rare and usually carries a drastic prognosis. To our knowledge, this is the longest remission of transformed mycosis fungoides seen after autograft. It highlights the value of this method in aggressive transformed mycosis fungoides, especially in patients ineligible for allograft.
  Annales de Dermatologie et de Vénéréologie 11/2009; 136(11):800-5. · 0.72 Impact Factor
• Article: [Multiple papules on a circumcision wound].

  E Marinho, F Bouscarat
  Annales de Dermatologie et de Vénéréologie 03/2009; 136(2):199-201. · 0.72 Impact Factor
• Article: [Pyoderma gangrenosum with aseptic spleen abscess].

  N Brahimi, E Maubec, O Boccara, E Marinho, L Valeyrie-Allanore, C Lecaille, V Sebban, B Hersent, C Picard-Dahan, V Descamps, B Crickx
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  ABSTRACT: Pyoderma gangrenosum is a neutrophilic dermatosis in which systemic involvement is rare. It may be associated with systemic disease. We report a case of pyoderma gangrenosum in the spleen. A 68-year-old man presenting pyoderma gangrenosum with pustules and stage I multiple myeloma was admitted for asthenia and abdominal pain. There were no skin lesions. Laboratory tests showed inflammatory syndrome with polynuclear leucocytes of 25,000/mm(3). CAT scans and abdominal ultrasound revealed a splenic abscess. A spleen biopsy was performed and histological examination showed polynuclear leukocyte infiltration, while cultures were negatives. Diagnosis of pyoderma gangrenosum with splenic involvement was made. Increased systemic corticosteroid therapy produced a successful outcome. Haematological findings remained unchanged. Spleen involvement in pyoderma gangrenosum is very rare and can mimic an infectious process. In such cases, routine screening is essential for associated diseases, particularly haematological malignancies.
  Annales de Dermatologie et de Vénéréologie 02/2009; 136(1):46-9. · 0.72 Impact Factor
• Article: [Melanoma in invisible naevus spilus].

  M Livory, V Descamps, F Pelletier, E Maubec, B Faivre, E Marinho, P Humbert, B Crickx, F Aubin
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  ABSTRACT: Diagnosis of naevus lesions may be complex where they contain little or no pigmentation. Naevus spilus (or naevus on naevus) is, generally, readily identified by the difference in pigmentation between overlying and underlying naevi and healthy skin. Malignant transformation of naevus spilus is rare. We report two cases of melanoma in which surgical procedures revealed underlying melanocyte lesions, diagnosed at histology but undetectable on clinical examination. Two patients were operated for melanoma in which surgery, at a site remote from the melanoma, suggested incomplete relapse despite the fact that previous clinical examination had indicated healthy skin. A diagnosis was made of melanoma in invisible naevus spilus. Diagnosis of melanoma in invisible naevus spilus may be suspected where several naevi are found together in a specific area. The main problem is the therapeutic stance to be adopted since complete excision of the underlying naevi is difficult in practice. Wood's light examination may be helpful.
  Annales de Dermatologie et de Vénéréologie 02/2008; 135(1):48-52. · 0.72 Impact Factor
• Article: [Symptomatic hypokalemia caused by meglumine antimoniate].

  S Bouvresse, E Matichard, E Mahé, E Marinho, A Soria, M Devillière, V Descamps, B Crickx
  Annales de Dermatologie et de Vénéréologie 05/2007; 134(4 Pt 1):387-8. · 0.72 Impact Factor
• Article: [Panniculitis induced by interferon beta-1a vascular toxicity].

  A Soria, E Maubec, M-C Henry-Feugeas, E Marinho, P Le Bozec, M-G Huisse, M-A Pocidalo, V Descamps, B Crickx
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  ABSTRACT: Interferon-beta-1b is a valuable first-line therapy for patients with relapsing-remitting multiple sclerosis. Many non-severe cutaneous reactions to recombinant interferon beta are described at injection sites. Panniculitis after subcutaneous injection of beta interferon is a rare adverse event; we describe two such cases at beta interferon injection sites. Two women aged 22 years and 45 years with severe multiple sclerosis receiving immunotherapy with beta interferon were admitted to an emergency department following the appearance of extremely painful induration at injection sites rendering walking impossible after several months of interferon injections. One of the patients had fever. Histology tests showed vasculitis and capillary thrombosis in one-woman and dermal oedema in the other. MRI scanners showed extensive avascular necrosis of soft tissue without fasciitis in both patients. Interferon withdrawal and surgical debridement was carried out in one case and beta interferon was successfully reintroduced in both cases. Only two cases have been reported of panniculitis induced by subcutaneous beta interferon injection. Clinically, such cases may mimic infectious processes. The present cases show that MRI may be useful in diagnosis and that the vascular toxicity of interferon beta probably plays a role in panniculitis. Temporary withdrawal of treatment, rotation of several injection sites and alternative routes of administration may all be proposed.
  Annales de Dermatologie et de Vénéréologie 05/2007; 134(4 Pt 1):374-7. · 0.72 Impact Factor
• Article: [Haemolytic uremic syndrome and acute mesenteric ischemia caused by interferon-alpha-2b in the treatment of Kaposi's sarcoma in an AIDS patient].

  I Zaraa, E Maubec, L Valeyrie-Allanore, M Essig, A Charachon, D Chosidow, M-P Debray, E Marinho, C Picard-Dahan, V Descamps, B Crickx
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  ABSTRACT: Interferon alpha is approved for the treatment of Kaposi's sarcoma in HIV infected patients. Hemolytic and uremic syndrome (HUS) is a rare side-effect of interferon alpha and has been reported primarily in chronic myelogenous leukemia. A 44-year-old HIV-infected woman from Cameroon was admitted for treatment of cutaneous Kaposi's sarcoma. Two days later, she presented severe HUS. Abdominal pains subsequently revealed non-occlusive mesenteric ischemia. The patient rapidly improved after interferon withdrawal. To our knowledge this is the first case of HUS induced by interferon alpha given for Kaposi's sarcoma. Further, no cases of acute mesenteric ischemia have been reported with interferon alpha. It is possible that the condition may have been induced or aggravated by HUS or a low infusion rate. Interferon can exert vascular toxicity on both the mesenteric vessels and the renal vessels in a setting of microangiopathy.
  Annales de Dermatologie et de Vénéréologie 02/2007; 134(1):65-7. · 0.72 Impact Factor
• Article: [Multinucleate cell angiohistiocytoma].

  I Zaraa, E Maubec, M-D Vignon-Pennamen, E Marinho, E Matichard, V Descamps, B Crickx
  Annales de Dermatologie et de Vénéréologie 06/2006; 133(5 Pt 1):496-7. · 0.72 Impact Factor
• Article: [Facial rash in a pregnant woman].

  Y Lounis, L Valeyrie-Allanore, C Picard-Dahan, E Marinho, V Descamps, B Crickx
  Annales de Dermatologie et de Vénéréologie 04/2006; 133(3):283-5. · 0.72 Impact Factor
• Article: [MALT (Mucosal Associated Lymphoid Tissue) lymphoma of the palpebral conjunctiva].

  A Cauvain, A Delmer, M-J Godeau, T Molina, C Durdux, E Marinho, B Crickx, V Descamps
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  ABSTRACT: MALT (Mucosal Associated Lymphoid Tissue) lymphomas of the conjunctiva belong to the extranodal marginal zone B-cell lymphomas. This site, while standard, is uncommon. A pink papular tumor developed on the lower eyelid of a 59-year-old woman. Sarcoidosis was diagnosed 9 years earlier associated with mediastinal lymphadenopathy and erythema nodosum not requiring treatment. Histological examination yielded a diagnosis of conjunctival MALT lymphoma. No visceral involvement was demonstrated. Radiotherapy (30 Gy) induced a complete response. A remote lesion developed on the patient's arm 18 months later. No other sites were found. Further radiotherapy (26 Gy) again induced complete remission. No new lesions were seen after 24 months of follow-up. This case is interesting because of the association of a MALT lymphoma and previous sarcoidosis, described in the literature as "sarcoidosis-lymphoma syndrome". Association of sarcoidosis with MALT lymphoma is infrequent. Treatment of conjunctival MALT lymphoma is standardized. Radiotherapy offers excellent efficacy and is well tolerated at this site. Regular and long-term follow-up is required. Local and distant relapse can occur.
  Annales de Dermatologie et de Vénéréologie 03/2006; 133(2):168-70. · 0.72 Impact Factor
• Article: Docetaxel in anthracycline-pretreated AIDS-related Kaposi's sarcoma: a retrospective study.

  J Autier, C Picard-Dahan, E Marinho, M Grossin, P Yeni, C Leport, J-L Vildé, B Crickx, V Descamps
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  ABSTRACT: Kaposi's sarcoma (KS) is a potentially life-threatening multifocal neoplasm. Despite the significant decline in the incidence of acquired immune deficiency syndrome (AIDS)-related KS with the use of highly active antiretroviral therapy (HAART), some patients, even those with a good immune restoration, still have aggressive disease. Liposomal anthracyclines or combination chemotherapy are widely used but adverse effects limit their utilization. We studied the efficacy and tolerance of docetaxel in the treatment of AIDS-related KS after pretreatment with anthracycline. PATIENTS/METHODS AND MAIN OUTCOME MEASURE: A retrospective cohort study was done. Nine human immunodeficiency virus (HIV)-infected patients were treated from 1997 to 2002 with docetaxel. Tumour response was evaluated using the AIDS Clinical Trial Group (ACTG) staging criteria. Clinical and biological toxicity was evaluated. AIDS status with HIV viral load and CD4 T-cell count were measured at the beginning and at the end of the treatment. A major (complete or partial) response and a stabilization of the disease were demonstrated in seven and two patients, respectively. Grade 4 neutropenia and thrombocytopenia were observed in four of nine and one of nine patients, respectively. One patient died after sepsis. Docetaxel has a good and rapid efficacy in anthracycline-pretreated patients with severe AIDS-related KS. Phase II/III trials should be done to compare docetaxel with liposomal anthracyclines as a first-line treatment.
  British Journal of Dermatology 06/2005; 152(5):1026-9. · 3.67 Impact Factor
• Article: [Purplish nodules on the arms].

  D Farhi, C Picard-Dahan, E Marinho, T Petit, P Oberlin, V Descamps, B Crickx
  Annales de Dermatologie et de Vénéréologie 12/2004; 131(11):1005-7. · 0.72 Impact Factor
• Article: [A reticulated, pigmented, erythematous eruption].

  Y-T Nguyen, E Mahe, E Marinho, V Descamps, S Belaich, B Crickx
  Annales de Dermatologie et de Vénéréologie 02/2003; 130(1 Pt 1):63-4. · 0.72 Impact Factor
• Article: [Ectopic breast cancer of the axilla].

  E Amsler, B Sigal-Zafrani, E Marinho, S Aractingi
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  ABSTRACT: Breast cancer is the most frequent cancer occurring in women. These cancers may rarely develop within ectopic breast tissue. We report a case of ectopic axillary lobular carcinoma presenting as an isolated skin lesion with prolonged evolution. A 62 year-old women had a cutaneous lesion located in her left axilla for the past 4 years. The skin biopsy showed an infiltrating lobular carcinoma. A mammogram and an MRI were as unremarkable as two past mammograms performed since the beginning of the skin lesion. Surgical resection with lymph node dissection, associated with radiotherapy and hormonotherapy with tamoxifen, led to complete remission. Ectopic breast tissue is subject to physiological and pathologic changes such as benign or malignant tumours. Cancer occurring in ectopic breast tissue remains rare but this diagnosis must be suspected when confronted with a skin lesion or mass located near the normal breasts.
  Annales de Dermatologie et de Vénéréologie 01/2003; 129(12):1389-91. · 0.72 Impact Factor
• Article: [Hyperpigmentation on black skin].

  L Barthés-Anidjar, I Mimieux, E Marinho, F Prigent, S Havard, C Martinet
  Annales de Dermatologie et de Vénéréologie 05/2002; 129(4 Pt 1):443-5. · 0.72 Impact Factor